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solubility enhancement -by pH change & complexation

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swapnil_pharmacist
swapnil_pharmacist

A college level seminar...Exact author not known... two of the Solubilty enhancement approaches... Regards..- Swapnil Sanghavi

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SEMINAR ON SOLUBILITY ENHANCEMENT BY 1. ALTERATION IN pH OF THE SOLVENT SYSTEM 2. COMLEXATION TECHNIQUES
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],/39 Lower pKa Stronger the Acid More ionization Higher pKa Stronger the Base More ionization
[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],/39 ,[object Object],pH Solubility mg/ml 1.2 0.70 6.2 0.86 7.4 4.10 8.4 43.90
[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],/39
[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],/39 Complexes stacked can be homogeneous or mixed.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],/39 ,[object Object],[object Object]
[object Object],/39 RM β CD( Randomly methylated β -CD) HP β CD( Hydroxy propyl β -CD)* HP γ CD(Hydroxy propyl γ -CD) DM β CD( 2,4- dimethyl β -CD)** SBE β CD( Sulfobutylether β -CD)
[object Object],[object Object],[object Object],[object Object],/39
[object Object],/39 From Frömming and Szejtli: Cyclodextrins in Pharmacy Kluwer Acad. Press, Dordrecht, 1994 .
[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],/39
[object Object],/39 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39 CD formulation: Diazepam 5.0 mg HP  CD 60.0 mg Sodium chloride 6.0 mg Purified water ad 1.00 ml About 93% water.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],/39
[object Object],World-wide there are close to 30 cyclodextrin containing pharmaceutical products on the market and most of them are marketed in more than one country. Almost half of them contain the natural  CD. /39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],/39
 

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Editor's Notes

  1. 10/02/11
  2. 10/02/11
  3. 10/02/11