SNC Lavalin Pharmaceutical Brochure

1. SECTORS OF EXPE RTISE
Agriculture
Agrifood
Chemicals and Petroleum
Defence
Environment
Facilities and Operations Management
Industrial and Manufacturing
Infrastructure
Mining and Metallurgy
Pharmaceuticals
Research and Development
Bulk Pharmaceutical Chemicals
Pharmaceuticals
Biotechnology
Support Services
Power
Pulp and Paper
Telecommunications
SOLUTIONS THROUGH
PARTNERING

2. IN NOVATION WITH G LOBAL REACH
SNC-Lavalin is one of the leading groups of engineering and construction
companies in the world, and a global leader in the ownership and manage-
ment of infrastructure. Founded in 1911, SNC-Lavalin is acknowledged for its
world class technical expertise, project and construction management, and
procurement and financial arrangement services – all delivered locally to
clients anywhere in the world through its extensive international network
of offices, partners and suppliers.
SNC-Lavalin Pharma
SNC-Lavalin Pharma, a member of the carry out all stages of project execution, and
EXPERTISE
SNC-Lavalin Group, has over 15 years of global supply specialized expertise for any challenge
• Research and
experience and is one of the world’s leading in the industry.
Development
engineering and construction firms in the life SNC-Lavalin Pharma’s services, combined
• Bulk Pharmaceutical
sciences sector. Its experienced team of over with its expertise, allow it to deliver personalized
Chemicals
700 personnel has met tight deadlines and solutions to its clients. Add to this the innovation
• Pharmaceuticals
technical challenges for companies of all sizes, and creativity that SNC-Lavalin Pharma’s teams
• Biotechnology
including most of the world’s pharmaceutical giants. bring to each mandate, and clients can be
• Support Services
SNC-Lavalin Pharma has a firm understanding assured of customized, leading-edge solutions
of the global market and maintains a broad base that meet their highest expectations.
of expertise in order to be a true single source From traditional fee-per-service, to turnkey
solution for its clients. Working from Centres of mandates, SNC-Lavalin Pharma meets all its
Excellence in Canada, the United States, clients’ needs.
Belgium, France and India, its teams of experts
I N T E R N AT I O N A L N E T WO R K
SNC-Lavalin has been active internationally for 40 years, building a multicultural
network that spans five continents. Today it has offices in major cities across Canada,
and in over 30 countries around the world.
GLOBAL REACH
• Montreal, Canada
• Quebec City, Canada
• Calgary, Canada
• Toronto, Canada
• Philadelphia (Exton), USA
• Brussels, Belgium
• Lyon, France
• Mumbai, India
• SNC-Lavalin International
Network
“SNC-LAVALIN” Reference in this brochure to “SNC-Lavalin” means, as the context may require, SNC-Lavalin Group Inc. and all or some of its subsidiaries or joint ventures,
or SNC-Lavalin Group Inc. or one or more of its subsidiaries or joint ventures.

