SlideShare a Scribd company logo
1 of 23
Ibogaine Therapy:
Forms and Dose Regimens


     Howard S. Lotsof, B.F.A., C.M.A.
                President
        Dora Weiner Foundation
           Staten Island, NY
       http://www.doraweiner.org
Forms in Current Use

• Botanical - root bark

• Total alkaloid extract


• purified ibogaine
Tabernanthe iboga shrub
Roots contain ibogaine
Total Alkaloid Extract




 Large piece 2cm x 2cm, approx 4 grams
        Estimate 15% ibogaine
             Courtesy Sara Glatt
Ibogaine HCl




   99.4% purity
All forms have
multiple treatment
applications
1. Chemical use disorders
2. Pain management
3. Psychotherapy
4. Initiatory sessions
Each form has

1. Different onset
2. Different duration of
   action
3. And significant diversity
   across the patient
   population
Onset of Effects (min)

160
140
120
100
                           Full Effect
 80
 60                        Onset
 40
 20
  0
       HCl   Extract
Period of visuaization (hours)

16
14
12                             Extended
10
                               Visualization
 8
 6                             Onset
 4
 2
 0
         HCl   Extract
Duration of Action (days)

10
 9
 8
 7                           Residual
 6
 5
 4                           Principal
 3
 2
 1
 0
       HCl   Extract
Effect on sleep (weeks)

10
 9
 8
 7                             Residual
 6
 5
 4                             Principal
 3
 2
 1
 0
      HCl
Dose and Dose Regimen

   1. Single dose
   2. Multiple
     1. Escalating
     2. Deescalating
     3. Linear
All doses are representative. Doses,
including single administration doses are
determined on a patient by patient basis.
The graphs of dose regimens and
information that follow should not be used
by persons without experience to self-
administer or administer to others any
dose of ibogaine or total alkaloid extract
of Tabernanthe iboga .
Single dose regimens usually fall between
10mg/kg and 22mg/kg depending on type
of therapy offered: opioid dependence,
stimulant dependence, psychospiritual,
etc. Most doses fall in the 15mg/kg -
20mg/kg dose range to reach full
therapeutic effects.
ibogaine HCl (mg/hour)
             20mg methadone
              total - 1000mg
400
350       350
300
250
200              175    175    175          HCl
150                                   125
100
 50
  0
      0         h1     h2     h3     h4
ibogaine HCl (mg/kg/hour)
             stimulant therapy
                courtesy Eric Taub



16
14
12
10                     10
                                          HCl
 8
 6
 4
         2.5                          3
 2
     0             h2                h3
ibogaine HCl (mg/kg/hour)
                 heroin therapy
                total 21.5mg.kg
                      courtesy Eric Taub



16
14              14
12
10
                                           HCl
 8
 6
                       5
 4
 2       2.5
     0         1h    h12
ibogaine HCl (mg/kg/hour)
                methadone therapy
                 total 36.5 mg/kg
                             courtesy Eric Taub



16
14
12                                 12
10
 8                                                                  HCl
 6
 4                                       3        3   3   3
     2.5   2.5   2.5   2.5   2.5
 2
     0
           13 23 30 34 36 59 68 77 89
                                                              100
extract (grams/hour)
                heroin therapy
                 total 7 grams
                  courtesy Sara Glatt



6
5
4
3       3    3                          Exract
2
1                    1

0
    0       12    36          48
extract (grams/hour/day)
                    methadone therapy
                       total 11 grams
                        courtesy Sara Glatt



6
5
4
3       3    3                                         Exract
2
1                  1    1      1       1       1

0
    0       12    36   d2   d4     d6         d8 d10
extract (grams/hour)
                        HCl (mg/hour)
                    methadone 300mg/day
                        total extract 9 grams
                          total HCl 400mg
                          courtesy Marc Emery



6   5.2
5                       3.8
4                                               Exract
3
2                                               HCl
1           0.1   0.1           0.1     0.1
0
    0
          h72 h96 h120h168h192
All doses and dose regimens
shown or discussed are
representative and are not
indicated to be provided to any
other patient or subject. All doses
and dose regimens are made on a
patient by patient basis upon
knowledge and prior art.

