6. Vibrio cholerae Cholera Toxin B subunit A subunit Binds GM1 ganglioside (surface of epithelial cells) Carried to ER (retrograde transport) Endocytosis Reduced by protein disulfide isomerase in ER Cytosol Unfolding Refolding Interact with cytosolic ADP ribosylation factors Activate G protein Stimulate adenylate cyclase Inc. cAMP Open CFTR Cl released in lumen; secretion of HCO 3 , Na + & water
44. Haemophilus influenzae Characteristics & Growth Requirements: Species X Factor V Factor Hemolysis H. influenzae H. parainfluenzae H. ducreyi H. haemolyticus H. parahaemolyticus H. aprophilus + - + + - - + + - + + - - - - + + -
71. Species Animal Pathology B. melitensis Goats Acute and severe infection B. suis Swine Chronic with suppurative lesions; caseating granulomas B. abortus Cattle Mild disease without suppuration; Non-caseating granulomas of the RES (LN, liver, spleen, BM) B. canis Dogs Mild disease