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Chironi a n
 S P R I N G / S U M M E R 2 012




                                   New York Medical College




                                                                INSIDE:
                                                Social Media in Medicine
                                               Researchers Stalk Cancer
                                              and Cardiovascular Disease
                                                    Medicine + Music =
                                              One Extraordinary Professor
Chironi a n
	                                 New York Medical College
	       A Member of the Touro College and University System




EDITORIAL
                                                                             TABLE OF CONTENTS
Editor
Donna E. Moriarty, M.P.H. ’04

Writers
Nelly Edmondson Gupta	               Alicia Prater, Ph.D. ’07                01	 PARTING THOUGHTS FROM THE OUTGOING DEAN
Andrea Kott, M.P.H.	                 Cynthia A. Read
Lori-Ann Perrault	                   Marjorie Roberts
Melissa F. Pheterson                                                         FEATURES
Contributors                                                                 02	 AN EXPERT AT PROBING FOR ANSWERS
Chirag Upreti	                       Elizabeth Kertowidjojo                  	  Zbigniew Darzynkiewicz, M.D., Ph.D., develops the technology and methods
Editorial Board                                                                  for understanding cell proliferation, opening doors to more effective cancer
Doris Bucher, Ph.D.	                 Jennifer Minieri-Arroyo, M.S. ’06           treatment.
Catharine Crea	                      Alberto Nasjletti, M.D.
Eileen M. Dieck, M.D. ’86	           James O’Brien, Ph.D.                    06	PIECES OF THE CARDIOVASCULAR PUZZLE
Rhea Dornbush, Ph.D., M.P.H.	        Matthew A. Pravetz, O.F.M., Ph.D. ’88   	 Huang, M.D., Ph.D., studies estrogen, blood flow and blood pressure, and
                                                                                 An
Michael Goligorsky, M.D., Ph.D.	     Ira Schwartz, Ph.D.                         how they fit together.
Thomas Hintze, Ph.D. ’80	            Michal L. Schwartzman, Ph.D.
Maximilian Klein	                    Paul Wallach, M.D.                      10	MAKING A MENU FOR LIFE WITH MUSIC AND MEDICINE
Julie A. Kubaska, M.S.	              Gary P. Wormser, M.D.                   	   Stephen E. Moshman, M.D., gives equal time to his main passions.
Edmund LaGamma, M.D. ’76
                                                                             14	 IS MEDICINE READY FOR SOCIAL MEDIA?
Design Curran  Connors, Inc.	       Photography William Taufic
                                                                             	 proponents claim the use of new media in medicine is a boon, causing
                                                                                 Its
ADMINISTRATION                                                                   shifting paradigms, seismic changes, and better connections online and off.
Edward C. Halperin, M.D., M.A., Chancellor for Health Affairs and
  Chief Executive Officer
Alan Kadish, M.D., President
Ralph A. O’Connell, M.D., Dean, School of Medicine
                                                                             STUDENTS AND FELLOWS
Francis L. Belloni, Ph.D., Dean, Graduate School of Basic Medical Sciences   18	 BEYOND SKIN DEEP
Robert W. Amler, M.D., Dean, School of Health Sciences and Practice and
                                                                             	 learning to treat the skin—the mirror of internal diseases—dermatology
                                                                                 In
  Vice President, Government
                                                                                 residents inject dermatologic care into a host of other specialties.
Office of Public Relations
Donna E. Moriarty, M.P.H. ’04, Associate Vice President, Communications      22	STUDENT ATHLETES COMPETE TO STAY MENTALLY AND
Lori-Ann Perrault, Public Information Editor                                     PHYSICALLY FIT
Kevin R. Cummings, M.P.S., M.P.H. ’00, Director, Web Communications          	   John Nunez, Izuchukwu Ibe and Andrea Love
Karla Cambron, Department Administrator
                                                                             26	 GRADUATE STUDENTS EXPLAIN IT ALL
Please direct all inquiries to:
                                                                             	   Chirag Upreti and Elizabeth Kertowidjojo
New York Medical College/Chironian, Valhalla, NY 10595. We authorize
the use of any material with attribution to New York Medical College.

                                                                             ALUMNI NEWS
Chironian is published semi-annually by the Office of Public Relations.
We welcome reader feedback. Contact us at (914) 594-4536 or
chironian@nymc.edu.
                                                                             28	 IRINA ELLISON, PH.D. ’05
NEW YORK MEDICAL COLLEGE AFFILIATES                                          	   Stamping Out Smoking and Building Community
Academic Medical Center
Westchester Medical Center                                                   30	 SUSAN J. BLAKENEY, M.S. ’92, M.P.H. ’10
University Hospital                                                          	   Two Degrees, Two Paths to Making a Difference
Metropolitan Hospital Center                                                 32	 TIMOTHY HSIEH, M.D. ’98
Specialty Hospital                                                           	   An Easterner, Now at Home in Oklahoma
The New York Eye and Ear Infirmary
Affiliated Hospitals
Benedictine Hospital                   Richmond University Medical           CLASS NOTES AND PHOTOS
Calvary Hospital                          Center
Greenwich Hospital                     Saint Joseph’s Regional Medical       09	COMMENCEMENT
Hoboken University Medical Center         Center, Paterson (NJ)              29	 IN MEMORIAM
Jamaica Hospital Medical Center        Saint Joseph’s Medical Center,
Keller Army Community Hospital,           Yonkers                            30	MILESTONES
   West Point                          Saint Vincent’s Medical Center,
                                                                             33	 ALUMNI REUNIONS
Lenox Hill Hospital                       Bridgeport (CT)
Montefiore Medical Center,             Sound Shore Medical Center
   North Division                         of Westchester
Mount Vernon Hospital                  Terence Cardinal Cooke Health
Northern Westchester Hospital             Care Center
   Center                              VA Hudson Valley Health Care
Norwalk Hospital                          System
Phelps Memorial Hospital Center                                              ON THE COVER:
Affiliated Ambulatory Care Programs                                          For practitioners and their patients, new media—consisting of social media platforms, portable applications (“apps”)
Center for Comprehensive Health Practice                                     and mobile devices—are becoming a force to be reckoned with in health care today. Pew Surveys show that 44 million
Open Door Family Medical Centers                                             health care apps were downloaded in 2011. Our cover photo imagines a future that might not be so far-fetched.
Westchester Institute for Human Development                                  iPad image courtesy of www3d4medical.com. Photo by William Taufic, ©2012, all rights reserved.


     Follow us on Twitter @NYMC_tweets
Parting Thoughts
f r o m                        t h e                   O u t g o i n g                                             D e a n

                                 On June 1, the day after New         Touro’s president, was appointed president of New York
                                 York Medical College cele­           Medical College. Following a nationwide academic search,
                                 brates its 153rd Commence­           a candidate was selected to lead New York Medical College
                                 ment in Carnegie Hall, I will        into the future. We are all very pleased to inform you that on
                                 step down as dean of the             May 1, Edward C. Halperin, M.D., M.A., became chancellor
                                 School of Medicine. As I plan        for health affairs and chief executive officer of New York
                                 to tell some 362 graduates           Medical College.
                                 and their families and friends,
                                                                      A graduate of Yale School of Medicine, Dr. Halperin completed
                                 the first time I went to medical
                                                                      an internship in internal medicine at Stanford and his residency
                                 school it took me only four
                                                                      at Harvard’s Massachusetts General Hospital. He spent 23
                                 years to get through; this time
                                                                      years at Duke University, where he rose to become chairman
it required sixteen. You do slow down as you get older, but in
                                                                      of the Department of Radiation Oncology and vice dean of the
my defense, medical education is much more complex today.
                                                                      School of Medicine. He also earned a Master of Arts in Liberal
The 174 newly minted physicians of the Class of 2012 matched          Studies there. Before coming to the College, Dr. Halperin was
in twenty medical specialties at strong teaching hospitals            dean of the School of Medicine at the Univer­ ity of Louisville.
                                                                                                                    s
around the country. We are very proud of our graduates; they          I had the privilege of getting to know Ed when we were both
will enhance the reputation of New York Medical College               serving on the Council of Deans. I can assure you New York
wherever they go. The about-to-enter Class of 2016 is shaping         Medical College is in very good hands.
up as I write this. From more than 11,000 applicants, 1,400
                                                                      Dr. Halperin will also serve as provost for biomedical affairs
were selected to interview for admission to a class of 190.
                                                                      at Touro, and will serve as executive dean of the School of
Their personal characteristics, diversity and academic creden­
                                                                      Medicine after I step down. With his ten years of experience as
tials predict a very strong class, and we are glad to note that
                                                                      a medical school vice dean and dean, Dr. Halperin is eminently
our robust applicant pool—among the largest in the nation—
                                                                      qualified to serve in this capacity until we begin a search for a
allows us to select the very best candidates.
                                                                      new dean—probably in the coming academic year.
The last two years have presented the College with challenges
                                                                      One of the first concrete (literally and figuratively) results of the
and opportunities. When Saint Vincent’s Hospital in Manhattan
                                                                      Touro affiliation will be the construction of a new clinical skills
closed in 2010, we were required to reassign 50 medical students
                                                                      center, which is expected to open in 2013. Watch for more
to clerkships at other teaching hospitals and to place 300
                                                                      news about this exciting development—and for more in future
“orphaned” residents in GME programs. It was a monumental
                                                                      issues of Chironian, both about and by Dr. Halperin, a prolific
challenge that was successfully met thanks to the cooperation
                                                                      writer and speaker who was chosen to deliver this year’s
of our teaching affiliates, Westchester Medical Center and
                                                                      Commencement address.
Metropolitan Hospital Center. Helping to ease the burden were
new or expanded affiliations with Keller Army Hospital at West        In my final weeks as dean, I received numerous calls and visits
Point, Lenox Hill Hospital in New York City, Phelps Memorial          from colleagues and students stopping by to say goodbye and
Hospital Center in Sleepy Hollow, N.Y., and Saint Joseph’s            wish me the best. With great tact, I told them that I planned to
Health Care System in Paterson, N.J. This complicated logisti­        stay on the faculty, teaching in the Department of Psy­ hi­ try
                                                                                                                              c a
cal exercise would not have been possible without the support         and Behavioral Sciences. I have thoroughly enjoyed the honor
of our clinical chairs, program directors and the good will of        and challenge of serving as dean and, prior to Dr. Halperin’s
organized medicine. I want to express my gratitude to Paul M.         arrival, as provost. The best reward is the assurance that
Wallach, M.D., vice dean for medical education, Richard G.            during my tenure, with the unwavering support of the Board
McCarrick, M.D., vice dean for graduate medical education             of Trustees, department chairs, faculty and administration,
and affiliations, and Gladys M. Ayala, M.D., M.P.H., senior           approximately 3,000 individuals received M.D. degrees from
associate dean for student affairs, for playing key roles in the      New York Medical College, and are now in residency or prac­
effort, which provided the opportunity to explore new models          tice, shaping the future of medicine.
for the curriculum.
                                                                      Sincerely,
The transition from sponsorship by the Archdiocese of New
York to the Touro College and University System was com­
pleted this academic year. This historic undertaking was carried
out in the best academic tradition of collegiality, with input from   Ralph A. O’Connell, M.D.
faculty, administration and students. Alan H. Kadish, M.D.,           Immediate Past Provost and Dean, School of Medicine
02   : :   Spring/Summer 2012




An Expert at
                                Probing
C H I R O N I A N   : :   New York Medical College   : :   03




for Answers
Zbigniew Darzynkiewicz, M.D., Ph.D., develops the technology
and methods for understanding cell proliferation, opening doors
to more effective cancer treatment.


By Alicia M. Prater, Ph.D. ’07



T
         he “War on Cancer” marked its 40th anniversary in           Dr. Darzynkiewicz has the distinction of being a pioneer in the
         December—a long time in anybody’s book, but not             field, a man who has been at the forefront of cell cycle, cell
         long enough to come up with a reliable cure for any of      proliferation, and apoptosis research since before he joined
the thousands of symptoms that use uncontrolled cell growth          New York Medical College in 1990. In addition to directing
to thrive. President Richard M. Nixon began using the metaphor       the Brander Cancer Research Institute (BCRI), he also holds
in speeches to support the National Cancer Act, a historic bill      professorships in the departments of pathology, medicine,
passed at the close of 1971 to initiate federal government           and microbiology and immunology. His research, which has
spending for cancer research. Scientists and physicians could        earned him international repute, has been supported by grants
approach their studies from the laboratory or by clinically treat­   from the NIH and the National Cancer Institute, including a
ing patients with medicinal remedies specifically designed           prestigious MERIT award for his research on the effects of
around their genetic make-ups in a process now called trans­         anticancer drugs on the cell cycle. He was also a recipient of a
lational, or bench to bedside, treatment. At New York Medical        grant from NASA to develop new technologies for cell staining
College and affiliated Westchester Medical Center, there are         and analysis applicable to the micro-gravity conditions of the
nearly 20 investigators with M.D. and Ph.D. degrees who have         Space Station. He is the holder of eight U.S. patents, author
spent their entire lives waging the war. One of them, Zbigniew       or editor of 15 books, and has published nearly 700 peer-
Darzynkiewicz, M.D., Ph.D., has been point man at the cellular       reviewed articles.
level, achieving world renown for his dogged pursuit of answers
                                                                     COLLEAGUES IN CYTOMETRY
to a puzzle: how to turn cancer cells against themselves,
                                                                     Frank Traganos, Ph.D., professor of experimental pathology
instead of taking more human lives.
                                                                     and of medicine and associate director of BCRI, has worked
When a cell is damaged, chemical signals are activated that          with Dr. Darzynkiewicz for more than three decades and
drive the cell to die without affecting nearby healthy cells.        co-authored more than 120 papers with him. “He has made
Knowing how to control this process, known as apoptosis,             numerous contributions to our understanding of the processes
could allow doctors to control tumor growth with little, if any,     and mechanisms underlying cell proliferation, cell death, and
toxicity to healthy cells. Research examining the differences        cell damage by investigating processes at the single cell level,”
between apoptotic and normal cells uses techniques that dif­         says Dr. Traganos. In 1992, the two collaborated with other
ferentiate between the molecular attributes of individual cells.     colleagues on a paper published in Cytometry describing the
04   : :   Spring/Summer 2012