More Related Content

Viewers also liked

Viewers also liked (12)

How to create a culture where innovation thrives
How to create a culture where innovation thrivesHow to create a culture where innovation thrives
How to create a culture where innovation thrives
 
Panduan ppdb 2015 depan
Panduan ppdb 2015 depanPanduan ppdb 2015 depan
Panduan ppdb 2015 depan
 
Ie admission essay
Ie admission essayIe admission essay
Ie admission essay
 
CLC project
CLC projectCLC project
CLC project
 
Panduan ppdb 2015
Panduan ppdb 2015Panduan ppdb 2015
Panduan ppdb 2015
 
Product comparison
Product comparisonProduct comparison
Product comparison
 
5 s game
5 s game5 s game
5 s game
 
Encotec -Company Presentation_Apr 2016
Encotec -Company Presentation_Apr 2016Encotec -Company Presentation_Apr 2016
Encotec -Company Presentation_Apr 2016
 
Spectrum of Projects - ENCOTEC
Spectrum of Projects - ENCOTECSpectrum of Projects - ENCOTEC
Spectrum of Projects - ENCOTEC
 
Program kerja wakasek kesiswaan
Program  kerja wakasek  kesiswaanProgram  kerja wakasek  kesiswaan
Program kerja wakasek kesiswaan
 
Cooking vocabulary
Cooking vocabularyCooking vocabulary
Cooking vocabulary
 
Shri Sambhavana
Shri SambhavanaShri Sambhavana
Shri Sambhavana
 

Similar to Elephant Sunshine

October 3 - Roman Paskulin
October 3 - Roman PaskulinOctober 3 - Roman Paskulin
October 3 - Roman Paskulinibogainealliance
 
CPC PENN Stress Meeting 2012_1
CPC PENN Stress Meeting 2012_1CPC PENN Stress Meeting 2012_1
CPC PENN Stress Meeting 2012_1Stacia Lewandowski
 
International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
 
Arenla Presentation.pptx
Arenla Presentation.pptxArenla Presentation.pptx
Arenla Presentation.pptxSaithanpari
 
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...iosrphr_editor
 
Bhumika's final poster 36x72
Bhumika's final poster 36x72Bhumika's final poster 36x72
Bhumika's final poster 36x72Bhumika Goswami
 
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...iosrphr_editor
 
b1. Bioassay of ACTH.pdf
b1. Bioassay of ACTH.pdfb1. Bioassay of ACTH.pdf
b1. Bioassay of ACTH.pdfVISHALJADHAV100
 
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of PharmacyIOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
 
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of PharmacyIOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacyiosrphr_editor
 
In vitro shoot multiplication in okra (Ablemonschus esculentues).
In vitro shoot multiplication in okra (Ablemonschus esculentues).In vitro shoot multiplication in okra (Ablemonschus esculentues).
In vitro shoot multiplication in okra (Ablemonschus esculentues).TAJNE SACHIN
 
Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...
Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...
Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...Arthur Stem
 
Formulation and Evaluation of immediate release tablet in treatment of overac...
Formulation and Evaluation of immediate release tablet in treatment of overac...Formulation and Evaluation of immediate release tablet in treatment of overac...
Formulation and Evaluation of immediate release tablet in treatment of overac...BhuminJain1
 
Chemical composition and bioactivity of essential oils of seed
Chemical composition and bioactivity of essential oils of seedChemical composition and bioactivity of essential oils of seed
Chemical composition and bioactivity of essential oils of seedAlexander Decker
 
Synthesis of Iodo Ester Azide
Synthesis of Iodo Ester AzideSynthesis of Iodo Ester Azide
Synthesis of Iodo Ester Azideweston manter
 

