1. WELCOME
3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 1

2. RESEARCH UPDATES ON DRUGS IN
MUKHADOOSHIKA(ACNE VULGARIS)
Under the guidelines of
Dr. Ashalatha M
Professor and HOD
Dept of Dravyaguna
GAMC
Bangalore- 09
By
Dr. Thriveni D.P.
Final year MD
Dept. of Dravyaguna
GAMC
Bangalore-09
3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 2

3. Content
 Introduction
 Acne treatment modalities and kind of drugs
 Ayurvedic perspective
 Bioactive compounds in Acne
 Researches
 Few herbal drugs
 Conclusion
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4. Introduction
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5. Classical references
 ‘Kshudra Rogas’ (SU.Ni.13)
 Kshudraroga pratisheda (A.H.U.31,32)
 Varnya, Vayasthapana (Ch.Su.4/8).
 Shasti Upkramas (SU.Chi.1/68- 78).
 Kshudraroga chikitsa-Chakradata
 Sarangdhara Samhita - certain special Lepas
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6. Kind of drugs useful in MUKHADOOSHIKA
 Varnya gana
 Shothahara
 Pandukarana
 Mrudukarana
 Darunikarana
 Avasadana
 Utsadana
 Vranaropana
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7. Treatment modality of Acne vulgaris
1. To counteract excess sebum and androgen‐
‐ Sebostatics,
Antiandrogen
2. To get rid of P.acne ‐ Antibiotics
3. To treat lesion ‐ Comedolytics,
Anti‐inflammatory
4. For regenerative ‐ Steroid
Antioxidants
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8. Bioactive compounds
Glycoside Antioxidant, Antibiotic, Anti-
(Phenolic,Flavonoids) inflammatory
Tannin(hydrosible) -Antimicrobial, Anti-
inflammatory, Antipruritic effects
Condensed tannin(Isoflavones) -Anti-cellulite , Viscoelastic
properties
Fatty acids (Omega-3& omega-6) optimizes permeability in the skin
Volatile oil -Antibacterial, increases the
permiabillity, healing
Terpenoid -Anti-inflammatory
Sesquiterpene -Antimicrobial
Vitamin A Sebostatic, Anti-inflammatory
Vitamin E Antioxidant
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9. Researches
 Rathod Suresh- The study of Shalmali w.s.r.to its efficacy on
Mukhadooshika 2002, Tilaka Ayurveda College Pune.
 Agravat H.P - Yuvan Pidaka and role of Lodhradi Lepa
there in (Acne )
 Sandeep Sagare - Comparative study on Vachadi Lepa and
Mruttika Lepa in Mukhadooshika with special reference to
Acne Vulgaris.
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10. Lodhra- Symplocos racemosa
 Part used ‐ Stembark
 Action‐ vranaropana,grahi
Constituents Action
Phenolic glycoside- Anti-inflammatory
symploracemoside
Alkaloid- Antiseptic,
loturine,collutrine Antioxidant
(Ref‐Kerala Ayurveda vaidyam)
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11. Vacha- Acorus calamus
 Part used‐ Rhizome
 Action‐ lekhana
Constituent Action
Monoterpene Anti‐
Terpineol inflammatory
(Ref;Birla Institute of technology and
science,Pharmacy group)
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12. Yasti – Glycirrhiza glabra
Part used- root
Action- vranaropana,
raktadoshahara
Constituent Action
Gycyrrhizin Anti‐inflammatory
Glabridin Hinders
Liquiritin melanogenesis
(Ref;Birla Institute of technology and science,Pharmacy
group)
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13. Manjista- Rubia cordifolia
Part used- root
Action- varnya,raktaprasadana
Constituents Action
Manjistin Anti-inflammtory
Anthroquinone Antibacterial
Antioxidant
(Ref; Review of Articles on Ayurveda and natural
products )
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14. Shalmali- Bombax ceiba
 Part used- spines
 Action – grahi,pittasranashana
Constituent Action
Shamimin ‐Antimicrobial
Oxalate ‐Disintegrates
hard tissue
(Ref‐ Himalaya drug company,Bangalore)
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15. Kola- Zizyphus jujuba
Part used‐ Fruitpulp
Action – grahi,
Constituent Action
Triterpinoid Anti‐
inflammatory
Flavaonoid Antioxidant
Saponin Enhances the
penetration
Essential oil Healing
(Ref;Kerala Ayurveda vaidyam)
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16. Conclusion
 Ayurveda also given importance to
cosmetics with therapeutics
 There are lot of researches done and carrying out on
Mukhadooshika to find still more effficient one.
 Further there is a scope for studying these dravyas in
more detail with respect to pharmacokinetics.
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17. THANKING
YOU
3/9/2012 Dept of Dravyaguna,GAMC,Bangalore 17