Doxycycline Tablets (Doxt-S) are used to treat infections of the nose, ears, lung, skin, bone, stomach and bladder, chest, urethra, womb and rectum. It is also used to treat severe acne, dental infections, sexually-transmitted diseases (STD) such as syphilis or gonorrhoea. It can also be used to treat and prevent malaria as well as anthrax.

1. Doxycycline Tablets
Doxycycline Tablets (Doxt S) is used to treat infections
of the nose, ears, lung, skin, bone, stomach and bladder,
chest, urethra, womb and rectum. Generic Doxycycline
may be used in combination with amoebicides, which are
used to treat parasites.
Doxt S is also used to treat dental infections, sexuallytransmitted diseases (STD) such as syphilis or
gonorrhoea. It can also be used to treat and prevent
malaria as well as anthrax.
Generic Doxycycline may also be used to treat severe
acne.
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2. Doxycycline Tablets
Active Ingredient
The active pharmaceutical ingredients
contained in Doxt S tablets is
Doxycycline Hyclate.
Each 100 mg tablet contains
Doxycycline Hyclate equivalent to 100
mg Doxycycline.
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3. Doxycycline Tablets
Chemical Structure
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4. Doxycycline Tablets
Recommended Dosage
The recommended dosage of Doxycycline tablets is
given below:
➔The recommended adult
dose in adults is 200 mg on
the first day of treatment followed by a maintenance
dose of 100 mg/day. This may be given as either a
single dose or divided doses administered every 12
hours.
➔In the management of more severe infections, 200 mg
daily should be given throughout the treatment period.
Therapy should be continued at least 24-48 hours after
symptoms and fever has subsided. If used in
streptococcal infections, therapy should be continued for
10 days to prevent the development of rheumatic fever
or glomerulonephritis.
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5. Doxycycline Tablets
Recommended Dosage
The recommended dosage of Doxycycline tablets
is given below:
➔For children over 12 years of age, the
recommended dosage schedule for those under 50
kg is 4 mg/kg on the first day and 2 mg/kg daily
subsequently. For children over 50 kg the usual
adult dose is used.
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6. Doxycycline Tablets
Contraindications
contraindicated in
patients with the following conditions:
Doxycycline
tablets
are
Known hypersensitivity to Doxycycline Hyclate or
any inactive component of this medication.
➔Rare cases of benign intracranial hypertension
have been reported after taking tetracyclines and
oral retinoids, such as isotretinoin or etretinate, and
vitamin A. Concomitant treatment is therefore
contraindicated.
➔Doxycycline is contraindicated in children under
the age of 12 years and in pregnancy.
➔
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7. Doxycycline Tablets
Side Effects of Doxycycline Tablets
The most common adverse effects of Doxycycline
tablets are gastrointestinal effects which are
attributed to irritation of the mucosa. Such
effects include anorexia, nausea, diarrhoea,
glossitis,
dysphagia,
enterocolitis
and
inflammatory lesions (with monilial overgrowth)
in the anogenital region.
Instances of oesophagitis and oesophageal
ulceration have been reported. It appears that
most of these patients took doxycycline
immediately before going to bed.
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8. Doxycycline Tablets
Warnings And Precautions
Use of Doxycycline tablets may result in overgrowth of
nonsusceptible
organisms,
including
fungi.
If
superinfection occurs, the antibiotic should be
discontinued and appropriate therapy instituted.
➔Bulging
fontanels in infants and benign intracranial
hypertension in adults have been reported in individuals
receiving tetracyclines. These conditions disappeared
when the medicine was discontinued.
➔Incision and drainage or other surgical procedures should
be performed in conjunction with antibiotic therapy, when
indicated.
➔
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9. Doxycycline Tablets
Warnings And Precautions
Prescribing Doxycycline Hyclate in the absence of
proven or strongly suspected bacterial infection or a
prophylactic indication is unlikely to provide benefit to
the patient and increases the risk of the development
of drug-resistant bacteria.
➔If
you are taking iron or calcium preparations
(including vitamin preparations that contain iron or
calcium) or antacids, you must take them at least two
hours before or two hours after Doxycycline to make
sure there is no problem with absorption.
➔
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10. Doxycycline Tablets
Overdose Symptoms
Tetracyclines, including Doxycycline, generally have
low toxicity.
Severe toxicity following acute overdosage of
Doxycycline tablets is unlikely, with nausea and
vomiting being the most common effects after
ingestion of therapeutic and overdose amounts.
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11. Doxycycline Tablets
Overdose Treatment
Treatment of Doxycycline overdose may include
immediate discontinuation of medication, dilution
with water or milk and general supportive care.
Antacids may be useful in managing gastric
irritation.
In most cases, gastrointestinal decontamination is
not required. Plasma levels are not clinically useful
and specific laboratory monitoring is not needed
unless otherwise indicated.
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12. Doxycycline Tablets
Doxt-S Tablets from Dr. Reddy's
Laboratories, India
For more information click here
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