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BADRAWY MRCP Revision
‫اﻟرﺣﯾم‬ ‫اﻟرﺣﻣن‬ ‫ﷲ‬ ‫ﺑﺳم‬
This is a collection of commonly
tested facts for part 1
MRCP ...including the 100
commonly te...
a must read before part 1 ...
U'll find at least 20-30
Questions in your MRCP 1
exam from these notes.
‫ﷲ‬ ‫ﺷﺎء‬ ‫إن‬ 1b
B...
Somatisation vs
hypochondria
2a
BADRAWY MRCP Revision
Somatisation = patient
concerned about Symptoms.
HypochonDria = patient
concerned about underlying
Disease eg Cancer.
2b
B...
DiGeorge syndrome =
affects what type of cell?
3a
BADRAWY MRCP Revision
- a T-cell disorder
3b
BADRAWY MRCP Revision
Antithrombotic therapy in
bioprosthetic vs
mechanical heart valves
4a
BADRAWY MRCP Revision
- bioprosthetic: aspirin -
mechanical: warfarin +
aspirin
4b
BADRAWY MRCP Revision
Goodpasture's syndrome -
histology?
5a
BADRAWY MRCP Revision
- IgG deposits on renal
biopsy - anti-GBM
antibodies
5b
BADRAWY MRCP Revision
Adrenaline induced
ischaemia treatment
6a
BADRAWY MRCP Revision
- phentolamine
6b
BADRAWY MRCP Revision
Complete heart block
following a MI?
7a
BADRAWY MRCP Revision
- right coronary artery
lesion
7b
BADRAWY MRCP Revision
Wilson's disease: diagnosis
8a
BADRAWY MRCP Revision
- serum caeruloplasmin is
decreased
8b
BADRAWY MRCP Revision
Fluctuating
confusion/consciousness in
elderly plus/minus
deterioration ?
9a
BADRAWY MRCP Revision
chronic subdural. Can last
even longer than 6 months
9b
BADRAWY MRCP Revision
Acute promyelocytic
leukaemia translocation
10a
BADRAWY MRCP Revision
- t(15;17)
10b
BADRAWY MRCP Revision
Dermatophyte nail
infections Rx
11a
BADRAWY MRCP Revision
- use oral terbinafine
11b
BADRAWY MRCP Revision
Actions of BNP
12a
BADRAWY MRCP Revision
- vasodilator - diuretic and
natriuretic - suppresses
both sympathetic tone and
the renin-angiotensin-
aldosterone system
...
Burning thigh pain - ?nerve
compression
13a
BADRAWY MRCP Revision
? meralgia paraesthetica -
lateral cutaneous nerve of
thigh compression
13b
BADRAWY MRCP Revision
URTI symptoms +
amoxicillin --> rash
14a
BADRAWY MRCP Revision
?glandular fever
14b
BADRAWY MRCP Revision
IgM paraproteinaemia -
15a
BADRAWY MRCP Revision
?Waldenstrom's
macroglobulinaemia
15b
BADRAWY MRCP Revision
Absolute risk reduction =
16a
BADRAWY MRCP Revision
= (Control event rate) -
(Experimental event rate)
16b
BADRAWY MRCP Revision
Terlipressin - MoA?
17a
BADRAWY MRCP Revision
= constriction of the
splanchnic vessels
17b
BADRAWY MRCP Revision
Localising bitemporal
hemianopia - upper
quadrant defect > lower
quadrant defect.
18a
BADRAWY MRCP Revision
= inferior chiasmal
compression, commonly a
pituitary tumour
18b
BADRAWY MRCP Revision
Tear-drop poikilocytes ?
19a
BADRAWY MRCP Revision
= myelofibrosis
19b
BADRAWY MRCP Revision
Localising bitemporal
hemianopia - upper
quadrant defect > lower
quadrant defect.
20a
BADRAWY MRCP Revision
= superior chiasmal
compression, commonly a
craniopharyngioma
20b
BADRAWY MRCP Revision
Imatinib - MoA
21a
BADRAWY MRCP Revision
= tyrosine kinase inhibitor
used in CML
21b
BADRAWY MRCP Revision
Flushing, diarrhoea,
bronchospasm, tricuspid
stenosis, pellagra -
diagnosis?
22a
BADRAWY MRCP Revision
--> carcinoid with liver
mets
22b
BADRAWY MRCP Revision
Flash pulmonary oedema,
U&Es worse on ACE
inhibitor, asymmetrical
kidneys: ?diagnosis
23a
BADRAWY MRCP Revision
--> renal artery stenosis -
do MR angiography
23b
BADRAWY MRCP Revision
Collapse + ARF =
24a
BADRAWY MRCP Revision
--> rhabdomyolysis - treat
with IV fluids
24b
BADRAWY MRCP Revision
Statistical power =
25a
BADRAWY MRCP Revision
1 - the probability of a type
II error
25b
BADRAWY MRCP Revision
Sarcoidosis CXR stages
26a
BADRAWY MRCP Revision
1 = BHL - 2 = BHL +
infiltrates - 3 = infiltrates -
4 = fibrosis
26b
BADRAWY MRCP Revision
Calculating breakthrough
morphine dose?
27a
BADRAWY MRCP Revision
1/6th of daily morphine
dose
27b
BADRAWY MRCP Revision
Post-natal depression
incidence?
28a
BADRAWY MRCP Revision
10% of women
28b
BADRAWY MRCP Revision
COPD - when to start
LTOT?
29a
BADRAWY MRCP Revision
2 measurements of pO2 <
7.3 kPa
29b
BADRAWY MRCP Revision
Stroke thrombolysis time
limit?
30a
BADRAWY MRCP Revision
4.5 hours
30b
BADRAWY MRCP Revision
1mg prednisolone = ?
hydrocortisone
31a
BADRAWY MRCP Revision
4mg hydrocortisone
31b
BADRAWY MRCP Revision
Finasteride MoA
32a
BADRAWY MRCP Revision
5 alpha-reductase inhibitor
- inhibits conversion of
testosterone to
dihydrotestosterone
32b
BADRAWY MRCP Revision
Finasteride treatment of
BPH may take how long
before results are seen?
33a
BADRAWY MRCP Revision
6 months
33b
BADRAWY MRCP Revision
DVLA restriction post-
seizure
34a
BADRAWY MRCP Revision
6 months
34b
BADRAWY MRCP Revision
Rx for Hypertension in
diabetics -
35a
BADRAWY MRCP Revision
ACE-inhibitors are first-
line regardless of age
35b
BADRAWY MRCP Revision
Dysphagia affecting both
solids and liquids from the
start - think?
36a
BADRAWY MRCP Revision
achalasia
36b
BADRAWY MRCP Revision
Loss of corneal reflex - key
differential?
37a
BADRAWY MRCP Revision
acoustic neuroma
37b
BADRAWY MRCP Revision
Factor V Leiden mutation
results in?
38a
BADRAWY MRCP Revision
activated protein C
resistance
38b
BADRAWY MRCP Revision
Key treatments in migraine
- acute vs prophylactic
39a
BADRAWY MRCP Revision
acute: 5-HT1 agonist -
prophylaxis: beta-blocker
39b
BADRAWY MRCP Revision
Congenital heart disease -
acyanotic - most common
cause:
40a
BADRAWY MRCP Revision
acyanotic: VSD most
common cause
40b
BADRAWY MRCP Revision
Glitazones: MoA
41a
BADRAWY MRCP Revision
agonists of PPAR-gamma
receptors
41b
BADRAWY MRCP Revision
Atrial fibrillation -
cardioversion rx:
42a
BADRAWY MRCP Revision
amiodarone + flecainide
42b
BADRAWY MRCP Revision
Adult Life Support (ALS)
adrenaline doses -
43a
BADRAWY MRCP Revision
anaphylaxis: 0.5ml 1:1,000
IM - cardiac arrest: 10ml
1:10,000 IV or 1ml of
1:1000 IV
43b
BADRAWY MRCP Revision
Bartter's syndrome ?
44a
BADRAWY MRCP Revision
AR inherited cause of
hypokalaemia associated
with normotension
44b
BADRAWY MRCP Revision
Miller Fisher syndrome -
CFs?
45a
BADRAWY MRCP Revision
areflexia, ataxia,
ophthalmoplegia
45b
BADRAWY MRCP Revision
Polycythaemia rubra vera
progression?
46a
BADRAWY MRCP Revision
around 5-15% progress to
myelofibrosis or AML
46b
BADRAWY MRCP Revision
malt workers' lung -
pathogen
47a
BADRAWY MRCP Revision
Aspergillus clavatus
47b
BADRAWY MRCP Revision
Urticaria - common drug
cause?
48a
BADRAWY MRCP Revision
Aspirin
48b
BADRAWY MRCP Revision
Antiphospholipid
syndrome in pregnancy
treatment
49a
BADRAWY MRCP Revision
aspirin + LMWH
49b
BADRAWY MRCP Revision
Causes of raised transfer
factor?
50a
BADRAWY MRCP Revision
asthma, haemorrhage, left-
to-right shunts,
polycythaemia
50b
BADRAWY MRCP Revision
Beta-blocker overdose
management:
51a
BADRAWY MRCP Revision
atropine + glucagon
51b
BADRAWY MRCP Revision
Hereditary haemorrhagic
telangiectasia - inheritance
52a
BADRAWY MRCP Revision
autosomal dominant
52b
BADRAWY MRCP Revision
Alpha-1 antitrypsin
deficiency inheritance
53a
BADRAWY MRCP Revision
autosomal recessive / co-
dominant
53b
BADRAWY MRCP Revision
Aortic stenosis
management:
54a
BADRAWY MRCP Revision
AVR if symptomatic,
otherwise cut-off is
gradient of 50 mmHg
54b
BADRAWY MRCP Revision
Live attenuated vaccines -
55a
BADRAWY MRCP Revision
BCG - MMR - oral polio -
yellow fever - oral typhoid
55b
BADRAWY MRCP Revision
Atrial fibrillation: rate
control rx -
56a
BADRAWY MRCP Revision
beta blockers (preferable to
digoxin)
56b
BADRAWY MRCP Revision
Aortic stenosis - most
common cause <65 yrs:
57a
BADRAWY MRCP Revision
bicuspid aortic valve
57b
BADRAWY MRCP Revision
Most common cardiac
defect in Turner's
syndrome?
58a
BADRAWY MRCP Revision
Bicuspid aortic valve
58b
BADRAWY MRCP Revision
Porphyria cutanea tarda -
CP?
59a
BADRAWY MRCP Revision
Bullae on hands ,blistering
photosensitive rash -
hypertrichosis -
hyperpigmentation, fragile
SKIN torn by minor trauma
59...
Amiodarone MoA
60a
BADRAWY MRCP Revision
Blocks potassium channels
60b
BADRAWY MRCP Revision
Visual changes secondary
to drugs - blue vision?
Yellow-green vision?
61a
BADRAWY MRCP Revision
blue vision: Viagra ('the
blue pill') - yellow-green
vision: digoxin
61b
BADRAWY MRCP Revision
HRT: adding a progestogen
increases the risk of?
62a
BADRAWY MRCP Revision
breast cancer
62b
BADRAWY MRCP Revision
Common cause of tumour
lysis syndrome?
