Which of the following statements describes an effect of acetylcholine on synaptic transmission? Acetylcholine breaks down cholinesterase so that less cholinesterase is present in the synapse. Acetylcholine binds to the post-synaptic cell to cause soduim channels to open. Acetylcholine blocks the release of donepezil so that less donepezil is present in the synapse. Acetylcholine replaces donepezil on the post-synaptic cell to cause potassium channels to open..