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Breast Cancer Prevention
Modifiable Lifestyle Factors
Diana M. Addis, MD, FACS
Summit Medical Group
Breast Surgeon
October 31, 2020
Why is Prevention Important?
• Reduce the number of new cases
• Reduce the number of deaths
• Lessen physical problems for patients
• Lessen emotional and financial distress
on patients and their families
• Decrease burden on healthcare system,
employers, and the public (LESS $$$)
Source: cancer.gov
Methods of Prevention
• Avoid or control things known to cause
cancer:
 Diet
 Lifestyle
 Environment
• Detect pre-cancerous condition early
Source: cancer.gov
What makes a good
screening test?
• Low risk
• Least invasive
• Inexpensive
• Reliable
• Accessible
• Able to repeat with little patient impact
Source: Breathing Easy: Lung Cancer Prevention and Screening, Dr. Jessie S. Wilt, Summit Medical Group
Breast Cancer
Copyrights apply
USPSTF Guidelines for
Breast Cancer Screening
 All women aged 50-74 years
• Repeat every 2 years
 Selective screening of women age 40-49
• Repeat every 1-2 years
 Insufficient evidence to assess balance of
benefits and harms in women >75 years
Breast Cancer Risk Factors
• A personal history of breast cancer or high-risk lesion
found by biopsy
• A family history of breast cancer, particularly in a
mother, sister or daughter (first degree relative)
• History of radiation therapy
• Evidence of a specific genetic mutation
(BRCA1/BRCA2 mutation)
 Women who carry defects on either of these genes are at
greater risk for developing breast cancer.
Reducing Breast Cancer Risk
• Keep a healthy weight
• Exercise regularly
• Limit alcohol consumption
• Don’t smoke
• Breastfeed your children, if possible.
• Understand the possible risks of using estrogen-containing
contraceptives or hormone replacement therapy
• If you have a family history of breast cancer, or have tested
positive for BRCA1 and BRCA2 genes, talk to your doctor about
other ways to lower your risk.
Gail Model Breast Cancer Risk
Factors
• Current Age
• Age at Menarche (first period)
• Age at 1st live birth
• # of 1st degree relatives w/ Breast
cancer
• # of breast biopsies
• Presence of ADH
Additional Risk Factors
• Age of dx of family
• 2nd degree relatives
• Alcohol intake
• Physical Activity
• HRT
• Lactation history
• Height
• Weight
• Mammographic
density
Overweight/Obese
• Maintaining your ideal body weight
 Most important modifiable risk factor
 Postmenopausal
 Link seen in women who gain weight
later in life
 Estrogen levels are higher
Exercise
• Being Fit
 Decreases breast cancer risk
 Dept. of Health and Human
Services:
• 150 min/week moderate activity or
• 75min/week vigorous activity
 25% reduction in breast cancer risk
• Postmenopausal
• Most vigorous exercise
Healthy Diet
• Mediterranean Diet - plant based,
with moderate amount of dairy, poultry
and eggs.
 EVOO, mixed nuts
 Vegetables
• Large amounts
• Dark green and yellow
 Legumes & Whole grains
 Avoid red meat
Alcohol
• Do not drink at all
OR……
• Limit to 1 drink per day
• Risk is dose related
Sleep
• Maintain regular nighttime
sleep
• Melatonin
Smoking
• Link between smoking and
breast cancer
Exposure
• Limit exposure to
carcinogens
• Limit radiation exposure
Conclusion
• Stay Healthy
 Maintain normal body weight
 Stay Fit- Exercise 3-7hr / week
• Eat Smart
• Sleep Well
• Be Calm
Questions
This Photo by Unknown Author is licensed under CC
BY-NC

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Breast Cancer Prevention - Modifiable Lifestyle Factors - Diana N. Addis, MD, FACS - 10.31.2020