 molecular attributes that characterize apoptotic cells in flow       work is important, because “if replicated, in vivo the findings
 cytometry. Now considered a landmark paper, it has been              would have broad applicability, even though it can take a long
 cited more than 1,500 times—and Dr. Darzynkiewicz has                time to see clinical applications.”
 written a host of other papers with citations numbering in
                                                                      In the 1970s and 1980s, the understanding behind fighting can­
 the hundreds.
                                                                      cer was to poison the malignant cells, which resulted in devas­
 He coined the term cell necrobiology, or the biology of cell         tating side effects that made cancer a word spoken only in
 death, and is credited with developing techniques for analyz­        hushed tones of dread. During this period, Dr. Darzynkiewicz’s
 ing cell kinetics, tumor progression and cell senescence. He         lab successfully characterized the mechanism of action of
 discovered the basis for identifying a cellular resting phase        anti-cancer drugs that were effective at lower doses, resulting
 known as “quiescent” or G 0. Although his name is not quite          in less toxicity to the patient than most of the drugs in use at
 a household word, he is perhaps best known for developing            that time. One of those drugs was mitoxantrone, which is cur­
 the TUNEL assay (TUNEL stands for terminal deoxynucleotidyl          rently used in the treatment of metastatic breast cancer, acute
 transferase dUTP nick end labeling), which remains one of the        myeloid leukemia and non-Hodgkin’s lymphoma.
 most widely used techniques for measuring apoptosis. But his
                                                                      GOING WITH THE FLOW
 work goes beyond simply trying to understand cell suicide.
                                                                      Shortly after being named director of the Flow Cytometry Core
 After earning his M.D. from the Medical University of Warsaw,        Facility at Sloan-Kettering he was recruited to New York Medi­
 Poland, in 1960, Zbigniew Darzynkiewicz earned the equiv­            cal College. Zalmen Arlin, M.D., tapped Dr. Darzynkiewicz to
 alent of a Ph.D. on the basis of a thesis on the teratogenic         head the College’s new Cancer Research Institute, founded
 actions of insulin in the chicken embryo. He developed a fasci­      the summer before to enable research in the etiology, classi­
 nation with cell biology “because the analysis of molecular          fication, diagnosis and treatment of tumors. The key to this
 mechanisms in individual cells reveals the mystery of life.” His     research would be flow cytometry, which allows variability
 early work focused on developing new methods for studying            among cancer cells to be evaluated in terms of their sensitiv­
 enzymes in individual cells using radioisotope-labeled enzyme        ity to anticancer drugs. “The knowledge of such variability
 inhibitors. Two years later he accepted a position at the            is essential in design­ng clinical treatments that may be suc­
                                                                                            i
 Karolinska Institute in Stockholm, Sweden, which, he says,           cessful in eradicating all cancer cells and thereby preventing
 “was the Mecca for cell biologists because of the capability to      cancer relapse,” says Dr. Darzynkiewicz.
 measure DNA and RNA content in individual cells.”
                                                                      With flow cytometric measurements, apoptosis moved to the
 ADVANCING METHODOLOGY                                                forefront. When damaged, normal cells become senescent,
 With the methods and equipment available at that time,               but tumor cells do not have the same ability to respond. Lack­
 Dr. Darzynkiewicz was capable of measuring 80 cells per              ing any damage control mechanism, they die via apoptosis, a
 day—a pittance compared to the thousands per second he               pattern of events that is so orderly the process is often called
 measures now. Over the years the technology, and his capa­           programmed cell death. This difference can be exploited to
 bility, advanced with radioisotope labeling and autoradiography,     increase the response to cancer treatment.
 and then with flow cytometry and fluorescent probes capable
                                                                      “New strategies are being developed and tested in pre-clinical
 of identifying a variety of cell attributes. He expanded on each
                                                                      studies to enhance the susceptibility of cancer cells to radia­
 of these approaches to explore mechanisms underlying cell
                                                                      tion and DNA-damaging drugs by increasing their propensity
 proliferation and the response of cells to anticancer drugs.
                                                                      for cell suicide,” explains Dr. Darzynkiewicz. “Attempts are also
 In the late 1960s it was time to head for the U.S. There he          being made to force cancer cells to undergo ‘cellular senes­
 held positions at SUNY Buffalo and the Boston Biomedical             cence,’ which permanently halts their reproductive capability.”
 Research Institute before moving on to positions in New York
                                                                      His lab is also studying the mechanisms in normal, non-tumor
 at Memorial Sloan-Kettering Cancer Center and Cornell
                                                                      cells to understand resistance to DNA damage. The goal is
 University Graduate School of Medical Sciences, where he
                                                                      the same as it has been for the past three decades: to ease
 met Dr. Traganos. “I was fascinated—not so much by the
                                                                      the injurious side effects of radiotherapy and chemotherapy by
 technology as with the biological problems this technology
                                                                      reducing toxicity to healthy cells.
 could help solve,” he says. In their early work together at
 Sloan-Kettering, Dr. Darzynkiewicz and Dr. Traganos evalu­           Speaking with Dr. Darzynkiewicz, one gets the sense that new
 ated potential chemotherapeutic drugs in vitro, and their work       avenues in basic research are closely intertwined rather than
 today is still in vitro. Dr. Traganos explains that the cell-based   disconnected areas of study. In the past his work has integrated
C H I R O N I A N     : :   New York Medical College   : :   05




The Darzynkiewicz team is well acquainted with the sophisticated technology that aids in his research. From left are Frank Traganos, Ph.D., M.D./Ph.D. student
Elise McKenna, Dr. Darzynkiewicz, Dorota Halicka, M.D., Ph.D., Jiangwei Li, Ph.D., and Jan Kunicki. Not pictured is Hong Zhao, Ph.D.




chemotherapy with apoptosis, and now it integrates cancer                          determine the mechanism of anti-cancer drugs. And many
biology with the process of aging.                                                 probes used world­ ide for detecting different stages of cell
                                                                                                       w
                                                                                   differentiation were developed by his lab, including acridine
Dr. Darzynkiewicz’s work in DNA damage also spans several
                                                                                   orange and BrdU incorporation into nucleic acids. “We are one
decades. He was the first to show that the genetic defect in
                                                                                   step ahead because we’ve been developing the technology,”
DNA repair in xeroderma pigmentosum can be corrected. And
                                                                                   he says.
in 2010 he published work on double-stranded breaks and the
carcinogenicity of tobacco smoke. His laboratory also detected                     The probes used in cytometry can include different molecules,
constitutive DNA damage signaling as a consequence of oxi­                         such as fluorescence-tagged antibodies or stains. The anti­
dative metabolism. He explains, “This oxidative DNA damage                         bodies used as probes can be specific for cell surface pro­
causes DNA replication stress which, when combined with                            teins or indirectly labeled by a secondary antibody. Regardless
cellular growth driven by the mTOR (mammalian target of                            of the type of probe, they are important in a variety of research
rapamycin) pathway, is considered to be the major cause of                         areas and have a greater impact over time as more about the
aging and predisposes an individual to cancer.” In addition to                     role of a particular protein in the cell is understood. Dr.
rapamycin, the diabetes medication metformin and vitamin D                         Darzynkiewicz’s lab includes a cell sorter as well as a four-laser
are potential agents for suppressing the mTOR pathway. This                        scanning cytom­ ter, both with multiple channels for detecting
                                                                                                     e
suppression could create leaner and healthier cells, a context                     different types of fluorescence.
of aging currently being studied in Dr. Darzynkiewicz’s lab.
                                                                                   In terms of sheer lab output, Dr. Darzynkiewicz ranks at the
SETTING THE STANDARD                                                               top of the fields of cell cycle, flow cytometry and apoptosis.
Without flow cytometry and similar techniques “the work                            He explains that his accomplishments in different areas of cell
Dr. Darzynkiewicz does would be decades behind,” says                              biology are due to the development of new methods for prob­
Dr. Traganos. His colleague agrees. “Without these tools, our                      ing individual cells at the molecular level. With these methods
research would be impossible,” Dr. Darzynkiewicz admits.                           cell growth, proliferation, carcinogenesis and response to anti­
His current work, supported by a grant from the NIH, aims to                       tumor treatments can be studied.
develop probes to study the DNA damage response and
                                                                                   And in this, his thirty-third year of continuous funding,
aging processes. He is already credited with developing
                                                                                   Zbigniew Darzynkiewicz, M.D., Ph.D., continues to probe
probes identifying individual stages of the cell cycle to
                                                                                   cells for answers. ■
06   : :   Spring/Summer 2012




  

Pieces of the
Cardiovascular Puzzle
An Huang, M.D., Ph.D., studies estrogen, blood flow and blood
pressure, and how they fit together.


By Cynthia A. Read



A
         re you among the one percent?        need for better understanding becomes       professors, so her interest in medicine
         The question is not about what       even more critical.                         developed early. But her path was tem­
         you may think it is. It refers to                                                porarily derailed by the harsh reforms of
                                              An Huang, M.D., Ph.D., associate profes­
the percentage of Americans who enjoy                                                     the Chinese Cultural Revolution. At the
                                              sor in the Department of Physiology, is
ideal cardiovascular health, according to                                                 time she graduated from high school,
                                              studying one aspect of this challenge:
a position paper released by the American                                                 many students were being forced out of
                                              the gender-specific regulation of endo­
Heart Association last March. The figure                                                  cities and effectively exiled to work in
                                              thelial function in arterioles, the tiny
is actually less than one percent.                                                        factories or farms, rather than going to
                                              blood vessels that branch out from arter­
                                                                                          college. In 1977, after these policies
Heart disease is still the leading cause of   ies throughout the body. Her research,
                                                                                          changed, Huang was among the first
death—not only in the U.S., but in every      supported by a series of grants from the
                                                                                          group of students allowed to enter college.
major developed country. The myth that        National Institutes of Health, is part of
                                                                                          She received her M.D. from Shanghai
it is primarily a man’s problem has also      a multi-faceted, multi-department pro­
                                                                                          Second Medical University in 1982 and
been debunked. In fact, more women’s          gram at the College that pairs basic sci­
                                                                                          was directed by the government to enter
lives are claimed by cardiovascular dis­      ence and clinical research in a quest to
                                                                                          the practice of general surgery.
ease than by cancer, chronic respiratory      improve the outcomes in diseases that
disease, Alzheimer’s disease, and acci­       affect the heart and circulatory system.    By the time China began to open to the
dents combined. When factoring in                                                         outside world in 1990, Dr. Huang had
                                              FROM CHINA TO NEW YORK
deaths from stroke, diabetes and other                                                    earned an M.S. and a Ph.D. in surgery.
                                              The youngest of four children, An Huang
diseases that are related to problems                                                     Feeling that she’d advanced in her pro­
                                              grew up in the People’s Republic of
with blood flow and blood pressure, the                                                   fession as far as she could in her home
                                              China. Both of her parents were medical
                                                                                          country, she was eager to see what she
C H I R O N I A N   : :   New York Medical College   : :   07




might learn elsewhere. Although she was       After their daughter Angela was born in         Hypertension from overly constricted
still thinking about pursuing her clinical    1996, Dr. Huang brought her to work             blood vessels increases the workload
interests, she landed a position as a         in her bassinet when she was only a             on the heart, leading to thickening of the
research fellow in the Depart­ ent of
                               m              month old so the family research proj­          heart muscle (myocardial hypertrophy),
Physiology in 1992. And, in what she          ects could continue.                            often followed by heart failure. Women
calls “one of the luckiest moments in my                                                      have a bigger vasodilator response than
                                              GENDER DIFFERENCES
life,” she met the late Gabor Kaley, Ph.D.,                                                   men and, before menopause, a lower
                                              Beginning with her first research projects
who served for 37 years as chairman                                                           risk of heart disease. It appears that estro­
                                              with Drs. Kaley and Sun, along with Akos
of the Department of Physiology. “He                                                          gen is responsible. When the ovaries
                                              Koller, M.D., Ph.D., professor of physiol­
taught me everything about research,”                                                         are removed from experimental animals
                                              ogy, Dr. Huang has investigated microcir­
she says. “It was my great honor to be                                                        such as rats, the females have a reduced
                                              culation—the term for the small blood
able to work with Dr. Kaley. It would have                                                    dilator response, but if the same females
                                              vessels embedded in organs that are
been impossible for me to become an                                                           are given estrogen after ovariectomy, the
                                              responsible for the distribution of blood
established scientist without him.”                                                           dilator response returns.
                                              within the organ tissues and for maintain­
The College brought Dr. Huang an addi­        ing blood pressure. The arterioles carry        In their initial studies, Dr. Huang and her
tional gift: Dong Sun, M.D., who was          blood to the capillaries and, like all blood    collaborators explored the mechanisms
also a product of the first wave after the    vessels, are lined with a thin layer of cells   of nitric oxide (NO) in dilating arterioles in
Cultural Revolution, was then a Ph.D.         comprising the endothelium. Among the           rats and mice. When synthesized in the
student under Dr. Kaley. The two came         many functions of endothelial cells are         endothelium of blood vessels, nitric oxide
halfway around the globe to meet on the       controlling the dilation and constriction       is also called endothelium-derived relax­
Valhalla campus, and married in 1994.         of the arterioles.                              ing factor, so named for its ability, when
08   : :   Spring/Summer 2012




“All the
  expertise I
  need is here
  at NYMC.”                                    Assisting Dr. Huang in her study of gender-specific regulation of endothelial function in arterioles are, from
                                               left: Dong Sun, M.D., Ph.D., Hongyan Wu, technician, and Caroline Ojaimi, Ph.D.




released from the endothelium, to signal       exists, which genes are involved, what                   somewhat protected from cardiovascu­
the surrounding smooth muscle to relax.        earlier influences come into play, and                   lar events. She has also provided signifi­
This dilates the vessel and increases          how changes in vasodilation, and there­                  cant evidence on the relevancy of the
blood flow, therefore decreasing blood         fore in the regulation of blood pressure,                microcirculation in vascular biology and
pressure. The team showed that estro­          are related to aging associated with                     medicine.”
gen increases the expression and activity      menopause.
                                                                                                        LOOKING AHEAD
of eNOS, the enzyme that synthesizes NO.
                                               “All the expertise I need is here at                     Dr. Huang thinks that better understand­
Genetically modified mice that lack the
                                               NYMC,” she says. She continues to col­                   ing the mechanisms by which estrogen
gene to produce eNOS, and therefore
                                               laborate with her husband and with                       regulates the dilation of blood vessels
lack nitric oxide, are hypertensive—yet
                                               co-investigator Caroline Ojaimi, Ph.D.,                  could lead to improved treatment for
still, female mice have better regulation of
                                               assistant professor of physiology. She                   menopausal women, and her research
blood pressure than males do.
                                               also receives support from Edward J.                     could point to a new therapeutic target
So Dr. Huang’s next step was to study          Messina, Ph.D. ’73, professor, and                       to improve cardiovascular function where
how estrogen affects the dilation of           Thomas Hintze, Ph.D. ’80, professor and                  NO is deficient.
blood vessels independent of the activity      chairman of the Depart­ ent of Physiology,
                                                                      m
                                                                                                        That is down the road, however. For
of nitric oxide. She discovered additional     as well as other members of the depart­
                                                                                                        now, Dr. Huang relies on a motto of
endothelial mediators were dependent           ment. Dr. Messina says, “It has been a
                                                                                                        sorts: “Be solid at every step,” she says,
on cytochrome P450 (CYP). She has              pleasure and an honor to watch the
                                                                                                        “keep going, and never give up.” It has
also learned that different forms of CYP       growth of Dr. Huang as an independent
                                                                                                        served her well, not only in her years of
are responsible for the release of other       investigator. I am impressed with her
                                                                                                        research at New York Medical College
vasodilators in rats, mice and humans.         research success, which has offered
                                                                                                        but in the life journey that brought her
Because this sequence seems specific           important clues to our understanding
                                                                                                        more than 7,000 miles from Shanghai
to females, Dr. Huang has begun to             as to why premenopausal women are
                                                                                                        to Valhalla. ■
explore why these gender difference
2012encement!
    Our omm
                                                                                                                  C H I R O N I A N   : :   New York Medical College    : :   09