63a
BADRAWY MRCP Revision
Burkitt's lymphoma
63b
BADRAWY MRCP Revision
EBV: associated
malignancies?
64a
BADRAWY MRCP Revision
Burkitt's lymphoma -
Hodgkin's lymphoma -
nasopharyngeal carcinoma
64b
BADRAWY MRCP Revision
Variables used to calculate
eGFR?
65a
BADRAWY MRCP Revision
CAGE - Creatinine, Age,
Gender, Ethnicity
65b
BADRAWY MRCP Revision
Aortic stenosis - most
common cause >65 yrs:
66a
BADRAWY MRCP Revision
calcification
66b
BADRAWY MRCP Revision
What drugs are now
preferred to thiazides in the
treatment of hypertension?
67a
BADRAWY MRCP Revision
Calcium channel blockers
67b
BADRAWY MRCP Revision
DVLA advice post CVA:
68a
BADRAWY MRCP Revision
cannot drive for 1 month
68b
BADRAWY MRCP Revision
DVLA advice following
angioplasty -
69a
BADRAWY MRCP Revision
cannot drive for 1 week
69b
BADRAWY MRCP Revision
DVLA advice post multiple
TIAs:
70a
BADRAWY MRCP Revision
cannot drive for 3 months
70b
BADRAWY MRCP Revision
DVLA advice post MI -
71a
BADRAWY MRCP Revision
cannot drive for 4 weeks
71b
BADRAWY MRCP Revision
Epilepsy medication: first-
line - partial seizure:
72a
BADRAWY MRCP Revision
carbamazepine
72b
BADRAWY MRCP Revision
Trigeminal neuralgia -
first-line Rx?
73a
BADRAWY MRCP Revision
carbamazepine
73b
BADRAWY MRCP Revision
Trastuzumab (Herceptin) -
important SE?
74a
BADRAWY MRCP Revision
cardiotoxicity
74b
BADRAWY MRCP Revision
Schistosoma haematobium
75a
BADRAWY MRCP Revision
causes haematuria
75b
BADRAWY MRCP Revision
Horner's syndrome -
anhydrosis of head, arm,
trunk =
76a
BADRAWY MRCP Revision
central lesion: stroke,
syringomyelia
76b
BADRAWY MRCP Revision
Chickenpox exposure in
pregnancy - first step?
77a
BADRAWY MRCP Revision
check antibodies
77b
BADRAWY MRCP Revision
CLL - treatment?
78a
BADRAWY MRCP Revision
chlorambucil
78b
BADRAWY MRCP Revision
ADPKD type 1
chromosome
79a
BADRAWY MRCP Revision
chromosome 16 = 85% of
cases
79b
BADRAWY MRCP Revision
Chemo agent associated
with hypomagnesaemia?
80a
BADRAWY MRCP Revision
Cisplatin
80b
BADRAWY MRCP Revision
Rx Infertility in PCOS -
81a
BADRAWY MRCP Revision
clomifene is superior to
metformin
81b
BADRAWY MRCP Revision
JVP: C wave - physiological
correlate
82a
BADRAWY MRCP Revision
closure of the tricuspid
valve
82b
BADRAWY MRCP Revision
Episodic eye pain,
lacrimation, nasal
stuffiness occurring daily -
?diagnosis
83a
BADRAWY MRCP Revision
cluster headache
83b
BADRAWY MRCP Revision
Burkitt's lymphoma - gene
translocation?
84a
BADRAWY MRCP Revision
c-myc
84b
BADRAWY MRCP Revision
Animal bite treatment
85a
BADRAWY MRCP Revision
co-amoxiclav
85b
BADRAWY MRCP Revision
Drug metabolism - phase II
components?
86a
BADRAWY MRCP Revision
conjugation
86b
BADRAWY MRCP Revision
Viagra contraindications
87a
BADRAWY MRCP Revision
contraindicated by nitrates
and nicorandil
87b
BADRAWY MRCP Revision
Main indication for HRT?
88a
BADRAWY MRCP Revision
control of vasomotor
symptoms
88b
BADRAWY MRCP Revision
First line investigation for
PE according to current
BTS guidelines?
89a
BADRAWY MRCP Revision
CTPA
89b
BADRAWY MRCP Revision
hypokalaemic metabolic
alkalosis - endocrine
condition?
90a
BADRAWY MRCP Revision
Cushing's syndrome
90b
BADRAWY MRCP Revision
Hemiballism (involuntary,
sudden, jerking
movements) = caused by?
91a
BADRAWY MRCP Revision
damage to the subthalamic
nucleus
91b
BADRAWY MRCP Revision
Acute myeloid leukaemia -
poor prognosis
92a
BADRAWY MRCP Revision
deletion of chromosome 5
or 7
92b
BADRAWY MRCP Revision
Most common psychiatric
problem in Parkinson's
disease?
93a
BADRAWY MRCP Revision
depression
93b
BADRAWY MRCP Revision
Investigation for Carcinoid
94a
BADRAWY MRCP Revision
Diagnosis: urinary 5-HIAA
94b
BADRAWY MRCP Revision
Adenosine interactions
95a
BADRAWY MRCP Revision
dipyridamole enhances
effect - aminophylline
reduces effect
95b
BADRAWY MRCP Revision
Dystrophia myotonica -
DM1 CFs
96a
BADRAWY MRCP Revision
DM1 - distal weakness
initially - autosomal
dominant - diabetes -
dysarthria
96b
BADRAWY MRCP Revision
Restless leg syndrome -
management
97a
BADRAWY MRCP Revision
dopamine agonists such as
ropinirole
97b
BADRAWY MRCP Revision
Change to steroid dose in
people on long term tx if
intercurrent illness?
98a
BADRAWY MRCP Revision
Double doses
98b
BADRAWY MRCP Revision
Rheumatoid arthritis -
HLA association?
99a
BADRAWY MRCP Revision
DR4
99b
BADRAWY MRCP Revision
HRT: unopposed oestrogen
increases risk of?
100a
BADRAWY MRCP Revision
endometrial cancer
100b
BADRAWY MRCP Revision
Bosentan - MoA, uses?
101a
BADRAWY MRCP Revision
endothelin-1 receptor
antagonist used if negative
response to acute
vasodilator testing in
pulmonary hypertension
101b
BAD...
Pemphigus vulgaris key
features?
102a
BADRAWY MRCP Revision
Epidermal, desmoglein 3,
involves mucosa, flaccid
non-pruritic blisters,
younger people
102b
BADRAWY MRCP Revision
Head injury followed by
lucid interval?
103a
BADRAWY MRCP Revision
Epidural haematoma
103b
BADRAWY MRCP Revision
Zollinger-Ellison syndrome
- CFs
104a
BADRAWY MRCP Revision
epigastric pain and
diarrhoea
104b
BADRAWY MRCP Revision
Key contraindication to
buproprion?
105a
BADRAWY MRCP Revision
epilepsy
105b
BADRAWY MRCP Revision
Ciclosporin side-effects
106a
BADRAWY MRCP Revision
everything is increased -
fluid, BP, K+, hair, gums,
glucose
106b
BADRAWY MRCP Revision
Activated protein C
resistance =
107a
BADRAWY MRCP Revision
Factor V Leiden, the most
common inherited
thrombophilia
107b
BADRAWY MRCP Revision
Diabetes diagnosis:
108a
BADRAWY MRCP Revision
fasting > 7.0, random > 11.1
- if asymptomatic need two
readings
HbA1c of 6.5% or greater is
now diagnostic (WHO 2011)
108...
investigation of choice for
upper airway compression
109a
BADRAWY MRCP Revision
Flow volume loop
109b
BADRAWY MRCP Revision
Common antibiotic causes
of cholestasis
110a
BADRAWY MRCP Revision
Flucloxacillin + co-
amoxiclav
110b
BADRAWY MRCP Revision
Ethylene glycol toxicity
management -
111a
BADRAWY MRCP Revision
fomepizole. Also ethanol /
haemodialysis
111b
BADRAWY MRCP Revision
Benzodiazepines enhance
the effect of which
neurotransmitter?
112a
BADRAWY MRCP Revision
GABA, the main inhibitory
neurotransmitter
112b
BADRAWY MRCP Revision
Signet ring cells =
113a
BADRAWY MRCP Revision
Gastric adenocarcinoma
113b
BADRAWY MRCP Revision
Screening for
haemochromatosis -
114a
BADRAWY MRCP Revision
general population:
transferrin saturation >
ferritin - family members:
HFE genetic testing
114b
BADRAWY MRCP Revision
SSRI + NSAID interaction?
115a
BADRAWY MRCP Revision
GI bleeding risk - give a
PPI
115b
BADRAWY MRCP Revision
Tricyclic overdose - rx
116a
BADRAWY MRCP Revision
give IV bicarbonate
116b
BADRAWY MRCP Revision
ITP - rx
117a
BADRAWY MRCP Revision
give oral prednisolone
117b
BADRAWY MRCP Revision
PHaeochromocytoma -
118a
BADRAWY MRCP Revision
give PHenoxybenzamine
before beta-blockers
118b
BADRAWY MRCP Revision
Exenatide MoA
119a
BADRAWY MRCP Revision
Glucagon-like peptide-1
(GLP-1) mimetic
119b
BADRAWY MRCP Revision
Philadelphia translocation
and prognosis?
120a
BADRAWY MRCP Revision
good prognosis in CML,
poor prognosis in AML +
ALL
120b
BADRAWY MRCP Revision
Absence seizures prognosis
121a
BADRAWY MRCP Revision
good: 90-95% become
seizure free in adolescence
121b
BADRAWY MRCP Revision
Bronchiectasis: most
common organism?
122a
BADRAWY MRCP Revision
Haemophilus influenzae
122b
BADRAWY MRCP Revision
Cyclophosphamide SE:
123a
BADRAWY MRCP Revision
haemorrhagic cystitis -
prevent with mesna
123b
BADRAWY MRCP Revision
Genital ulcers - painful:
124a
BADRAWY MRCP Revision
herpes >> chancroid
124b
BADRAWY MRCP Revision
CT head showing temporal
lobe changes - think what?
125a
BADRAWY MRCP Revision
herpes simplex
encephalitis,temporoparietal
attentuation -
subacute onset i.e. Several
days.
125b
BADRAWY MRCP Revision
most common cause of
sudden cardiac death in the
young
126a
BADRAWY MRCP Revision
HOCM
126b
BADRAWY MRCP Revision
U waves on ECG
127a
BADRAWY MRCP Revision
Hypokalaemia -
127b
BADRAWY MRCP Revision
Liddle's syndrome:
128a
BADRAWY MRCP Revision
hypokalaemia +
hypertension
128b
BADRAWY MRCP Revision
Hashimoto's thyroiditis key
features?
129a
BADRAWY MRCP Revision
hypothyroidism + goitre +
anti-TPO
129b
BADRAWY MRCP Revision
Asymmetrical symptoms in
PD suggest what cause?
130a
BADRAWY MRCP Revision
Idiopathic Parkinson's
130b
BADRAWY MRCP Revision
NSTEMI/unstable angina
Rx. 6 month mortality risk
>1.5% vs 6m risk >3%
131a
BADRAWY MRCP Revision
if > 1.5% clopidogrel for 12
months - if > 3%
angiography within 96
hours
131b
BADRAWY MRCP Revision
Primary biliary cirrhosis -
the M rule mnemonic?