  • 1. Breast Cancer Prevention Modifiable Lifestyle Factors Diana M. Addis, MD, FACS Summit Medical Group Breast Surgeon October 31, 2020
  • 2.
  • 3. Why is Prevention Important? • Reduce the number of new cases • Reduce the number of deaths • Lessen physical problems for patients • Lessen emotional and financial distress on patients and their families • Decrease burden on healthcare system, employers, and the public (LESS $$$) Source: cancer.gov
  • 4. Methods of Prevention • Avoid or control things known to cause cancer:  Diet  Lifestyle  Environment • Detect pre-cancerous condition early Source: cancer.gov
  • 5. What makes a good screening test? • Low risk • Least invasive • Inexpensive • Reliable • Accessible • Able to repeat with little patient impact Source: Breathing Easy: Lung Cancer Prevention and Screening, Dr. Jessie S. Wilt, Summit Medical Group
  • 8. USPSTF Guidelines for Breast Cancer Screening  All women aged 50-74 years • Repeat every 2 years  Selective screening of women age 40-49 • Repeat every 1-2 years  Insufficient evidence to assess balance of benefits and harms in women >75 years
  • 9. Breast Cancer Risk Factors • A personal history of breast cancer or high-risk lesion found by biopsy • A family history of breast cancer, particularly in a mother, sister or daughter (first degree relative) • History of radiation therapy • Evidence of a specific genetic mutation (BRCA1/BRCA2 mutation)  Women who carry defects on either of these genes are at greater risk for developing breast cancer.
  • 10. Reducing Breast Cancer Risk • Keep a healthy weight • Exercise regularly • Limit alcohol consumption • Don’t smoke • Breastfeed your children, if possible. • Understand the possible risks of using estrogen-containing contraceptives or hormone replacement therapy • If you have a family history of breast cancer, or have tested positive for BRCA1 and BRCA2 genes, talk to your doctor about other ways to lower your risk.
  • 11. Gail Model Breast Cancer Risk Factors • Current Age • Age at Menarche (first period) • Age at 1st live birth • # of 1st degree relatives w/ Breast cancer • # of breast biopsies • Presence of ADH
  • 12. Additional Risk Factors • Age of dx of family • 2nd degree relatives • Alcohol intake • Physical Activity • HRT • Lactation history • Height • Weight • Mammographic density
  • 13. Overweight/Obese • Maintaining your ideal body weight  Most important modifiable risk factor  Postmenopausal  Link seen in women who gain weight later in life  Estrogen levels are higher
  • 14. Exercise • Being Fit  Decreases breast cancer risk  Dept. of Health and Human Services: • 150 min/week moderate activity or • 75min/week vigorous activity  25% reduction in breast cancer risk • Postmenopausal • Most vigorous exercise
  • 15. Healthy Diet • Mediterranean Diet - plant based, with moderate amount of dairy, poultry and eggs.  EVOO, mixed nuts  Vegetables • Large amounts • Dark green and yellow  Legumes & Whole grains  Avoid red meat
  • 16. Alcohol • Do not drink at all OR…… • Limit to 1 drink per day • Risk is dose related
  • 17. Sleep • Maintain regular nighttime sleep • Melatonin
  • 18. Smoking • Link between smoking and breast cancer
  • 19. Exposure • Limit exposure to carcinogens • Limit radiation exposure
  • 20.
  • 21. Conclusion • Stay Healthy  Maintain normal body weight  Stay Fit- Exercise 3-7hr / week • Eat Smart • Sleep Well • Be Calm
  • 22. Questions This Photo by Unknown Author is licensed under CC BY-NC

Editor's Notes

  1. Frequently asked about anything that can be done to prevent disease or recurrence.
  2. Diet: Regular exposure to alcohol is known to induce cancer of the esophagus Lifestyle: Women who have unprotected sex with numerous heterosexual partners are at increased risk for contracting the HPV virus, which is the #1 cause of cervical cancer Environment: Exposure to Asbestos is known to be a cause of lung cancer Detect precancerous conditions early using SCREENING TESTS, which looks for disease BEFORE the patient has symptoms Goal is to detect cancer in the earliest and potentially most curable stage
  3. But most breast cancers occurs in women with NO family history
  4. Fixed risk factors: Being female Aging (40: 0.5%; age 50: 2%; age 70: 7%) Overall: Anything that prolongs uninterrupted menstrual cycle.
  5. NCI: 18K deaths may be prevented PostMen ¾ of cancers are ER + ER levels are 50-100% higher
  6. Greatest benefit seen in thinner women. Translates to a 25% risk reduction
  7. 1 drink per day has a small increase 2-5 drinks per day has a 1.5 increased risk Lifetime exercise
  8. Studies show that women nightshift workers have an increased risk. Melatonin is decreased with lack of sleep Set sleep time, avoid caffeine 4hr prior, No screens 1hr prior. Bed for sleep only
  9. Chronic stress can increase hormone levels epi/nor epi/ cortisol Metabolic syndrome- Central obesity,htn; inc chol inc blood sugar Leads to CVD and Diabetes