2. Biomedical Cluster Map
CLINICAL
RESEARCH
y
PHARMACEUTICALS er Bi
oi
MEDICAL
ov m TECHNOLOGY
i sc Bioprocessing ag
D in
ug Chemical Synthesis g
r
D
Genomics & Proteomics
Industry Industry
Sectors Molecular & Cell Biology Sectors
C Bioengineering &
oh
B or Nanotechnology
lls
io t
ce
m St
HEALTHCARE ar ud Computational
em
SERVICES & ke ie Biology
St
rs s BIOTECHNOLOGY
DELIVERY
TRANSLATIONAL
RESEARCH

3. Co-investment, VC funding
RISC grants, infrastructure, tax
breaks
INDUSTRY
Pharma MEaT Biotech Clinical Trials Overseas
Clinical Trials
s )
ev
t
c ine
d s c Singapore Clinical
y& vic
e
/ va
er e
ell
s Trials
c ov h /d (c
g dis tec i cs
Dru M ed olo g
Bi
Mission-oriented BENCH Translational /
Investigational BEDSIDE
Research Institutes Medicine NMRC / HSA
• IMCB, GIS, BTI Set up by Clinical Research Programmes
• IBN, BII, A*STAR / BMRC • Focus, strategy
• CMM, SICS Human Capital
STN
• Development, recruitment
Research Consortia SCS
Infrastructure
• SBIC • SIgN DPF Office • For Clinical Trials
• SSCC • Biomarkers SCCS Regulatory Framework
MBBS PhD / BMS IF / • IRBs
CSI awards
Academic BENCH SIgN = Singapore Immunology Network
SSCC = Singapore Stem Cell Consortium
MEaT = Medical Enginering and Technology
IMCB = Institute of Molecular & Cell Biology STN = Singapore Tissue Network
GIS = Genome Institute of Singapore SCS = Singapore Cancer Syndicate
BTI = Bioprocessing Technical Institute SCCS = Singapore Consortium of Cohort Studies
NUS, NTU IBN = Institute of Bioengineering and Nanotechnology
BII = Bioinformatics Institute
DPF = Data Privacy Framework
CMM = Centre for Molecular Medicine
BMS IF = Biomedical International Fellowship
SICS = Singapore Institute for Clinical Sciences CSI = Clincian Scientist Investigatorship
SBIC = Singapore Bioimaging Consortium IRBs = Institutional Review Boards

4. BIOMEDICAL RESEARCH
Basic Translational Clinical
A*STAR Biomedical Research Council Ministry Of Health
Singapore Institute for National Healthcare Group
Research Institutes Institute of Medicinal Biology Clinical Sciences (SICS) • National University Hospital
(IMB) • The Cancer Institute
• Institute of Molecular & • Tan Tock Seng Hospital
• Develop programmes in
Cell Biology − Singapore Oncogenome Group • Communicable Disease Centre
Translational Clinical Medicine
− Regenerative Medicine • National Skin Centre
• Genome Institute of − Epithelial Biology
• Develop critical resources:
Singapore - Singapore Tissue Network Singapore Health Services
- Singapore Consortium of • Singapore General Hospital
• Institute of Cohort Studies • National Cancer Centre
Bioengineering & • National Heart Centre
Nanotechnology • Develop Clinician Scientists: • Singapore National Eye Centre
- Clinician Scientist • KK Women and Children’s Hospital
• Bioprocessing Investigatorship (CSI) Awards • National Neuroscience Institute
Technology Institute - PhD training for medical
doctors Ministry of Health HQ
• Bioinformatics Institute Consortia - Biomedical International - Ethical regulations/framework for
Fellowships clinical research e.g. IRBs
− Singapore Cancer Syndicate
− Singapore Bioimaging SICS @ Kent Ridge
Consortium - Genetic Medicine
National Medical Research Council
− Singapore Stem Cell - Virology/Infectious Diseases
- Clinical research strategy
Consortium
- Grant management
− Singapore Immunology SICS @ Outram
- Manpower development
Extramural Network (2008-2010)
− Member of Intl Cancer − Cardiovascular Diseases
Grants Biomarker Consortium − Eye Diseases
Health Sciences Authority
- Evaluation capabilities for new
technologies
UNIVERSITIES

5. Bench to Bedside to Industry Cycle
PHARMA
INDUSTRY
BENCH BEDSIDE
Key performers: Key performers:
research institutes, Interaction strengthened by new hospitals, specialist
universities entities arising from hospital- centres
medical school partnerships
Grow health
Develop strong Be preferred site services, public
investigational for early phase health research
med capability clinical trials in Asia
Establish flagship programmes from bench-to-bedside
(heart/ metabolic, neuro, cancer, eye, infectious disease)
Build critical mass of human capital, supernumerary to clinical service needs

