My talk from SMI ELN conference looking at the ELN landscape:
• Business drivers
- Comparing the different sectors and disciplines
• Build or buy?
• An overview of the solution space
• Patterns of success
3. Copies of these slides
http://www.amphora-research.com/
My blog: http://elnblog.com 2
4. About Amphora
• Started in ELNs in 1996
• Globally deployed, fully electronic ELN
for Kodak
• Grew from there...
• Now work with large & small companies
• Biotechs, Pharma, Chemicals
http://www.amphora-research.com/
My blog: http://elnblog.com 3
5. Some people we work with
http://www.amphora-research.com/
6. Some people we work with
http://www.amphora-research.com/
7. What we do
• Patent Evidence Creation & Preservation
• Make lawyers happy
• Which means you can make scientists
happy
http://www.amphora-research.com/
My blog: http://elnblog.com 5
8. What we do
• Sometimes our stuff is used...
• Standalone
• In conjunction with other “ELN”
products
• With in house systems
http://www.amphora-research.com/
My blog: http://elnblog.com 6
9. Why me?
• We do the Patent Evidence problem
• You still need to make the scientists happy
• So we get a ring-side seat on some of
these problems
• We cross all the different ELN industries
http://www.amphora-research.com/
My blog: http://elnblog.com 7
10. ELN Landscape
• Business drivers - comparing the different
sectors and disciplines
• Build or buy?
• An overview of the solution space
• Patterns of success
http://www.amphora-research.com/
My blog: http://elnblog.com 8
11. Why?
• Why do we care about the ELN landscape?
• Because it helps us all communicate
• Perspective on the lessons learned in other
areas
http://www.amphora-research.com/
My blog: http://elnblog.com 9
12. The “ELN” Word
• Very ambiguous
• Probably best if you didn’t use it
• Say what you mean
http://www.amphora-research.com/
My blog: http://elnblog.com 10
13. What do you mean?
• The term “ELN” means different things to
different people
• Somewhere the scientists will work
• A Patent Evidence system (& long term
record)
http://www.amphora-research.com/
My blog: http://elnblog.com 11
14. What is an ELN?
Corporate aspects
(Records, IP protection, Sharing)
Medicinal Chemistry
Process Chemistry
Molecular Biology
Pharmacology
Etc.