Similar to Elephant Sunshine (18)

October 3 - Roman Paskulin
October 3 - Roman PaskulinOctober 3 - Roman Paskulin
October 3 - Roman Paskulin
 
CPC PENN Stress Meeting 2012_1
CPC PENN Stress Meeting 2012_1CPC PENN Stress Meeting 2012_1
CPC PENN Stress Meeting 2012_1
 
International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)International Journal of Pharmaceutical Science Invention (IJPSI)
International Journal of Pharmaceutical Science Invention (IJPSI)
 
Arenla Presentation.pptx
Arenla Presentation.pptxArenla Presentation.pptx
Arenla Presentation.pptx
 
Drugs
DrugsDrugs
Drugs
 
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
 
Bhumika's final poster 36x72
Bhumika's final poster 36x72Bhumika's final poster 36x72
Bhumika's final poster 36x72
 
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
IOSR Journal of Pharmacy (IOSRPHR), www.iosrphr.org, call for paper, research...
 
Problem Set One
Problem Set OneProblem Set One
Problem Set One
 
b1. Bioassay of ACTH.pdf
b1. Bioassay of ACTH.pdfb1. Bioassay of ACTH.pdf
b1. Bioassay of ACTH.pdf
 
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of PharmacyIOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
 
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of PharmacyIOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
IOSRPHR(www.iosrphr.org) IOSR Journal of Pharmacy
 
In vitro shoot multiplication in okra (Ablemonschus esculentues).
In vitro shoot multiplication in okra (Ablemonschus esculentues).In vitro shoot multiplication in okra (Ablemonschus esculentues).
In vitro shoot multiplication in okra (Ablemonschus esculentues).
 
Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...
Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...
Sugarcane Ash and Sugarcane Ash-Derived Silica Nanoparticles Alter Cellular M...
 
Formulation and Evaluation of immediate release tablet in treatment of overac...
Formulation and Evaluation of immediate release tablet in treatment of overac...Formulation and Evaluation of immediate release tablet in treatment of overac...
Formulation and Evaluation of immediate release tablet in treatment of overac...
 
ACE Poster
ACE PosterACE Poster
ACE Poster
 
Chemical composition and bioactivity of essential oils of seed
Chemical composition and bioactivity of essential oils of seedChemical composition and bioactivity of essential oils of seed
Chemical composition and bioactivity of essential oils of seed
 
Synthesis of Iodo Ester Azide
Synthesis of Iodo Ester AzideSynthesis of Iodo Ester Azide
Synthesis of Iodo Ester Azide
 

Recently uploaded

Call Girls Gwalior Just Call 8617370543 Top Class Call Girl Service Available
Call Girls Gwalior Just Call 8617370543 Top Class Call Girl Service AvailableCall Girls Gwalior Just Call 8617370543 Top Class Call Girl Service Available
Call Girls Gwalior Just Call 8617370543 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Ooty Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Ooty Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Ooty Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Ooty Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...Sheetaleventcompany
 
Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...
Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...
Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...Dipal Arora
 
Call Girls Haridwar Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Haridwar Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Haridwar Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Haridwar Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Siliguri Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Siliguri Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Siliguri Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Siliguri Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Top Rated Bangalore Call Girls Mg Road ⟟ 9332606886 ⟟ Call Me For Genuine S...
Top Rated Bangalore Call Girls Mg Road ⟟   9332606886 ⟟ Call Me For Genuine S...Top Rated Bangalore Call Girls Mg Road ⟟   9332606886 ⟟ Call Me For Genuine S...
Top Rated Bangalore Call Girls Mg Road ⟟ 9332606886 ⟟ Call Me For Genuine S...narwatsonia7
 
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service AvailableDipal Arora
 
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋TANUJA PANDEY
 
Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...
Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...
Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...Ishani Gupta
 
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...Dipal Arora
 
Call Girls Bareilly Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Bareilly Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Bareilly Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Bareilly Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Call Girls Tirupati Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Tirupati Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Tirupati Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Tirupati Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...Dipal Arora
 