1
      C                                                                                                                      2




                                                                                            3




                                                                               4




                                                                                                                            7




                                                 5                                                                          8




                                                                                            6
                                                                                                              9




    PHOTOS

    1: Drs. Alan Kadish, Karl Adler, Edward Halperin,
                                                           3:  rustee Ronald F. Poe, President Alan Kadish, M.D.,
                                                               T                                                        6:  r. Halperin with Rabbi Moshe Krupka.
                                                                                                                           D
       Francis Belloni, Ralph O’Connell and Robert Amler,      Honoree Karl P. Adler, M.D., and Board Chairman
                                                                                                                        7:  ace Bearer, Fredrick Z. Bierman, M.D.
                                                                                                                           M
       and Mr. David Raab.                                     Dr. Mark Hasten.
                                                                                                                        8:  chool of Medicine graduates capture the excitement
                                                                                                                           S
    2: Chancellor and CEO Edward C. Halperin, M.D., M.A.,
                                                           4:  raduates from the Graduate School of Basic
                                                               G
                                                                                                                           in Carnegie Hall.
       gives the Commencement address.                         Medical Sciences.
                                                                                                                        9:  raduates from the School of Health Sciences
                                                                                                                           G
                                                            5:  rs. Kadish, Hasten and Halperin.
                                                               D
                                                                                                                           and Practice.
10   : :   Spring/Summer 2012




Music and
 Medicine
Making a Menu for Life with




                                }Stephen E. Moshman, M.D.,
                                                                         }
                                    gives equal time to his main passions.
C H I R O N I A N   : :   New York Medical College   : :   11




By Marjorie Roberts



T        he Department of Medicine is a challenging and
         exceptional place to work. Many members of the fac­
         ulty were recruited to the Valhalla campus by friends
and colleagues from their previous lives. A case in point is
Stephen E. Moshman, M.D., who radiates energy, caring and
                                                                    has mentored students who are learning to make critical
                                                                    decisions that will impact how they practice medicine the rest
                                                                    of their lives. “My greatest passions are medicine and music,
                                                                    but I am ardent about a lot of things,” he admits, and he is
                                                                    not exaggerating. The mere mention of baseball, history and
collegiality on a daily basis—weekends included. This not only      astronomy causes his eyes to light up and his voice to rise
enables him to perform an unusual variety of tasks for his job,     in intensity.
but also allows him to have a second life filled with music. This
                                                                    You can only wonder how he is able to find the spiritual
spring, his dual passions for teaching and music became a
                                                                    wherewithal and physical strength to staff, rehearse and con­
perfect storm that honored Dr. Moshman for both his roles. He
                                                                    duct the Einstein orchestra in four concerts a year. Ask him,
was promoted to Professor of Clinical Medicine, a title he will
                                                                    and this Renaissance man replies, “I can do it because I am
cherish in recognition of his 43 years of service to medicine—10
                                                                    a very happy man.”
at the College and Westchester Medical Center (WMC)—and
gratification for acknowledgement of his 30th anniversary year      BEING HAPPY
as founder, composer, and conductor of the Albert Einstein          How happy is he? Enough to spar with the colleague who
Symphony Orchestra, serving the Bronx community through             recruited him from Einstein and its affiliated Montefiore Hospital:
the talents of 60 mostly non-professional musicians with a          William H. Frishman, M.D., the Barbara and William Rosenthal
concert agenda each year.                                           Professor and Chairman of Medicine. They were both faculty
                                                                    members at Einstein, where Moshman spent 30 years before
Medicine inspires him to teach, for Moshman a sacred word
                                                                    coming to the College. They take their sworn allegiance to
that covers everything he does for the young heroes who follow
                                                                    differing New York baseball teams as set in stone, yet their
in his path. As director of the third-year medicine clerkship, he
12   : :   Spring/Summer 2012




}
In both the classroom and the orchestra pit,
Stephen Moshman dictates what happens from the
moment he walks into the room.                                                                                                 }
love of the game is reason enough to sustain their friendship.      the Adult Primary Care Clinic and his teaching duties in the
“Baseball is the only sport. I come alive when pitchers and         Pre-Internship Program, formerly called the Fifth Pathway. As to
catchers report for spring training,” says Moshman, a former        the variety of situations in which he finds himself, Dr. Moshman
Brooklyn Dodger fan. He is ready to take on another frus­           expresses his satisfaction with volunteering for unscheduled
trating year as a Met supporter, but he wouldn’t want it any        teaching assignments by insisting that, “I have always consid­
other way.                                                          ered myself a militant non-specialist. I accept these assign­
                                                                    ments with enthusiasm. After all, teaching medicine is 75
Robert G. Lerner, M.D., vice chairman of the Department of
                                                                    percent of what I do and I absolutely relish it all.” Dr. Frishman
Medicine at the College and chief of hematology at WMC,
                                                                    concurs: “We go back 40 years. Currently, every July, he and
shares Moshman’s double appreciation of teaching and music.
                                                                    I share the welcoming lectures for the new clerkship students
The Moshmans and Lerners, who have enjoyed many perfor­
                                                                    and we teach together on the wards at WMC. He is also very
mances of the Einstein Orchestra, also attend Lincoln Center
                                                                    active in recruiting house staff for Valhalla.”
events together. “I have been very impressed with everything
he’s done,” says Dr. Lerner, although it is Moshman’s work          When pre-concert time rolls around, you wouldn’t know from
ethic that draws Lerner’s greatest interest and admiration.         his disposition that he was stressed. Norma Moshman, who
“I got to know him better when he and I began teaching              sounds as laid back as the husband she is describing, offers
second-year students along with his brother, Eliot Moshman,         this assessment:
[M.D., clinical assistant professor of medicine], an internist in
                                                                    “For the most part he is very relaxed. He doesn’t worry. He
White Plains who plays French horn in the orchestra.”
                                                                    may have trepidations about a certain passage the orchestra
There is also Norma Moshman, Stephen’s wife, who is coordi­         is having trouble with, but in 30 years the orchestra has never
nator for the Internal Medicine Residency Program. Together         failed him.” Any changes planned for season 31? “He doesn’t
the Moshmans make up a sort of parents-by-proxy situation,          wear tails and the musicians just wear black jackets, although
which makes it seem like there are Moshmans everywhere.             at the March concert the orchestra wore what is called
Stephen claims he never repeats a task two days in a row, but       Broadway Black. Stephen wore a silver tie and they all really
certain responsibilities are his alone. He teaches “Foundations     looked good. Now they are considering wearing Broadway
of Clinical Medicine,” a mandatory course for first- and second-    Black all the time.”
year students. And there is “Harvey,” a favorite mechanism
                                                                    NATURAL BORN TEACHER
that involves an inventive way to teach, sometimes using musi­
                                                                    In both the classroom and the orchestra pit, Stephen
cal sounds for emphasis.
                                                                    Moshman dictates what happens from the moment he walks
AN APPRECIATIVE COLLEAGUE                                           into the room. In between he gets as close as he can by
The Harvey Cardiopulmonary Patient Simulator is a digital life      becoming an excellent teacher who, like any good performer,
size model of a patient with lots of heart problems, which can      makes things exciting. A slew of teaching awards attest to his
be dialed up at will. Cardiac pathology and proper diagnosis        tremendous teaching talents and famous sense of humor. But
are the basic skills that Harvey helps teach to third-year stu­     can he continue to do everything himself? With the orchestra,
dents, pre-internship students, interns and residents.              this encompasses making the selections to be played (many
                                                                    are his own compositions), choosing the soloists and even
Among Dr. Moshman’s other purviews are the residency
                                                                    writing the program notes before he rehearses the musicians
program in internal medicine where he is deputy director,
                                                                    and conducts the day of the performance. He has been
C H I R O N I A N   : :   New York Medical College   : :   13




immersed in this medical/musical arrangement all his life,        past season there were six players from New York Medical
and there is one doctor/musician who has been a part of           College; about one-third of the group are medical students,
most of it.                                                       faculty and house staff, and the rest are from the community.
                                                                  Dr. Moshman believes his is one of the longest running com­
Etta Eskridge, M.D., Ph.D., now an assistant professor of med­
                                                                  munity orchestras in the city, and “certainly, the only medical
icine at the College, was 22 when she met Steve Moshman.
                                                                  school-affiliated orchestra.”
Both had earned their undergraduate degrees at the University
of Rochester; she chose Einstein for medical school while he      Dr. Moshman has established that even in his spare time, he is
selected the University of Buffalo. She found out he was          devoted to the students who are his audience—in and out of
looking for musicians for a new orchestra he was assembling       hospital settings. Just as he learned to play the violin from his
and she played the viola, a rare commodity in terms of slots to   father, his first teacher who made music such an integral part
be filled. The rest, since 1982 and then some, is history. Four   of his upbringing, he makes himself available to those who
years ago Dr. Moshman recruited her to join Westchester           need help—even the ones who come around only when he
Medical Center, where she is a hospitalist and director of        hosts his annual pool party at his Dobbs Ferry, N.Y., home
palli­ative care.                                                 (which, by the way, was designed by a student of Frank Lloyd
                                                                  Wright). The party is Dr. Moshman’s way of plying his guests
“He is like a savant,” she says of Moshman. “He is a walking
                                                                  with art and the finer things in life. He has no ulterior motive for
encyclopedia of knowledge, and he writes the best program
                                                                  this gesture, and no message is intended or implied—other
notes ever…He has given all of us an unbelievable gift—the
                                                                  than to enjoy life and art, which are all around us. ■
opportunity to play music—and we do a pretty good job.” This



  
14   : :   Spring/Summer 2012




Is MEDICINE Ready
for Social Media?
Its proponents claim the use of new media in medicine is
a boon, causing shifting paradigms, seismic changes, and
better connections online and off.
C H I R O N I A N   : :   New York Medical College   : :   15




By Melissa F. Pheterson




T
      witter, tablets, texting: these are    using them for health care purposes,            Among the speakers was Kent Bottles,
      means and methods of social            and 44 million health apps were down­           M.D., who serves as the social media
      media now surging in popularity.       loaded in 2011. Even the prestigious            liaison for the Association of American
They are also revolutionizing medical        Mayo Clinic in Minnesota has started a          Medical Colleges. “Most older medical
practice and education, including            Center for Social Media to train physi­         educators like myself are ‘digital immi­
at New York Medical College. From            cians in social media strategy.                 grants’ who still speak the new language
three-dimensional views of anatomy                                                           with an accent,” says Dr. Bottles, a
                                             “When I first started to meet with groups
to classroom discussions sparked by                                                          Senior Fellow at The Thomas Jefferson
                                             about social media in medicine, their
text-messaging, the wealth of material                                                       University School of Popula­ion Health
                                                                                                                           t
                                             eyes were rolling,” recalls Dr. Luks. “They
summoned by a few finger-taps helps                                                          in Philadelphia. “It is the medical stu­
                                             thought it meant posting what you had
educators share and receive critical                                                         dents who are the digital natives that
                                             for dinner or checking in at Starbucks.
findings, more fully engages students                                                        are really leading the way. I think it’s
                                             But as in all professions, the immediacy
with the curricula, and helps doctors                                                        relevant that the topic was introduced
                                             and interactivity of social media helps
build stronger connections, online and                                                       [to NYMC] at a medical student confer­
                                             us clinicians humanize our presence
off, with patients.                                                                          ence and not by faculty.”
                                             and foster our relevance in a world
“Why am I on social media? Because           that’s increasingly going online.               TRANSFORMING MEDICINE
I’m social,” says Howard Luks, M.D. ’91.                                                     Resources for doctors. Smart phones
                                             “They’re talking about us, talking about
The associate professor of orthopedic                                                        and tablets, equipped with task-specific
                                             health,” he declares. “Now it’s up to us
surgery at the College and chief of                                                          programs (called “apps”), make a wealth
                                             to jump into that conversation. If we
sports medicine and arthroscopy at                                                           of clinical information and references
                                             don’t control our own message, others
Westchester Medical Center likes to                                                          readily available on a portable screen.
                                             will define who we are.”
add, “That means sincere, open, collab­                                                      Among College faculty, popular apps
orative, interested, authentic, and like­    The College has been doing its part to          include Epocrates RX, a mobile drug
able.” (He’ll admit the acronym is not       join in. In April, the annual Student Physi­    reference database, Medscape, a medi­
original, but it’s been re-tweeted many      cian Awareness Day (SPAD), organized            cal reference guide, and Diagnosaurus,
times behind his Twitter handle, @hjluks.)   by first-year medical students, was             a database of diseases and symptoms.
Dr. Luks writes several blogs on ortho­      devoted to exploring “iMedicine: The
                                                                                             Resources for patients. Social media
pedic surgery and social media, has          Role of Social Media in Medicine,” with
                                                                                             is changing the doctor-patient dynamic:
5,000 Twitter followers, and offers iPads    renowned experts convening to discuss
                                                                                             how doctors reach out and what kinds
in the exam room with videos to edu­         how social media is altering the nature
                                                                                             of information patients bring into the
cate his patients. “Why confine my           of patient care, medical education and
                                                                                             office or hospital. Apps can help doc­
expertise to the four walls of my prac­      community outreach. The event was
                                                                                             tors engage with their patients by dem­
tice?” he asks.                              well-attended, and in social media (or
                                                                                             onstrating procedures using 3-D views
                                             SoMe) parlance, there was a great deal
For doctors and patients alike, social                                                       of anatomy, displaying test results, and
                                             of chatter and following activity that
media is triggering a paradigm shift in                                                      sending text message reminders of
                                             nudged the College’s profile a bit higher
health care. Pew Surveys show that                                                           appointments and vaccinations. In
                                             in the Twittersphere.
17 percent of mobile phone users are                                                         between office visits, doctors and
16   : :   Spring/Summer 2012




                                patients can communicate directly via text or Twitter messages, or even brief video
                                messages, the form preferred by more than half of the patients Dr. Luks surveyed.
                                “Email,” he says, “is passé.”