http://www.amphora-research.com/
My blog: http://elnblog.com 12
15. Patent Evidence
• Typically this is a broad, thin layer
• Consistently applied across the whole
company
• Keep it out of the scientific systems
• Single, well defined place
• Under the control of Custodian
http://www.amphora-research.com/
My blog: http://elnblog.com 13
16. Patent Evidence
• Typically this is a broad, thin layer
• Consistently applied across the whole
company
• Keep it out of the scientific systems
• Single, well defined place
• Under the control of Custodian
http://www.amphora-research.com/
My blog: http://elnblog.com 13
17. Industry/Company Type
• Life Sciences
• Biotech or Pharma
• Biology Vs Chemistry
• Diverse Chemicals
http://www.amphora-research.com/
My blog: http://elnblog.com 14
18. Biotech Vs Pharma
• Pharma tend to be much more “Mature” organisations
• Everything is done in an Enterprise Way
• Often have a large amount of established code
• Instincts are to buy, but have the resources to build
• Biotech can be much lighter on their feet
• Simpler problems
• Smaller, younger organisations
• Instinct is to build for competitive advantage,
management often to buy
http://www.amphora-research.com/
My blog: http://elnblog.com 15
19. Differences that make a
Difference
• There are 2 key aspects which impact the
character of your ELN implementation
• Regulated Vs Unregulated
• Industry
http://www.amphora-research.com/
My blog: http://elnblog.com 16
20. Regulated or not?
• If you are regulated, chances you are talking
about process automation, enforcement,
and compliance
• This isn’t easy, but it is
• Relatively unambiguous
• Fairly well mapped already
http://www.amphora-research.com/
My blog: http://elnblog.com 17
21. ELNs in a Regulated
Area
• The functions of a “Notebook” will often
be done electronically by something else
• It won’t be called an “Electronic Lab
Notebok”
• Mixing regulated none regulated generally
makes life unbearably exciting
http://www.amphora-research.com/
My blog: http://elnblog.com 18
22. Chemistry Vs Biology
• In Life Sciences, the biggest distinction is
between Chemists and Biologists
http://www.amphora-research.com/
My blog: http://elnblog.com 19
23. Chemistry
• Chemistry is pretty structured
• Buy (or build) them a Chemistry-centric
ELN and let them get on with it
• The selection process is detailed but at
least the work relatively consistently
http://www.amphora-research.com/
My blog: http://elnblog.com 20
24. Sources of Chemistry
ELNs
• If you’re a big pharma, you’re probably
already set
• With varying success - this isn’t easy
• Solutions
• Buy off the shelf
• Build from what you have
• Vendor capture
http://www.amphora-research.com/
My blog: http://elnblog.com 21
25. Sources of Chemistry
• In Biotechs, you probably can’t afford to
build or do vendor capture
• Unless Cheminformatics is a core strength
• So you’re going to have do as much as you
can with off-the-shelf (customised as
needed)
• Nice selection of vendors, have fun!
http://www.amphora-research.com/
My blog: http://elnblog.com 22
26. Biology
• Massive diversity
• Lots of Microsoft Office and other “non
ELN” applications
• Best approach is to get out of their way
http://www.amphora-research.com/
My blog: http://elnblog.com 23
27. Biology-specific ELNs
• There are some biology-specific ELNs
• Rely on the construction of templates for each
area
• Work well for very structured areas
• Hard to deploy over a large area because of
diversity
• Quickly run into the “You’ve just made Excel
harder to use” problem
http://www.amphora-research.com/
My blog: http://elnblog.com 24
28. Examples
• Biology in Janssen (IQPC Brussels 2007)
• Really good example of in-depth analysis
of process
• 98% approval rate on a project that size
is pretty stunning
http://www.amphora-research.com/
My blog: http://elnblog.com 25
29. Small/Medium
Chemicals
• Lots of point solutions
• Rarely have the money do to anything
other than implement an off-the-shelf
package in a small area
• Relatively simple problem
• Significant successes in certain cases
http://www.amphora-research.com/
My blog: http://elnblog.com 26
30. Large Chemicals
• Somewhat boring places you may or may
not have heard of
• But employ 1,000 of scientists and make
most of the fun stuff in your house and car
• e.g. companies like Kodak, BASF, PPG,
Milliken, USG, etc.
http://www.amphora-research.com/
My blog: http://elnblog.com 27
31. Large Chemicals
• Massive diversity
• R&D is typically very close to the customer
• Tight timescales
• Low tolerance for “non-value add”
activities
• Not as much “Chemistry” as you’d think
http://www.amphora-research.com/
My blog: http://elnblog.com 28
32. Large Chemicals
• The ELN project will “Open the can of
worms” in terms of
• The tools people are using
• The records they are creating
• The patent evidence that is generated
http://www.amphora-research.com/
My blog: http://elnblog.com 29
33. General Purpose ELNs
• “You all use the same Paper notebook don’t
you?”
• “So surely you can all use the same
Electronic notebook?”
