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Ulcerative colitis ayurvedic view
1. A CLINICAL TRIAL TO EVALUATE THE EFFICACY OF
PICCHA VASTHI IN REDUCING THE SIGNS AND
SYMPTOMS OF ULCERATIVE COLITIS
Simi Ravindran
Dr.Simi Ravindran
Assistant professor
Govt.Ayurveda college Kannur
simisreehari@gmail.com
Wats up-9496370179
2. Contents
Introduction
Anatomy and physiology of colon
Ulcerative colitis- Modern view
Anatomy and physiology
Ulcerative colitis -Ayurvedic perspective
Drug review
Methodology of research
Conclusion
3. Anatomy
ā¢ The large intestine constitutes the terminal part of the digestive
system.
ā¢ It is responsible for recovery of 1-1.5 l of electrolyte ārich fluid
entering it.
ā¢ Allow the body to maintain fluid and electrolyte balance.
ā¢ Formation of low volume, solid stools, and permits less frequent
defecation.
ā¢ Provide environment of low oxygen tension conducive to bacterial
colonization. .
ā¢ Approximately 1.5 m long and capacity when filled by enema is 2L
of volume, resident volume is 200 ml, and intracolonic volume is
750 ml.
ā¢ Histology
ā¢ Mucosa
ā¢ Submucosa
ā¢ Circular muscles
ā¢ Longitudinal muscle
ā¢ Serosa
4. Concentration of fecal effluent through water and
electrolyte absorption
Bacterial Growth
Production of Vitamins & Electrolytes
Muscular Action of the colon
Stool Transit & Defecation
Physiology
5. Ulcerative colitis
Etymology
Ulcerative: means relating to, causing, or marked by an ulcer
or ulcers.
Colitis: means inflammation of the colon.
Defenition
Ulcerative colitis is an inflammatory disorder that causes
ulcers and irritation in the inner lining of the colon of the
colonic mucosa, characterized by relapses and remissions.
7. Clinical feautures
ā¢ Bloody diarrhea
ā¢ Increased bowel
frequency
ā¢ Passage of mucus with
stool
ā¢ Abdominal cramps
ā¢ Abdominal distension
ā¢ Anorexia
ā¢ Signs -tachycardia, fever,
abdominal tenderness or
distension.
ā¢ malaise, weight loss
Related to activity-
ā¢ Apthous Ulcers
ā¢ Erythema Nodosum
ā¢ Finger Clubbing
ā¢ Occular-conjunctivitis
ā¢ Episcleritis
ā¢ Iritis
ā¢ Arthritis
ā¢ Osteoporosis
Unrelated to activity
ā¢ Gallstones
ā¢ Sacroiliitis
ā¢ Arthralgia
ā¢ Nutritional Deficiency
8. Ulcerative Colitis-Types
Ulcerative proctitis:limited to the rectum. diarrhea, bloody
stool, pain in the rectal area, and a sense of urgency to
empty the bowel.
Proctosigmoiditis: rectum and the sigmoid colon.diarrhea,
bloody stool, cramps and pain in the rectal area, and
moderate pain on the left side of the abdomen
Left-sided colitis: Left-sided colitis affects the entire left
side of the colon, from the rectum to splenic flexure.
diarrhea, bleeding, weight loss ,loss of appetite, and
sometimes severe pain on the left side of abdomen.
Pancolitis: If the entire colon is affected, the term pancolitis
is used ("pan" meaning total).
9. Establish the severity
Clinical and radiological criteria table for assessing the
severity of Ulcerative colitis
Feature Mild Moderate severe
Motions/day <4 >4-6 >6Large
Rectal bleeding Small Moderate Large
amounts
Temperature Apyrexial Intermediate >37.8C
on 2days
out of 4
Pulse rate Normal Intermediate >90b.p.m
Hemoglobin 11g/dl Intermediate <0.5g/dl
ESR <20mm/h Intermediate >30mm/h
15. Management
The principals of management are
Prompt treatment of acute attacks.
Maintenance therapy to reduce the relapse rate.
Selection of patients for colectomy.
Detection of colorectal carcinoma.
Patient education is essential to ensure early presentation
during relapse.
16. 5-ASA Compounds
Medications to Suppress the Immune System
Surgery
ā¢ standard ileostomy
ā¢ continent ostomy
ā¢ ileo-anal pull-through
17. Prognosis
The pattern of relapse and remission one year after
diagnosis tends to continue for any individual.