132a
BADRAWY MRCP Revision
IgM - anti-Mitochondrial
antibodies, M2 subtype -
Middle aged females
132b
BADRAWY MRCP Revision
What is rheumatoid factor?
133a
BADRAWY MRCP Revision
IgM antibody against IgG
133b
BADRAWY MRCP Revision
CLL - investigation of
choice?
134a
BADRAWY MRCP Revision
immunophenotyping
134b
BADRAWY MRCP Revision
Nicotinic acid MoA
135a
BADRAWY MRCP Revision
increases HDL levels
135b
BADRAWY MRCP Revision
Essential tremor:
inheritance, aggravants /
relievants
136a
BADRAWY MRCP Revision
Inheritance: AD
Aggravants: Arms
outstretched
Relievants: Alcohol,
propanolol
136b
BADRAWY MRCP Revision
Ciclosporin + tacrolimus -
MOA:
137a
BADRAWY MRCP Revision
inhibit calcineurin thus
decreasing IL-2
137b
BADRAWY MRCP Revision
Statins - MoA?
138a
BADRAWY MRCP Revision
inhibit HMG-CoA
reductase, the rate-limiting
enzyme in hepatic
cholesterol synthesis
138b
BADRAWY MRCP Revision
Bisphosphonates MoA
139a
BADRAWY MRCP Revision
inhibit osteoclasts,prevent
steroid incduced
osteoperosis
(vitamin D also).
139b
BADRAWY MRCP Revision
Clopidogrel MoA:
140a
BADRAWY MRCP Revision
inhibits ADP binding to
platelet receptors
140b
BADRAWY MRCP Revision
Dipyridamole - MoA
141a
BADRAWY MRCP Revision
inhibits phosphodiesterase
141b
BADRAWY MRCP Revision
Digoxin - MoA
142a
BADRAWY MRCP Revision
inhibits the Na+/K+
ATPase pump
142b
BADRAWY MRCP Revision
Isoniazid SEs:
143a
BADRAWY MRCP Revision
inhibits the P450 system,
causes peripheral
neuropathy
143b
BADRAWY MRCP Revision
Allopurinol MoA
144a
BADRAWY MRCP Revision
inhibits xanthine oxidase
144b
BADRAWY MRCP Revision
Symptom control in non-
CF bronchiectasis?
145a
BADRAWY MRCP Revision
inspiratory muscle training
+ postural drainage
145b
BADRAWY MRCP Revision
Complete heart block
following an ANterior MI -
?pacing
146a
BADRAWY MRCP Revision
is AN indication for pacing,
unlike with an inferior MI
146b
BADRAWY MRCP Revision
Streptococcus pneumoniae
147a
BADRAWY MRCP Revision
is associated with cold
sores
147b
BADRAWY MRCP Revision
Streptococcus bovis
endocarditis
148a
BADRAWY MRCP Revision
is associated with
colorectal cancer
148b
BADRAWY MRCP Revision
Legionella pneumophilia
149a
BADRAWY MRCP Revision
is best diagnosed by the
urinary antigen test
149b
BADRAWY MRCP Revision
Complete heart block
following an INferior MI - ?
pacing
150a
BADRAWY MRCP Revision
Is Not an indication for
pacing, unlike with an
anterior MI
150b
BADRAWY MRCP Revision
Most common cause of
occupational asthma?
151a
BADRAWY MRCP Revision
Isocyanates
151b
BADRAWY MRCP Revision
Lichen sclerosus:
152a
BADRAWY MRCP Revision
itchy white spots typically
seen on the vulva of elderly
women
152b
BADRAWY MRCP Revision
Polycythaemia rubra vera -
genetic cause?
153a
BADRAWY MRCP Revision
JAK2 mutation
153b
BADRAWY MRCP Revision
Hypertension - step 4 rx?
154a
BADRAWY MRCP Revision
K+ < 4.5 then
spironolactone - K+ > 4.5
then higher-dose thiazide-
like diuretic
154b
BADRAWY MRCP Revision
Pneumonia in an alcoholic
- pathogen?
155a
BADRAWY MRCP Revision
Klebsiella
155b
BADRAWY MRCP Revision
BTS COPD: breathless
despite PRN inhalers, and
FEV1 < 50%
156a
BADRAWY MRCP Revision
LABA + ICS or LAMA
156b
BADRAWY MRCP Revision
BTS COPD: breathless
despite PRN inhalers, and
FEV1 > 50%:
157a
BADRAWY MRCP Revision
LABA or LAMA
157b
BADRAWY MRCP Revision
Polymorphic eruption of
pregnancy - CFs?
158a
BADRAWY MRCP Revision
Last trimester, may see
vesicles, but no blistering
158b
BADRAWY MRCP Revision
Cerebellar signs,
contralateral sensory loss &
ipsilateral Horner's =
159a
BADRAWY MRCP Revision
Lateral medullary
syndrome - PICA lesion -
159b
BADRAWY MRCP Revision
Mucocutaneous ulceration
following travel - key
differential?
160a
BADRAWY MRCP Revision
Leishmania brasiliensis
160b
BADRAWY MRCP Revision
Most common presenting
symptom in myelofibrosis?
161a
BADRAWY MRCP Revision
lethargy
161b
BADRAWY MRCP Revision
Safest TCA in overdosage?
162a
BADRAWY MRCP Revision
Lofepramine
162b
BADRAWY MRCP Revision
Second heart sound (S2) -
loud, soft, fixed split,
reversed split?
163a
BADRAWY MRCP Revision
loud: hypertension - soft:
AS - fixed split: ASD -
reversed split: LBBB
163b
BADRAWY MRCP Revision
ESR in polycythaemia
rubra vera
164a
BADRAWY MRCP Revision
low
164b
BADRAWY MRCP Revision
Oxygen dissociation curve -
shifts Left?
165a
BADRAWY MRCP Revision
Lower oxygen delivery -
Lower acidity, temp, 2-3
DPG - also HbF,
carboxy/methaemoglobin -
165b
BADRAWY MRCP Revision
Most common lung cancer
type in non-smokers?
166a
BADRAWY MRCP Revision
Lung adenocarcinoma -
peripheral lesion
166b
BADRAWY MRCP Revision
Gallop rhythm (S3) is an
early sign of?
167a
BADRAWY MRCP Revision
LVF
167b
BADRAWY MRCP Revision
Hodgkin's lymphoma - best
prognosis =
168a
BADRAWY MRCP Revision
lymphocyte predominant
168b
BADRAWY MRCP Revision
Patients with Sjogren's
syndrome have an
increased risk of which
malignancy?
169a
BADRAWY MRCP Revision
lymphoid malignancies
169b
BADRAWY MRCP Revision
Rx for Mycoplasma
pneumonia
170a
BADRAWY MRCP Revision
Macrolides. If allergic
=doxycycline
170b
BADRAWY MRCP Revision
Eclampsia - first-line
treatment
171a
BADRAWY MRCP Revision
magnesium sulphate
171b
BADRAWY MRCP Revision
Sarcoidosis prognosis?
172a
BADRAWY MRCP Revision
Majority of patients get
better without treatment
172b
BADRAWY MRCP Revision
PTH level in primary
hyperparathyroidism
173a
BADRAWY MRCP Revision
may be normal
173b
BADRAWY MRCP Revision
TNF-#alpha# inhibitors
174a
BADRAWY MRCP Revision
may reactivate TB
174b
BADRAWY MRCP Revision
Choosing prosthetic heart
valves
175a
BADRAWY MRCP Revision
mechanical valves last
longer and tend to be given
to younger patients
175b
BADRAWY MRCP Revision
Prolactinoma management
-medical or surgical?
176a
BADRAWY MRCP Revision
medical therapy is almost
always first-line
176b
BADRAWY MRCP Revision
Autosomal recessive
conditions tend to be ??
with what exceptions?
177a
BADRAWY MRCP Revision
Metabolic. Exception =
inherited ataxias
177b
BADRAWY MRCP Revision
Acne rosacea treatment: -
178a
BADRAWY MRCP Revision
mild/moderate: topical
metronidazole -
severe/resistant: oral
tetracycline
178b
BADRAWY MRCP Revision
Kearns-Sayre syndrome -
179a
BADRAWY MRCP Revision
mitochondrial inheritance -
onset < 20-years-old -
external ophthalmoplegia -
retinitis pigmentosa
179b
BADRAWY MRCP Revis...
Common topical steroids
and their potency?
180a
BADRAWY MRCP Revision
moderate: Clobetasone
butyrate 0.05% - potent:
Betamethasone valerate 0.1%
- very potent: Clobetasol
propionate 0.05%
180b...
Magnesium sulphate -
monitoring
181a
BADRAWY MRCP Revision
monitor reflexes +
respiratory rate
181b
BADRAWY MRCP Revision
Cetuximab - MoA?
182a
BADRAWY MRCP Revision
monoclonal antibody
against the epidermal
growth factor receptor
182b
BADRAWY MRCP Revision
Trastuzumab (Herceptin) -
183a
BADRAWY MRCP Revision
monoclonal antibody that
acts on the HER2/neu
receptor
183b
BADRAWY MRCP Revision
Anorexia features -
184a
BADRAWY MRCP Revision
most things low - G's and
C's raised: growth
hormone, glucose, salivary
glands, cortisol,
cholesterol, carotinaemia
184b
B...
Rises first following MI?
185a
BADRAWY MRCP Revision
Myoglobin
185b
BADRAWY MRCP Revision
Hypercholesterolaemia
rather than
hypertriglyceridaemia:
186a
BADRAWY MRCP Revision
nephrotic syndrome,
cholestasis,
hypothyroidism
186b
BADRAWY MRCP Revision
Signs suggesting TTP
rather than HUS?
187a
BADRAWY MRCP Revision
Neuro signs and purpura
point towards TTP
187b
BADRAWY MRCP Revision
Motor neuron disease -
treatment:
188a
BADRAWY MRCP Revision
NIV is better than riluzole
188b
BADRAWY MRCP Revision
AF treatment: young man,
no TIA or risk factors,
189a
BADRAWY MRCP Revision
no treatment is now
preferred to aspirin
189b
BADRAWY MRCP Revision
Hodgkin's lymphoma -
most common type =
190a
BADRAWY MRCP Revision
nodular sclerosing
190b
BADRAWY MRCP Revision
Renal tubular acidosis -
anion gap?
191a
BADRAWY MRCP Revision
normal anion gap
191b
BADRAWY MRCP Revision
Urinary incontinence + gait
abnormality + dementia.
Diagnosis?
192a
BADRAWY MRCP Revision
normal pressure
hydrocephalus
192b
BADRAWY MRCP Revision
Rx metastatic bone pain
193a
BADRAWY MRCP Revision
NSAIDs, bisphosphonates
or radiotherapy
193b
BADRAWY MRCP Revision
Acromegaly diagnosis?
194a
BADRAWY MRCP Revision
oral glucose tolerance with
growth hormone
measurements
194b
BADRAWY MRCP Revision
Cushing's syndrome - best
test to diagnose?
195a
BADRAWY MRCP Revision
overnight dexamethasone
suppression test
195b
BADRAWY MRCP Revision
Drug metabolism - phase I
components?