                                Telemedicine, the concept of caring for patients remotely, is also gaining ground.
                                Dr. Bottles cites research predicting that by 2016, three million patients will be moni­
                                tored via their smartphones, rather than in hospitals, for chronic conditions like heart
                                disease and diabetes.

                                Social media can empower the patient without imperiling the doctor, stresses
                                Dr. Bottles. “Some patients want to record their interactions during office visits, but
Photo by Susan Woog Wagner      many physicians are reluctant to embrace social media because of fears of malprac­
                                tice suits,” he says. “And yet, studies have shown that patients retain only 50 percent
                                of what the doctor tells them during an office visit, and half of what the patient does
                                remember is remembered incorrectly.”

                                So instead of fearing the patient who comes in with reams of information printed from
                                the Internet, doctors can seize the chance to guide patients as they search for repu­
                                table articles, e-mail information after appointments, or maintain a blog or website
                                with concise answers to common questions. Says Dr. Luks: “Some doctors will shy
                                away from a patient coming in with material they’ve Googled, whereas I’m turning on
                                the iPad, hitting Google, saying ‘There are 600 articles on medicine published every
                                day; let’s see if anything was posted today that’s pertinent to your case.’”

                                Resources for both. Increasing numbers of clinicians and researchers have now
                                launched Twitter accounts, whereby they can issue brief messages called tweets to
                                a group of followers, comprising doctors and patients alike. Tweets might include
                                links to new medical findings, spotlight topics posted by other experts, or offer
                                advice on medical issues or healthy living. More than 1,300 physicians have now
                                registered their Twitter feeds on twitterdoctors.net, and communities are emerging
                                online among doctors (Doximity.com, a social networking site for physicians) and
                                patients (PatientsLikeMe.com, a forum for people with similar health conditions to
                                support and advise each other).

                                BEYOND THE CLASSROOM
                                One morning before class, Daniel Peters, M.D., F.A.C.S., assistant professor of cell
                                biology and anatomy, noticed his students deeply absorbed in their phones. “It was
                                clear that almost everyone was texting away furiously, trying to get out that last mes­
                                sage before class started,” Peters says. He also noted these same students hadn’t
                                yet responded to emails he’d sent a few days earlier. “I realized that email was obso­
                                lete to them: in their world, it served no purpose and it was too slow and inefficient
                                for real-time needs.” But a text or tweet would pop up instantly on their phones,
                                compelling them to respond. As an experiment, Peters began to send messages to
                                the class via Twitter, posing questions and offering points for reflection to spur critical
                                thinking and discussion among his students.

                                “Twitter allowed me to put ideas in their heads outside of class, when they might be
                                together in some social situation, and use the opportunity to have an open and free
                                discussion,” he says. “I was also trying to show that they always had to be think­
                                ing—the thought process does not, and should not, stop as soon as class is out.”
C H I R O N I A N   : :   New York Medical College    : :   17




                                                                                                                           43.7%
IN A FACULTY SURVEY, 85 RESPONDENTS WERE ASKED:                                                                  40.2%
                                                                                                                                        34.5%

Which social media platform do
                                                                                           33.3%




you use: Facebook, Twitter,
LinkedIn, YouTube or Google+?                                                                          10.3%




Among students, the study groups             posts Twitter and Facebook updates on        American Medical Association has
known as “journal clubs” now benefit         behalf of the College several times per      released social media guidelines sug­
from instant access to groundbreaking        week. “The institution becomes more          gesting that doctors use the maximum
news in medicine, with Twitter alerts        real to them, more personal, through         privacy settings for each mode of online
outpacing the snail’s-paced peer-review      social media activity. It’s a way to         communication, and consider using
model that produces journals.                spread news to our students and              separate profiles for personal and pro­
                                             employees about what is happening            fessional use. Many hospitals and prac­
 “Physicians and researchers in far-flung
                                             here, and offers a window for prospec­       tices now raise the issue with patients
locations can discuss articles and
                                             tive students, parents and alumni to         as soon as they check in, presenting a
exchange knowledge instantly,” says
                                             peer through and see what we’re up to.”      contract with waivers or disclaimers.
first-year medical student Neil Shah,
chair of the committee that organized        RED FLAGS                                    “Once I learned about social media, I
SPAD. “The flow of information is the        In the uncharted waters of social media,     realized the user has controls,” says
biggest way social media has helped          new ethical and legal dilemmas can           Anthony Sozzo, M.A., M.S.Ed., associ­
improve academic medicine.”                  pose unexpected hazards. Should doc­         ate dean for student affairs, who main­
                                             tors or professors initiate and accept       tains a popular page on student financial
For institutions like New York Medical
                                             “friend” requests from patients or stu­      planning, and who has produced pod­
College, social networking sites also
                                             dents? What if a patient solicits medical    casts and YouTube video clips for, and
provide an opportunity to reach out to
                                             advice online that ends up flawed?           with, the students. “You can still main­
prospective students, current students
                                             What if a medical student or resident        tain a professional presence on social
and alumni. The Office of Public Rela­
                                             posts descriptive comments of a clinical     media.” That synthesis of clinical excel­
tions, responsible for the College’s offi­
                                             experience, inadvertently violating HIPAA    lence and social media was among the
cial social media presence, is now
                                             rules governing patient privacy? These       major objectives at SPAD, with a live
encouraging other departments and
                                             issues are a “major concern,” says Shah,     Twitter feed enhancing discussion and
groups to establish their own presence
                                             but doctors, professors and institutions     debate even further.
in social media, using guidelines posted
                                             can protect themselves by educating
on the College’s website.                                                                 Because of SPAD, the College will gain
                                             students and patients about the perils
                                                                                          a significant amount of attention, kudos
“Curating and sharing information with       of social media. “Anyone using social
                                                                                          and support,” says Dr. Luks. If it means
an audience of followers on social           media,” says Kent Bottles, “needs to
                                                                                          dissolving the barriers to communica­
media is a way to engage people, and         think about the permanent and public
                                                                                          tion, then New York Medical College
get them talking with us about some­         nature of anything on Twitter and
                                                                                          has added a few more instruments to
thing that is of interest to them,” says     Facebook.” Howard Luks emphasizes
                                                                                          its black bag. ■
Donna Moriarty, M.P.H. ’04, associate        that he doesn’t treat patients via social
vice president of communications, who        media, only shares information. The
18   : :   Spring/Summer 2012




                                BEYOND
                                SKIN
                                DEEP
                                In learning to treat the
                                skin—the mirror of
                                internal diseases—
                                dermatology residents
                                inject dermatologic
                                care into a host of
                                other specialties.
C H I R O N I A N   : :   New York Medical College   : :   19




                                                                   experiences she and the other residents gain from treating
                                                                   patients, says Jodi Langer, M.D., who serves as co-chief resi­
                                                                   dent with William Rietkerk, M.D.

                                                                   MANY CALLED, FEW CHOSEN
                                                                   Considered among the nation’s best, the New York Medical
                                                                   College dermatology residency program is very competitive.
                                                                   From more than 300 applicants, just three are chosen annu­
                                                                   ally. To be selected, says Dr. Safai, a resident “must have an
                                                                   intelligent mind and be able to quickly retrieve and grasp a lot
                                                                   of information.” She or he also must be a clear thinker, a good
                                                                   writer and an effective “people person.” Finally, says Dr. Safai,
                                                                   residents must be able to learn independently and be good
                                                                   team players.

By Nelly Edmondson Gupta                                           In fact, the competition for dermatology residency slots has
                                                                   become increasingly stiff nationwide. “When I took over, resi­



I
   n 1993, Bijan Safai, M.D., professor of dermatology, took       dents were mostly selected from the New York area,” says
   over as chairman of the Department of Dermatology at            Dr. Safai. “Now we get the best applicants from all over
   New York Medical College in Valhalla. Several years later,      the country.”
he moved the residency program from Westchester to upper
                                                                   In addition to working with a wide variety of interesting patients,
Manhattan’s Metropolitan Hospital Center, a public hospital
                                                                   one of the best things about the NYMC program, say the resi­
and College affiliate that treats many underserved patients.
                                                                   dents, is the solid grounding in both clinical work and pathology.
This move turned out to be a boon for both the residency
                                                                   “One of the things that initially attracted me to NYMC was this
program and the patient population it serves.
                                                                   clinical-pathologic correlation,” says first-year resident James
“I brought the residency to the patients,” says Dr. Safai. By      Highsmith, M.D. In other programs, he explains, residents may
that he means that taking care of a more diverse, inner city       learn to read pathology slides, but not necessarily the slides
population gives the future dermatologists under his tutelage      they themselves have prepared from biopsies. “It’s nice to see
an opportunity to treat the full spectrum of clinical diseases.    the clinical picture—your patients—and then review their biopsy
The residents care for everything from acne to leprosy to toxic    slides under the microscope,” says Dr. Highsmith. “It really
epidermal necrolysis (TEN), a potentially deadly skin disease      helps you learn and remember.”
that usually results from a drug reaction.
                                                                   TEACHER, TEACH THYSELF
There are other benefits as well. “One of the great things about   Yet another draw for the NYMC program is the fact that all
working at Metropolitan Hospital is that we see patients from      dermatology residents have plenty of opportunities to teach
varied ethnicities,” says first-year resident Lavanya Krishnan,    as well as learn. Each week the residents complete multiple
M.D., one of 10 residents currently enrolled in the College-       academic duties, including journal reviews of medical and sur­
sponsored program. Many skin diseases, she explains, pre­          gical dermatology, Kodachrome sessions (clinical slides used
sent very distinctively in different types of skin. For example,   for diagnostic practice), pathology training and book review
rashes that appear on deeply pigmented skin tend to be more        lectures. The residents take turns delivering lectures to their
subtle or textured. If a doctor isn’t well-versed in these skin    peers on topics in the main textbook. In order to answer ques­
differences, making an accurate diagnosis can be especially        tions and provide background and context, the designated
challenging.                                                       lecturer must go beyond the text, thereby deepening his or
                                                                   her knowledge base.
Residents’ learning touches on the entire spectrum of medical
dermatology, including immunologic diseases of the skin,           The dermatology residents also teach medical students and
cutaneous lymphomas and sarcomas, drug eruptions, genetic          give lectures to other departments. “Medical students have a
syndromes affecting the skin, and dermatologic emergencies.        limited exposure to dermatologic disease during med school,
They also learn how to perform laser surgery, Mohs micro­          but many other specialties, such as internal medicine and
graphic surgery, blepharoplasty and skin cancer removal. In        pediatrics, need significant knowledge about the skin,” explains
short, they learn it all. “We could write a textbook” with the     Richard McCarrick, M.D., vice dean for graduate medical
20   : :   Spring/Summer 2012




                                                                                                       Dermatology director and department
                                                                                                       chair Bijan Safai, M.D., above, says
                                                                                                       the highly competitive program at
                                                                                                       New York Medical College admits
                                                                                                       only three new residents per year.
                                                                                                       Residents Lavanya Krishnan, M.D.,
                                                                                                       and William Rietkerk, M.D., prepare
                                                                                                       to treat a patient at Metropolitan
                                                                                                       Hospital Center.



education and affiliations. “So they rely on the dermatology        been migrating away from primary care and general surgery. As
residents to build their knowledge of skin diseases.”               a recent article in The New York Times noted, dermatology—like
                                                                    plastic surgery and otolaryngology—provides relatively controlla­
Although relatively few patients are admitted to hospitals solely
                                                                    ble hours, autonomy, and improved quality of life, and has the
because of skin conditions, they may have skin problems in tan­
                                                                    added benefit of being the kind of doctor patients actually like
dem with other disorders. For example, a psychiatric patient may
                                                                    and want to visit.
be admitted in crisis, and a subsequent physical exam reveals a
rash or severe lesions on his lower back. Having dermatology        Second-year resident Kathryn Russell, M.D., says that while she
residents available for consult enables the psychiatric team to     was growing up in Sarasota, Fla., her dermatologist “was the
provide comprehensive care. “There is a tremendous benefit          only doctor I enjoyed going to.” Every year, her mother took
to having a derm residency in a hospital that goes far beyond       fair-skinned, redheaded Kathryn to a dermatologist for a full-
treating patients who present with primary skin problems,” says     body skin exam; the Russells have a family history of skin can­
Dr. McCarrick. “Throughout the hospital, having derm residents      cer and Kathryn is at increased risk. Instead of dreading these
and attendings is clinically and educationally very helpful.”       medical visits, she actually looked forward to learning about
                                                                    her skin, hair and nails during her examinations. Dermatology
The residents truly must learn to master the art of diagnosis in
                                                                    “is a very fulfilling field because patients really appreciate you,”
order to recognize underlying systemic conditions. In fact, the
                                                                    she says. “You treat them, and they look better—and feel bet­
residents and their supervising attending physicians provide der­
                                                                    ter about themselves.”
matologic consultation for all inpatient services and ambulatory
care programs. They have to know the basics of internal medi­       HAVING SKIN IN THE GAME
cine, pediatrics, neurology, surgery and psychiatry to be able to   “There’s a whole list of reasons to go into dermatology,” says
competently integrate dermatologic care into all of these fields.   second-year resident Robert Lott, M.D. He points out that
                                                                    research in the field of cutaneous immunology and molecular
IT’S NATIONAL AND PERSONAL
                                                                    biology of skin is moving at a rapid pace. “As a result, we are
Indeed, dermatology has been getting more respect from all
                                                                    developing a better understanding of the immunologic and
quarters lately, and is now the most competitive specialty. In
                                                                    molecular pathogenesis of skin disease leading to optimized
recent years, many American medical school graduates have
                                                                    diagnosis, management and treatment of patients,” he says.
C H I R O N I A N      : :   New York Medical College   : :   21




These new developments are helping researchers create                                 used for growing hair and curing some of the blistering dis­
“designer drugs” for the treatment of skin-related autoimmune                         eases of childhood, and skin manifestations of graft vs. host
diseases, like psoriasis. “Many systems collide in the skin,”                         disease, a serious condition that can develop after bone
notes co-chief resident Langer. “The skin is a mirror of internal                     marrow transplantation.
diseases, with sequelae from immunologic, neurologic, infec­
                                                                                      “Dermatology is a rapidly evolving field, and cutting-edge in
tious, endocrine and neoplastic processes.” This “collision”
                                                                                      terms of new technology,” adds Dr. McCarrick. “Dermatologists
is evident in many systemic diseases, such as lupus, some
                                                                                      are in great demand, and there’s a shortage in many parts of
cancers, hypercholesterolemia and liver disease, which often
                                                                                      the country.”
show up first on the skin. In other words, adds Dr. Langer,
“The research we’re doing on skin may have greater applica­                           Drs. McCarrick and Safai believe this group of residents will
tions beyond the skin.”                                                               become experts and leaders in the field. Every year, says
                                                                                      Dr. Safai, he continues to be pleasantly surprised. “Our der­
Each year, every NYMC dermatology resident must undertake
                                                                                      matology residents are committed and diligent, and they are
an intensive research project. This year, they are studying
                                                                                      here to learn. They study hard, help each other and work well
a broad array of topics, including polymorphisms of non-
                                                                                      as a team.” ■
melanoma skin cancers, skin stem cells, which can be



Residents gather weekly for peer-teaching sessions. Clockwise from the presenter, Pantea Hashemi, M.D., are Jodi Langer, M.D.; David Weinstein, M.D.; Jennifer
Leininger, M.D.; Lavanya Krishnan, M.D.; Robert Lott, M.D.; William Rietkerk, M.D.; Jennifer Vickers, M.D.; Kathryn Russell, M.D.; and Bijan Safai, M.D., professor
and chairman. Not pictured is resident James Highsmith, M.D.