90% have intermittent activity and 50% are in remission at
any one time.20% will relapse every year and 10% have
continous symptoms
Prolonged remission on maintance therapy occurs ,with 50-
60%remaining in remission for more than 2 years,but <5%
are symptom- free for 15 years
31. Samprapthi
nidanaas
Vatha pitta kapha
Incresed drava guna
and sara guna of pitta
Agni dusti
Aharapachana hamprers
Amayuktha pakva apakva
misrita anna
Malasanchaya in pak asaya
Rakthadusti formation of vrina
Punah punah sleshma samsritha raktha
mala pravritti
Incresed usna and
teekshna guna of
pitta.apana vaigunya
34. Apathya vihara
Langhana,Vamana karma,Poorna visrama, Nidra, Activities
making mind happy.
Snana, abhyanga, avagaha, guru ,snigda bhojana, vyayama,
agni santapa should be avoided by atisara rogi as per the
text of Chakradatta.
37. Ingredients Dose
saindhava 3 gm
makshika 120 ml
Madhuytastyadi taila 120 ml
Mahatiktaka grutha 120 ml
Salmali vrinta putapaka
mixed with ksheera
240 ml
Kalka of yasti and tagara 48 gm
Astanga hridaya atisara chikitsa
38. Salmali putapaka swarasa.
Atisara pravahagno raktarukpittadahaha
amatisara samano raktatisaranasanaā¦.ā(nighantu
ratnakara)
āPakvatisarasamano hanthi ghora sa
pravahikaā¦.ā(madanapala nighantu)
āPravahika atisara ama
kaphapittasradahanut....ā(kaiya deva nighantu)
āAvedanam ssampakvam deeptagne
suchirothitham
Nanavarmnamatisaram putapakairupacharelā¦ā.
Chakra datta2/74)-
39. Mahatiktaka grutham
Grahani chikitsa theindication is there āpittagrahanyam tal
peyam kustoktamtiktakam cha yalā .Mahatiktaka grutham
is indicated in the kusta chikitsa .phala sruti includes paittika
grahani.athisaras
Madhuyastyadi tailam
A combination of Madhura rasa drugs, mentioned in
vatasonitha prakarana, having raktha prasadana and
brumhana properties.The main ingredient is yastimadhu
,which is pittasamana,can used in four
forms.pana,nasya,anuvasana,abhyanga.
41. Methodology of research
Out line of the study
ā¢ Extensive literary survey
ā¢ Clinical work
Selection of cases
Population
The population comprises of patients diagnosed of ulcerative colitis
,who satisfy the inclusion criteria.12 patients are included in the
study
Inclusion Criteria
Ulcerative colitis patients diagnosed by colonoscopy and biopsy
Age between 18-60 years
Both sex are included
Patient willing to participate
Exclusion criteria
Diseases other than ulcerative colitis
Age below 18 yrs and above 60 yrs
Other severe debilitating diseases
Patients not willing for the study
42. Study design
The present study is before and after study with out
control.no blinding was done
Time and duration of the study
The total period of the study was 18 months
Assessment criteria
Blood with stool
Assessment was done form grade ā0āto ā3ā according to the
following criteria
Passage of blood with stool
ā¢ Grade 0 - no blood
ā¢ Gradae1 - occasional
ā¢ Grade2 - moderate amount
ā¢ Grade3 - excessive amount
43. Passage of mucus with stool
ā¢ Grade 0 - no mucus
ā¢ Grade1 - occasional
ā¢ Grade2 - moderate amount
ā¢ Grade3 - excessive amount
Increased frequency of motion(in a
day)
ā¢ Grade 0 - normal no of stools
for this patient
ā¢ Gradae1 - 1-2 /day extra
stools per day
ā¢ Grade2 - 3-4 extra stools
per day
ā¢ Grade3 - 5 or more extra
stools per day
Diarrhea
ā¢ Grade 0 - no diarrhea
ā¢ Gradae1 1-2 times
ā¢ Grade2 - 5-8
ā¢ Grade3 - more than 8
times
Abdominal cramps
ā¢ Grade 0 - not present
ā¢ Gradae1 - occasional
ā¢ Grade2 - 3-4 times
ā¢ Grade3 - always
44. Anorexia
ā¢ Grade 0 - no anorexia
ā¢ Gradae1 - occasional
interest for diet
or food
ā¢ Grade2 feels hungry but
could not able
to take food
ā¢ Grade3 - no interest for
diet or food
Abdominal distension
ā¢ Grade 0 -no
abdominal distension
ā¢ Gradae1 - occasional
ā¢ Grade2 - after taking food
ā¢ Grade3 - always associated
Blood
Hb
TC
DC
ESR
RBS
Urine
ā¢ Sugar
ā¢ Albumin
ā¢ Deposits
Stool
ā¢ Color
ā¢ Consistency
ā¢ Microscopic
ā¢ Occult blood
ā¢ Proctoscopy
45. Hypothetical conclusion
Null hypothesis
Piccha vasthi is not significant in the reducing signs and symptoms of
Ulcerative colitis.
