1. Scientists Identify Molecular Basis for DNA Breakage, a Hallmark of Cancer Cells Targeting PTEN May Prevent Skin Cancer MOLECULAR BIOLOGY SIMÓN RESTREPO ARISMENDY Medicine Student UPB

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4. INTRODUCTION Soundslikeaneasything, butit´s a verycomplex molecular process Even a tinymistake in the DNA replication can cause terrible diseaslikecancer

5. TARGETING PTEN MAY PREVENT CANCER ScienceDaily (july26, 2011)

6. TARGETING PTEN MAY PREVENT CANCER PTEN proteins promote cellular repair Non-melanome skin cancer is the most common cancer in the United States.

7. TARGETING PTEN MAY PREVENT CANCER Cells with low PTEN protein were more likely to hace UVB-induced skin cancers. Reduced levels of PTEN proteins could lead to cancer and tumor progression.

8. TARGETING PTEN MAY PREVENT CANCER Increasing PTEN protein activity could reduce skin cancer and tumor progression.

9. OBSERVATION This study, has made a breakthrough the understanding the PTEN protein function and the way to prevent skin cancer and tumor progression, which is a huge and a really important step in the war against oncology diseases.

10. SCIENTIST IDENTIFY MOLECULAR BASIS FOR DNA BREAKAGE, A HALLMARK OF CANCER CELLS SCIENCEDAILY (JULY 19, 2011)

11. Scientistidentify Molecular Basisfor DNA Breakage, A Hallmark Of CancerCells The DNA encodes the entire genetic information required for building the proteins of the cell. Under stress condition, DNA usually breaks.

12. Scientistidentify Molecular Basisfor DNA Breakage, A Hallmark Of CancerCells DNA breaks leads in an uncontrolled cell division and at the end in a cancer development The study shed a light on the regulation of DNA replication along the fragile sites

13. ScientistIdentify Molecular Basisfor DNA Breakage, A Hallmark Of CancerCells Fragilesites, wherethe DNA breakagebegins, is a sitethatslow and also can stop DNA replication.

14. OPINION This study, has made a breakthrough the understanding the PTEN protein function and the way to prevent skin cancer and tumor progression, which is a huge and a really important step in the war against oncology diseases.

15. MedicalUtility

16. MedicalUtility . Bothstudiescouldletthescientisthave more tooltokeepinvestingationaround more genetictroublesthatcouldend in cancer

17. MedicalUtility Foundingcancergenetic causes and allthe molecular processthatincreaseposibilty of developingthisdiseas, couldend in somenutritionregimthatgivestheposibiltytopreventsomespecificcancer.

18. Medicalutility Scientistcoulddevelopbettertreatmentsoreven a cure forcancer.

19. BIBLIOGRAPHY TargetinPTEN maypreventskinCancer. American AssociationforCancerResearch. 2011, July 26. ScienceDaily [online]. RetrievedAugust 6, 2011, from http://www.sciencedaily.com/releases/2011/07/110726132351.htm Scientistsidentify molecular basisfor DNA breakage, a hallmark of cancercells.. HebrewUniversity of Jerusalem. 2011, July 19. ScienceDaily [online]. RetrievedAugust 6, 2011, fromhttp://www.sciencedaily.com/releases/2011/07/110719094023.htm Martinez S Lina María. Biologia Molecular. 6 ed. Medellin. UPB. Fac Medicina. 2011, 74-75p

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