196a
BADRAWY MRCP Revision
oxidation, reduction,
hydrolysis
196b
BADRAWY MRCP Revision
Antiphospholipid
syndrome: APPT, PLTs
197a
BADRAWY MRCP Revision
Paradoxically prolonged
APTT + low platelets
197b
BADRAWY MRCP Revision
Progressive supranuclear
palsy CFs?
198a
BADRAWY MRCP Revision
Absent voluntary downward
gaze, normal dolls eye . i.e.
Occulomotor nuclei intact,
supranuclear Pathology.
parkinsonism
19...
SSRI with high incidence of
discontinuation symptoms?
199a
BADRAWY MRCP Revision
Paroxetine
199b
BADRAWY MRCP Revision
Collapsing pulse - which
congenital heart defect?
200a
BADRAWY MRCP Revision
Patent ductus arteriosus -
200b
BADRAWY MRCP Revision
Vincristine - important SE?
201a
BADRAWY MRCP Revision
peripheral neuropathy
201b
BADRAWY MRCP Revision
Drugs with zero-order
(saturation) kinetics -
202a
BADRAWY MRCP Revision
phenytoin - alcohol
202b
BADRAWY MRCP Revision
Causes of gingival
hyperplasia?
203a
BADRAWY MRCP Revision
phenytoin, ciclosporin,
calcium channel blockers
and AML
203b
BADRAWY MRCP Revision
TTP first-line Rx?
204a
BADRAWY MRCP Revision
Plasma exchange
204b
BADRAWY MRCP Revision
Painful third nerve palsy -
key differential?
205a
BADRAWY MRCP Revision
posterior communicating
artery aneurysm
205b
BADRAWY MRCP Revision
Horner's syndrome -
anhydrosis absent =
206a
BADRAWY MRCP Revision
post-ganglionic lesion:
carotid artery
206b
BADRAWY MRCP Revision
Rx Minimal change
glomerulonephritis?
207a
BADRAWY MRCP Revision
prednisolone
207b
BADRAWY MRCP Revision
Horner's syndrome -
anhydrosis of just face =
208a
BADRAWY MRCP Revision
pre-ganglionic lesion:
Pancoast's, cervical rib
208b
BADRAWY MRCP Revision
Causes of raised prolactin?
209a
BADRAWY MRCP Revision
pregnancy - prolactinoma -
physiological - polycystic ovarian
syndrome - primary
hypothyroidism -
phenothiazines,
metoclop...
Taxanes (e.g. Docetaxel)
MoA?
210a
BADRAWY MRCP Revision
prevent microtubule
disassembly
210b
BADRAWY MRCP Revision
Infective endocarditis -
strongest risk factor
211a
BADRAWY MRCP Revision
previous episode of
infective endocarditis
211b
BADRAWY MRCP Revision
Ptosis + dilated pupil vs
Ptosis + constricted pupil
212a
BADRAWY MRCP Revision
Ptosis + dilated pupil = 3rd
nerve palsy; Ptosis +
constricted pupil =
Horner's
212b
BADRAWY MRCP Revision
Lichen - planus:
213a
BADRAWY MRCP Revision
purple, pruritic, papular,
polygonal rash on flexor
surfaces. Wickham's striae
over surface. Oral
involvement common
213b
...
Oxygen dissociation curve -
shifts Right?
214a
BADRAWY MRCP Revision
Raised oxygen delivery -
Raised acidity, temp, 2-3
DPG
214b
BADRAWY MRCP Revision
HbA1C - when to recheck
after change in therapy?
215a
BADRAWY MRCP Revision
recheck after 2-3 months
215b
BADRAWY MRCP Revision
Inferior MI -
216a
BADRAWY MRCP Revision
right coronary artery lesion
216b
BADRAWY MRCP Revision
Farmers lung pathogen
217a
BADRAWY MRCP Revision
Saccharopolyspora
rectivirgula
217b
BADRAWY MRCP Revision
Erythema nodosum is
associated with a good
prognosis in what systemic
condition?
218a
BADRAWY MRCP Revision
sarcoidosis
218b
BADRAWY MRCP Revision
Combined B- and T-cell
disorders
219a
BADRAWY MRCP Revision
SCID WAS ataxic (SCID,
Wiskott-Aldrich syndrome,
ataxic telangiectasia)
219b
BADRAWY MRCP Revision
Pulsus alternans?
220a
BADRAWY MRCP Revision
seen in left ventricular
failure
220b
BADRAWY MRCP Revision
HOCM - poor prognostic
factor on echo =
221a
BADRAWY MRCP Revision
septal wall thickness of >
3cm
221b
BADRAWY MRCP Revision
Detecting occupational
asthma?
222a
BADRAWY MRCP Revision
Serial peak flow
measurements at work and
at home
222b
BADRAWY MRCP Revision
Mycoplasma diagnosis
223a
BADRAWY MRCP Revision
Serology
223b
BADRAWY MRCP Revision
Dx Addison's disease
224a
BADRAWY MRCP Revision
short synacthen test
224b
BADRAWY MRCP Revision
Epilepsy medication: first-
line - generalised seizure:
225a
BADRAWY MRCP Revision
sodium valproate -
225b
BADRAWY MRCP Revision
Syringomyelia - CFs?
226a
BADRAWY MRCP Revision
spinothalamic sensory loss
(pain and temperature)
226b
BADRAWY MRCP Revision
Asthma diagnosis - first
line investigation in
intermediate probability?
227a
BADRAWY MRCP Revision
Spirometry
227b
BADRAWY MRCP Revision
Paraneoplastic features of
lung cancer - squamous cell
vs small cell?
228a
BADRAWY MRCP Revision
squamous cell: PTHrp,
clubbing, HPOA - small
cell: ADH, ACTH, Lambert-
Eaton syndrome
228b
BADRAWY MRCP Revision
Pneumonia following
influenza - pathogen?
229a
BADRAWY MRCP Revision
Staphylococcus aureus
pneumonia
229b
BADRAWY MRCP Revision
Most common cause of
endocarditis if < 2 months
post valve surgery
230a
BADRAWY MRCP Revision
Staphylococcus
epidermidis
230b
BADRAWY MRCP Revision
Asthma diagnosis - first
line investigation in high
probability?
231a
BADRAWY MRCP Revision
Start treatment
231b
BADRAWY MRCP Revision
Infective endocarditis -
good prognosis
232a
BADRAWY MRCP Revision
streptococcal infection
232b
BADRAWY MRCP Revision
Most common cause of
endocarditis
233a
BADRAWY MRCP Revision
Streptococcus viridans
233b
BADRAWY MRCP Revision
Antipsychotics in the
elderly -> risk of?
234a
BADRAWY MRCP Revision
stroke and VTE
234b
BADRAWY MRCP Revision
Autosomal dominant
conditions tend to be ?? -
with what exceptions?
235a
BADRAWY MRCP Revision
Structural. Exceptions =
hyperlipidaemia type II,
hypokalaemic periodic
paralysis
235b
BADRAWY MRCP Revision
Cluster headache - acute
treatment
236a
BADRAWY MRCP Revision
subcutaneous sumatriptan
+ 100% O2
236b
BADRAWY MRCP Revision
Bullous pemphigoid key
features?
237a
BADRAWY MRCP Revision
Subepidermal,
hemidesmosomal BP
antigens, rarely involves
mucosa, tense pruritic
blisters, older people
237b
BADRAWY MRCP ...
Diagnosing insulinoma?
238a
BADRAWY MRCP Revision
supervised prolonged
fasting
238b
BADRAWY MRCP Revision
Cryptosporidium diarrhoea
Rx
239a
BADRAWY MRCP Revision
Supportive therapy
239b
BADRAWY MRCP Revision
Contraindications to lung
cancer surgery
240a
BADRAWY MRCP Revision
SVC obstruction, FEV < 1.5,
MALIGNANT pleural
effusion, and vocal cord
paralysis
240b
BADRAWY MRCP Revision
Reason for ^sweating in
acromegaly
241a
BADRAWY MRCP Revision
sweat gland hypertrophy
241b
BADRAWY MRCP Revision
Alcohol withdrawal time to
symptoms/signs
242a
BADRAWY MRCP Revision
symptoms: 6-12 hours -
seizures: 36 hours -
delirium tremens: 72 hours
242b
BADRAWY MRCP Revision
Genital ulcers - painless:
243a
BADRAWY MRCP Revision
syphilis >
lymphogranuloma
venereum + granuloma
inguinale
243b
BADRAWY MRCP Revision
Philadelphia translocation?
244a
BADRAWY MRCP Revision
t(9;22)
244b
BADRAWY MRCP Revision
Congenital heart disease -
cyanotic - most common
cause:
245a
BADRAWY MRCP Revision
TGA most common at
birth, Fallot's most
common overall -
245b
BADRAWY MRCP Revision
Melanoma: single most
important prognostic factor
246a
BADRAWY MRCP Revision
the invasion depth of the
tumour
246b
BADRAWY MRCP Revision
Diuretic cause of
hypercalcaemia?
247a
BADRAWY MRCP Revision
Thiazides
247b
BADRAWY MRCP Revision
Disproportionate
microcytic anaemia -
think?
248a
BADRAWY MRCP Revision
think beta-thalassaemia
trait
248b
BADRAWY MRCP Revision
Hashimoto's thyroiditis is
associated with which
malignancy?
249a
BADRAWY MRCP Revision
thyroid lymphoma
249b
BADRAWY MRCP Revision
Impetigo - rx
250a
BADRAWY MRCP Revision
topical fusidic acid --> oral
flucloxacillin / topical
retapamulin
250b
BADRAWY MRCP Revision
Chlamydia - treatment
251a
BADRAWY MRCP Revision
treat with azithromycin or
doxycycline
251b
BADRAWY MRCP Revision
JVP: giant v waves
252a
BADRAWY MRCP Revision
tricuspid regurgitation
252b
BADRAWY MRCP Revision
Associations in
mesangiocapillary /
membranoproliferative
GN. Type 1 vs Type 2
253a
BADRAWY MRCP Revision
type 1: cryoglobulinaemia,
hepatitis C - type 2: partial
lipodystrophy
253b
BADRAWY MRCP Revision
Aortic dissection - Type A
254a
BADRAWY MRCP Revision
type A - ascending aorta -
control BP(IV labetalol) +
surgery
254b
BADRAWY MRCP Revision
Aortic dissection - Type B
255a
BADRAWY MRCP Revision
type B - descending aorta -
control BP(IV labetalol), no
surgery
255b
BADRAWY MRCP Revision
Diagnosing systemic
mastocytosis?
256a
BADRAWY MRCP Revision
Urinary histamine
256b
BADRAWY MRCP Revision
Vigabatrin - important SE?
257a
BADRAWY MRCP Revision
V for Vigabatrin - V for
Visual field defects
257b
BADRAWY MRCP Revision
Ventricular tachycardia -
which antiarrhythmic is
contraindicated?
258a
BADRAWY MRCP Revision
verapamil
258b
BADRAWY MRCP Revision
macrophages containing
Periodic acid-Schiff (PAS)
granules
259a
BADRAWY MRCP Revision
Whipple's disease jejunal
biopsy
259b
BADRAWY MRCP Revision
PCI - biggest RF for stent
thrombosis?