Alternate hypothesis
Piccha vasthi is significant in reducing the signs and symptoms of Ulcerative
colitis.
46. Observation analysis and
interpretation
The data relating to the study were conveniently segregated into four
heading as follows:-
Demographic data.
Out of the total patients, females and males were in equal ratio.
75% of the people were married and 25% were unmarried
The study reveals that 66.7% of patients are Hindus, 25% are in Christian
religion and 8.3% are Muslims.
While considering the socio-economic status 41.7% are from middle class
33. 3% from high class and 25% are poor class.
58.3% of the patients are from rural areas and 41.7% from urban areas.
In this study, 41.7% are educated, up to high school level, 25% are
graduates, 16.7% have pre degree, and 16.7% were illiterate.
66.7% of the patients underwent the study have sedentary and mental
stress ,while 25% have physical exercise and 8.3% were have both physical
and mental stress.
47. Prakriti:
ā¢ Vata-Pitta Prakriti dominated -50% of the people are belonging to vatha pitta
prakruti,30% were kapha pitta prakruti,20% were vath kapha prakruti..
ā¢ Half of the patients have day work, 33.3% have night work and 16.7% have
irregular timings in work.
ā¢ 41.7% working more than 8 hours, 33.3% working in between 6-8 hours,
and 16.7% work less than 6 hours.
ā¢ 75% have irregular intake of food habits and 25% regular intake of food.
48. ā¢ 50 % have no addiction and 25% have addiction of smoking and
the rest quarter having the addiction of alcohol.
ā¢ 58.3% have moderate exercise and 41.7% have heavy exercise.
ā¢ Data related to chronicity reveals that half of the patients have
chronicity between 5-10 years ,16.7% have 10-15 years and 33.3%
have 0-5 years of duration.
ā¢ The symptoms of Ulcerative colitis precipitated by emotional stress
accompanied by food in 50% of the patients .In 16.7% food is the
causative factor for aggravating symptoms, and in 33.3%
,emotional stress is the aggravating factor.
ā¢ 58.3% have feeling of anxiety and 41.7% , not have feeling
of anxiety.
ā¢ Initial insomnia presnt is 50% of the patients and absent in rest.
49. ā¢ Among 12 patients 91.7% having score-grade 2 in rectal bleeding,
and 8.3% of grade 1
ā¢ 58.3% have grade 1 in passage of mucus, and 41.7% have grade 2
that is moderate amount of mucus passing with stool.
ā¢ 50% have grade 2 and 50 % have grade 3 in bowel frequency
ā¢ 50%have grade 2 and 50 % have grade 3 in bowel frequency
ā¢ 50%have grade 2 and 50 % have grade 3 in abdominal cramps.
ā¢ Among 12 patients 58.3% have grade 2 and 41.7 have grade 3 in
severity of anorexia
ā¢ 58.3% having grade 1 and 41.7 % having grade 2 in abdominal
distension
50. Effectiveness of treatment Blood with stool,
BT,AT and Follow up
The p value is <0.01 which
shows that the treatment is
highly significant in
reducing the blood with
stool. After 30 days of
follow up mean difference
with before vasthi is 1.5
and paired ātā value is 10
and p value is <0.01 shows
that the treatment is highly
significant in the follow up
period.
0.0
0.5
1.0
1.5
2.0
2.5
BV AV 15th day 30th day
Mean
score
51. Passage of mucus with stool
The p value is <0.01 which
shows that the treatment is
highly significant in reducing
the mucus with stool. After 30
days of follow up, mean
difference with before vasthi is
0.83 and paired ātā value is 4
and p value is <0.01 shows
that the treatment is
significance in the follow up
period.
