3. Why is Prevention Important?
• Reduce the number of new cases
• Reduce the number of deaths
• Lessen physical problems for patients
• Lessen emotional and financial distress
on patients and their families
• Decrease burden on healthcare system,
employers, and the public (LESS $$$)
Source: cancer.gov
4. Methods of Prevention
• Avoid or control things known to cause
cancer:
Diet
Lifestyle
Environment
• Detect pre-cancerous condition early
Source: cancer.gov
5. What makes a good
screening test?
• Low risk
• Least invasive
• Inexpensive
• Reliable
• Accessible
• Able to repeat with little patient impact
Source: Breathing Easy: Lung Cancer Prevention and Screening, Dr. Jessie S. Wilt, Summit Medical Group
8. USPSTF Guidelines for
Breast Cancer Screening
All women aged 50-74 years
• Repeat every 2 years
Selective screening of women age 40-49
• Repeat every 1-2 years
Insufficient evidence to assess balance of
benefits and harms in women >75 years
9. Breast Cancer Risk Factors
• A personal history of breast cancer or high-risk lesion
found by biopsy
• A family history of breast cancer, particularly in a
mother, sister or daughter (first degree relative)
• History of radiation therapy
• Evidence of a specific genetic mutation
(BRCA1/BRCA2 mutation)
Women who carry defects on either of these genes are at
greater risk for developing breast cancer.
10. Reducing Breast Cancer Risk
• Keep a healthy weight
• Exercise regularly
• Limit alcohol consumption
• Don’t smoke
• Breastfeed your children, if possible.
• Understand the possible risks of using estrogen-containing
contraceptives or hormone replacement therapy
• If you have a family history of breast cancer, or have tested
positive for BRCA1 and BRCA2 genes, talk to your doctor about
other ways to lower your risk.
11. Gail Model Breast Cancer Risk
Factors
• Current Age
• Age at Menarche (first period)
• Age at 1st live birth
• # of 1st degree relatives w/ Breast
cancer
• # of breast biopsies
• Presence of ADH
12. Additional Risk Factors
• Age of dx of family
• 2nd degree relatives
• Alcohol intake
• Physical Activity
• HRT
• Lactation history
• Height
• Weight
• Mammographic
density
13. Overweight/Obese
• Maintaining your ideal body weight
Most important modifiable risk factor
Postmenopausal
Link seen in women who gain weight
later in life
Estrogen levels are higher
14. Exercise
• Being Fit
Decreases breast cancer risk
Dept. of Health and Human
Services:
• 150 min/week moderate activity or
• 75min/week vigorous activity
25% reduction in breast cancer risk
• Postmenopausal
• Most vigorous exercise
15. Healthy Diet
• Mediterranean Diet - plant based,
with moderate amount of dairy, poultry
and eggs.
EVOO, mixed nuts
Vegetables
• Large amounts
• Dark green and yellow
Legumes & Whole grains
Avoid red meat
16. Alcohol
• Do not drink at all
OR……
• Limit to 1 drink per day
• Risk is dose related
Frequently asked about anything that can be done to prevent disease or recurrence.
Diet: Regular exposure to alcohol is known to induce cancer of the esophagus
Lifestyle: Women who have unprotected sex with numerous heterosexual partners are at increased risk for contracting the HPV virus, which is the #1 cause of cervical cancer
Environment: Exposure to Asbestos is known to be a cause of lung cancer
Detect precancerous conditions early using SCREENING TESTS, which looks for disease BEFORE the patient has symptoms
Goal is to detect cancer in the earliest and potentially most curable stage
But most breast cancers occurs in women with NO family history
Fixed risk factors:
Being female
Aging (40: 0.5%; age 50: 2%; age 70: 7%)
Overall: Anything that prolongs uninterrupted menstrual cycle.
NCI: 18K deaths may be prevented
PostMen ¾ of cancers are ER +
ER levels are 50-100% higher
Greatest benefit seen in thinner women.
Translates to a 25% risk reduction
1 drink per day has a small increase
2-5 drinks per day has a 1.5 increased risk
Lifetime exercise
Studies show that women nightshift workers have an increased risk.
Melatonin is decreased with lack of sleep
Set sleep time, avoid caffeine 4hr prior, No screens 1hr prior. Bed for sleep only
Chronic stress can increase hormone levels epi/nor epi/ cortisol
Metabolic syndrome- Central obesity,htn; inc chol inc blood sugar
Leads to CVD and Diabetes