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MECHANISMS OF INTERNAL TRANSPORT 
Several types of internal transport have 
evolved in animals 
• In cnidarians and 
flatworms, the 
gastrovascular cavity 
functions in both 
– digestion 
– internal transport 
Figure 23.2A 
Mouth 
Circular 
canal
Simple organisms 
When your body is only 2-cell layers thick, you can get 
supplies in and waste out just through diffusion 
– all cells within easy reach of fluid 
Jellyfish Hydra
Circulatory systems 
• All animals have: 
– muscular pump = heart 
– tubes = blood vessels 
– circulatory fluid = “blood” 
open closed 
hemolymph blood
• Most animals have a separate circulatory system, 
either open or closed 
• Open systems 
– A heart pumps blood through open-ended 
vessels into spaces between cells 
Figure 23.2B 
Pores 
Tubular heart
• Closed systems 
– A heart pumps blood through arteries and 
capillary beds 
– The blood returns to the heart via veins 
Artery 
(O2-rich blood) 
Arteriole 
Capillary beds 
Venule 
Vein 
Atrium 
Ventricle 
Heart 
Artery 
(O2-poor blood) 
Gill 
capillaries
Two-chambered heart 
• The simplest vertebrate 
heart is the two-chambered 
heart, seen 
in fishes. 
• A single atrium receives 
blood from the body 
cells. A ventricle sends 
blood to the gills to 
collect oxygen.
Three-chambered heart 
• Separate atria allow 
some separation of 
oxygenated and 
deoxygenated blood, 
which was an advantage 
for land organisms 
(reptiles, amphibians). 
• Though blood can mix in 
the ventricle, mixing is 
minimal. Some reptiles 
have partial separation of 
the ventricle.
Four-chambered heart 
• The four-chambered 
heart, seen in birds and 
mammals, allows 
complete separation of 
oxygenated and 
deoxygenated blood. 
• Complete separation is 
necessary to support a 
fast metabolism found 
in homeotherms.
Evolution of circulatory system 
fish amphibian reptiles birds & mammals 
2 chamber 3 chamber 3 chamber 4 chamber 
A A 
V 
A A A A 
V V V V 
V 
A 
Not everyone has a 4-chambered heart
• The cardiovascular system of land vertebrates 
has two circuits 
• The pulmonary circuit 
– conveys blood between 
the heart and gas-exchange 
tissues 
• The systemic circuit 
– carries blood between 
the heart and the rest 
of the body 
Lung capillaries 
PULMONARY 
CIRCUIT 
A 
V 
Right 
SYSTEMIC 
CIRCUIT 
A 
V 
Left 
Systemic capillaries
Blood clots plug leaks when blood vessels 
are injured 
Figure 23.16B 
• When a blood vessel 
is damaged, platelets 
respond 
– They help trigger the 
formation of an 
insoluble fibrin clot 
that plugs the leak
Figure 23.16A 
1 2 Platelet plug forms 3 Fibrin clot traps 
Injury to lining of blood 
vessel exposes connective 
tissue; platelets adhere 
Platelet releases chemicals 
that make nearby platelets sticky 
blood cells 
Connective 
tissue 
Platelet 
plug 
Clotting factors from: 
Platelets 
Damaged cells 
Calcium and 
other factors 
in blood plasma 
Prothrombin Thrombin 
Fibrinogen Fibrin
Connection: Stem cells offer a potential cure for 
leukemia and other blood cell diseases 
Figure 23.17 
• All blood cells develop 
from stem cells in bone 
marrow 
– Such cells may prove 
valuable for treating 
certain blood disorders
BLOOD GROUP SYSTEM
The Rh Factor 
Rh-Positive Rh-Negative 
Contains the Rh antigen No Rh antigen 
Will make antibodies 
if given Rh-positive blood 
Agglutination can 
occur if given Rh +ve blood 
Clinically, it is 
very important 
for a female to 
know her Rh type 
if she becomes 
pregnant.
Circulatory System 
Blood Vessels
Blood vessels 
arteries 
arterioles 
capillaries 
venules arterioles 
venules 
artery 
veins 
veins
Arteries: Built for their job 
• Arteries 
– blood flows away from heart 
– thicker walls 
• provide strength for high pressure 
pumping of blood 
– elastic & stretchable 
• maintains blood 
pressure even 
when heart relaxes
Major arteries 
to brain & left arm to right arm 
pulmonary 
artery 
aorta carotid = to head 
pulmonary 
artery = 
to lungs 
coronary 
arteries 
to body
Coronary artery bypass 
bypass surgery
Veins: Built for their job 
• Veins 
– blood returns back to heart 
– thinner-walled 
• blood travels back to heart 
at low speed & pressure 
• why low pressure? 