Call Girls Agra Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Agra Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Agra Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Agra Just Call 8250077686 Top Class Call Girl Service AvailableDipal Arora
 
O963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
O963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In AhmedabadO963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
O963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In AhmedabadGenuine Call Girls
 
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...Taniya Sharma
 
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...astropune
 
Top Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any Time
Top Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any TimeTop Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any Time
Top Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any TimeCall Girls Delhi
 
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...aartirawatdelhi
 

Recently uploaded (20)

Call Girls Gwalior Just Call 8617370543 Top Class Call Girl Service Available
Call Girls Gwalior Just Call 8617370543 Top Class Call Girl Service AvailableCall Girls Gwalior Just Call 8617370543 Top Class Call Girl Service Available
Call Girls Gwalior Just Call 8617370543 Top Class Call Girl Service Available
 
Call Girls Ooty Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Ooty Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Ooty Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Ooty Just Call 8250077686 Top Class Call Girl Service Available
 
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
Call Girls Service Jaipur {9521753030} ❤️VVIP RIDDHI Call Girl in Jaipur Raja...
 
Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...
Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...
Call Girls Visakhapatnam Just Call 9907093804 Top Class Call Girl Service Ava...
 
Call Girls Haridwar Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Haridwar Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Haridwar Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Haridwar Just Call 8250077686 Top Class Call Girl Service Available
 
Call Girls Siliguri Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Siliguri Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Siliguri Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Siliguri Just Call 8250077686 Top Class Call Girl Service Available
 
Top Rated Bangalore Call Girls Mg Road ⟟ 9332606886 ⟟ Call Me For Genuine S...
Top Rated Bangalore Call Girls Mg Road ⟟   9332606886 ⟟ Call Me For Genuine S...Top Rated Bangalore Call Girls Mg Road ⟟   9332606886 ⟟ Call Me For Genuine S...
Top Rated Bangalore Call Girls Mg Road ⟟ 9332606886 ⟟ Call Me For Genuine S...
 
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service AvailableCall Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
Call Girls Dehradun Just Call 9907093804 Top Class Call Girl Service Available
 
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
VIP Hyderabad Call Girls Bahadurpally 7877925207 ₹5000 To 25K With AC Room 💚😋
 
Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...
Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...
Mumbai ] (Call Girls) in Mumbai 10k @ I'm VIP Independent Escorts Girls 98333...
 
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
Best Rate (Patna ) Call Girls Patna ⟟ 8617370543 ⟟ High Class Call Girl In 5 ...
 
Call Girls Bareilly Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Bareilly Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Bareilly Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Bareilly Just Call 8250077686 Top Class Call Girl Service Available
 
Call Girls Tirupati Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Tirupati Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Tirupati Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Tirupati Just Call 8250077686 Top Class Call Girl Service Available
 
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
Best Rate (Guwahati ) Call Girls Guwahati ⟟ 8617370543 ⟟ High Class Call Girl...
 
Call Girls Agra Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Agra Just Call 8250077686 Top Class Call Girl Service AvailableCall Girls Agra Just Call 8250077686 Top Class Call Girl Service Available
Call Girls Agra Just Call 8250077686 Top Class Call Girl Service Available
 
O963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
O963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In AhmedabadO963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
O963O942363 Call Girls In Ahmedabad Escort Service Available 24×7 In Ahmedabad
 
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
(👑VVIP ISHAAN ) Russian Call Girls Service Navi Mumbai🖕9920874524🖕Independent...
 
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
♛VVIP Hyderabad Call Girls Chintalkunta🖕7001035870🖕Riya Kappor Top Call Girl ...
 
Top Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any Time
Top Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any TimeTop Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any Time
Top Quality Call Girl Service Kalyanpur 6378878445 Available Call Girls Any Time
 
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
Night 7k to 12k Navi Mumbai Call Girl Photo 👉 BOOK NOW 9833363713 👈 ♀️ night ...
 