   • A REAL HONOR  
   In February, Dr. Safai was elected president of the Physician Affiliate Group of New York (PAGNY), made up of more than 2,500 phy­ icians
                                                                                                                                    s
   and health care professionals who provide services to the half dozen hospitals that comprise the New York City Health and Hospitals
   Corporation (HHC), the largest public health system in the U.S. “It is quite an honor for me to be trusted by my colleagues and elected as
   president of such an important organization,” Dr. Safai says.
22   : :   Spring/Summer 2012
C H I R O N I A N   : :   New York Medical College   : :   23




John Nunez,
Izuchukwu Ibe
and Andrea Love:
Student Athletes
Compete to Stay
Mentally and                                                                                                              John
                                                                                                                               Nun
                                                                                                                                  ez

Physically Fit
By Andrea Kott, M.P.H.



T
         he biggest disconnect in pre­         JOHN NUNEZ, SOCCER                           “I’m playing at a higher level than I ever
         paring for a career in the health     School of Health Sciences and                thought I’d play,” says Nunez, who now
         sciences may be how unhealthy         Practice                                     competes among world class players.
the journey can be. Too little sleep, too      As John Nunez tells it, two things saved     His level of commitment might seem
much fast food and not enough exercise         him during his first semester as a doc­      incompatible with doctoral studies.
are the pillars of life for medical students   toral candidate in physical therapy: the     Indeed, Nunez says some classmates
and graduate students. That is, unless         camaraderie of classmates and playing        scratch their heads when he closes his
they are so committed to fitness that          semi-pro soccer. “It was the hardest         books and leaves for practice. Yet for
their success depends on it.                   academic semester of my life,” the           this 27-year-old, who is both exuberant
                                               second-year PT student says, recalling       and calm, there is no choice. In the first
John Nunez, Izuchukwu Ibe and Andrea
                                               a schedule that included neuro­ cience,
                                                                                s           place, playing soccer keeps him aca­
Love are such fitness-philes. They don’t
                                               physiology and exercise science. Then,       demically focused. “It keeps you on top
jog or take the occasional Zumba class.
                                               two months before school started, he         of your school work,” he says. Second,
They train for marathons, compete in
                                               was invited to try out for the Cosmo­        being fit is critical for physical therapists,
semi-pro soccer tournaments and prac­
                                               politan League—the Cadillac of amateur       who often must lift patients heavier than
tice black belt judo. They would no
                                               soccer leagues. It was a fantasy come        themselves and are uniquely positioned
more miss a workout than they would
                                               true for the lifelong soccer player, who     to inspire patients toward greater levels
cut a class, clinic or lab.
                                               had always dreamed of playing college-       of health. “As a medical professional,
                                               level soccer (he played Division 1 at        you should demonstrate fitness and
                                               College of the Holy Cross) or going          good health to patients,” Nunez says.
                                               into medicine.
Ss 2012 chironian
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  • 1. Chironi a n S P R I N G / S U M M E R 2 012 New York Medical College INSIDE: Social Media in Medicine Researchers Stalk Cancer and Cardiovascular Disease Medicine + Music = One Extraordinary Professor
  • 2. Chironi a n New York Medical College A Member of the Touro College and University System EDITORIAL TABLE OF CONTENTS Editor Donna E. Moriarty, M.P.H. ’04 Writers Nelly Edmondson Gupta Alicia Prater, Ph.D. ’07 01 PARTING THOUGHTS FROM THE OUTGOING DEAN Andrea Kott, M.P.H. Cynthia A. Read Lori-Ann Perrault Marjorie Roberts Melissa F. Pheterson FEATURES Contributors 02 AN EXPERT AT PROBING FOR ANSWERS Chirag Upreti Elizabeth Kertowidjojo Zbigniew Darzynkiewicz, M.D., Ph.D., develops the technology and methods Editorial Board for understanding cell proliferation, opening doors to more effective cancer Doris Bucher, Ph.D. Jennifer Minieri-Arroyo, M.S. ’06 treatment. Catharine Crea Alberto Nasjletti, M.D. Eileen M. Dieck, M.D. ’86 James O’Brien, Ph.D. 06 PIECES OF THE CARDIOVASCULAR PUZZLE Rhea Dornbush, Ph.D., M.P.H. Matthew A. Pravetz, O.F.M., Ph.D. ’88 Huang, M.D., Ph.D., studies estrogen, blood flow and blood pressure, and An Michael Goligorsky, M.D., Ph.D. Ira Schwartz, Ph.D. how they fit together. Thomas Hintze, Ph.D. ’80 Michal L. Schwartzman, Ph.D. Maximilian Klein Paul Wallach, M.D. 10 MAKING A MENU FOR LIFE WITH MUSIC AND MEDICINE Julie A. Kubaska, M.S. Gary P. Wormser, M.D. Stephen E. Moshman, M.D., gives equal time to his main passions. Edmund LaGamma, M.D. ’76 14 IS MEDICINE READY FOR SOCIAL MEDIA? Design Curran Connors, Inc. Photography William Taufic proponents claim the use of new media in medicine is a boon, causing Its ADMINISTRATION shifting paradigms, seismic changes, and better connections online and off. Edward C. Halperin, M.D., M.A., Chancellor for Health Affairs and   Chief Executive Officer Alan Kadish, M.D., President Ralph A. O’Connell, M.D., Dean, School of Medicine STUDENTS AND FELLOWS Francis L. Belloni, Ph.D., Dean, Graduate School of Basic Medical Sciences 18 BEYOND SKIN DEEP Robert W. Amler, M.D., Dean, School of Health Sciences and Practice and learning to treat the skin—the mirror of internal diseases—dermatology In   Vice President, Government residents inject dermatologic care into a host of other specialties. Office of Public Relations Donna E. Moriarty, M.P.H. ’04, Associate Vice President, Communications 22 STUDENT ATHLETES COMPETE TO STAY MENTALLY AND Lori-Ann Perrault, Public Information Editor PHYSICALLY FIT Kevin R. Cummings, M.P.S., M.P.H. ’00, Director, Web Communications John Nunez, Izuchukwu Ibe and Andrea Love Karla Cambron, Department Administrator 26 GRADUATE STUDENTS EXPLAIN IT ALL Please direct all inquiries to: Chirag Upreti and Elizabeth Kertowidjojo New York Medical College/Chironian, Valhalla, NY 10595. We authorize the use of any material with attribution to New York Medical College. ALUMNI NEWS Chironian is published semi-annually by the Office of Public Relations. We welcome reader feedback. Contact us at (914) 594-4536 or chironian@nymc.edu. 28 IRINA ELLISON, PH.D. ’05 NEW YORK MEDICAL COLLEGE AFFILIATES Stamping Out Smoking and Building Community Academic Medical Center Westchester Medical Center 30 SUSAN J. BLAKENEY, M.S. ’92, M.P.H. ’10 University Hospital Two Degrees, Two Paths to Making a Difference Metropolitan Hospital Center 32 TIMOTHY HSIEH, M.D. ’98 Specialty Hospital An Easterner, Now at Home in Oklahoma The New York Eye and Ear Infirmary Affiliated Hospitals Benedictine Hospital Richmond University Medical CLASS NOTES AND PHOTOS Calvary Hospital Center Greenwich Hospital Saint Joseph’s Regional Medical 09 COMMENCEMENT Hoboken University Medical Center Center, Paterson (NJ) 29 IN MEMORIAM Jamaica Hospital Medical Center Saint Joseph’s Medical Center, Keller Army Community Hospital, Yonkers 30 MILESTONES West Point Saint Vincent’s Medical Center, 33 ALUMNI REUNIONS Lenox Hill Hospital Bridgeport (CT) Montefiore Medical Center, Sound Shore Medical Center North Division of Westchester Mount Vernon Hospital Terence Cardinal Cooke Health Northern Westchester Hospital Care Center Center VA Hudson Valley Health Care Norwalk Hospital System Phelps Memorial Hospital Center ON THE COVER: Affiliated Ambulatory Care Programs For practitioners and their patients, new media—consisting of social media platforms, portable applications (“apps”) Center for Comprehensive Health Practice and mobile devices—are becoming a force to be reckoned with in health care today. Pew Surveys show that 44 million Open Door Family Medical Centers health care apps were downloaded in 2011. Our cover photo imagines a future that might not be so far-fetched. Westchester Institute for Human Development iPad image courtesy of www3d4medical.com. Photo by William Taufic, ©2012, all rights reserved. Follow us on Twitter @NYMC_tweets
  • 3. Parting Thoughts f r o m t h e O u t g o i n g D e a n On June 1, the day after New Touro’s president, was appointed president of New York York Medical College cele­ Medical College. Following a nationwide academic search, brates its 153rd Commence­ a candidate was selected to lead New York Medical College ment in Carnegie Hall, I will into the future. We are all very pleased to inform you that on step down as dean of the May 1, Edward C. Halperin, M.D., M.A., became chancellor School of Medicine. As I plan for health affairs and chief executive officer of New York to tell some 362 graduates Medical College. and their families and friends, A graduate of Yale School of Medicine, Dr. Halperin completed the first time I went to medical an internship in internal medicine at Stanford and his residency school it took me only four at Harvard’s Massachusetts General Hospital. He spent 23 years to get through; this time years at Duke University, where he rose to become chairman it required sixteen. You do slow down as you get older, but in of the Department of Radiation Oncology and vice dean of the my defense, medical education is much more complex today. School of Medicine. He also earned a Master of Arts in Liberal The 174 newly minted physicians of the Class of 2012 matched Studies there. Before coming to the College, Dr. Halperin was in twenty medical specialties at strong teaching hospitals dean of the School of Medicine at the Univer­ ity of Louisville. s around the country. We are very proud of our graduates; they I had the privilege of getting to know Ed when we were both will enhance the reputation of New York Medical College serving on the Council of Deans. I can assure you New York wherever they go. The about-to-enter Class of 2016 is shaping Medical College is in very good hands. up as I write this. From more than 11,000 applicants, 1,400 Dr. Halperin will also serve as provost for biomedical affairs were selected to interview for admission to a class of 190. at Touro, and will serve as executive dean of the School of Their personal characteristics, diversity and academic creden­ Medicine after I step down. With his ten years of experience as tials predict a very strong class, and we are glad to note that a medical school vice dean and dean, Dr. Halperin is eminently our robust applicant pool—among the largest in the nation— qualified to serve in this capacity until we begin a search for a allows us to select the very best candidates. new dean—probably in the coming academic year. The last two years have presented the College with challenges One of the first concrete (literally and figuratively) results of the and opportunities. When Saint Vincent’s Hospital in Manhattan Touro affiliation will be the construction of a new clinical skills closed in 2010, we were required to reassign 50 medical students center, which is expected to open in 2013. Watch for more to clerkships at other teaching hospitals and to place 300 news about this exciting development—and for more in future “orphaned” residents in GME programs. It was a monumental issues of Chironian, both about and by Dr. Halperin, a prolific challenge that was successfully met thanks to the cooperation writer and speaker who was chosen to deliver this year’s of our teaching affiliates, Westchester Medical Center and Commencement address. Metropolitan Hospital Center. Helping to ease the burden were new or expanded affiliations with Keller Army Hospital at West In my final weeks as dean, I received numerous calls and visits Point, Lenox Hill Hospital in New York City, Phelps Memorial from colleagues and students stopping by to say goodbye and Hospital Center in Sleepy Hollow, N.Y., and Saint Joseph’s wish me the best. With great tact, I told them that I planned to Health Care System in Paterson, N.J. This complicated logisti­ stay on the faculty, teaching in the Department of Psy­ hi­ try c a cal exercise would not have been possible without the support and Behavioral Sciences. I have thoroughly enjoyed the honor of our clinical chairs, program directors and the good will of and challenge of serving as dean and, prior to Dr. Halperin’s organized medicine. I want to express my gratitude to Paul M. arrival, as provost. The best reward is the assurance that Wallach, M.D., vice dean for medical education, Richard G. during my tenure, with the unwavering support of the Board McCarrick, M.D., vice dean for graduate medical education of Trustees, department chairs, faculty and administration, and affiliations, and Gladys M. Ayala, M.D., M.P.H., senior approximately 3,000 individuals received M.D. degrees from associate dean for student affairs, for playing key roles in the New York Medical College, and are now in residency or prac­ effort, which provided the opportunity to explore new models tice, shaping the future of medicine. for the curriculum. Sincerely, The transition from sponsorship by the Archdiocese of New York to the Touro College and University System was com­ pleted this academic year. This historic undertaking was carried out in the best academic tradition of collegiality, with input from Ralph A. O’Connell, M.D. faculty, administration and students. Alan H. Kadish, M.D., Immediate Past Provost and Dean, School of Medicine
  • 4. 02 : : Spring/Summer 2012 An Expert at Probing
  • 5. C H I R O N I A N : : New York Medical College : : 03 for Answers Zbigniew Darzynkiewicz, M.D., Ph.D., develops the technology and methods for understanding cell proliferation, opening doors to more effective cancer treatment. By Alicia M. Prater, Ph.D. ’07 T he “War on Cancer” marked its 40th anniversary in Dr. Darzynkiewicz has the distinction of being a pioneer in the December—a long time in anybody’s book, but not field, a man who has been at the forefront of cell cycle, cell long enough to come up with a reliable cure for any of proliferation, and apoptosis research since before he joined the thousands of symptoms that use uncontrolled cell growth New York Medical College in 1990. In addition to directing to thrive. President Richard M. Nixon began using the metaphor the Brander Cancer Research Institute (BCRI), he also holds in speeches to support the National Cancer Act, a historic bill professorships in the departments of pathology, medicine, passed at the close of 1971 to initiate federal government and microbiology and immunology. His research, which has spending for cancer research. Scientists and physicians could earned him international repute, has been supported by grants approach their studies from the laboratory or by clinically treat­ from the NIH and the National Cancer Institute, including a ing patients with medicinal remedies specifically designed prestigious MERIT award for his research on the effects of around their genetic make-ups in a process now called trans­ anticancer drugs on the cell cycle. He was also a recipient of a lational, or bench to bedside, treatment. At New York Medical grant from NASA to develop new technologies for cell staining College and affiliated Westchester Medical Center, there are and analysis applicable to the micro-gravity conditions of the nearly 20 investigators with M.D. and Ph.D. degrees who have Space Station. He is the holder of eight U.S. patents, author spent their entire lives waging the war. One of them, Zbigniew or editor of 15 books, and has published nearly 700 peer- Darzynkiewicz, M.D., Ph.D., has been point man at the cellular reviewed articles. level, achieving world renown for his dogged pursuit of answers COLLEAGUES IN CYTOMETRY to a puzzle: how to turn cancer cells against themselves, Frank Traganos, Ph.D., professor of experimental pathology instead of taking more human lives. and of medicine and associate director of BCRI, has worked When a cell is damaged, chemical signals are activated that with Dr. Darzynkiewicz for more than three decades and drive the cell to die without affecting nearby healthy cells. co-authored more than 120 papers with him. “He has made Knowing how to control this process, known as apoptosis, numerous contributions to our understanding of the processes could allow doctors to control tumor growth with little, if any, and mechanisms underlying cell proliferation, cell death, and toxicity to healthy cells. Research examining the differences cell damage by investigating processes at the single cell level,” between apoptotic and normal cells uses techniques that dif­ says Dr. Traganos. In 1992, the two collaborated with other ferentiate between the molecular attributes of individual cells. colleagues on a paper published in Cytometry describing the