6. Overall Grant/ Support Framework
Research Grants
Talent Support [Support research projects/ programmes] Infrastructure
[Salary support +
[Devt support]
research grants]
Strategic/ Investigator-led
Programmatic Research
Increasing seniority and support
Singapore
Translational
Translational & Strategic
Research
Clinical Research Infra
Investigatorship [Research building,
Research Grant Individual investigational med
Research Grants unit, animal facility]
Clinician Scientist
Award
Academic
Programmatic Exploratory/ Research
Grants Developmental Organisation
Healthcare
Research Grants
Scholarship

7. Development of Translational/Clinical Research (TCR)
Human Capital
A new pool of physicians scientists
freed of clinical service obligations
Singapore Translational Research Clinician Scientist Award.
Investigatorship Award.
International and Singaporean Young Singapore Physician Scientist
Senior Physician Scientist awards awards (70 per year)
(15 per year) Full salary and an internationally
Similar to Howard Hughes Medical Institute award – competitive research grant for 3 years
full salary and lab support
for 5 years)

8. Bench to Bedside Research Funding Programs
Funds for teams of basic
and clinical scientists
Infrastructure to support TCR
Translational/Clinical Research (TCR)
flagship Awards *Academic Medical Centers
AMCs established through union of
medical school and tertiary hospital under a
Targeted research programs in common governance
each of the following therapeutic areas:
cancer, neuroscience, cardiovascular/ *Investigational Medicine Units
metabolism, infectious diseases, Clinical research units (2)
opthalmology – for early in man clinical investigation
S$25 M over 5 years for each program – S$20 M each
*Singapore Clinical Research Institute
Trans-Singapore clinical research
organisations to support therapeutic
trials sponsored by pharmaceutical companies
– S$6 M per annum

9. Translational Research
From Bench to Bedside
Institute of Medical Biology (IMB)
Executive Director: Prof Birgit Lane
IMB studies the mechanisms of human disease in order to discover
new and effective therapeutic strategies for an improved quality of
life.
Research Areas:
• Singapore Oncogenome Project
• Papilloma Virology
• Epithelial Biology
• Developmental and Regenerative
Biology
• Regenerative Medicine
• Stem Cell Biology
• Mesenchymal Stem Cells

10. Translational Research
From Bench to Bedside
Singapore Institute for Clinical Sciences (SICS)
Executive Director: Prof Judith Swain
Using innovative approaches and technologies to enable the efficient and
effective study of human health and diseases
Research Areas:
• Genetic Medicine
• Hepatic Diseases
• Metabolic Diseases
SICS is headquartered at Biopolis, with labs both at:
• The Brenner Centre for Molecular Medicine
• Nanos @ Biopolis

11. Translational Research
From Bench to Bedside
Experimental Therapeutics Centre (ETC)
Chief Executive Officer: Prof Sir David Lane
• Build up capabilities and resources required for early stage drug
discovery and development
• Help advance the drug candidates to a stage that is considered
commercially more attractive to industry

12. Attracting International Talent (Whales)
When physician-scientists Judith Swain and
Ed Holmes take up their posts in
Singapore…, they will join a star-studded
community at one of the world’s most
Dr Edward Holmes
rapidly developing biomedical research Executive Dy Chmn
Sir David Lane
centres. …they are the latest of many (TCSG), BMRC &
Executive Director, IMCB & Executive
Dy Chmn (BSTG), BMRC Chmn, NMRC
Western scientists who have headed for
the impressive facilities of the tiny city-
state. Dr Judith
Swain
Naturejobs, 5 Jul 06
Executive
Director, SICS
Dr Birgitte Lane Dr Philippe Kourilsky
Executive Chairman, SIgN
Sir George Radda Director, IMB
Chairman, SBIC
Dr Phil Ingham
PI, IMCB
Dr Jackie Ying Dr Neal Copeland &
Dr Edison Liu Dr Yoshiaki Ito Dr Jean Paul
Executive Dr Axel Ullrich Dr Nancy Jenkins
Executive Director, PI, IMCB Thiery
Director, IBN Director, SOG Lab PIs, IMCB
GIS PI, IMCB
2001 2002 2003 2004 2005 2006

13. Human Capital: International Guppies
MIT Stanford MIT
Physics Chemical Engineering Bio Engineering
(Malaysia) (Shanghai) (Hong Kong)
MIT Stanford MIT
Chemical Engineering Computer Science Chemical Engineering
(Germany) (India) (Vietnam)

14. Human Capital: Singapore Guppies
Rockefeller Stanford Stanford
Bacteriology Biochemistry Biochemistry
Medicine/PhD Medicine/PhD Computer Science
Duke Camrbidge, London Carnegie-Mellon

15. Nurturing & Developing Human Capital
689 Potential and Completed PhDs
NSS(PhD) - 4-5 yrs
193**
overseas
NSS(BS) - 3 yrs 72 Completed
231* PhDs***
AGS - 4 yrs
193 at partner
universities
Correct as at 24th September 2007 IF 58
*Of which, 68 BS and 1 MBBS are NSFs.
**Includes 1 GMS (MD-PhD) scholar. 4 Completed
***Includes scholars who are currently attached pending PhD
conferment (NUS & NTU takes up to 9 months for conferment.)