pH Partition Hypothesis
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This is helpful for studying What is pH Partition Hypothesis?... What are the assumptions of pH Partition Hypothesis?... Helpful for Pharmacy and Medical students....
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Cellular uptake of drugs can occur through passive diffusion of small molecules or active transport of larger particles via endocytosis, exocytosis, phagocytosis, or pinocytosis. Transport across epithelial barriers relies on passive diffusion, carriers, or endocytosis. Extravasation from blood vessels depends on permeability and physicochemical drug properties, while lymphatic uptake drains drug molecules from tissues. The reticuloendothelial system phagocytoses pathogens and debris from circulation and tissues.
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The release of the drug substance from the drug product leading to the bioavailability of the drug substance. The assessment of drug product performance is imp. Since bioavailability is related both to the pharmacodynamic responses and the adverse events. The performance tests relate the quality of a drug product to clinical safety and efficacy.
Bioavailability studies are drug product performance studies used to define
the effect of changes in the physicochemical properties of the drug substance, the formulation of the drug, and the manufacturing process of the drug product.
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This document reviews mucoadhesive drug delivery systems. It discusses:
1) Mucoadhesive systems remain in close contact with mucous membranes, increasing drug bioavailability and promoting local or systemic effects.
2) Mucoadhesion is explained by six theories: electronic, adsorption, wettability, diffusion, fracture, and mechanical. In vitro and in vivo methods study its mechanisms.
3) The mechanisms of mucoadhesion involve an initial contact stage where the formulation spreads over the mucus, followed by a consolidation stage where moisture activates adhesive bonding between polymer chains and mucin glycoproteins via diffusion and dehydration theories.
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The document discusses the results of a study on the impact of COVID-19 lockdowns on air pollution. The study found that lockdowns led to significant short-term reductions in nitrogen dioxide and fine particulate matter pollution globally as economic activities slowed. However, the improvements in air quality were temporary and pollution levels rose back to pre-pandemic levels as restrictions eased and activity resumed.
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Introduction
Advantages and disadvantages
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Introduction ,BDDS. principle of mucoadhesion ,advantages and disadvantages of BDDS ,Formulation and evaluation of BDDS
REGULATORY AND INDUSTRY VIEWS ON QbD, SCIENTIFICALLY BASED QbD- EXAMPLES OF A...
The pharmaceutical Quantity by Design (QbD) is a systemic approach to development that begins with predefined objectives and emphasizes product and process understanding and process control, based on sound science and quantity risk management.
QbD has been adopted by U.S Food and Drug Administration (FDA) for the discovery, development and manufacture of drugs.
Quality- by- design (QbD) is a concept introduces by the International Conference on Harmonization (ICH) Q8 guidelines.
Compaction profiles
This ppt covers some parts of COMPRESSION AND COMPACTION in which it has been explained only about Compaction Profiles
Liposomes
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Computer simulations in pharmacokinetics and pharmacodynamics can model the whole organism, isolated tissues, and individual organs. Whole organism simulations use lumped-parameter models that represent the body with a small number of differential equations, or physiological models that use more differential equations to describe organs in detail. Isolated tissue and organ simulations often use distributed blood tissue exchange models for organs like the heart and liver. These simulations aim to integrate organ-specific models with whole-body models to improve predictive capabilities in areas like pharmacokinetics.
microspheres types , preparation and evaluation
definition , advantages,disadvantages ,types of microspheres, examples, preparation methods , evaluation .
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The document discusses how the dosage form impacts drug absorption in the gastrointestinal tract. It summarizes that solutions show the fastest and most complete absorption as they do not have dissolution problems. Suspensions also absorb relatively quickly due to their small particle size. Capsules and tablets must undergo dissolution and disintegration processes first. Coated tablets have an additional step of the coating dissolving or disrupting before drug absorption can occur. The dosage form selection can make over a 60-fold difference in a drug's absorption rate or extent.
Invitro drug product performance
This document discusses various aspects of in vitro drug product performance testing and evaluation, including dissolution profile comparisons, meeting dissolution requirements, problems in dissolution testing, and in vitro-in vivo correlation (IVIVC). It describes model-independent and model-dependent approaches to comparing dissolution profiles using difference factor (f1) and similarity factor (f2). It also discusses the four levels of IVIVC (A, B, C, and multiple C) and their applications and limitations. Finally, it covers considerations for drug product stability and design.
Diffusion parameters.pptx
This document discusses diffusion parameters and their effects on drug release and absorption. It defines diffusion as the movement of substances from areas of high concentration to low concentration. Several parameters that affect diffusion are described, including drug solubility, formulation factors, concentration gradient, surface area, route of administration, gastric emptying, food intake, and intestinal motility. Metabolism of drugs in the gastrointestinal tract can also impact diffusion. Examples are provided to illustrate diffusion concepts.
Insitu gel drug delivery system
The document discusses in situ gel drug delivery systems, which are liquid before administration but gel after contact with bodily fluids or tissues. It describes various polymers used to form in situ gels via temperature, pH, or ion triggers. It also categorizes in situ gel systems based on their gelation mechanism and administration route.
Large & Small Volume Parenteral
This document provides an overview of large and small volume parenteral preparations. It begins with definitions of parenteral preparations and routes of administration. Advantages and disadvantages of the parenteral route are discussed. General requirements for parenteral dosage forms like containers, glass types, closures, and aseptic areas are covered. Parenteral preparations are classified based on volume as small volume parenterals (SVP) and large volume parenterals (LVP). Physiological considerations like pH, buffer, tonicity, and stabilizers are explained. Formulation considerations for various parenteral preparations are provided. The manufacturing process including cleaning, preparation, filtration, filling, sealing, and sterilization is outlined. Key evaluation tests like sterility testing,
Mucoadhesive drug delivery system Mali vv ppt
This document discusses mucoadhesive drug delivery systems (MDDS). It begins by defining MDDS as systems that use the bioadhesive properties of certain polymers to target and prolong the release of drugs at mucous membranes. It then covers the basics of mucous membranes and their structure, composition, and functions. The document discusses the need for MDDS to enhance drug absorption, prolong drug residence time, and target drug delivery. It also outlines the advantages and disadvantages of MDDS, various routes of administration, mechanisms of mucoadhesion, theories of mucoadhesion, mucoadhesive polymers, and methods of evaluating MDDS. In the end, it provides some applications of MDDS such as vaccine delivery, cancer
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Optimization techniques in pharmaceutical formulation and processing
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REGULATORY AND INDUSTRY VIEWS ON QbD, SCIENTIFICALLY BASED QbD- EXAMPLES OF A...
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ROLE OF DOSAGE FORM IN GASTRO-INTESTINAL ABSORPTION
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Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
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Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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