3. SOLUTIONS TH ROUG H PARTNERING
SNC-Lavalin Pharma’s professionals are market leaders in engineering, construction and
validation projects with expertise in biotechnology and pharmaceutical process engineering,
as well as regulatory compliance.
GLAXOSMITHKLINE (GSK), MERCK FROSST, CANADA
BELGIUM Since 1988, SNC-Lavalin
SNC-Lavalin Pharma has Pharma has successfully
worked in partnership with GSK provided engineering services
on several projects, including for projects valued at over
an EPCMV mandate for a new CAN $250 million, related
state-of-the-art Quality Control to pharmaceutical R&D and
(QC) laboratory. This will production activities for
centralize all QC activities for Merck Frosst in Montreal,
GSK Biologicals in Belgium. Quebec. From project scope
The new facilities represent an definition to project turn over,
investment of approximately SNC-Lavalin Pharma provided
€ 114 million and consist of all services including project
BL2 and BL3 laboratories, management, conceptual
encompassing a total floor surface of 110,000 m2. SNC-Lavalin design, feasibility studies, value engineering, automation, process
Pharma is also developing an additional EPCMV mandate for a new and building design, clean utilities, construction supervision,
Vaccine Production Facility at the GSK Wavre Site, in Belgium. start-up, commissioning and validation.
NOVOCOL PFIZER, FRANCE
PHARMACEUTICAL, SNC-Lavalin Pharma produced
CANADA qualification design-build
SNC-Lavalin Pharma has studies for Pfizer for a fine
worked with Novocol to develop chemistry unit, including
a long-term, multi-phase plant 11 enamelled reactors.
expansion for its Canadian Additional projects included
operations. Each phase the expansion of complementary
increased production capacity facilities, such as a solvent
and improved operational distillation column, a fire
efficiencies. As of early 2005, protection system, and the
the first two phases were addition of HASTELLOY ®
completed as turnkey projects, reactors and drying filters.
which included concept
development, engineering, construction and validation.
SANOFI PASTEUR, SPIMACO, SAUDI ARABIA
CANADA AND USA SNC-Lavalin Pharma has
Since 1997, SNC-Lavalin executed various projects at
Pharma has successfully the Al Qassim SPIMACO plant,
executed a variety of which manufactures oral
engineering and validation liquids and suspensions,
projects, of varying magnitude creams, solid dosage forms
and complexity, for sanofi and injectables. SNC-Lavalin
pasteur. Projects have required Pharma's services have
extensive knowledge of sterile included the design of new
filling requirements, as well as and existing aseptic filling
purification, formulation and suites, biotech suites
freeze drying processes. (including BL2), oral solid
SNC-Lavalin Pharma has also forms cephalosporin production
demonstrated its strengths in packaging, laboratory (BL3), facilities and support infrastructure for manufacturing requirements.
production and warehousing facilities. It also provided construction management and validation services.

4. RIGHT-SIZED SE RVICES FOR INTEG RATE D SOLUTIONS
SNC-Lavalin Pharma’s services may be selected and combined to provide the appropriate solution to
meet its clients’ requirements. SNC-Lavalin Pharma knows that project teams must blend harmoniously
into the structure and culture of client organizations for a successful project outcome. To ensure this, its
projects are executed using a coordinated, multi-disciplinary team that includes client stakeholders
from the outset.
PROCESS ARCHITECTURE FACILITY ENGINEERING
• Definition, URS & Programming • Mechanical, Electrical, Civil, Structural
• General & Equipment Arrangements • Plant & Clean Utilities
• Material & Personnel Flow • IT, Voice, Data, Security
• Construction Documents • Building Automation & Controls
• Site Reviews & Supervision • HAZOP & FMEA
PROCESS ENGINEERING PROCESS AUTOMATION
• Process Definition, URS & FS • Manufacturing Strategy Assessment
• PFD & P&ID • Control/Instrument Gap Analysis
• Equipment & Instrumentation • CSV Life Cycle, GAMP Methodology
• Clean Utilities • MES/SCADA/PIMS/HMI Assessment
• CIP & SIP Systems • PLC & DCS Programming
DESIGN VISUALIZATION ROBOTICS
• 3-D Modeling of Building, Process & Equipment • Opportunity, Feasibility, Simulations & Engineering
• Process & Lighting Simulations • Integration of Peripheral Equipment
• Realistic Visualization • Mechanical & Electrical Design
• Integrating Models into Photographs • Robot, PLC & HMI Programming
• 3-D Animation & Virtual Visits • Manufacturing & Assembly
VALIDATION & COMPLIANCE PROJECT MANAGEMENT
• Quality Systems, Audits, Risk Assessment, Training • EPCMV; Single Source Global Scope
• Process, Equipment, Computer Systems, Facility, • EPCM; Lead Integrated Team
Environmental, Cleaning Validation • Lump Sum Turnkey
• VMP, EDR/DQ, Protocols, SOP • Design + Bid + Build
• PM+ Windows & Planning
PROCUREMENT CONSTRUCTION MANAGEMENT
• Purchasing & Expediting • Sub-Contracting Local Forces
• Material Control & Inspection • Change Control & Reporting
• Logistics Management • Safety & Site Logistics
• Worldwide Staff • Pro-active Build Clean Program
• Network on all Continents • QC and Progress Tracking
FLEXIBILITY TO UNDERTAKE PROJECTS
OF ANY SIZE OR DURATION objectives and technical limitations are carefully evaluated.
A flexible approach to project execution distinguishes SNC-Lavalin This crucial first stage is carried out to exacting standards
Pharma from other large engineering and construction companies. before moving on to the preliminary and detailed engineering,
Project delivery solutions can be standardized or customized, procurement, construction, commissioning, and finally, facility
according to the project schedule, budget, complexity and start-up, validation and operation. This complete scope of project
client requirements. services provides additional depth to the range of technical
SNC-Lavalin Pharma’s project execution methodology services available to its clients.
encompasses all the criteria necessary to meet the business and While SNC-Lavalin Pharma’s corporate capabilities are
technical objectives of the mandate. Its Project Life Cycle begins extensive, it will always choose the solution that best benefits
with early stage feasibility and concept studies where business the client.