– far from heart 
• blood flows because muscles 
contract when we move 
– squeeze blood through veins 
– valves in large veins 
Blood flows 
toward heart 
Open valve 
Closed valve 
• in larger veins one-way valves 
allow blood to flow only toward heart 
• Presence of deoxygenated blood imparts bluish black 
color to veins
Major Veins 
pulmonary 
vein = 
from lung 
superior 
vena cava = 
from 
upper body 
pulmonary 
vein = 
from lung 
inferior 
vena cava = from lower body
Structure-function relationship 
• Capillaries 
– very thin walls 
– allows diffusion of 
materials across capillary 
• O2, CO2, H2O, 
food, waste 
• Very slow movement 
• Artery—arterioles— 
capillaries--veins--venules 
body cell 
O2 
food 
waste 
CO2
Location of Heart in Thorax
Layers of 
Heart 
• Epicardium (most superficial) 
– Visceral pleura 
• Myocardium (middle layer) 
– Cardiac muscle 
– Contracts 
• Endocardium (inner) 
– Endothelium on CT 
– Lines the heart 
– Creates the valves
Pulmonary 
artery 
Superior 
vena cava 
RIGHT 
ATRIUM 
Pulmonary 
veins 
Semilunar 
valve 
Atrioventricular 
valve 
Inferior 
vena cava 
Aorta 
Pulmonary 
artery 
LEFT 
ATRIUM 
Pulmonary 
veins 
Semilunar 
valve 
Atrioventricular 
valve 
RIGHT 
VENTRICLE 
LEFT 
VENTRICLE
Aorta 
3 2 
RIGHT VENTRICLE 
1 
Capillaries 
of right lung 
Capillaries 
of left lung 
3 
4 
LEFT ATRIUM 
5 
LEFT VENTRICLE 
6 
7 
Capillaries of 
Head and arms 
8 
Capillaries of 
abdominal organs 
and legs 
9 
Superior 
vena cava 
10 
Inferior 
vena cava 
11 
RIGHT ATRIUM 
Pulmonary 
vein 
Aorta 
Pulmonary 
vein 
Pulmonary 
artery 
Pulmonary 
artery
The heart contracts and relaxes rhythmically 
• Diastole 
– Blood flows from the 
veins into the heart 
chambers 
SYSTOLE 
Figure 23.6 
Heart is 
relaxed. 
AV valves 
are open. 
1 2 
3 
Atria 
contract. 
Ventricles 
contract. 
Semilunar 
valves 
are open. 
DIASTOLE 
0.4 sec 
0.1 sec 
0.3 sec 
• Systole 
– The atria briefly 
contract and fill the 
ventricles with blood 
– Then the ventricles 
contract and propel 
blood out
Mammalian Conducting Pathways 
SA node initiates the action potential 
◦Depolarization spreads rapidly via internodal 
pathway through the walls of the atria. 
• Depolarization reaches atrioventricular (AV) 
node which communicates signal to the 
ventricle. 
• AV node causes signal delay 
◦allows atrium to finish contracting before 
ventricles contract.
Cardiac Output 
Cardiac Output (CO) = the amount of blood 
that the heart pumps per unit time. 
• CO = HR x SV 
• Heart rate (HR) =(72) beats per minute 
• Stroke volume (SV) = (80cm3)amount of 
blood pumped per beat
Circulation of Blood 
• 2 part system 
– Circulation to lungs 
• blood gets O2 from lungs 
• drops off CO2 to lungs 
• brings O2-rich blood from lungs to 
heart 
– Circulation to body 
• pumps O2-rich blood to body 
• picks up nutrients from digestive 
system 
• collects CO2 & cell wastes 
lungs 
heart 
body 
Circulation 
to lungs 
Circulation 
to body
Cardiovascular Blood Flow 
• HeartArteries(conducting-distributing) 
ArteriolesCapillaries of tissues 
• At Capillaries O2 is delivered and CO2 picked up 
• CapillariesVenulesVeinsHeart 
• Portal System: Special vascular circulation where blood 
goes through 2 capillary beds before returning to the heart 
to achieve other function. Begins and end in capillaries. 
– (eg) Hepatic Portal System: aids digestion by picking up digestive 
nutrients from stomach + intestines and delivers to liver for 
processing/storage 
– Pick-up occurs at capillaries of stomach and intestine 
– Via Hepatic Portal Vein goes to capillaries of liver 
– Via Hepatic Vein blood goes back to heart
Hepatic Portal System
Tissue Fluid
Tissue Fluid 
• What is the role of tissue fluid? 