260a
BADRAWY MRCP Revision
withdrawal of antiplatelets
260b
BADRAWY MRCP Revision
Alport's syndrome
inheritance
261a
BADRAWY MRCP Revision
X-linked dominant (in the
majority)
261b
BADRAWY MRCP Revision
Keloid scars - more
common in who and what
body part?
262a
BADRAWY MRCP Revision
young, black, male adults
on the sternum
262b
BADRAWY MRCP Revision
Ankylosing spondylitis: CFs
263a
BADRAWY MRCP Revision
Features - the 'A's
• Apical fibrosis (CXR)
• Anterior uveitis
• Aortic regurgitation
• Achilles tendonitis
• AV node bloc...
Septic arthritis - most
common organism?
264a
BADRAWY MRCP Revision
Staphylococcus aureus
264b
BADRAWY MRCP Revision
Low levels of which type of
complement are associated
with SLE?
265a
BADRAWY MRCP Revision
C3, C4a and C4b
265b
BADRAWY MRCP Revision
What should you check
before starting
azathioprine?
266a
BADRAWY MRCP Revision
Check thiopurine
methyltransferase
deficiency (TPMT) before
treatment
266b
BADRAWY MRCP Revision
When to start allopurinol
in gout?
267a
BADRAWY MRCP Revision
>= 2 attacks in 12 month
period.
267b
BADRAWY MRCP Revision
Which cytokine is most
important in
pathophysiology of
rheumatoid arthritis?
268a
BADRAWY MRCP Revision
TNF
268b
BADRAWY MRCP Revision
Nitric oxide - key effects
269a
BADRAWY MRCP Revision
Vasodilation - mainly
venodilation
Inhibits platelet
aggregation
269b
BADRAWY MRCP Revision
Superiority vs equivalence
vs non-inferiority. What
sample sizes?
270a
BADRAWY MRCP Revision
Superiority trial --> large
sample size needed.
270b
BADRAWY MRCP Revision
Clotting factors affected by
warfarin?
271a
BADRAWY MRCP Revision
Mnemonic = 1972 (Simon)
- 10, 9, 7 and 2.
271b
BADRAWY MRCP Revision
Adrenal cortex - what part
releases what?
272a
BADRAWY MRCP Revision
Mnemonic GFR - ACD
1) Glomerulosa (outer):
Aldosterone
2) Fasciculata (middle): Cortisol
3) Reticularis (on inside): DHEA
...
Obese T2DM with
abnormal LFTs - think of
what disease?
273a
BADRAWY MRCP Revision
non-alcoholic fatty liver
disease
273b
BADRAWY MRCP Revision
EBV-associated
malignancies
274a
BADRAWY MRCP Revision
Burkitt's lymphoma
Hodgkin's lymphoma
nasopharyngeal carcinoma
HIV-associated central nervous
system lymphomas
Hairy leuko...
Associations between
hypermetropia/myopia and
glaucoma?
275a
BADRAWY MRCP Revision
Acute angle closure glaucoma
is associated with
hypermetropia, where as
primary open-angle glaucoma
is associated with myo...
Antiphospholipid
syndrome: key triad of
features
276a
BADRAWY MRCP Revision
arterial/venous
thrombosis, miscarriage,
livedo reticularis
276b
BADRAWY MRCP Revision
Types of cells seen in CLL?
277a
BADRAWY MRCP Revision
CLL is caused by a
monoclonal proliferation of
B-cell lymphocytes
277b
BADRAWY MRCP Revision
Atrial natriuretic peptide -
effect on vessels?
278a
BADRAWY MRCP Revision
Atrial natriuretic peptide -
powerful vasodilator
278b
BADRAWY MRCP Revision
Most common cause of
primary
hyperaldosteronism
279a
BADRAWY MRCP Revision
Bilateral idiopathic adrenal
hyperplasia is the most
common cause of primary
hyperaldosteronism
279b
BADRAWY MRCP Revision
Obesity - NICE bariatric
referral cut offs
280a
BADRAWY MRCP Revision
NICE bariatric referral cut-
offs
with risk factors (T2DM, BP
etc): > 35 kg/m^2
no risk factors: > 40 kg/m^2
280b
BADRAWY ...
CT most commonly
associated with PBC
281a
BADRAWY MRCP Revision
Sjogren's syndrome
281b
BADRAWY MRCP Revision
How names of ART drugs
relate to function
282a
BADRAWY MRCP Revision
HIV drugs, rule of thumb:
NRTIs end in 'ine'
Pis: end in 'vir'
NNRTIs: nevirapine,
efavirenz
282b
BADRAWY MRCP Revision
Interpreting the ACR
results
283a
BADRAWY MRCP Revision
in non-diabetics an ACR greater than 30
mg/mmol is considered clinically
significant proteinuria
in diabetics microalbumin...
Which antiepileptic is safe
in breast feeding?
284a
BADRAWY MRCP Revision
Breast feeding is acceptable
with nearly all anti-
epileptic drugs
284b
BADRAWY MRCP Revision
ATN or prerenal uraemia?
285a
BADRAWY MRCP Revision
In prerenal uraemia think
of the kidneys holding on
to sodium to preserve
volume
285b
BADRAWY MRCP Revision
Renal stones on x-ray
286a
BADRAWY MRCP Revision
cystine stones: semi-
opaque
urate + xanthine stones:
radio-lucent
286b
BADRAWY MRCP Revision
Isoretinoin adverse effects?
287a
BADRAWY MRCP Revision
teratogenicity - females MUST be
taking contraception
low mood
dry eyes and lips
raised triglycerides
hair thinning
nose b...
An important and common
interaction with statins?
288a
BADRAWY MRCP Revision
Statins +
erythromycin/clarithromycin
- an important and common
interaction
288b
BADRAWY MRCP Revision
Low CSF glucose but viral
aetiology in meningitis?
289a
BADRAWY MRCP Revision
Mumps meningitis is
associated with a low
glucose in up to a third of
patients
289b
BADRAWY MRCP Revision
Type of bladder cancer
association with
schistosomiasis
290a
BADRAWY MRCP Revision
SchistoSomiaSiS is a risk
factor for SquamouS cell
bladder cancer
290b
BADRAWY MRCP Revision
%tage of people with Hep C
developing cirrhosis?
291a
BADRAWY MRCP Revision
Liver cirrhosis will develop
in around 20-30% of
patients over 20-30 years
291b
BADRAWY MRCP Revision
Rash on buttocks
292a
BADRAWY MRCP Revision
Dermatitis herpetiformis
(coeliac dx).
292b
BADRAWY MRCP Revision
Obese woman,
papilledema/headache
293a
BADRAWY MRCP Revision
Benign Intercanial
Hypertention.
293b
BADRAWY MRCP Revision
Drug induced pneumonitis
294a
BADRAWY MRCP Revision
methotrexate or
amiodarone.
294b
BADRAWY MRCP Revision
foreign travel, macpap
rash/flu like illnes
295a
BADRAWY MRCP Revision
HIV acute.
295b
BADRAWY MRCP Revision
Splenectomy
296a
BADRAWY MRCP Revision
need pneumococcal vaccine
AT LEAST 2 weeks pre-op
and for life.
296b
BADRAWY MRCP Revision
Primary
hrperparathyroidism
297a
BADRAWY MRCP Revision
high Ca, normal/low PO4,
normal/high PTH (in
elderly).
297b
BADRAWY MRCP Revision
Middle aged man with
KNEE arthritis
298a
BADRAWY MRCP Revision
gonococcal sepsis (older
people ➜​ Staph).
298b
BADRAWY MRCP Revision
Sarcoidosis, erythema
nodosum, arthropathy
299a
BADRAWY MRCP Revision
Loffgrens syndrome
benign, no Rx needed or
NSAIDs
299b
BADRAWY MRCP Revision
TREMOR postural, slow
progression,titubation,
300a
BADRAWY MRCP Revision
benign essential TREMOR
AutDom.
300b
BADRAWY MRCP Revision
Contraindications lung
Surgery
301a
BADRAWY MRCP Revision
FEV dec bp 130/90, Ace
inhibitors (if proteinuria
analgesic induced
headache.
301b
BADRAWY MRCP Revision
1.5 cm difference btwn
kidneys
302a
BADRAWY MRCP Revision
Renal artery stenosis ➜​
Magnetic resonance
angiogram.
302b
BADRAWY MRCP Revision
Temporal tenderness
303a
BADRAWY MRCP Revision
temporal arteritis ➜ ​
steroids > 90% ischemic
neuropathy, 10%
retinal art occlusion.
303b
BADRAWY MRCP Revision
cluster headache.
304a
BADRAWY MRCP Revision
Severe retroorbital, daily
headache, lacrimation
304b
BADRAWY MRCP Revision
Diagnosis of polyuria
305a
BADRAWY MRCP Revision
water deprivation test, then
DDAVP
305b
BADRAWY MRCP Revision
Causes of villous atrophy
306a
BADRAWY MRCP Revision
coeliac (lymphocytic
infiltrate), Whipples , dec Ig,
lymphoma, trop sprue (Rx
tetracycline).
306b
BADRAWY MRCP Revision
Hepatitis B with general
deterioration
307a
BADRAWY MRCP Revision
hepaocellular carcinoma
307b
BADRAWY MRCP Revision
Albumin normal, total
protein high
308a
BADRAWY MRCP Revision
myeloma (hypercalcemia,
electrophoresis).
308b
BADRAWY MRCP Revision
HBsAg positive, HB DNA
not detectable
309a
BADRAWY MRCP Revision
chornic carirer
309b
BADRAWY MRCP Revision
Aortic Stenosis
310a
BADRAWY MRCP Revision
s2 paradoxical split, length
proportional to severity
310b
BADRAWY MRCP Revision
Loud S1
311a
BADRAWY MRCP Revision
MS, hyperdynamic, short
PR
311b
BADRAWY MRCP Revision
Soft S1
312a
BADRAWY MRCP Revision
immobile MS, MR.
312b
BADRAWY MRCP Revision
Loud S2
313a
BADRAWY MRCP Revision
hypertension, AS
313b
BADRAWY MRCP Revision
Fixed split
314a
BADRAWY MRCP Revision
ASD
314b
BADRAWY MRCP Revision
Opening snap
315a
BADRAWY MRCP Revision
MOBILE MS, severe near
S2
315b
BADRAWY MRCP Revision
HOCM/MVP
316a
BADRAWY MRCP Revision
inc by standing,valsalva,
dec by squating (# all
others)
316b
BADRAWY MRCP Revision
HOCM
317a
BADRAWY MRCP Revision
Sudden death athlete, FH,
Rx. Amiodarone, ICD
317b
BADRAWY MRCP Revision
Guillan Barre syndrome
318a
BADRAWY MRCP Revision
check VITAL CAPACITY.
318b
BADRAWY MRCP Revision
Horners
319a
BADRAWY MRCP Revision
sweating lost in upper face
only - lesion proximal to
common carotid artery.
319b
BADRAWY MRCP Revision
Internuclear
opthalmoplegia
320a
BADRAWY MRCP Revision
medial longitudinal
fasciculus connects CN
nucleus 3-4.
320b
BADRAWY MRCP Revision
Perinauds syndrome
321a
BADRAWY MRCP Revision
dorsal midbrain syndrome,
damaged midrain and superior
colliculus: impaired upgaze (cf
PSNP), lid retraction, convergence
...
