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Dibip technology

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Dibip technology

  1. 1. T T T 1681.8397 1681.8397 1681.8397 5 5 5 T T7 T7 T7 T T T 1481.8099 1995.1389 T 1481.8099 1995.1389 1481.8099 1995.1389 T T T T 37 T T T 37 909.4676 2495.27912837.3934 37 3519.8990 12 1492.7842 909.4676 3519.8990 909.4676 3519.8990 12 12 2495.27912837.3934 2495.27912837.3934 2298.37632704.3640 61. 3501.0 1492.7842 61. 3501.0 1492.7842 61. 3501.0 16 5 2298.37632704.3640 2298.37632704.3640 1 16 1 16 1 325 14 5 325 14 5 325 14 1000 1500 2000 2500 3000 3500 24 1000 1500 2000 2500 3000 350024 1000 1500 2000 2500 3000 350024 ISB DIBIP www.isbiotechnology.com Via Fantoli 16/15 (Milano) Director : Dr. Simone Cristoni Mail to : info@isbiotechnology.com DynamIc BIomarker Profile Early stage cancer diagnosis is possible now Ion Source & Biotechnologies 1
  2. 2. T T T 1681.8397 1681.8397 1681.8397 5 5 5 T T7 T7 T7 T T T 1481.8099 1995.1389 T 1481.8099 1995.1389 1481.8099 1995.1389 T T T T 37 T T T 37 909.4676 2495.27912837.3934 37 3519.8990 12 1492.7842 909.4676 3519.8990 909.4676 3519.8990 12 12 2495.27912837.3934 2495.27912837.3934 2298.37632704.3640 61. 3501.0 1492.7842 61. 3501.0 1492.7842 61. 3501.0 16 5 2298.37632704.3640 2298.37632704.3640 1 16 1 16 1 325 14 5 325 14 5 325 14 1000 1500 2000 2500 3000 3500 24 1000 1500 2000 2500 3000 350024 1000 1500 2000 2500 3000 350024 ISB www.isbiotechnology.com Via Fantoli 16/15 (Milano) Director : Dr. Simone Cristoni Mail to : info@isbiotechnology.com Open source metabolic profiling Ion Source & Biotechnologies Early stage cancer diagnosis through 2
  3. 3. Apparatus for early stage cancer Diagnsosis DynamIc Biomarker Profile (DIBIP) + + OnLine DIBIP LC-MS USIS Data elaboration system References 1) Cristoni S. et al. Rapid Commun Mass Spectrom. 2009 Sep;23(17):2839-45 2) Cristoni S. PCT International patent n. (WO 2007/131682) 3
  4. 4. DIBIP data collection and elaboration description  Creation of different mass spectra library (ex. 2 libraries: controls and patients).  The mass spectra are inserted in the correct library to create an effective database (to be enlarged by further insertion of other spectra). Each mass spectrum represents the entire plasma peptide & metabolite profile of a person. (*, or an other biological fluid)  An unknown sample is directly compared with each single profile of the database and it is automatically allocated in one or in the other library by similarity. CONTROLS’ LIBRARY PATIENTS’ LIBRARY UNKNOWN SAMPLE The whole plasma metabolite profile of an unknown sample is directly compared with each MS spectrum of both libraries and classified by similarity. 4
  5. 5. DIBIP diagnosis data elaboration flow Plasma from Plasma from Plasma from unknown subjects control subjects unhealthy patients DIBIP data DIBIP data DIBIP data Control library Control library Unhealthy library DIAGNOSIS 5
  6. 6. Results 94 % of Correct diagnosis!!!!!!! Sensitivity: 94% Selectivity: 94%
  7. 7. Results Elaboration platform will be made freely available at: http://www.isbiotechnology.com/
  8. 8. T T T 1681.8397 1681.8397 1681.8397 5 5 5 T T7 T7 T7 T T T 1481.8099 1995.1389 T T 1481.8099 1995.1389 T 1481.8099 1995.1389 T 37 T T 37 T T 37 909.4676 12 2495.27912837.3934 3519.8990 909.4676 3519.8990 909.4676 3519.8990 1492.7842 12 12 2495.27912837.3934 2495.27912837.3934 2298.37632704.3640 61. 3501.0 1492.7842 61. 3501.0 1492.7842 61. 3501.0 16 5 2298.37632704.3640 2298.37632704.3640 1 16 1 16 1 325 14 5 325 14 5 325 14 1000 1500 2000 2500 3000 3500 1000 24 1500 2000 2500 3000 350024 1000 1500 2000 2500 3000 350024 Team Dr. Cristina Canton Biologist Dr. Martina Soldaini Marketing Dr. Ombretta Repetto Biologist ISB Dr. Alessandro Finiguerra Chemist Dr. Simone Cristoni General Manager Dr. Lorenzo Zingaro Laboratory Manager Dr. Vincenza Flora Dibari Bioinformatician Dr. Pablo Martínez-Lozano Marie Curie researcher Ion Source & Biotechnologies 8

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