  • 6. 04 : : Spring/Summer 2012 molecular attributes that characterize apoptotic cells in flow work is important, because “if replicated, in vivo the findings cytometry. Now considered a landmark paper, it has been would have broad applicability, even though it can take a long cited more than 1,500 times—and Dr. Darzynkiewicz has time to see clinical applications.” written a host of other papers with citations numbering in In the 1970s and 1980s, the understanding behind fighting can­ the hundreds. cer was to poison the malignant cells, which resulted in devas­ He coined the term cell necrobiology, or the biology of cell tating side effects that made cancer a word spoken only in death, and is credited with developing techniques for analyz­ hushed tones of dread. During this period, Dr. Darzynkiewicz’s ing cell kinetics, tumor progression and cell senescence. He lab successfully characterized the mechanism of action of discovered the basis for identifying a cellular resting phase anti-cancer drugs that were effective at lower doses, resulting known as “quiescent” or G 0. Although his name is not quite in less toxicity to the patient than most of the drugs in use at a household word, he is perhaps best known for developing that time. One of those drugs was mitoxantrone, which is cur­ the TUNEL assay (TUNEL stands for terminal deoxynucleotidyl rently used in the treatment of metastatic breast cancer, acute transferase dUTP nick end labeling), which remains one of the myeloid leukemia and non-Hodgkin’s lymphoma. most widely used techniques for measuring apoptosis. But his GOING WITH THE FLOW work goes beyond simply trying to understand cell suicide. Shortly after being named director of the Flow Cytometry Core After earning his M.D. from the Medical University of Warsaw, Facility at Sloan-Kettering he was recruited to New York Medi­ Poland, in 1960, Zbigniew Darzynkiewicz earned the equiv­ cal College. Zalmen Arlin, M.D., tapped Dr. Darzynkiewicz to alent of a Ph.D. on the basis of a thesis on the teratogenic head the College’s new Cancer Research Institute, founded actions of insulin in the chicken embryo. He developed a fasci­ the summer before to enable research in the etiology, classi­ nation with cell biology “because the analysis of molecular fication, diagnosis and treatment of tumors. The key to this mechanisms in individual cells reveals the mystery of life.” His research would be flow cytometry, which allows variability early work focused on developing new methods for studying among cancer cells to be evaluated in terms of their sensitiv­ enzymes in individual cells using radioisotope-labeled enzyme ity to anticancer drugs. “The knowledge of such variability inhibitors. Two years later he accepted a position at the is essential in design­ng clinical treatments that may be suc­ i Karolinska Institute in Stockholm, Sweden, which, he says, cessful in eradicating all cancer cells and thereby preventing “was the Mecca for cell biologists because of the capability to cancer relapse,” says Dr. Darzynkiewicz. measure DNA and RNA content in individual cells.” With flow cytometric measurements, apoptosis moved to the ADVANCING METHODOLOGY forefront. When damaged, normal cells become senescent, With the methods and equipment available at that time, but tumor cells do not have the same ability to respond. Lack­ Dr. Darzynkiewicz was capable of measuring 80 cells per ing any damage control mechanism, they die via apoptosis, a day—a pittance compared to the thousands per second he pattern of events that is so orderly the process is often called measures now. Over the years the technology, and his capa­ programmed cell death. This difference can be exploited to bility, advanced with radioisotope labeling and autoradiography, increase the response to cancer treatment. and then with flow cytometry and fluorescent probes capable “New strategies are being developed and tested in pre-clinical of identifying a variety of cell attributes. He expanded on each studies to enhance the susceptibility of cancer cells to radia­ of these approaches to explore mechanisms underlying cell tion and DNA-damaging drugs by increasing their propensity proliferation and the response of cells to anticancer drugs. for cell suicide,” explains Dr. Darzynkiewicz. “Attempts are also In the late 1960s it was time to head for the U.S. There he being made to force cancer cells to undergo ‘cellular senes­ held positions at SUNY Buffalo and the Boston Biomedical cence,’ which permanently halts their reproductive capability.” Research Institute before moving on to positions in New York His lab is also studying the mechanisms in normal, non-tumor at Memorial Sloan-Kettering Cancer Center and Cornell cells to understand resistance to DNA damage. The goal is University Graduate School of Medical Sciences, where he the same as it has been for the past three decades: to ease met Dr. Traganos. “I was fascinated—not so much by the the injurious side effects of radiotherapy and chemotherapy by technology as with the biological problems this technology reducing toxicity to healthy cells. could help solve,” he says. In their early work together at Sloan-Kettering, Dr. Darzynkiewicz and Dr. Traganos evalu­ Speaking with Dr. Darzynkiewicz, one gets the sense that new ated potential chemotherapeutic drugs in vitro, and their work avenues in basic research are closely intertwined rather than today is still in vitro. Dr. Traganos explains that the cell-based disconnected areas of study. In the past his work has integrated
  • 7. C H I R O N I A N : : New York Medical College : : 05 The Darzynkiewicz team is well acquainted with the sophisticated technology that aids in his research. From left are Frank Traganos, Ph.D., M.D./Ph.D. student Elise McKenna, Dr. Darzynkiewicz, Dorota Halicka, M.D., Ph.D., Jiangwei Li, Ph.D., and Jan Kunicki. Not pictured is Hong Zhao, Ph.D. chemotherapy with apoptosis, and now it integrates cancer determine the mechanism of anti-cancer drugs. And many biology with the process of aging. probes used world­ ide for detecting different stages of cell w differentiation were developed by his lab, including acridine Dr. Darzynkiewicz’s work in DNA damage also spans several orange and BrdU incorporation into nucleic acids. “We are one decades. He was the first to show that the genetic defect in step ahead because we’ve been developing the technology,” DNA repair in xeroderma pigmentosum can be corrected. And he says. in 2010 he published work on double-stranded breaks and the carcinogenicity of tobacco smoke. His laboratory also detected The probes used in cytometry can include different molecules, constitutive DNA damage signaling as a consequence of oxi­ such as fluorescence-tagged antibodies or stains. The anti­ dative metabolism. He explains, “This oxidative DNA damage bodies used as probes can be specific for cell surface pro­ causes DNA replication stress which, when combined with teins or indirectly labeled by a secondary antibody. Regardless cellular growth driven by the mTOR (mammalian target of of the type of probe, they are important in a variety of research rapamycin) pathway, is considered to be the major cause of areas and have a greater impact over time as more about the aging and predisposes an individual to cancer.” In addition to role of a particular protein in the cell is understood. Dr. rapamycin, the diabetes medication metformin and vitamin D Darzynkiewicz’s lab includes a cell sorter as well as a four-laser are potential agents for suppressing the mTOR pathway. This scanning cytom­ ter, both with multiple channels for detecting e suppression could create leaner and healthier cells, a context different types of fluorescence. of aging currently being studied in Dr. Darzynkiewicz’s lab. In terms of sheer lab output, Dr. Darzynkiewicz ranks at the SETTING THE STANDARD top of the fields of cell cycle, flow cytometry and apoptosis. Without flow cytometry and similar techniques “the work He explains that his accomplishments in different areas of cell Dr. Darzynkiewicz does would be decades behind,” says biology are due to the development of new methods for prob­ Dr. Traganos. His colleague agrees. “Without these tools, our ing individual cells at the molecular level. With these methods research would be impossible,” Dr. Darzynkiewicz admits. cell growth, proliferation, carcinogenesis and response to anti­ His current work, supported by a grant from the NIH, aims to tumor treatments can be studied. develop probes to study the DNA damage response and And in this, his thirty-third year of continuous funding, aging processes. He is already credited with developing Zbigniew Darzynkiewicz, M.D., Ph.D., continues to probe probes identifying individual stages of the cell cycle to cells for answers. ■
  • 8. 06 : : Spring/Summer 2012    Pieces of the Cardiovascular Puzzle An Huang, M.D., Ph.D., studies estrogen, blood flow and blood pressure, and how they fit together. By Cynthia A. Read A re you among the one percent? need for better understanding becomes professors, so her interest in medicine The question is not about what even more critical. developed early. But her path was tem­ you may think it is. It refers to porarily derailed by the harsh reforms of An Huang, M.D., Ph.D., associate profes­ the percentage of Americans who enjoy the Chinese Cultural Revolution. At the sor in the Department of Physiology, is ideal cardiovascular health, according to time she graduated from high school, studying one aspect of this challenge: a position paper released by the American many students were being forced out of the gender-specific regulation of endo­ Heart Association last March. The figure cities and effectively exiled to work in thelial function in arterioles, the tiny is actually less than one percent. factories or farms, rather than going to blood vessels that branch out from arter­ college. In 1977, after these policies Heart disease is still the leading cause of ies throughout the body. Her research, changed, Huang was among the first death—not only in the U.S., but in every supported by a series of grants from the group of students allowed to enter college. major developed country. The myth that National Institutes of Health, is part of She received her M.D. from Shanghai it is primarily a man’s problem has also a multi-faceted, multi-department pro­ Second Medical University in 1982 and been debunked. In fact, more women’s gram at the College that pairs basic sci­ was directed by the government to enter lives are claimed by cardiovascular dis­ ence and clinical research in a quest to the practice of general surgery. ease than by cancer, chronic respiratory improve the outcomes in diseases that disease, Alzheimer’s disease, and acci­ affect the heart and circulatory system. By the time China began to open to the dents combined. When factoring in outside world in 1990, Dr. Huang had FROM CHINA TO NEW YORK deaths from stroke, diabetes and other earned an M.S. and a Ph.D. in surgery. The youngest of four children, An Huang diseases that are related to problems Feeling that she’d advanced in her pro­ grew up in the People’s Republic of with blood flow and blood pressure, the fession as far as she could in her home China. Both of her parents were medical country, she was eager to see what she
  • 9. C H I R O N I A N : : New York Medical College : : 07 might learn elsewhere. Although she was After their daughter Angela was born in Hypertension from overly constricted still thinking about pursuing her clinical 1996, Dr. Huang brought her to work blood vessels increases the workload interests, she landed a position as a in her bassinet when she was only a on the heart, leading to thickening of the research fellow in the Depart­ ent of m month old so the family research proj­ heart muscle (myocardial hypertrophy), Physiology in 1992. And, in what she ects could continue. often followed by heart failure. Women calls “one of the luckiest moments in my have a bigger vasodilator response than GENDER DIFFERENCES life,” she met the late Gabor Kaley, Ph.D., men and, before menopause, a lower Beginning with her first research projects who served for 37 years as chairman risk of heart disease. It appears that estro­ with Drs. Kaley and Sun, along with Akos of the Department of Physiology. “He gen is responsible. When the ovaries Koller, M.D., Ph.D., professor of physiol­ taught me everything about research,” are removed from experimental animals ogy, Dr. Huang has investigated microcir­ she says. “It was my great honor to be such as rats, the females have a reduced culation—the term for the small blood able to work with Dr. Kaley. It would have dilator response, but if the same females vessels embedded in organs that are been impossible for me to become an are given estrogen after ovariectomy, the responsible for the distribution of blood established scientist without him.” dilator response returns. within the organ tissues and for maintain­ The College brought Dr. Huang an addi­ ing blood pressure. The arterioles carry In their initial studies, Dr. Huang and her tional gift: Dong Sun, M.D., who was blood to the capillaries and, like all blood collaborators explored the mechanisms also a product of the first wave after the vessels, are lined with a thin layer of cells of nitric oxide (NO) in dilating arterioles in Cultural Revolution, was then a Ph.D. comprising the endothelium. Among the rats and mice. When synthesized in the student under Dr. Kaley. The two came many functions of endothelial cells are endothelium of blood vessels, nitric oxide halfway around the globe to meet on the controlling the dilation and constriction is also called endothelium-derived relax­ Valhalla campus, and married in 1994. of the arterioles. ing factor, so named for its ability, when
  • 10. 08 : : Spring/Summer 2012 “All the expertise I need is here at NYMC.” Assisting Dr. Huang in her study of gender-specific regulation of endothelial function in arterioles are, from left: Dong Sun, M.D., Ph.D., Hongyan Wu, technician, and Caroline Ojaimi, Ph.D. released from the endothelium, to signal exists, which genes are involved, what somewhat protected from cardiovascu­ the surrounding smooth muscle to relax. earlier influences come into play, and lar events. She has also provided signifi­ This dilates the vessel and increases how changes in vasodilation, and there­ cant evidence on the relevancy of the blood flow, therefore decreasing blood fore in the regulation of blood pressure, microcirculation in vascular biology and pressure. The team showed that estro­ are related to aging associated with medicine.” gen increases the expression and activity menopause. LOOKING AHEAD of eNOS, the enzyme that synthesizes NO. “All the expertise I need is here at Dr. Huang thinks that better understand­ Genetically modified mice that lack the NYMC,” she says. She continues to col­ ing the mechanisms by which estrogen gene to produce eNOS, and therefore laborate with her husband and with regulates the dilation of blood vessels lack nitric oxide, are hypertensive—yet co-investigator Caroline Ojaimi, Ph.D., could lead to improved treatment for still, female mice have better regulation of assistant professor of physiology. She menopausal women, and her research blood pressure than males do. also receives support from Edward J. could point to a new therapeutic target So Dr. Huang’s next step was to study Messina, Ph.D. ’73, professor, and to improve cardiovascular function where how estrogen affects the dilation of Thomas Hintze, Ph.D. ’80, professor and NO is deficient. blood vessels independent of the activity chairman of the Depart­ ent of Physiology, m That is down the road, however. For of nitric oxide. She discovered additional as well as other members of the depart­ now, Dr. Huang relies on a motto of endothelial mediators were dependent ment. Dr. Messina says, “It has been a sorts: “Be solid at every step,” she says, on cytochrome P450 (CYP). She has pleasure and an honor to watch the “keep going, and never give up.” It has also learned that different forms of CYP growth of Dr. Huang as an independent served her well, not only in her years of are responsible for the release of other investigator. I am impressed with her research at New York Medical College vasodilators in rats, mice and humans. research success, which has offered but in the life journey that brought her Because this sequence seems specific important clues to our understanding more than 7,000 miles from Shanghai to females, Dr. Huang has begun to as to why premenopausal women are to Valhalla. ■ explore why these gender difference
