Node.js in 2021 discusses new features in Node.js 14.x and 15.x like multithreading and QUIC support. It also covers challenges for the next decade such as meeting enterprise requirements around reliability and security. Key points of engineering culture with Node.js include recommending layered architectures, solid principles and design patterns, and techniques for handling errors and asynchronous programming. The document provides an example of an onion architecture and new strategies for Node.js applications.