http://www.amphora-research.com/
My blog: http://elnblog.com 30
34. General Purpose ELNs
• You can do it for small numbers of users
and certain styles of work
• Where workflow is important
• For large numbers of users
• The diversity in process will kill you
• You end up building an expensive version
of Word & Excel
http://www.amphora-research.com/
My blog: http://elnblog.com 31
35. General Purpose ELNs
Functionality
Number of users
http://www.amphora-research.com/
My blog: http://elnblog.com 32
36. General Purpose ELNs
Functionality
Possible
Number of users
http://www.amphora-research.com/
My blog: http://elnblog.com 32
37. General Purpose ELNs
Functionality
Possible
Possible
Number of users
http://www.amphora-research.com/
My blog: http://elnblog.com 32
38. General Purpose ELNs
Functionality
Possible
Doomed to fail
The organisation will frustrate you
Possible
Number of users
http://www.amphora-research.com/
My blog: http://elnblog.com 32
39. Front end tools
• Most organisations will end up providing
different front ends to different users
• Examples
• BMS, Solvay, J&J, BASF, all the other large
companies
http://www.amphora-research.com/
My blog: http://elnblog.com 33
40. Patents
• As a rule, what you need to do from a
Patent perspective is pretty generic
• You might have some specific needs, but
95% of what you need can be done off the
shelf
• This is one area where you want to stick
with best practice and leave it alone
http://www.amphora-research.com/
My blog: http://elnblog.com 34
41. Records Management
• The Cinderella of ELN projects
• Desperately important
• Clearly something that’s dependent on your
own processes
http://www.amphora-research.com/
My blog: http://elnblog.com 35
42. Build or Buy?
• I don’t believe there’s one true answer here
• There’s a resurgence in components to allow a “Build”
decision
• e.g. Cheminformatics as a service
• Decision will be down to
• Internal capabilities
• Degree of specialisation
• Ultimately all project teams will be constructing an “ELN
System” from components – whether they are called “ELN”s,
or other lower-level parts
http://www.amphora-research.com/
My blog: http://elnblog.com 36
43. Conclusions
• Our original question
• Some thoughts
http://www.amphora-research.com/
My blog: http://elnblog.com 37
44. Our Questions
• What’s the differences that make a
difference?
• What simple things can you do to
increase your chance of success?
http://www.amphora-research.com/
My blog: http://elnblog.com 38
45. Differences
• Life Sciences Vs Everyone else
• In Life Sciences
• Biology Vs Chemistry
• Biotech-ish Vs Pharma-ish
• Regulated or not?
http://www.amphora-research.com/
My blog: http://elnblog.com 39
46. Beware the ELN word
• Say what you mean
• Expect different front ends to support
different work
http://www.amphora-research.com/
My blog: http://elnblog.com 40
47. Changing the world
• Unless you have been specifically charged
with changing the workflow
• Don’t pick the fight
• You’re there to support the science
• Today and in the future
http://www.amphora-research.com/
My blog: http://elnblog.com 41
48. Conclusions
• They’ve probably already got what they
need anyway
• Or a very good idea of what they need
• That’s why they asked for an ELN in the
first place
http://www.amphora-research.com/
My blog: http://elnblog.com 42
49. Conclusion
• If you are charged with changing the
workflow
• That’s your project, not “ELN” or
whatever
• Try to keep the scope as small as possible
• Size and diversity will kill you
http://www.amphora-research.com/
My blog: http://elnblog.com 43
50. Patent Evidence
• Stick with best practice unless you really
know what you are doing
• One single system
http://www.amphora-research.com/
My blog: http://elnblog.com 44
51. Conclusion
• Chemistry - buy, or build, the best you can
• Biology - get out of their way
• Large chemicals - you’ll never fully
understand everything in detail
http://www.amphora-research.com/
My blog: http://elnblog.com 45
52. Thank You
• Slides will be on our web site tonight
• Any questions?
http://www.amphora-research.com/
My blog: http://elnblog.com 46
Editor's Notes
The Kodak ELN was the largest ELN
And is the oldest, fully electronic ELN around, been through a number of generations
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We’re trying to give you a map to see how all the bits fit together
We call this Broad Vs Deep
Others have similar diagrams
This is our gig
Less overhead
Sometimes don’t have any regulated activity
You have some large Biotechs who are like Pharmas
Before we start, it is important to talk about some of the “Differences” that “Make a difference” in terms of how you will need to approach this.
So you’re really looking at just getting on with it
LIMS
SDMS etc.
Examples of this are Incyte etc.
The low tolerance is a reason why you need to be careful about rolling stuff out there
Generally if you see a case study like this, it is a smaller company