It is the fluid which allows the exchange of 
substances between the blood and cells 
• What substances are found in tissue fluid? 
glucose, amino acids, fatty acids, salts and 
oxygen = all delivered to the cells. 
carbon dioxide and other waste substances = 
removed from the cells.
Return of tissue fluid 
• Most tissue fluid is returned to the blood 
plasma via the capillaries. 
– Hydrostatic pressure at the venule end of the 
capillary is higher outside the capillary and tissue 
fluid is forced back in. 
– Osmotic forces (resulting from the proteins in the 
plasma) pull water back into capillaries. 
• Remaining tissue fluid enters the lymph 
vessels – drain back into the veins close to the 
heart.
Lymph 
• Lymph is moved by: 
– Light yellow viscous fluid formed from tissue fluid 
by special lymph capillaries for passage into 
venous blood. 
– No venous blood, no platelets, lymphocytes and 
WBC present. 
– Contraction of body muscles (aided by valves in 
the lymph vessels)
42 
Lymphatic System 
• One way system: to the 
heart 
• Return of collected 
excess tissue fluid 
• Return of leaked protein 
• “Lymph” is this fluid 
• Edema results if system 
blocked or surgically 
removed
Lymph System
44 
Lymphoid Organs 
• Lymph nodes 
• Spleen 
• Thymus 
• Tonsils 
• Small intestine & 
appendix aggregated 
lymphoid nodules
45 
• Lymph capillaries 
– Have one way minivalves allowing 
excess fluid to enter but not leave 
– Picks up bacteria and viruses as well as 
proteins, electrolytes and fluid 
(lymph nodes destroy most pathogens)
46
47 
• Lymph capillaries 
– Absent from bone, bone marrow, teeth, CNS 
– Enter lymphatic collecting vessels 
• Lymphatic collecting vessels 
– Similar to blood vessels (3 layers), but thin & delicate 
– Superficial ones in skin travel with superficial veins 
– Deep ones of trunk and digestive viscera travel with deep 
arteries 
– Very low pressure 
– Distinctive appearance on lymphangiography 
– Drain into lymph nodes
48 
• Lymph nodes: bean shaped organs along 
lymphatic collecting vessels 
• Up to 1 inch in size 
• Clusters of both deep and superficial LNs
Congenital Heart Disease 
• One of most common congenital 
abnormalities 
– 8 in 1000 live births 
• Cause usually unknown 
• Defects develop in 1st 10 weeks 
• Malrotation defects 
• Expansion defects 
• Septal defects
Malformations with Obstruction to Flow 
• Embryonic vessels fail to expand properly 
• Coarctation of the aorta 
– high BP in arms but low BP in legs 
– low blood flow to kidneys 
– 50% of cases also have PDA
Pericardial Disease 
• Pericarditis 
– usually viral infection 
– atypical chest pain 
– friction rub 
• Pericardial effusion 
– may occur in noninflammatory conditions 
– hemopericardium
Complex Permanent Tissue 
Vascular Tissues -: 
 Specialized for long-distance transport of water and dissolved 
substances. 
 Contain transfer ceIIs, fibers in addition to parenchyma and 
conducting ceIIs 
 Location- the veins in Ieaves 
A. XYLEM or WOOD 
GW xyIos w/c means “wood” 
 transports water and dissolved nutrients from the roots to aII parts of a plant. 
direction of transport is upward. 
Tracheids 
Vessels 
Xylem fibres or collenchyma 
Xylem parenchyma 
Living 
Dead
• Tracheids 
– Characteristics 
 tapered elongated cells 
dead at functional maturity 
connect to each other through pits 
secondary cell walls strengthened with lignin 
– Functions 
 transport of water & dissolved minerals(?) from cell to cell via pits. 
Support 
• Vessel Elements 
– Characteristics 
Long tube like and wider than tracheids 
possess thinner cell walls than tracheids 
Aligned end-to-end to form long water-pipes 
dead at functional maturity 
– Functions 
 transport of water plus dissolved minerals 
support
• Xylem fibre: 
 Dead, lignified sclerenchymatous cells supportive in funtion. 
• Xylem Parenchyma: 
 Living parenchymatous cells – helps in storage of food 
 Lateral conduction of sap.