Elephant Sunshine

  • 1. Ibogaine Therapy: Forms and Dose Regimens Howard S. Lotsof, B.F.A., C.M.A. President Dora Weiner Foundation Staten Island, NY http://www.doraweiner.org
  • 2. Forms in Current Use • Botanical - root bark • Total alkaloid extract • purified ibogaine
  • 5. Total Alkaloid Extract Large piece 2cm x 2cm, approx 4 grams Estimate 15% ibogaine Courtesy Sara Glatt
  • 6. Ibogaine HCl 99.4% purity
  • 7. All forms have multiple treatment applications 1. Chemical use disorders 2. Pain management 3. Psychotherapy 4. Initiatory sessions
  • 8. Each form has 1. Different onset 2. Different duration of action 3. And significant diversity across the patient population
  • 9. Onset of Effects (min) 160 140 120 100 Full Effect 80 60 Onset 40 20 0 HCl Extract
  • 10. Period of visuaization (hours) 16 14 12 Extended 10 Visualization 8 6 Onset 4 2 0 HCl Extract
  • 11. Duration of Action (days) 10 9 8 7 Residual 6 5 4 Principal 3 2 1 0 HCl Extract
  • 12. Effect on sleep (weeks) 10 9 8 7 Residual 6 5 4 Principal 3 2 1 0 HCl
  • 13. Dose and Dose Regimen 1. Single dose 2. Multiple 1. Escalating 2. Deescalating 3. Linear
  • 14. All doses are representative. Doses, including single administration doses are determined on a patient by patient basis. The graphs of dose regimens and information that follow should not be used by persons without experience to self- administer or administer to others any dose of ibogaine or total alkaloid extract of Tabernanthe iboga .
  • 15. Single dose regimens usually fall between 10mg/kg and 22mg/kg depending on type of therapy offered: opioid dependence, stimulant dependence, psychospiritual, etc. Most doses fall in the 15mg/kg - 20mg/kg dose range to reach full therapeutic effects.
  • 16. ibogaine HCl (mg/hour) 20mg methadone total - 1000mg 400 350 350 300 250 200 175 175 175 HCl 150 125 100 50 0 0 h1 h2 h3 h4
  • 17. ibogaine HCl (mg/kg/hour) stimulant therapy courtesy Eric Taub 16 14 12 10 10 HCl 8 6 4 2.5 3 2 0 h2 h3
  • 18. ibogaine HCl (mg/kg/hour) heroin therapy total 21.5mg.kg courtesy Eric Taub 16 14 14 12 10 HCl 8 6 5 4 2 2.5 0 1h h12
  • 19. ibogaine HCl (mg/kg/hour) methadone therapy total 36.5 mg/kg courtesy Eric Taub 16 14 12 12 10 8 HCl 6 4 3 3 3 3 2.5 2.5 2.5 2.5 2.5 2 0 13 23 30 34 36 59 68 77 89 100
  • 20. extract (grams/hour) heroin therapy total 7 grams courtesy Sara Glatt 6 5 4 3 3 3 Exract 2 1 1 0 0 12 36 48
  • 21. extract (grams/hour/day) methadone therapy total 11 grams courtesy Sara Glatt 6 5 4 3 3 3 Exract 2 1 1 1 1 1 1 0 0 12 36 d2 d4 d6 d8 d10
  • 22. extract (grams/hour) HCl (mg/hour) methadone 300mg/day total extract 9 grams total HCl 400mg courtesy Marc Emery 6 5.2 5 3.8 4 Exract 3 2 HCl 1 0.1 0.1 0.1 0.1 0 0 h72 h96 h120h168h192
  • 23. All doses and dose regimens shown or discussed are representative and are not indicated to be provided to any other patient or subject. All doses and dose regimens are made on a patient by patient basis upon knowledge and prior art.

Editor's Notes

  1. Workshop participants will be asked if they have a copy of the manual. If everyone has a copy, fine. If not, those who do not want the manual will be asked to give their copy to someone who wants a copy.