Acute red eye
322a
BADRAWY MRCP Revision
acute closed angle
glaucoma >> less common
(ant uveitis, scleritis,
episcleritis, subconjuntival
hemmorrhage).
322b
BADRAW...
Sweats and weight gain
323a
BADRAWY MRCP Revision
insulinoma.
323b
BADRAWY MRCP Revision
Diagnostic test for asthma
324a
BADRAWY MRCP Revision
morning dip in PEFR
>20%.
324b
BADRAWY MRCP Revision
Causes of SIADH
325a
BADRAWY MRCP Revision
chest/cerebral/pancreas Pathology
, porphyria, malignancy, Drugs
(carbamazepine, chlorpropamide,
clofibrate, atipsychotics...
Causes of central DI
326a
BADRAWY MRCP Revision
tumor, infiltration, trauma
326b
BADRAWY MRCP Revision
Causes of Nephrogenic DI
327a
BADRAWY MRCP Revision
Lithium, amphoteracin,
domeclocycline, prologed
hypercalcemia/hypornatremia,
FAMILIAL X linked type
327b
BADRAWY MRCP Revi...
Returned from airline
flight, TIA
328a
BADRAWY MRCP Revision
paradoxical embolus do
TEE.
328b
BADRAWY MRCP Revision
Alcoholic, given glucose
develops nystagmus
329a
BADRAWY MRCP Revision
B1 deficiency (wernickes).
329b
BADRAWY MRCP Revision
Mono-artropathy with
thiazide
330a
BADRAWY MRCP Revision
gout (neg birefringence).
NO ALLOPURINOL for
acute.
330b
BADRAWY MRCP Revision
MC Cause of gout
331a
BADRAWY MRCP Revision
dec urinary excretion
331b
BADRAWY MRCP Revision
Painful 3rd nerve palsy
332a
BADRAWY MRCP Revision
posterior communicating
artery aneurysm till proven
otherwise
332b
BADRAWY MRCP Revision
Late complication of
scleroderma
333a
BADRAWY MRCP Revision
pulmonary hypertention ±
fibrosis
333b
BADRAWY MRCP Revision
Mouth/genital ulcers and
oligarthritis
334a
BADRAWY MRCP Revision
behcets (also eye /SKIN
lesions, DVT)
334b
BADRAWY MRCP Revision
Cavernous sinus syndrome
335a
BADRAWY MRCP Revision
3rd nerve palsy, proptosis,
periorbital swelling, conj
injection
335b
BADRAWY MRCP Revision
Asymetric parkinsons
336a
BADRAWY MRCP Revision
likely to be idiopathic
336b
BADRAWY MRCP Revision
Obese, NIDDM ​♀ with
abnormal LFT's
337a
BADRAWY MRCP Revision
NASH
337b
BADRAWY MRCP Revision
Ipsilateral ataxia, Horners,
contralateral loss
pain/temp
338a
BADRAWY MRCP Revision
PICA stroke (lateral
medulary syndrome of
Wallenburg)
338b
BADRAWY MRCP Revision
Distal, asymetric
arthropathy
339a
BADRAWY MRCP Revision
PSORIASIS
339b
BADRAWY MRCP Revision
Episodic headache with
tachycardia
340a
BADRAWY MRCP Revision
Pheochromocytoma
340b
BADRAWY MRCP Revision
Very raised WCC
341a
BADRAWY MRCP Revision
ALWAYS think of
leukemia.
341b
BADRAWY MRCP Revision
Diagnosis of CLL
342a
BADRAWY MRCP Revision
immunophenotyping NOT
cytogenetics, NOT bone
marrow
342b
BADRAWY MRCP Revision
Prognostic factors for AML
343a
BADRAWY MRCP Revision
bm karyotype
(good/poor/standard) ​
343b
BADRAWY MRCP Revision
Pancytopenia with raised
MCV
344a
BADRAWY MRCP Revision
check B12/folate first
(other causes possible, but
do this FIRST). Often
associayed with phenytoin
use ➜ ↓​ ​ folate
344b
...
Anosmia, delayed puberty
345a
BADRAWY MRCP Revision
Kallmans syndrome
(hypogonadotrophic
hypogonadism)
345b
BADRAWY MRCP Revision
Commonest finding in
G6PD hamolysis
346a
BADRAWY MRCP Revision
haemoglobinuria
346b
BADRAWY MRCP Revision
Flank pain,
urinalysis:blood, protein
347a
BADRAWY MRCP Revision
renal vein thrombosis.
Causes: nephrotic
syndrome, RCC, amyloid,
acute pyelonephritis, SLE
,atiphospholipid syndrome
347b
...
Anemia in the elderly
assume
348a
BADRAWY MRCP Revision
GI malignancy
348b
BADRAWY MRCP Revision
Diptheria
349a
BADRAWY MRCP Revision
exudative pharyngitis,
lymphadenopathy, cardio
and neuro toxicity.
349b
BADRAWY MRCP Revision
Indurated plaques on
cheeks, scarring alopecia,
hyperkeratosis over hair
follicles
350a
BADRAWY MRCP Revision
Discoid LUPUS
350b
BADRAWY MRCP Revision
Wt loss, malabsoption, inc
ALP
351a
BADRAWY MRCP Revision
pancreatic cancer
351b
BADRAWY MRCP Revision
Wt loss, anemia
(macro/micro), no obvious
cause
352a
BADRAWY MRCP Revision
coeliac (diarrhea does NOT
have to be present)
352b
BADRAWY MRCP Revision
Hematuria, proteinuria,
best investigation
353a
BADRAWY MRCP Revision
if glomerulonephritis
suspected ​➜ renal biopsy
353b
BADRAWY MRCP Revision
Venous ulcer treatment
354a
BADRAWY MRCP Revision
exclude arteriopathy (eg
ABPI), control edema,
prevent infection,
compression bandaging.
354b
BADRAWY MRCP Revision
Fever, lymphadenopathy,
lymphocytosis, pharygitis
355a
BADRAWY MRCP Revision
EBV ➜ heterophile
antibodies
355b
BADRAWY MRCP Revision
GI bleed after endovascular
AAA Surgery
356a
BADRAWY MRCP Revision
aortoenteric fistula
356b
BADRAWY MRCP Revision
Functional
hypogonadotrophic
hypogonadism
357a
BADRAWY MRCP Revision
amennorhea. LH and FSH
both low.
All other hormones are
usually normal. Ferritin
low.
357b
BADRAWY MRCP Revision
Vitiligo - commonest
assoctions
358a
BADRAWY MRCP Revision
pernicious anemia ​ type 1
DM , autoimmune
addisons, autoimmune
thyoid
358b
BADRAWY MRCP Revision
Peripheral neuropathy
359a
BADRAWY MRCP Revision
a) B12 - rapid, dorsal columns (joint pos,
vibration), sensory
ataxia, pseudoathetosis of upperlimbs
b) diabetic - slow, s...
CNS abnormalities in HIV
360a
BADRAWY MRCP Revision
toxoplaasmosis (multiple ring
enhancing), lymphoma (solitary
lesion). HIV encephalopathy,
progressive multifocal
leucoence...
Travellers diarrohea
361a
BADRAWY MRCP Revision
chronic (>2 WEEKS) giardia
(incidious onset rx.
Metronidazole),
SALMONELLA (serious systemic
illness), E.coli (rx. Ciprofl...
If you see blood on
urinalysis forget about
362a
BADRAWY MRCP Revision
RAS
362b
BADRAWY MRCP Revision
Fasciculations
363a
BADRAWY MRCP Revision
Motor neurone diease
363b
BADRAWY MRCP Revision
Silvery white scale
364a
BADRAWY MRCP Revision
PSORIASIS
364b
BADRAWY MRCP Revision
Hypopigmented
365a
BADRAWY MRCP Revision
vitiligo/pityriasis versicolor
365b
BADRAWY MRCP Revision
Pretibial myxedema
366a
BADRAWY MRCP Revision
Graves
366b
BADRAWY MRCP Revision
R. Arthritis with nephritic
syndrome
367a
BADRAWY MRCP Revision
looks for amyloidosis, even
by rectal biopsy.
367b
BADRAWY MRCP Revision
Your valuable comments
are highly appreciated.