B. PhIoem 
 Greek word phloios meaning, “bark” 
 transports dissolved organic / food materials from the Ieaves to the 
different parts of the plant 
 glucose in phloem moves in aII directions 
• Sieve tubes 
• Companion cells 
• Phloem parenchyma 
• Phloem fibres 
Living 
Dead
• Sieve-tube Members 
– Characteristics 
 living cells arranged end-to-end to form food-conducting cells of 
the phloem 
 lack lignin in their cell walls, perforated walls made sieve plate 
mature cells lack nuclei and other cellular organelles 
 alive at functional maturity 
– Functions 
transport products of photosynthesis 
• Companion Cells 
– Characteristics 
• living cells adjacent to sieve-tube members 
• connected to sieve-tube members via plasmodesmata 
– Functions 
• support sieve-tube members 
• may assist in sugar loading into sieve-tube members
Transport in plants 
• Water and mineral nutrients 
must be absorbed by the roots 
and transported throughout the 
plant 
• Sugars must be transported from 
site of production, throughout 
the plant, and stored
Osmotic potential, solutes, and water 
movement
Low Ψp High Ψp
lower ψ 
lower ψ 
low ψ 
Transpiration 
creates tension 
higher ψ 
cohesion 
higher ψ 
higher ψ 
lower ψ higher ψ highest ψ
Cells turgid/Stoma open Cells flaccid/Stoma closed 
Radially oriented 
cellulose microfibrils 
Cell 
wall 
Vacuole 
Guard cell 
Changes in guard cell shape and stomatal opening 
and closing (surface view). Guard cells of a typical 
angiosperm are illustrated in their turgid (stoma open) 
and flaccid (stoma closed) states. The pair of guard 
cells buckle outward when turgid. Cellulose microfibrils 
in the walls resist stretching and compression in the 
direction parallel to the microfibrils. Thus, the radial 
orientation of the microfibrils causes the cells to increase 
in length more than width when turgor increases. 
The two guard cells are attached at their tips, so the 
increase in length causes buckling. 
(a) 
H2O 
H2O 
H2O 
K+ 
H2O H2O 
Role of potassium in stomatal opening and closing. 
The transport of K+ (potassium ions, symbolized 
here as red dots) across the plasma membrane and 
vacuolar membrane causes the turgor changes of 
guard cells. 
(b) 
H2O H2O 
H2O 
H2O 
H2O
How do plants regulate the transport of xylem sap? 
Stomata 
K+ is actively transported into and out of guard cells
How do plants regulate the transport of xylem sap? 
Stomata 
When [K+] is high, the amount of H20 is high, 
and guard cells open stomata
How do plants regulate the transport of xylem sap? 
Stomata 
When [K+] is low, the amount of H20 is low, 
and guard cells close stomata
How do plants regulate the transport of xylem sap? 
Stomata 
Light stimulates the uptake of K+ by 
guard cells, opening stomata
How do plants regulate the transport of xylem sap? 
Stomata 
Low [CO2] stimulates the uptake of K+ by 
guard cells, opening stomata
How do plants regulate the transport of xylem sap? 
Stomata 
Low H2O availability inhibits the uptake of K+ by 
guard cells, closing stomata
Adhesion and Cohesion Theory 
• Cohesion: polar 
water molecules 
tend to stick 
together with 
hydrogen bonds. 
• Adhesion: water 
molecules tend to 
stick to polar 
surfaces.
• Cohesion and 
adhesion cause 
water to “crawl” 
up narrow tubes. 
The narrower 
the tube the 
higher the same 
mass of water 
can climb. 
• Maximum 
height: 32 feet.
How do roots absorb water and minerals? 
• Roots absorb water and minerals in a 4-step 
process: 
– Active transport of minerals into root hairs. 
– Diffusion to the pericycle. 
– Active transport into the vascular cylinder. 
– Diffusion into the xylem.
How do roots absorb water and minerals? 
Symplastic route: 
Active transport occurs through 
proton pumps, that set up 
membrane potentials, that 
drive the uptake of mineral ions
How do roots absorb water and minerals? 
Apoplastic route: 
Some water and dissolved 
minerals passively diffuse into 
cell walls
How do roots absorb water and minerals? 
Solutes diffuse through the cells (or cell walls) of 
the epidermis and cortex (the 
innermost layer of which 
is the endodermis)
How do roots absorb water and minerals? 
The final layer of live cells actively transports 
solutes into their cell walls 
Solutes then diffuse into 
xylem vessels to be 
transported upward
How do roots absorb water and minerals? 
The final layer of live cells actively transports 
solutes into their cell walls 
The final layer may be an 
endodermal cell…
How do roots absorb water and minerals? 
The final layer of live cells actively transports 
solutes into their cell walls. 
… or a cell of the pericycle 
(outermost layer of stele)
Water transport
How does phloem transport phloem sap? 
Companion cells actively transport sugars into sieve-tube 
members (elements)
How does phloem transport phloem sap? 