5. 360˚ OF COM PLETE MAR KET SOLUTIONS
SNC-Lavalin Pharma provides clients with solutions for the pharmaceutical, biotechnology and life
sciences sectors. In addition to research, clinical supply and clinical trials, it also provides the best
scale-up, manufacturing, packaging and distribution solutions to its clients.
Whether your project is small by industry standards, or a large-scale undertaking, requiring
a long-term commitment, SNC-Lavalin Pharma will put its expertise to work in the most cost effective
and productive manner for you. It will apply its resources and expertise strategically so they are always
tailored to address specific project requirements and challenges, such as critical time-to-market or
budgetary constraints.
RESEARCH & DEVELOPMENT BULK PHARMACEUTICAL CHEMICALS
• Laboratories • Bulk Active, Intermediate & Excipient
• Quality Operations • Non-sterile, Sterile & Aseptic
• High Containment – BL1, 2 and 3 • Pilot Plants and Scale-up
• Pre-Clinical; Clinical – Phase I, II, III
• Kilo & Scale-up
PHARMACEUTICALS BIOTECHNOLOGY
• Solid Dosage • Biopharmaceutical Drug Substances
• Liquids, Creams & Ointments • Clinical Trial Materials
• Sterile Products & Injectables • Blood Products
• Nuclear Medicine • Vaccines
• Diagnostic & Medical Devices
SUPPORT SERVICES
• Packaging • Warehousing • Office & Ancillary Functions • Utilities & Infrastructure • Site Development
FINANCING
SNC-Lavalin Capital Inc., a financing subsidiary of SNC-Lavalin, tailored to the specific needs of each project, regardless of its
has arranged over US $5 billion worth of financing for projects size or location. SNC-Lavalin Capital also offers financing advice
worldwide. Its specialists, based throughout the world, help to third-party clients.
provide financing structures and risk management mechanisms

6. www.snclavalin.com/pharma
Head Office
Telephone:
1-800-505-5651
email: slp@snclavalin.com
NORTH AMERICA EUROPE ASIA
ALLENTOWN MONTRÉAL QUEBEC CITY BRUSSELS MUMBAI
SNC-Lavalin 8000 Decarie Blvd. 5500 des Galeries Blvd. S.A. Coppée-Courtoy N.V. /ICCE SNC-Lavalin
5012 Medical Center Circle 3rd Floor Suite 200 Avenue Louise 251 Engineering & Technology Pvt. Ltd.
Allentown, PA 18106 Montréal, Quebec Quebec City, Quebec Box 16 Mirchandani Business Park
USA Canada H4P 2S4 Canada G2K 2E2 B-1050 Brussels 6th Floor, Sakinaka, Andheri (East)
Belgium Mumbai - 400 072
Telephone: 610-391-1037 Telephone: 514-735-5651 Telephone: 418-621-5500 India
Telephone: (32-2) 643.15.11
Telephone: + 91 22 6720 7000
CALGARY PHILADELPHIA TORONTO LYON SNC-LAVALIN INT’L
Wiebe Forest Engineering SNC-Lavalin 789 Don Mills Road Sogequip S.A./Qualifarm AND PROCUREMENT
3613 - 33rd Street NW 436 Creamery Way, Suite 100 10th Floor C.D.12 Beijing, China
Calgary, Alberta Exton, PA 19341 Toronto, Ontario 69360 Solaize Shanghai, China
Canada T2L 2A7 USA Canada M3C 1T5 France Kuala Lumpur, Malaysia
Jakarta, Indonesia
Telephone: 403-670-7300 Telephone: 610-524-5920 Telephone: 416-422-4056 Telephone: 33 (0) 4 78 02 77 44