368a
BADRAWY MRCP Revision
Thank You
368b
BADRAWY MRCP Revision
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Last minute mrcp1 revision

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Last minute mrcp1 revision

  1. 1. BADRAWY MRCP Revision
  2. 2. ‫اﻟرﺣﯾم‬ ‫اﻟرﺣﻣن‬ ‫ﷲ‬ ‫ﺑﺳم‬ This is a collection of commonly tested facts for part 1 MRCP ...including the 100 commonly tested facts & > 200 more.... 1a BADRAWY MRCP Revision
  3. 3. a must read before part 1 ... U'll find at least 20-30 Questions in your MRCP 1 exam from these notes. ‫ﷲ‬ ‫ﺷﺎء‬ ‫إن‬ 1b BADRAWY MRCP Revision
  4. 4. Somatisation vs hypochondria 2a BADRAWY MRCP Revision
  5. 5. Somatisation = patient concerned about Symptoms. HypochonDria = patient concerned about underlying Disease eg Cancer. 2b BADRAWY MRCP Revision
  6. 6. DiGeorge syndrome = affects what type of cell? 3a BADRAWY MRCP Revision
  7. 7. - a T-cell disorder 3b BADRAWY MRCP Revision
  8. 8. Antithrombotic therapy in bioprosthetic vs mechanical heart valves 4a BADRAWY MRCP Revision
  9. 9. - bioprosthetic: aspirin - mechanical: warfarin + aspirin 4b BADRAWY MRCP Revision
  10. 10. Goodpasture's syndrome - histology? 5a BADRAWY MRCP Revision
  11. 11. - IgG deposits on renal biopsy - anti-GBM antibodies 5b BADRAWY MRCP Revision
  12. 12. Adrenaline induced ischaemia treatment 6a BADRAWY MRCP Revision
  13. 13. - phentolamine 6b BADRAWY MRCP Revision
  14. 14. Complete heart block following a MI? 7a BADRAWY MRCP Revision
  15. 15. - right coronary artery lesion 7b BADRAWY MRCP Revision
  16. 16. Wilson's disease: diagnosis 8a BADRAWY MRCP Revision
  17. 17. - serum caeruloplasmin is decreased 8b BADRAWY MRCP Revision
  18. 18. Fluctuating confusion/consciousness in elderly plus/minus deterioration ? 9a BADRAWY MRCP Revision
  19. 19. chronic subdural. Can last even longer than 6 months 9b BADRAWY MRCP Revision
  20. 20. Acute promyelocytic leukaemia translocation 10a BADRAWY MRCP Revision
  21. 21. - t(15;17) 10b BADRAWY MRCP Revision
  22. 22. Dermatophyte nail infections Rx 11a BADRAWY MRCP Revision
  23. 23. - use oral terbinafine 11b BADRAWY MRCP Revision
  24. 24. Actions of BNP 12a BADRAWY MRCP Revision
  25. 25. - vasodilator - diuretic and natriuretic - suppresses both sympathetic tone and the renin-angiotensin- aldosterone system 12b BADRAWY MRCP Revision
  26. 26. Burning thigh pain - ?nerve compression 13a BADRAWY MRCP Revision
  27. 27. ? meralgia paraesthetica - lateral cutaneous nerve of thigh compression 13b BADRAWY MRCP Revision
  28. 28. URTI symptoms + amoxicillin --> rash 14a BADRAWY MRCP Revision
  29. 29. ?glandular fever 14b BADRAWY MRCP Revision
  30. 30. IgM paraproteinaemia - 15a BADRAWY MRCP Revision
  31. 31. ?Waldenstrom's macroglobulinaemia 15b BADRAWY MRCP Revision
  32. 32. Absolute risk reduction = 16a BADRAWY MRCP Revision
  33. 33. = (Control event rate) - (Experimental event rate) 16b BADRAWY MRCP Revision
  34. 34. Terlipressin - MoA? 17a BADRAWY MRCP Revision
  35. 35. = constriction of the splanchnic vessels 17b BADRAWY MRCP Revision
  36. 36. Localising bitemporal hemianopia - upper quadrant defect > lower quadrant defect. 18a BADRAWY MRCP Revision
  37. 37. = inferior chiasmal compression, commonly a pituitary tumour 18b BADRAWY MRCP Revision
  38. 38. Tear-drop poikilocytes ? 19a BADRAWY MRCP Revision
  39. 39. = myelofibrosis 19b BADRAWY MRCP Revision
  40. 40. Localising bitemporal hemianopia - upper quadrant defect > lower quadrant defect. 20a BADRAWY MRCP Revision
  41. 41. = superior chiasmal compression, commonly a craniopharyngioma 20b BADRAWY MRCP Revision
  42. 42. Imatinib - MoA 21a BADRAWY MRCP Revision
  43. 43. = tyrosine kinase inhibitor used in CML 21b BADRAWY MRCP Revision
  44. 44. Flushing, diarrhoea, bronchospasm, tricuspid stenosis, pellagra - diagnosis? 22a BADRAWY MRCP Revision
  45. 45. --> carcinoid with liver mets 22b BADRAWY MRCP Revision
  46. 46. Flash pulmonary oedema, U&Es worse on ACE inhibitor, asymmetrical kidneys: ?diagnosis 23a BADRAWY MRCP Revision
  47. 47. --> renal artery stenosis - do MR angiography 23b BADRAWY MRCP Revision
  48. 48. Collapse + ARF = 24a BADRAWY MRCP Revision
  49. 49. --> rhabdomyolysis - treat with IV fluids 24b BADRAWY MRCP Revision
  50. 50. Statistical power = 25a BADRAWY MRCP Revision
  51. 51. 1 - the probability of a type II error 25b BADRAWY MRCP Revision
  52. 52. Sarcoidosis CXR stages 26a BADRAWY MRCP Revision
  53. 53. 1 = BHL - 2 = BHL + infiltrates - 3 = infiltrates - 4 = fibrosis 26b BADRAWY MRCP Revision
  54. 54. Calculating breakthrough morphine dose? 27a BADRAWY MRCP Revision
  55. 55. 1/6th of daily morphine dose 27b BADRAWY MRCP Revision
  56. 56. Post-natal depression incidence? 28a BADRAWY MRCP Revision
  57. 57. 10% of women 28b BADRAWY MRCP Revision
  58. 58. COPD - when to start LTOT? 29a BADRAWY MRCP Revision
  59. 59. 2 measurements of pO2 < 7.3 kPa 29b BADRAWY MRCP Revision
  60. 60. Stroke thrombolysis time limit? 30a BADRAWY MRCP Revision
  61. 61. 4.5 hours 30b BADRAWY MRCP Revision
  62. 62. 1mg prednisolone = ? hydrocortisone 31a BADRAWY MRCP Revision
  63. 63. 4mg hydrocortisone 31b BADRAWY MRCP Revision
  64. 64. Finasteride MoA 32a BADRAWY MRCP Revision
  65. 65. 5 alpha-reductase inhibitor - inhibits conversion of testosterone to dihydrotestosterone 32b BADRAWY MRCP Revision
  66. 66. Finasteride treatment of BPH may take how long before results are seen? 33a BADRAWY MRCP Revision
  67. 67. 6 months 33b BADRAWY MRCP Revision
  68. 68. DVLA restriction post- seizure 34a BADRAWY MRCP Revision
  69. 69. 6 months 34b BADRAWY MRCP Revision
  70. 70. Rx for Hypertension in diabetics - 35a BADRAWY MRCP Revision
  71. 71. ACE-inhibitors are first- line regardless of age 35b BADRAWY MRCP Revision
  72. 72. Dysphagia affecting both solids and liquids from the start - think? 36a BADRAWY MRCP Revision
  73. 73. achalasia 36b BADRAWY MRCP Revision
  74. 74. Loss of corneal reflex - key differential? 37a BADRAWY MRCP Revision
  75. 75. acoustic neuroma 37b BADRAWY MRCP Revision
  76. 76. Factor V Leiden mutation results in? 38a BADRAWY MRCP Revision
  77. 77. activated protein C resistance 38b BADRAWY MRCP Revision
  78. 78. Key treatments in migraine - acute vs prophylactic 39a BADRAWY MRCP Revision
  79. 79. acute: 5-HT1 agonist - prophylaxis: beta-blocker 39b BADRAWY MRCP Revision
  80. 80. Congenital heart disease - acyanotic - most common cause: 40a BADRAWY MRCP Revision
  81. 81. acyanotic: VSD most common cause 40b BADRAWY MRCP Revision
  82. 82. Glitazones: MoA 41a BADRAWY MRCP Revision
  83. 83. agonists of PPAR-gamma receptors 41b BADRAWY MRCP Revision
  84. 84. Atrial fibrillation - cardioversion rx: 42a BADRAWY MRCP Revision
  85. 85. amiodarone + flecainide 42b BADRAWY MRCP Revision
  86. 86. Adult Life Support (ALS) adrenaline doses - 43a BADRAWY MRCP Revision
  87. 87. anaphylaxis: 0.5ml 1:1,000 IM - cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV 43b BADRAWY MRCP Revision
  88. 88. Bartter's syndrome ? 44a BADRAWY MRCP Revision
  89. 89. AR inherited cause of hypokalaemia associated with normotension 44b BADRAWY MRCP Revision
  90. 90. Miller Fisher syndrome - CFs? 45a BADRAWY MRCP Revision
  91. 91. areflexia, ataxia, ophthalmoplegia 45b BADRAWY MRCP Revision
  92. 92. Polycythaemia rubra vera progression? 46a BADRAWY MRCP Revision
  93. 93. around 5-15% progress to myelofibrosis or AML 46b BADRAWY MRCP Revision
  94. 94. malt workers' lung - pathogen 47a BADRAWY MRCP Revision
  95. 95. Aspergillus clavatus 47b BADRAWY MRCP Revision
  96. 96. Urticaria - common drug cause? 48a BADRAWY MRCP Revision
  97. 97. Aspirin 48b BADRAWY MRCP Revision
  98. 98. Antiphospholipid syndrome in pregnancy treatment 49a BADRAWY MRCP Revision
  99. 99. aspirin + LMWH 49b BADRAWY MRCP Revision
  100. 100. Causes of raised transfer factor? 50a BADRAWY MRCP Revision
  101. 101. asthma, haemorrhage, left- to-right shunts, polycythaemia 50b BADRAWY MRCP Revision
  102. 102. Beta-blocker overdose management: 51a BADRAWY MRCP Revision
  103. 103. atropine + glucagon 51b BADRAWY MRCP Revision
  104. 104. Hereditary haemorrhagic telangiectasia - inheritance 52a BADRAWY MRCP Revision
  105. 105. autosomal dominant 52b BADRAWY MRCP Revision
  106. 106. Alpha-1 antitrypsin deficiency inheritance 53a BADRAWY MRCP Revision
  107. 107. autosomal recessive / co- dominant 53b BADRAWY MRCP Revision
  108. 108. Aortic stenosis management: 54a BADRAWY MRCP Revision
  109. 109. AVR if symptomatic, otherwise cut-off is gradient of 50 mmHg 54b BADRAWY MRCP Revision
  110. 110. Live attenuated vaccines - 55a BADRAWY MRCP Revision
  111. 111. BCG - MMR - oral polio - yellow fever - oral typhoid 55b BADRAWY MRCP Revision
  112. 112. Atrial fibrillation: rate control rx - 56a BADRAWY MRCP Revision
  113. 113. beta blockers (preferable to digoxin) 56b BADRAWY MRCP Revision
  114. 114. Aortic stenosis - most common cause <65 yrs: 57a BADRAWY MRCP Revision
  115. 115. bicuspid aortic valve 57b BADRAWY MRCP Revision
  116. 116. Most common cardiac defect in Turner's syndrome? 58a BADRAWY MRCP Revision
  117. 117. Bicuspid aortic valve 58b BADRAWY MRCP Revision
  118. 118. Porphyria cutanea tarda - CP? 59a BADRAWY MRCP Revision
  119. 119. Bullae on hands ,blistering photosensitive rash - hypertrichosis - hyperpigmentation, fragile SKIN torn by minor trauma 59b BADRAWY MRCP Revision
  120. 120. Amiodarone MoA 60a BADRAWY MRCP Revision
  121. 121. Blocks potassium channels 60b BADRAWY MRCP Revision
  122. 122. Visual changes secondary to drugs - blue vision? Yellow-green vision? 61a BADRAWY MRCP Revision
  123. 123. blue vision: Viagra ('the blue pill') - yellow-green vision: digoxin 61b BADRAWY MRCP Revision
  124. 124. HRT: adding a progestogen increases the risk of? 62a BADRAWY MRCP Revision
  125. 125. breast cancer 62b BADRAWY MRCP Revision
  126. 126. Common cause of tumour lysis syndrome? 63a BADRAWY MRCP Revision
  127. 127. Burkitt's lymphoma 63b BADRAWY MRCP Revision