Food (sugars) are then 
translocated from 
sources to sinks 
according to the 
Pressure-Flow Theory: 
1. At sources, sugars 
are actively 
transported into 
phloem
How does phloem transport phloem sap? 
Food (sugars) are then 
translocated from 
sources to sinks 
according to the 
Pressure-Flow Theory: 
2. Water follows by 
osmosis from source 
cells and xylem; 
this creates high 
pressure
How does phloem transport phloem sap? 
Food (sugars) are then 
translocated from 
sources to sinks 
according to the 
Pressure-Flow Theory: 
3. At the sink, sugars 
diffuse out of the 
phloem and water 
follows by osmosis; 
this creates low 
pressure
How does phloem transport phloem sap? 
Food (sugars) are then 
translocated from 
sources to sinks 
according to the 
Pressure-Flow Theory: 
Sugar solution flows 
from high to low 
pressure
How does phloem transport phloem sap? 
Food (sugars) are then 
translocated from 
sources to sinks 
according to the 
Pressure-Flow Theory: 
4. Water may be taken 
up by the transpiration 
stream in the xylem
How does phloem transport phloem sap? 
Pressure-Flow Theory
Circulation in plants and animals
Circulation in plants and animals
Circulation in plants and animals
Circulation in plants and animals

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Circulation in plants and animals

  • 1. MECHANISMS OF INTERNAL TRANSPORT Several types of internal transport have evolved in animals • In cnidarians and flatworms, the gastrovascular cavity functions in both – digestion – internal transport Figure 23.2A Mouth Circular canal
  • 2. Simple organisms When your body is only 2-cell layers thick, you can get supplies in and waste out just through diffusion – all cells within easy reach of fluid Jellyfish Hydra
  • 3. Circulatory systems • All animals have: – muscular pump = heart – tubes = blood vessels – circulatory fluid = “blood” open closed hemolymph blood
  • 4. • Most animals have a separate circulatory system, either open or closed • Open systems – A heart pumps blood through open-ended vessels into spaces between cells Figure 23.2B Pores Tubular heart
  • 5. • Closed systems – A heart pumps blood through arteries and capillary beds – The blood returns to the heart via veins Artery (O2-rich blood) Arteriole Capillary beds Venule Vein Atrium Ventricle Heart Artery (O2-poor blood) Gill capillaries
  • 6. Two-chambered heart • The simplest vertebrate heart is the two-chambered heart, seen in fishes. • A single atrium receives blood from the body cells. A ventricle sends blood to the gills to collect oxygen.
  • 7. Three-chambered heart • Separate atria allow some separation of oxygenated and deoxygenated blood, which was an advantage for land organisms (reptiles, amphibians). • Though blood can mix in the ventricle, mixing is minimal. Some reptiles have partial separation of the ventricle.
  • 8. Four-chambered heart • The four-chambered heart, seen in birds and mammals, allows complete separation of oxygenated and deoxygenated blood. • Complete separation is necessary to support a fast metabolism found in homeotherms.
  • 9. Evolution of circulatory system fish amphibian reptiles birds & mammals 2 chamber 3 chamber 3 chamber 4 chamber A A V A A A A V V V V V A Not everyone has a 4-chambered heart
  • 10. • The cardiovascular system of land vertebrates has two circuits • The pulmonary circuit – conveys blood between the heart and gas-exchange tissues • The systemic circuit – carries blood between the heart and the rest of the body Lung capillaries PULMONARY CIRCUIT A V Right SYSTEMIC CIRCUIT A V Left Systemic capillaries
  • 11.
  • 12. Blood clots plug leaks when blood vessels are injured Figure 23.16B • When a blood vessel is damaged, platelets respond – They help trigger the formation of an insoluble fibrin clot that plugs the leak
  • 13. Figure 23.16A 1 2 Platelet plug forms 3 Fibrin clot traps Injury to lining of blood vessel exposes connective tissue; platelets adhere Platelet releases chemicals that make nearby platelets sticky blood cells Connective tissue Platelet plug Clotting factors from: Platelets Damaged cells Calcium and other factors in blood plasma Prothrombin Thrombin Fibrinogen Fibrin
  • 14. Connection: Stem cells offer a potential cure for leukemia and other blood cell diseases Figure 23.17 • All blood cells develop from stem cells in bone marrow – Such cells may prove valuable for treating certain blood disorders
  • 16. The Rh Factor Rh-Positive Rh-Negative Contains the Rh antigen No Rh antigen Will make antibodies if given Rh-positive blood Agglutination can occur if given Rh +ve blood Clinically, it is very important for a female to know her Rh type if she becomes pregnant.
  • 18.