  • 11. 2012encement! Our omm C H I R O N I A N : : New York Medical College : : 09 1 C 2 3 4 7 5 8 6 9 PHOTOS 1: Drs. Alan Kadish, Karl Adler, Edward Halperin, 3: rustee Ronald F. Poe, President Alan Kadish, M.D., T 6: r. Halperin with Rabbi Moshe Krupka. D Francis Belloni, Ralph O’Connell and Robert Amler, Honoree Karl P. Adler, M.D., and Board Chairman 7: ace Bearer, Fredrick Z. Bierman, M.D. M and Mr. David Raab. Dr. Mark Hasten. 8: chool of Medicine graduates capture the excitement S 2: Chancellor and CEO Edward C. Halperin, M.D., M.A., 4: raduates from the Graduate School of Basic G in Carnegie Hall. gives the Commencement address. Medical Sciences. 9: raduates from the School of Health Sciences G 5: rs. Kadish, Hasten and Halperin. D and Practice.
  • 12. 10 : : Spring/Summer 2012 Music and Medicine Making a Menu for Life with }Stephen E. Moshman, M.D., } gives equal time to his main passions.
  • 13. C H I R O N I A N : : New York Medical College : : 11 By Marjorie Roberts T he Department of Medicine is a challenging and exceptional place to work. Many members of the fac­ ulty were recruited to the Valhalla campus by friends and colleagues from their previous lives. A case in point is Stephen E. Moshman, M.D., who radiates energy, caring and has mentored students who are learning to make critical decisions that will impact how they practice medicine the rest of their lives. “My greatest passions are medicine and music, but I am ardent about a lot of things,” he admits, and he is not exaggerating. The mere mention of baseball, history and collegiality on a daily basis—weekends included. This not only astronomy causes his eyes to light up and his voice to rise enables him to perform an unusual variety of tasks for his job, in intensity. but also allows him to have a second life filled with music. This You can only wonder how he is able to find the spiritual spring, his dual passions for teaching and music became a wherewithal and physical strength to staff, rehearse and con­ perfect storm that honored Dr. Moshman for both his roles. He duct the Einstein orchestra in four concerts a year. Ask him, was promoted to Professor of Clinical Medicine, a title he will and this Renaissance man replies, “I can do it because I am cherish in recognition of his 43 years of service to medicine—10 a very happy man.” at the College and Westchester Medical Center (WMC)—and gratification for acknowledgement of his 30th anniversary year BEING HAPPY as founder, composer, and conductor of the Albert Einstein How happy is he? Enough to spar with the colleague who Symphony Orchestra, serving the Bronx community through recruited him from Einstein and its affiliated Montefiore Hospital: the talents of 60 mostly non-professional musicians with a William H. Frishman, M.D., the Barbara and William Rosenthal concert agenda each year. Professor and Chairman of Medicine. They were both faculty members at Einstein, where Moshman spent 30 years before Medicine inspires him to teach, for Moshman a sacred word coming to the College. They take their sworn allegiance to that covers everything he does for the young heroes who follow differing New York baseball teams as set in stone, yet their in his path. As director of the third-year medicine clerkship, he
  • 14. 12 : : Spring/Summer 2012 } In both the classroom and the orchestra pit, Stephen Moshman dictates what happens from the moment he walks into the room. } love of the game is reason enough to sustain their friendship. the Adult Primary Care Clinic and his teaching duties in the “Baseball is the only sport. I come alive when pitchers and Pre-Internship Program, formerly called the Fifth Pathway. As to catchers report for spring training,” says Moshman, a former the variety of situations in which he finds himself, Dr. Moshman Brooklyn Dodger fan. He is ready to take on another frus­ expresses his satisfaction with volunteering for unscheduled trating year as a Met supporter, but he wouldn’t want it any teaching assignments by insisting that, “I have always consid­ other way. ered myself a militant non-specialist. I accept these assign­ ments with enthusiasm. After all, teaching medicine is 75 Robert G. Lerner, M.D., vice chairman of the Department of percent of what I do and I absolutely relish it all.” Dr. Frishman Medicine at the College and chief of hematology at WMC, concurs: “We go back 40 years. Currently, every July, he and shares Moshman’s double appreciation of teaching and music. I share the welcoming lectures for the new clerkship students The Moshmans and Lerners, who have enjoyed many perfor­ and we teach together on the wards at WMC. He is also very mances of the Einstein Orchestra, also attend Lincoln Center active in recruiting house staff for Valhalla.” events together. “I have been very impressed with everything he’s done,” says Dr. Lerner, although it is Moshman’s work When pre-concert time rolls around, you wouldn’t know from ethic that draws Lerner’s greatest interest and admiration. his disposition that he was stressed. Norma Moshman, who “I got to know him better when he and I began teaching sounds as laid back as the husband she is describing, offers second-year students along with his brother, Eliot Moshman, this assessment: [M.D., clinical assistant professor of medicine], an internist in “For the most part he is very relaxed. He doesn’t worry. He White Plains who plays French horn in the orchestra.” may have trepidations about a certain passage the orchestra There is also Norma Moshman, Stephen’s wife, who is coordi­ is having trouble with, but in 30 years the orchestra has never nator for the Internal Medicine Residency Program. Together failed him.” Any changes planned for season 31? “He doesn’t the Moshmans make up a sort of parents-by-proxy situation, wear tails and the musicians just wear black jackets, although which makes it seem like there are Moshmans everywhere. at the March concert the orchestra wore what is called Stephen claims he never repeats a task two days in a row, but Broadway Black. Stephen wore a silver tie and they all really certain responsibilities are his alone. He teaches “Foundations looked good. Now they are considering wearing Broadway of Clinical Medicine,” a mandatory course for first- and second- Black all the time.” year students. And there is “Harvey,” a favorite mechanism NATURAL BORN TEACHER that involves an inventive way to teach, sometimes using musi­ In both the classroom and the orchestra pit, Stephen cal sounds for emphasis. Moshman dictates what happens from the moment he walks AN APPRECIATIVE COLLEAGUE into the room. In between he gets as close as he can by The Harvey Cardiopulmonary Patient Simulator is a digital life becoming an excellent teacher who, like any good performer, size model of a patient with lots of heart problems, which can makes things exciting. A slew of teaching awards attest to his be dialed up at will. Cardiac pathology and proper diagnosis tremendous teaching talents and famous sense of humor. But are the basic skills that Harvey helps teach to third-year stu­ can he continue to do everything himself? With the orchestra, dents, pre-internship students, interns and residents. this encompasses making the selections to be played (many are his own compositions), choosing the soloists and even Among Dr. Moshman’s other purviews are the residency writing the program notes before he rehearses the musicians program in internal medicine where he is deputy director, and conducts the day of the performance. He has been
  • 15. C H I R O N I A N : : New York Medical College : : 13 immersed in this medical/musical arrangement all his life, past season there were six players from New York Medical and there is one doctor/musician who has been a part of College; about one-third of the group are medical students, most of it. faculty and house staff, and the rest are from the community. Dr. Moshman believes his is one of the longest running com­ Etta Eskridge, M.D., Ph.D., now an assistant professor of med­ munity orchestras in the city, and “certainly, the only medical icine at the College, was 22 when she met Steve Moshman. school-affiliated orchestra.” Both had earned their undergraduate degrees at the University of Rochester; she chose Einstein for medical school while he Dr. Moshman has established that even in his spare time, he is selected the University of Buffalo. She found out he was devoted to the students who are his audience—in and out of looking for musicians for a new orchestra he was assembling hospital settings. Just as he learned to play the violin from his and she played the viola, a rare commodity in terms of slots to father, his first teacher who made music such an integral part be filled. The rest, since 1982 and then some, is history. Four of his upbringing, he makes himself available to those who years ago Dr. Moshman recruited her to join Westchester need help—even the ones who come around only when he Medical Center, where she is a hospitalist and director of hosts his annual pool party at his Dobbs Ferry, N.Y., home palli­ative care. (which, by the way, was designed by a student of Frank Lloyd Wright). The party is Dr. Moshman’s way of plying his guests “He is like a savant,” she says of Moshman. “He is a walking with art and the finer things in life. He has no ulterior motive for encyclopedia of knowledge, and he writes the best program this gesture, and no message is intended or implied—other notes ever…He has given all of us an unbelievable gift—the than to enjoy life and art, which are all around us. ■ opportunity to play music—and we do a pretty good job.” This   
  • 16. 14 : : Spring/Summer 2012 Is MEDICINE Ready for Social Media? Its proponents claim the use of new media in medicine is a boon, causing shifting paradigms, seismic changes, and better connections online and off.
  • 17. C H I R O N I A N : : New York Medical College : : 15 By Melissa F. Pheterson T witter, tablets, texting: these are using them for health care purposes, Among the speakers was Kent Bottles, means and methods of social and 44 million health apps were down­ M.D., who serves as the social media media now surging in popularity. loaded in 2011. Even the prestigious liaison for the Association of American They are also revolutionizing medical Mayo Clinic in Minnesota has started a Medical Colleges. “Most older medical practice and education, including Center for Social Media to train physi­ educators like myself are ‘digital immi­ at New York Medical College. From cians in social media strategy. grants’ who still speak the new language three-dimensional views of anatomy with an accent,” says Dr. Bottles, a “When I first started to meet with groups to classroom discussions sparked by Senior Fellow at The Thomas Jefferson about social media in medicine, their text-messaging, the wealth of material University School of Popula­ion Health t eyes were rolling,” recalls Dr. Luks. “They summoned by a few finger-taps helps in Philadelphia. “It is the medical stu­ thought it meant posting what you had educators share and receive critical dents who are the digital natives that for dinner or checking in at Starbucks. findings, more fully engages students are really leading the way. I think it’s But as in all professions, the immediacy with the curricula, and helps doctors relevant that the topic was introduced and interactivity of social media helps build stronger connections, online and [to NYMC] at a medical student confer­ us clinicians humanize our presence off, with patients. ence and not by faculty.” and foster our relevance in a world “Why am I on social media? Because that’s increasingly going online. TRANSFORMING MEDICINE I’m social,” says Howard Luks, M.D. ’91. Resources for doctors. Smart phones “They’re talking about us, talking about The associate professor of orthopedic and tablets, equipped with task-specific health,” he declares. “Now it’s up to us surgery at the College and chief of programs (called “apps”), make a wealth to jump into that conversation. If we sports medicine and arthroscopy at of clinical information and references don’t control our own message, others Westchester Medical Center likes to readily available on a portable screen. will define who we are.” add, “That means sincere, open, collab­ Among College faculty, popular apps orative, interested, authentic, and like­ The College has been doing its part to include Epocrates RX, a mobile drug able.” (He’ll admit the acronym is not join in. In April, the annual Student Physi­ reference database, Medscape, a medi­ original, but it’s been re-tweeted many cian Awareness Day (SPAD), organized cal reference guide, and Diagnosaurus, times behind his Twitter handle, @hjluks.) by first-year medical students, was a database of diseases and symptoms. Dr. Luks writes several blogs on ortho­ devoted to exploring “iMedicine: The Resources for patients. Social media pedic surgery and social media, has Role of Social Media in Medicine,” with is changing the doctor-patient dynamic: 5,000 Twitter followers, and offers iPads renowned experts convening to discuss how doctors reach out and what kinds in the exam room with videos to edu­ how social media is altering the nature of information patients bring into the cate his patients. “Why confine my of patient care, medical education and office or hospital. Apps can help doc­ expertise to the four walls of my prac­ community outreach. The event was tors engage with their patients by dem­ tice?” he asks. well-attended, and in social media (or onstrating procedures using 3-D views SoMe) parlance, there was a great deal For doctors and patients alike, social of anatomy, displaying test results, and of chatter and following activity that media is triggering a paradigm shift in sending text message reminders of nudged the College’s profile a bit higher health care. Pew Surveys show that appointments and vaccinations. In in the Twittersphere. 17 percent of mobile phone users are between office visits, doctors and
  • 18. 16 : : Spring/Summer 2012 patients can communicate directly via text or Twitter messages, or even brief video messages, the form preferred by more than half of the patients Dr. Luks surveyed. “Email,” he says, “is passé.” Telemedicine, the concept of caring for patients remotely, is also gaining ground. Dr. Bottles cites research predicting that by 2016, three million patients will be moni­ tored via their smartphones, rather than in hospitals, for chronic conditions like heart disease and diabetes. Social media can empower the patient without imperiling the doctor, stresses Dr. Bottles. “Some patients want to record their interactions during office visits, but Photo by Susan Woog Wagner many physicians are reluctant to embrace social media because of fears of malprac­ tice suits,” he says. “And yet, studies have shown that patients retain only 50 percent of what the doctor tells them during an office visit, and half of what the patient does remember is remembered incorrectly.” So instead of fearing the patient who comes in with reams of information printed from the Internet, doctors can seize the chance to guide patients as they search for repu­ table articles, e-mail information after appointments, or maintain a blog or website with concise answers to common questions. Says Dr. Luks: “Some doctors will shy away from a patient coming in with material they’ve Googled, whereas I’m turning on the iPad, hitting Google, saying ‘There are 600 articles on medicine published every day; let’s see if anything was posted today that’s pertinent to your case.’” Resources for both. Increasing numbers of clinicians and researchers have now launched Twitter accounts, whereby they can issue brief messages called tweets to a group of followers, comprising doctors and patients alike. Tweets might include links to new medical findings, spotlight topics posted by other experts, or offer advice on medical issues or healthy living. More than 1,300 physicians have now registered their Twitter feeds on twitterdoctors.net, and communities are emerging online among doctors (Doximity.com, a social networking site for physicians) and patients (PatientsLikeMe.com, a forum for people with similar health conditions to support and advise each other). BEYOND THE CLASSROOM One morning before class, Daniel Peters, M.D., F.A.C.S., assistant professor of cell biology and anatomy, noticed his students deeply absorbed in their phones. “It was clear that almost everyone was texting away furiously, trying to get out that last mes­ sage before class started,” Peters says. He also noted these same students hadn’t yet responded to emails he’d sent a few days earlier. “I realized that email was obso­ lete to them: in their world, it served no purpose and it was too slow and inefficient for real-time needs.” But a text or tweet would pop up instantly on their phones, compelling them to respond. As an experiment, Peters began to send messages to the class via Twitter, posing questions and offering points for reflection to spur critical thinking and discussion among his students. “Twitter allowed me to put ideas in their heads outside of class, when they might be together in some social situation, and use the opportunity to have an open and free discussion,” he says. “I was also trying to show that they always had to be think­ ing—the thought process does not, and should not, stop as soon as class is out.”