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
BV AV 15th day 30th day
Mean
score
52. Incresed frequency of bowel
The p value is <0.01 which
shows that the treatment is
significant in reducing
increased frequency of
bowel immediately after
vasthi and during follow up.
0.0
0.5
1.0
1.5
2.0
2.5
3.0
BV AV 15th day 30th day
Mean
score
53. Diarrhoea
Before treatment mean was
1.5 in diarrhoea treatment,
and after vasthi it was 0
with mean difference of 1.5
with paired ātātest value 10.
The p value is <0.01 .after
follow uo mean is 0.5 with
mean difference of 1 and
paired 't'value is 8.1 The p
value is <0.01.shows that
the treatment is highly
significant immediate after
vasthi and follow up
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
BV AV 15th day 30th day
Mean
score
54. Abdominal cramps
Before treatment mean
was 1.5 in diarrhoea
treatment, and after vasthi
it was 0 with mean
difference of 1.5 with
paired ātātest value 10.
The p value is <0.01 .after
follow uo mean is 0.5 with
mean difference of 1 and
paired 't'value is 8.1 The p
value is <0.01.shows that
the treatment is highly
significant immediate after
vasthi and follow up
0.0
0.5
1.0
1.5
2.0
2.5
3.0
BV AV 15th day 30th day
Mean
score
55. Anorexia
In anorexia mean value before
treatment was 2.42 nd
immediately aftervasthi , it
was0.08 with mean difference
2.33 shows paired t value
12.4 the p value is <0.01.
After follow up mean is 0.08
with mean difference 2.33
which shows paired t value of
12.4, the p value is <0.01
which shows that the
treatment is significant in
reducing anorexia
immediately after vasthi and
follow up period.
0.0
0.5
1.0
1.5
2.0
2.5
3.0
BV AV 15th day 30th day
Mean
score
56. Abdominal distension
The p value is <0.01 which
shows that the treatment is
highly significant in reducing
the treatment of blood with
stool. After 30 days of follow
up mean is 0.50 with mean
difference of 0.92 and paired
ātā value is 6.2 and p value is
<0.01 shows that the
treatment is significance in the
follow up period.
0.0
0.2
0.4
0.6
0.8
1.0
1.2
1.4
1.6
BV AV 15th day 30th day
Mean
score
57. Effectiveness of treatment on Hb
The p value is <0.05, after
follow up the mean is 11.02
with a mean difference of
1.29 and pair ātātest shows
the value 5.8. The p value
is <0.01 which shows that
the treatment is significant
in increasing Hb level.
9.0
9.5
10.0
10.5
11.0
11.5
BV AV 15th day 30th day
Mean
score
58. Effectiveness of increase in
retention time of sneha vasthi
The p value is P<0.01. The
statistical analysis shows that
the retention time is
significantly increasing.
0.0
50.0
100.0
150.0
200.0
250.0
300.0
350.0
400.0
450.0
Day 1 Day 2 Day 4 Day 6 Day 8
Mean
score
59. Table Effectiveness of increase in
retention time of PV
The retention time of first
Piccha vasthi with mean of
3.5 and mean difference of
1.5 with second Piccha vasthi
ātā test shows 4.64 and p
values p<0.01. on fifth day
mean is 4.9 and with third day
the difference is 1.8 on
seventh day paired t is 4.25.
the p value p<0.01. the
statistical analysis show that
the retention time is
statistically increasing.
0.0
1.0
2.0
3.0
4.0
5.0
6.0
Day 3 Day 5 Day 7
Mean
score
60. conclusion
The main conclusions derived from the study are
In the present study alternate hypothesis were significantly satisfied.
The present study Piccha vasthi corrects the following symptoms after
vasthi and after follow up is proved to be highly significant.
ā¢ Presence of blood in stool
ā¢ presence of mucous in the stool
ā¢ diarrhoea .
ā¢ abdominal cramps
ā¢ Anorexia
ā¢ abdominal distension
ā¢ frequency of stools per day
61. ā¢ With the statistical analysis highly significant improvement were
observed in the heamatological values in Hb levels.
ā¢ The retension time is incresing because of getting asayabala after
vasthi
ā¢ Ahara paka ,dathu parinama and dathu posana are the main
processes deranged in the disease,which emaciated the patient
more and more with the progression of the disease.
ā¢ Mahatiktaka grutha present in the Picchavasthi of aid excellent
ropana as well as daha prasamana property,enhancing the general
guna of the Piccha vasthi.