  • 19. Blood vessels arteries arterioles capillaries venules arterioles venules artery veins veins
  • 20. Arteries: Built for their job • Arteries – blood flows away from heart – thicker walls • provide strength for high pressure pumping of blood – elastic & stretchable • maintains blood pressure even when heart relaxes
  • 21. Major arteries to brain & left arm to right arm pulmonary artery aorta carotid = to head pulmonary artery = to lungs coronary arteries to body
  • 22. Coronary artery bypass bypass surgery
  • 23. Veins: Built for their job • Veins – blood returns back to heart – thinner-walled • blood travels back to heart at low speed & pressure • why low pressure? – far from heart • blood flows because muscles contract when we move – squeeze blood through veins – valves in large veins Blood flows toward heart Open valve Closed valve • in larger veins one-way valves allow blood to flow only toward heart • Presence of deoxygenated blood imparts bluish black color to veins
  • 24. Major Veins pulmonary vein = from lung superior vena cava = from upper body pulmonary vein = from lung inferior vena cava = from lower body
  • 25. Structure-function relationship • Capillaries – very thin walls – allows diffusion of materials across capillary • O2, CO2, H2O, food, waste • Very slow movement • Artery—arterioles— capillaries--veins--venules body cell O2 food waste CO2
  • 26. Location of Heart in Thorax
  • 27. Layers of Heart • Epicardium (most superficial) – Visceral pleura • Myocardium (middle layer) – Cardiac muscle – Contracts • Endocardium (inner) – Endothelium on CT – Lines the heart – Creates the valves
  • 28. Pulmonary artery Superior vena cava RIGHT ATRIUM Pulmonary veins Semilunar valve Atrioventricular valve Inferior vena cava Aorta Pulmonary artery LEFT ATRIUM Pulmonary veins Semilunar valve Atrioventricular valve RIGHT VENTRICLE LEFT VENTRICLE
  • 29. Aorta 3 2 RIGHT VENTRICLE 1 Capillaries of right lung Capillaries of left lung 3 4 LEFT ATRIUM 5 LEFT VENTRICLE 6 7 Capillaries of Head and arms 8 Capillaries of abdominal organs and legs 9 Superior vena cava 10 Inferior vena cava 11 RIGHT ATRIUM Pulmonary vein Aorta Pulmonary vein Pulmonary artery Pulmonary artery
  • 30.
  • 31.
  • 32. The heart contracts and relaxes rhythmically • Diastole – Blood flows from the veins into the heart chambers SYSTOLE Figure 23.6 Heart is relaxed. AV valves are open. 1 2 3 Atria contract. Ventricles contract. Semilunar valves are open. DIASTOLE 0.4 sec 0.1 sec 0.3 sec • Systole – The atria briefly contract and fill the ventricles with blood – Then the ventricles contract and propel blood out
  • 33. Mammalian Conducting Pathways SA node initiates the action potential ◦Depolarization spreads rapidly via internodal pathway through the walls of the atria. • Depolarization reaches atrioventricular (AV) node which communicates signal to the ventricle. • AV node causes signal delay ◦allows atrium to finish contracting before ventricles contract.
  • 34. Cardiac Output Cardiac Output (CO) = the amount of blood that the heart pumps per unit time. • CO = HR x SV • Heart rate (HR) =(72) beats per minute • Stroke volume (SV) = (80cm3)amount of blood pumped per beat
  • 35. Circulation of Blood • 2 part system – Circulation to lungs • blood gets O2 from lungs • drops off CO2 to lungs • brings O2-rich blood from lungs to heart – Circulation to body • pumps O2-rich blood to body • picks up nutrients from digestive system • collects CO2 & cell wastes lungs heart body Circulation to lungs Circulation to body
  • 36. Cardiovascular Blood Flow • HeartArteries(conducting-distributing) ArteriolesCapillaries of tissues • At Capillaries O2 is delivered and CO2 picked up • CapillariesVenulesVeinsHeart • Portal System: Special vascular circulation where blood goes through 2 capillary beds before returning to the heart to achieve other function. Begins and end in capillaries. – (eg) Hepatic Portal System: aids digestion by picking up digestive nutrients from stomach + intestines and delivers to liver for processing/storage – Pick-up occurs at capillaries of stomach and intestine – Via Hepatic Portal Vein goes to capillaries of liver – Via Hepatic Vein blood goes back to heart
  • 39. Tissue Fluid • What is the role of tissue fluid? It is the fluid which allows the exchange of substances between the blood and cells • What substances are found in tissue fluid? glucose, amino acids, fatty acids, salts and oxygen = all delivered to the cells. carbon dioxide and other waste substances = removed from the cells.