  • 19. C H I R O N I A N : : New York Medical College : : 17 43.7% IN A FACULTY SURVEY, 85 RESPONDENTS WERE ASKED: 40.2% 34.5% Which social media platform do 33.3% you use: Facebook, Twitter, LinkedIn, YouTube or Google+? 10.3% Among students, the study groups posts Twitter and Facebook updates on American Medical Association has known as “journal clubs” now benefit behalf of the College several times per released social media guidelines sug­ from instant access to groundbreaking week. “The institution becomes more gesting that doctors use the maximum news in medicine, with Twitter alerts real to them, more personal, through privacy settings for each mode of online outpacing the snail’s-paced peer-review social media activity. It’s a way to communication, and consider using model that produces journals. spread news to our students and separate profiles for personal and pro­ employees about what is happening fessional use. Many hospitals and prac­ “Physicians and researchers in far-flung here, and offers a window for prospec­ tices now raise the issue with patients locations can discuss articles and tive students, parents and alumni to as soon as they check in, presenting a exchange knowledge instantly,” says peer through and see what we’re up to.” contract with waivers or disclaimers. first-year medical student Neil Shah, chair of the committee that organized RED FLAGS “Once I learned about social media, I SPAD. “The flow of information is the In the uncharted waters of social media, realized the user has controls,” says biggest way social media has helped new ethical and legal dilemmas can Anthony Sozzo, M.A., M.S.Ed., associ­ improve academic medicine.” pose unexpected hazards. Should doc­ ate dean for student affairs, who main­ tors or professors initiate and accept tains a popular page on student financial For institutions like New York Medical “friend” requests from patients or stu­ planning, and who has produced pod­ College, social networking sites also dents? What if a patient solicits medical casts and YouTube video clips for, and provide an opportunity to reach out to advice online that ends up flawed? with, the students. “You can still main­ prospective students, current students What if a medical student or resident tain a professional presence on social and alumni. The Office of Public Rela­ posts descriptive comments of a clinical media.” That synthesis of clinical excel­ tions, responsible for the College’s offi­ experience, inadvertently violating HIPAA lence and social media was among the cial social media presence, is now rules governing patient privacy? These major objectives at SPAD, with a live encouraging other departments and issues are a “major concern,” says Shah, Twitter feed enhancing discussion and groups to establish their own presence but doctors, professors and institutions debate even further. in social media, using guidelines posted can protect themselves by educating on the College’s website. Because of SPAD, the College will gain students and patients about the perils a significant amount of attention, kudos “Curating and sharing information with of social media. “Anyone using social and support,” says Dr. Luks. If it means an audience of followers on social media,” says Kent Bottles, “needs to dissolving the barriers to communica­ media is a way to engage people, and think about the permanent and public tion, then New York Medical College get them talking with us about some­ nature of anything on Twitter and has added a few more instruments to thing that is of interest to them,” says Facebook.” Howard Luks emphasizes its black bag. ■ Donna Moriarty, M.P.H. ’04, associate that he doesn’t treat patients via social vice president of communications, who media, only shares information. The
  • 20. 18 : : Spring/Summer 2012 BEYOND SKIN DEEP In learning to treat the skin—the mirror of internal diseases— dermatology residents inject dermatologic care into a host of other specialties.
  • 21. C H I R O N I A N : : New York Medical College : : 19 experiences she and the other residents gain from treating patients, says Jodi Langer, M.D., who serves as co-chief resi­ dent with William Rietkerk, M.D. MANY CALLED, FEW CHOSEN Considered among the nation’s best, the New York Medical College dermatology residency program is very competitive. From more than 300 applicants, just three are chosen annu­ ally. To be selected, says Dr. Safai, a resident “must have an intelligent mind and be able to quickly retrieve and grasp a lot of information.” She or he also must be a clear thinker, a good writer and an effective “people person.” Finally, says Dr. Safai, residents must be able to learn independently and be good team players. By Nelly Edmondson Gupta In fact, the competition for dermatology residency slots has become increasingly stiff nationwide. “When I took over, resi­ I n 1993, Bijan Safai, M.D., professor of dermatology, took dents were mostly selected from the New York area,” says over as chairman of the Department of Dermatology at Dr. Safai. “Now we get the best applicants from all over New York Medical College in Valhalla. Several years later, the country.” he moved the residency program from Westchester to upper In addition to working with a wide variety of interesting patients, Manhattan’s Metropolitan Hospital Center, a public hospital one of the best things about the NYMC program, say the resi­ and College affiliate that treats many underserved patients. dents, is the solid grounding in both clinical work and pathology. This move turned out to be a boon for both the residency “One of the things that initially attracted me to NYMC was this program and the patient population it serves. clinical-pathologic correlation,” says first-year resident James “I brought the residency to the patients,” says Dr. Safai. By Highsmith, M.D. In other programs, he explains, residents may that he means that taking care of a more diverse, inner city learn to read pathology slides, but not necessarily the slides population gives the future dermatologists under his tutelage they themselves have prepared from biopsies. “It’s nice to see an opportunity to treat the full spectrum of clinical diseases. the clinical picture—your patients—and then review their biopsy The residents care for everything from acne to leprosy to toxic slides under the microscope,” says Dr. Highsmith. “It really epidermal necrolysis (TEN), a potentially deadly skin disease helps you learn and remember.” that usually results from a drug reaction. TEACHER, TEACH THYSELF There are other benefits as well. “One of the great things about Yet another draw for the NYMC program is the fact that all working at Metropolitan Hospital is that we see patients from dermatology residents have plenty of opportunities to teach varied ethnicities,” says first-year resident Lavanya Krishnan, as well as learn. Each week the residents complete multiple M.D., one of 10 residents currently enrolled in the College- academic duties, including journal reviews of medical and sur­ sponsored program. Many skin diseases, she explains, pre­ gical dermatology, Kodachrome sessions (clinical slides used sent very distinctively in different types of skin. For example, for diagnostic practice), pathology training and book review rashes that appear on deeply pigmented skin tend to be more lectures. The residents take turns delivering lectures to their subtle or textured. If a doctor isn’t well-versed in these skin peers on topics in the main textbook. In order to answer ques­ differences, making an accurate diagnosis can be especially tions and provide background and context, the designated challenging. lecturer must go beyond the text, thereby deepening his or her knowledge base. Residents’ learning touches on the entire spectrum of medical dermatology, including immunologic diseases of the skin, The dermatology residents also teach medical students and cutaneous lymphomas and sarcomas, drug eruptions, genetic give lectures to other departments. “Medical students have a syndromes affecting the skin, and dermatologic emergencies. limited exposure to dermatologic disease during med school, They also learn how to perform laser surgery, Mohs micro­ but many other specialties, such as internal medicine and graphic surgery, blepharoplasty and skin cancer removal. In pediatrics, need significant knowledge about the skin,” explains short, they learn it all. “We could write a textbook” with the Richard McCarrick, M.D., vice dean for graduate medical
  • 22. 20 : : Spring/Summer 2012 Dermatology director and department chair Bijan Safai, M.D., above, says the highly competitive program at New York Medical College admits only three new residents per year. Residents Lavanya Krishnan, M.D., and William Rietkerk, M.D., prepare to treat a patient at Metropolitan Hospital Center. education and affiliations. “So they rely on the dermatology been migrating away from primary care and general surgery. As residents to build their knowledge of skin diseases.” a recent article in The New York Times noted, dermatology—like plastic surgery and otolaryngology—provides relatively controlla­ Although relatively few patients are admitted to hospitals solely ble hours, autonomy, and improved quality of life, and has the because of skin conditions, they may have skin problems in tan­ added benefit of being the kind of doctor patients actually like dem with other disorders. For example, a psychiatric patient may and want to visit. be admitted in crisis, and a subsequent physical exam reveals a rash or severe lesions on his lower back. Having dermatology Second-year resident Kathryn Russell, M.D., says that while she residents available for consult enables the psychiatric team to was growing up in Sarasota, Fla., her dermatologist “was the provide comprehensive care. “There is a tremendous benefit only doctor I enjoyed going to.” Every year, her mother took to having a derm residency in a hospital that goes far beyond fair-skinned, redheaded Kathryn to a dermatologist for a full- treating patients who present with primary skin problems,” says body skin exam; the Russells have a family history of skin can­ Dr. McCarrick. “Throughout the hospital, having derm residents cer and Kathryn is at increased risk. Instead of dreading these and attendings is clinically and educationally very helpful.” medical visits, she actually looked forward to learning about her skin, hair and nails during her examinations. Dermatology The residents truly must learn to master the art of diagnosis in “is a very fulfilling field because patients really appreciate you,” order to recognize underlying systemic conditions. In fact, the she says. “You treat them, and they look better—and feel bet­ residents and their supervising attending physicians provide der­ ter about themselves.” matologic consultation for all inpatient services and ambulatory care programs. They have to know the basics of internal medi­ HAVING SKIN IN THE GAME cine, pediatrics, neurology, surgery and psychiatry to be able to “There’s a whole list of reasons to go into dermatology,” says competently integrate dermatologic care into all of these fields. second-year resident Robert Lott, M.D. He points out that research in the field of cutaneous immunology and molecular IT’S NATIONAL AND PERSONAL biology of skin is moving at a rapid pace. “As a result, we are Indeed, dermatology has been getting more respect from all developing a better understanding of the immunologic and quarters lately, and is now the most competitive specialty. In molecular pathogenesis of skin disease leading to optimized recent years, many American medical school graduates have diagnosis, management and treatment of patients,” he says.
  • 23. C H I R O N I A N : : New York Medical College : : 21 These new developments are helping researchers create used for growing hair and curing some of the blistering dis­ “designer drugs” for the treatment of skin-related autoimmune eases of childhood, and skin manifestations of graft vs. host diseases, like psoriasis. “Many systems collide in the skin,” disease, a serious condition that can develop after bone notes co-chief resident Langer. “The skin is a mirror of internal marrow transplantation. diseases, with sequelae from immunologic, neurologic, infec­ “Dermatology is a rapidly evolving field, and cutting-edge in tious, endocrine and neoplastic processes.” This “collision” terms of new technology,” adds Dr. McCarrick. “Dermatologists is evident in many systemic diseases, such as lupus, some are in great demand, and there’s a shortage in many parts of cancers, hypercholesterolemia and liver disease, which often the country.” show up first on the skin. In other words, adds Dr. Langer, “The research we’re doing on skin may have greater applica­ Drs. McCarrick and Safai believe this group of residents will tions beyond the skin.” become experts and leaders in the field. Every year, says Dr. Safai, he continues to be pleasantly surprised. “Our der­ Each year, every NYMC dermatology resident must undertake matology residents are committed and diligent, and they are an intensive research project. This year, they are studying here to learn. They study hard, help each other and work well a broad array of topics, including polymorphisms of non- as a team.” ■ melanoma skin cancers, skin stem cells, which can be Residents gather weekly for peer-teaching sessions. Clockwise from the presenter, Pantea Hashemi, M.D., are Jodi Langer, M.D.; David Weinstein, M.D.; Jennifer Leininger, M.D.; Lavanya Krishnan, M.D.; Robert Lott, M.D.; William Rietkerk, M.D.; Jennifer Vickers, M.D.; Kathryn Russell, M.D.; and Bijan Safai, M.D., professor and chairman. Not pictured is resident James Highsmith, M.D. • A REAL HONOR   In February, Dr. Safai was elected president of the Physician Affiliate Group of New York (PAGNY), made up of more than 2,500 phy­ icians s and health care professionals who provide services to the half dozen hospitals that comprise the New York City Health and Hospitals Corporation (HHC), the largest public health system in the U.S. “It is quite an honor for me to be trusted by my colleagues and elected as president of such an important organization,” Dr. Safai says.
  • 24. 22 : : Spring/Summer 2012
  • 25. C H I R O N I A N : : New York Medical College : : 23 John Nunez, Izuchukwu Ibe and Andrea Love: Student Athletes Compete to Stay Mentally and John Nun ez Physically Fit By Andrea Kott, M.P.H. T he biggest disconnect in pre­ JOHN NUNEZ, SOCCER “I’m playing at a higher level than I ever paring for a career in the health School of Health Sciences and thought I’d play,” says Nunez, who now sciences may be how unhealthy Practice competes among world class players. the journey can be. Too little sleep, too As John Nunez tells it, two things saved His level of commitment might seem much fast food and not enough exercise him during his first semester as a doc­ incompatible with doctoral studies. are the pillars of life for medical students toral candidate in physical therapy: the Indeed, Nunez says some classmates and graduate students. That is, unless camaraderie of classmates and playing scratch their heads when he closes his they are so committed to fitness that semi-pro soccer. “It was the hardest books and leaves for practice. Yet for their success depends on it. academic semester of my life,” the this 27-year-old, who is both exuberant second-year PT student says, recalling and calm, there is no choice. In the first John Nunez, Izuchukwu Ibe and Andrea a schedule that included neuro­ cience, s place, playing soccer keeps him aca­ Love are such fitness-philes. They don’t physiology and exercise science. Then, demically focused. “It keeps you on top jog or take the occasional Zumba class. two months before school started, he of your school work,” he says. Second, They train for marathons, compete in was invited to try out for the Cosmo­ being fit is critical for physical therapists, semi-pro soccer tournaments and prac­ politan League—the Cadillac of amateur who often must lift patients heavier than tice black belt judo. They would no soccer leagues. It was a fantasy come themselves and are uniquely positioned more miss a workout than they would true for the lifelong soccer player, who to inspire patients toward greater levels cut a class, clinic or lab. had always dreamed of playing college- of health. “As a medical professional, level soccer (he played Division 1 at you should demonstrate fitness and College of the Holy Cross) or going good health to patients,” Nunez says. into medicine.