  • 40. Return of tissue fluid • Most tissue fluid is returned to the blood plasma via the capillaries. – Hydrostatic pressure at the venule end of the capillary is higher outside the capillary and tissue fluid is forced back in. – Osmotic forces (resulting from the proteins in the plasma) pull water back into capillaries. • Remaining tissue fluid enters the lymph vessels – drain back into the veins close to the heart.
  • 41. Lymph • Lymph is moved by: – Light yellow viscous fluid formed from tissue fluid by special lymph capillaries for passage into venous blood. – No venous blood, no platelets, lymphocytes and WBC present. – Contraction of body muscles (aided by valves in the lymph vessels)
  • 42. 42 Lymphatic System • One way system: to the heart • Return of collected excess tissue fluid • Return of leaked protein • “Lymph” is this fluid • Edema results if system blocked or surgically removed
  • 44. 44 Lymphoid Organs • Lymph nodes • Spleen • Thymus • Tonsils • Small intestine & appendix aggregated lymphoid nodules
  • 45. 45 • Lymph capillaries – Have one way minivalves allowing excess fluid to enter but not leave – Picks up bacteria and viruses as well as proteins, electrolytes and fluid (lymph nodes destroy most pathogens)
  • 46. 46
  • 47. 47 • Lymph capillaries – Absent from bone, bone marrow, teeth, CNS – Enter lymphatic collecting vessels • Lymphatic collecting vessels – Similar to blood vessels (3 layers), but thin & delicate – Superficial ones in skin travel with superficial veins – Deep ones of trunk and digestive viscera travel with deep arteries – Very low pressure – Distinctive appearance on lymphangiography – Drain into lymph nodes
  • 48. 48 • Lymph nodes: bean shaped organs along lymphatic collecting vessels • Up to 1 inch in size • Clusters of both deep and superficial LNs
  • 49.
  • 50. Congenital Heart Disease • One of most common congenital abnormalities – 8 in 1000 live births • Cause usually unknown • Defects develop in 1st 10 weeks • Malrotation defects • Expansion defects • Septal defects
  • 51.
  • 52.
  • 53.
  • 54.
  • 55.
  • 56.
  • 57. Malformations with Obstruction to Flow • Embryonic vessels fail to expand properly • Coarctation of the aorta – high BP in arms but low BP in legs – low blood flow to kidneys – 50% of cases also have PDA
  • 58. Pericardial Disease • Pericarditis – usually viral infection – atypical chest pain – friction rub • Pericardial effusion – may occur in noninflammatory conditions – hemopericardium
  • 59.
  • 60. Complex Permanent Tissue Vascular Tissues -:  Specialized for long-distance transport of water and dissolved substances.  Contain transfer ceIIs, fibers in addition to parenchyma and conducting ceIIs  Location- the veins in Ieaves A. XYLEM or WOOD GW xyIos w/c means “wood”  transports water and dissolved nutrients from the roots to aII parts of a plant. direction of transport is upward. Tracheids Vessels Xylem fibres or collenchyma Xylem parenchyma Living Dead
  • 61. • Tracheids – Characteristics  tapered elongated cells dead at functional maturity connect to each other through pits secondary cell walls strengthened with lignin – Functions  transport of water & dissolved minerals(?) from cell to cell via pits. Support • Vessel Elements – Characteristics Long tube like and wider than tracheids possess thinner cell walls than tracheids Aligned end-to-end to form long water-pipes dead at functional maturity – Functions  transport of water plus dissolved minerals support
  • 62. • Xylem fibre:  Dead, lignified sclerenchymatous cells supportive in funtion. • Xylem Parenchyma:  Living parenchymatous cells – helps in storage of food  Lateral conduction of sap.
  • 63. B. PhIoem  Greek word phloios meaning, “bark”  transports dissolved organic / food materials from the Ieaves to the different parts of the plant  glucose in phloem moves in aII directions • Sieve tubes • Companion cells • Phloem parenchyma • Phloem fibres Living Dead
  • 64. • Sieve-tube Members – Characteristics  living cells arranged end-to-end to form food-conducting cells of the phloem  lack lignin in their cell walls, perforated walls made sieve plate mature cells lack nuclei and other cellular organelles  alive at functional maturity – Functions transport products of photosynthesis • Companion Cells – Characteristics • living cells adjacent to sieve-tube members • connected to sieve-tube members via plasmodesmata – Functions • support sieve-tube members • may assist in sugar loading into sieve-tube members
  • 65.
  • 66. Transport in plants • Water and mineral nutrients must be absorbed by the roots and transported throughout the plant • Sugars must be transported from site of production, throughout the plant, and stored
  • 67. Osmotic potential, solutes, and water movement
  • 69.
  • 70. lower ψ lower ψ low ψ Transpiration creates tension higher ψ cohesion higher ψ higher ψ lower ψ higher ψ highest ψ
  • 71. Cells turgid/Stoma open Cells flaccid/Stoma closed Radially oriented cellulose microfibrils Cell wall Vacuole Guard cell Changes in guard cell shape and stomatal opening and closing (surface view). Guard cells of a typical angiosperm are illustrated in their turgid (stoma open) and flaccid (stoma closed) states. The pair of guard cells buckle outward when turgid. Cellulose microfibrils in the walls resist stretching and compression in the direction parallel to the microfibrils. Thus, the radial orientation of the microfibrils causes the cells to increase in length more than width when turgor increases. The two guard cells are attached at their tips, so the increase in length causes buckling. (a) H2O H2O H2O K+ H2O H2O Role of potassium in stomatal opening and closing. The transport of K+ (potassium ions, symbolized here as red dots) across the plasma membrane and vacuolar membrane causes the turgor changes of guard cells. (b) H2O H2O H2O H2O H2O
  • 72. How do plants regulate the transport of xylem sap? Stomata K+ is actively transported into and out of guard cells
  • 73. How do plants regulate the transport of xylem sap? Stomata When [K+] is high, the amount of H20 is high, and guard cells open stomata
  • 74. How do plants regulate the transport of xylem sap? Stomata When [K+] is low, the amount of H20 is low, and guard cells close stomata
  • 75. How do plants regulate the transport of xylem sap? Stomata Light stimulates the uptake of K+ by guard cells, opening stomata
  • 76. How do plants regulate the transport of xylem sap? Stomata Low [CO2] stimulates the uptake of K+ by guard cells, opening stomata
  • 77. How do plants regulate the transport of xylem sap? Stomata Low H2O availability inhibits the uptake of K+ by guard cells, closing stomata
  • 78. Adhesion and Cohesion Theory • Cohesion: polar water molecules tend to stick together with hydrogen bonds. • Adhesion: water molecules tend to stick to polar surfaces.
  • 79. • Cohesion and adhesion cause water to “crawl” up narrow tubes. The narrower the tube the higher the same mass of water can climb. • Maximum height: 32 feet.
  • 80.
  • 81. How do roots absorb water and minerals? • Roots absorb water and minerals in a 4-step process: – Active transport of minerals into root hairs. – Diffusion to the pericycle. – Active transport into the vascular cylinder. – Diffusion into the xylem.
  • 82.
  • 83.
  • 84. How do roots absorb water and minerals? Symplastic route: Active transport occurs through proton pumps, that set up membrane potentials, that drive the uptake of mineral ions
  • 85. How do roots absorb water and minerals? Apoplastic route: Some water and dissolved minerals passively diffuse into cell walls
  • 86. How do roots absorb water and minerals? Solutes diffuse through the cells (or cell walls) of the epidermis and cortex (the innermost layer of which is the endodermis)
  • 87. How do roots absorb water and minerals? The final layer of live cells actively transports solutes into their cell walls Solutes then diffuse into xylem vessels to be transported upward
  • 88. How do roots absorb water and minerals? The final layer of live cells actively transports solutes into their cell walls The final layer may be an endodermal cell…
  • 89. How do roots absorb water and minerals? The final layer of live cells actively transports solutes into their cell walls. … or a cell of the pericycle (outermost layer of stele)
  • 91. How does phloem transport phloem sap? Companion cells actively transport sugars into sieve-tube members (elements)
  • 92. How does phloem transport phloem sap? Food (sugars) are then translocated from sources to sinks according to the Pressure-Flow Theory: 1. At sources, sugars are actively transported into phloem
  • 93. How does phloem transport phloem sap? Food (sugars) are then translocated from sources to sinks according to the Pressure-Flow Theory: 2. Water follows by osmosis from source cells and xylem; this creates high pressure
  • 94. How does phloem transport phloem sap? Food (sugars) are then translocated from sources to sinks according to the Pressure-Flow Theory: 3. At the sink, sugars diffuse out of the phloem and water follows by osmosis; this creates low pressure
  • 95. How does phloem transport phloem sap? Food (sugars) are then translocated from sources to sinks according to the Pressure-Flow Theory: Sugar solution flows from high to low pressure
  • 96. How does phloem transport phloem sap? Food (sugars) are then translocated from sources to sinks according to the Pressure-Flow Theory: 4. Water may be taken up by the transpiration stream in the xylem
  • 97. How does phloem transport phloem sap? Pressure-Flow Theory