  128. 128. EBV: associated malignancies? 64a BADRAWY MRCP Revision
  129. 129. Burkitt's lymphoma - Hodgkin's lymphoma - nasopharyngeal carcinoma 64b BADRAWY MRCP Revision
  130. 130. Variables used to calculate eGFR? 65a BADRAWY MRCP Revision
  131. 131. CAGE - Creatinine, Age, Gender, Ethnicity 65b BADRAWY MRCP Revision
  132. 132. Aortic stenosis - most common cause >65 yrs: 66a BADRAWY MRCP Revision
  133. 133. calcification 66b BADRAWY MRCP Revision
  134. 134. What drugs are now preferred to thiazides in the treatment of hypertension? 67a BADRAWY MRCP Revision
  135. 135. Calcium channel blockers 67b BADRAWY MRCP Revision
  136. 136. DVLA advice post CVA: 68a BADRAWY MRCP Revision
  137. 137. cannot drive for 1 month 68b BADRAWY MRCP Revision
  138. 138. DVLA advice following angioplasty - 69a BADRAWY MRCP Revision
  139. 139. cannot drive for 1 week 69b BADRAWY MRCP Revision
  140. 140. DVLA advice post multiple TIAs: 70a BADRAWY MRCP Revision
  141. 141. cannot drive for 3 months 70b BADRAWY MRCP Revision
  142. 142. DVLA advice post MI - 71a BADRAWY MRCP Revision
  143. 143. cannot drive for 4 weeks 71b BADRAWY MRCP Revision
  144. 144. Epilepsy medication: first- line - partial seizure: 72a BADRAWY MRCP Revision
  145. 145. carbamazepine 72b BADRAWY MRCP Revision
  146. 146. Trigeminal neuralgia - first-line Rx? 73a BADRAWY MRCP Revision
  147. 147. carbamazepine 73b BADRAWY MRCP Revision
  148. 148. Trastuzumab (Herceptin) - important SE? 74a BADRAWY MRCP Revision
  149. 149. cardiotoxicity 74b BADRAWY MRCP Revision
  150. 150. Schistosoma haematobium 75a BADRAWY MRCP Revision
  151. 151. causes haematuria 75b BADRAWY MRCP Revision
  152. 152. Horner's syndrome - anhydrosis of head, arm, trunk = 76a BADRAWY MRCP Revision
  153. 153. central lesion: stroke, syringomyelia 76b BADRAWY MRCP Revision
  154. 154. Chickenpox exposure in pregnancy - first step? 77a BADRAWY MRCP Revision
  155. 155. check antibodies 77b BADRAWY MRCP Revision
  156. 156. CLL - treatment? 78a BADRAWY MRCP Revision
  157. 157. chlorambucil 78b BADRAWY MRCP Revision
  158. 158. ADPKD type 1 chromosome 79a BADRAWY MRCP Revision
  159. 159. chromosome 16 = 85% of cases 79b BADRAWY MRCP Revision
  160. 160. Chemo agent associated with hypomagnesaemia? 80a BADRAWY MRCP Revision
  161. 161. Cisplatin 80b BADRAWY MRCP Revision
  162. 162. Rx Infertility in PCOS - 81a BADRAWY MRCP Revision
  163. 163. clomifene is superior to metformin 81b BADRAWY MRCP Revision
  164. 164. JVP: C wave - physiological correlate 82a BADRAWY MRCP Revision
  165. 165. closure of the tricuspid valve 82b BADRAWY MRCP Revision
  166. 166. Episodic eye pain, lacrimation, nasal stuffiness occurring daily - ?diagnosis 83a BADRAWY MRCP Revision
  167. 167. cluster headache 83b BADRAWY MRCP Revision
  168. 168. Burkitt's lymphoma - gene translocation? 84a BADRAWY MRCP Revision
  169. 169. c-myc 84b BADRAWY MRCP Revision
  170. 170. Animal bite treatment 85a BADRAWY MRCP Revision
  171. 171. co-amoxiclav 85b BADRAWY MRCP Revision
  172. 172. Drug metabolism - phase II components? 86a BADRAWY MRCP Revision
  173. 173. conjugation 86b BADRAWY MRCP Revision
  174. 174. Viagra contraindications 87a BADRAWY MRCP Revision
  175. 175. contraindicated by nitrates and nicorandil 87b BADRAWY MRCP Revision
  176. 176. Main indication for HRT? 88a BADRAWY MRCP Revision
  177. 177. control of vasomotor symptoms 88b BADRAWY MRCP Revision
  178. 178. First line investigation for PE according to current BTS guidelines? 89a BADRAWY MRCP Revision
  179. 179. CTPA 89b BADRAWY MRCP Revision
  180. 180. hypokalaemic metabolic alkalosis - endocrine condition? 90a BADRAWY MRCP Revision
  181. 181. Cushing's syndrome 90b BADRAWY MRCP Revision
  182. 182. Hemiballism (involuntary, sudden, jerking movements) = caused by? 91a BADRAWY MRCP Revision
  183. 183. damage to the subthalamic nucleus 91b BADRAWY MRCP Revision
  184. 184. Acute myeloid leukaemia - poor prognosis 92a BADRAWY MRCP Revision
  185. 185. deletion of chromosome 5 or 7 92b BADRAWY MRCP Revision
  186. 186. Most common psychiatric problem in Parkinson's disease? 93a BADRAWY MRCP Revision
  187. 187. depression 93b BADRAWY MRCP Revision
  188. 188. Investigation for Carcinoid 94a BADRAWY MRCP Revision
  189. 189. Diagnosis: urinary 5-HIAA 94b BADRAWY MRCP Revision
  190. 190. Adenosine interactions 95a BADRAWY MRCP Revision
  191. 191. dipyridamole enhances effect - aminophylline reduces effect 95b BADRAWY MRCP Revision
  192. 192. Dystrophia myotonica - DM1 CFs 96a BADRAWY MRCP Revision
  193. 193. DM1 - distal weakness initially - autosomal dominant - diabetes - dysarthria 96b BADRAWY MRCP Revision
  194. 194. Restless leg syndrome - management 97a BADRAWY MRCP Revision
  195. 195. dopamine agonists such as ropinirole 97b BADRAWY MRCP Revision
  196. 196. Change to steroid dose in people on long term tx if intercurrent illness? 98a BADRAWY MRCP Revision
  197. 197. Double doses 98b BADRAWY MRCP Revision
  198. 198. Rheumatoid arthritis - HLA association? 99a BADRAWY MRCP Revision
  199. 199. DR4 99b BADRAWY MRCP Revision
  200. 200. HRT: unopposed oestrogen increases risk of? 100a BADRAWY MRCP Revision
  201. 201. endometrial cancer 100b BADRAWY MRCP Revision
  202. 202. Bosentan - MoA, uses? 101a BADRAWY MRCP Revision
  203. 203. endothelin-1 receptor antagonist used if negative response to acute vasodilator testing in pulmonary hypertension 101b BADRAWY MRCP Revision
  204. 204. Pemphigus vulgaris key features? 102a BADRAWY MRCP Revision
  205. 205. Epidermal, desmoglein 3, involves mucosa, flaccid non-pruritic blisters, younger people 102b BADRAWY MRCP Revision
  206. 206. Head injury followed by lucid interval? 103a BADRAWY MRCP Revision
  207. 207. Epidural haematoma 103b BADRAWY MRCP Revision
  208. 208. Zollinger-Ellison syndrome - CFs 104a BADRAWY MRCP Revision
  209. 209. epigastric pain and diarrhoea 104b BADRAWY MRCP Revision
  210. 210. Key contraindication to buproprion? 105a BADRAWY MRCP Revision
  211. 211. epilepsy 105b BADRAWY MRCP Revision
  212. 212. Ciclosporin side-effects 106a BADRAWY MRCP Revision
  213. 213. everything is increased - fluid, BP, K+, hair, gums, glucose 106b BADRAWY MRCP Revision
  214. 214. Activated protein C resistance = 107a BADRAWY MRCP Revision
  215. 215. Factor V Leiden, the most common inherited thrombophilia 107b BADRAWY MRCP Revision
  216. 216. Diabetes diagnosis: 108a BADRAWY MRCP Revision
  217. 217. fasting > 7.0, random > 11.1 - if asymptomatic need two readings HbA1c of 6.5% or greater is now diagnostic (WHO 2011) 108b BADRAWY MRCP Revision
  218. 218. investigation of choice for upper airway compression 109a BADRAWY MRCP Revision
  219. 219. Flow volume loop 109b BADRAWY MRCP Revision
  220. 220. Common antibiotic causes of cholestasis 110a BADRAWY MRCP Revision
  221. 221. Flucloxacillin + co- amoxiclav 110b BADRAWY MRCP Revision
  222. 222. Ethylene glycol toxicity management - 111a BADRAWY MRCP Revision
  223. 223. fomepizole. Also ethanol / haemodialysis 111b BADRAWY MRCP Revision
  224. 224. Benzodiazepines enhance the effect of which neurotransmitter? 112a BADRAWY MRCP Revision
  225. 225. GABA, the main inhibitory neurotransmitter 112b BADRAWY MRCP Revision
  226. 226. Signet ring cells = 113a BADRAWY MRCP Revision
  227. 227. Gastric adenocarcinoma 113b BADRAWY MRCP Revision
  228. 228. Screening for haemochromatosis - 114a BADRAWY MRCP Revision
  229. 229. general population: transferrin saturation > ferritin - family members: HFE genetic testing 114b BADRAWY MRCP Revision
  230. 230. SSRI + NSAID interaction? 115a BADRAWY MRCP Revision
  231. 231. GI bleeding risk - give a PPI 115b BADRAWY MRCP Revision
  232. 232. Tricyclic overdose - rx 116a BADRAWY MRCP Revision
  233. 233. give IV bicarbonate 116b BADRAWY MRCP Revision
  234. 234. ITP - rx 117a BADRAWY MRCP Revision
  235. 235. give oral prednisolone 117b BADRAWY MRCP Revision
  236. 236. PHaeochromocytoma - 118a BADRAWY MRCP Revision
  237. 237. give PHenoxybenzamine before beta-blockers 118b BADRAWY MRCP Revision
  238. 238. Exenatide MoA 119a BADRAWY MRCP Revision
  239. 239. Glucagon-like peptide-1 (GLP-1) mimetic 119b BADRAWY MRCP Revision
  240. 240. Philadelphia translocation and prognosis? 120a BADRAWY MRCP Revision
  241. 241. good prognosis in CML, poor prognosis in AML + ALL 120b BADRAWY MRCP Revision
  242. 242. Absence seizures prognosis 121a BADRAWY MRCP Revision
  243. 243. good: 90-95% become seizure free in adolescence 121b BADRAWY MRCP Revision
  244. 244. Bronchiectasis: most common organism? 122a BADRAWY MRCP Revision
  245. 245. Haemophilus influenzae 122b BADRAWY MRCP Revision
  246. 246. Cyclophosphamide SE: 123a BADRAWY MRCP Revision
  247. 247. haemorrhagic cystitis - prevent with mesna 123b BADRAWY MRCP Revision
  248. 248. Genital ulcers - painful: 124a BADRAWY MRCP Revision
  249. 249. herpes >> chancroid 124b BADRAWY MRCP Revision
  250. 250. CT head showing temporal lobe changes - think what? 125a BADRAWY MRCP Revision
  251. 251. herpes simplex encephalitis,temporoparietal attentuation - subacute onset i.e. Several days. 125b BADRAWY MRCP Revision
  252. 252. most common cause of sudden cardiac death in the young 126a BADRAWY MRCP Revision
  253. 253. HOCM 126b BADRAWY MRCP Revision
  254. 254. U waves on ECG 127a BADRAWY MRCP Revision
  255. 255. Hypokalaemia - 127b BADRAWY MRCP Revision
  256. 256. Liddle's syndrome: 128a BADRAWY MRCP Revision
  257. 257. hypokalaemia + hypertension 128b BADRAWY MRCP Revision
  258. 258. Hashimoto's thyroiditis key features? 129a BADRAWY MRCP Revision
  259. 259. hypothyroidism + goitre + anti-TPO 129b BADRAWY MRCP Revision
  260. 260. Asymmetrical symptoms in PD suggest what cause? 130a BADRAWY MRCP Revision
  261. 261. Idiopathic Parkinson's 130b BADRAWY MRCP Revision
  262. 262. NSTEMI/unstable angina Rx. 6 month mortality risk >1.5% vs 6m risk >3% 131a BADRAWY MRCP Revision
  263. 263. if > 1.5% clopidogrel for 12 months - if > 3% angiography within 96 hours 131b BADRAWY MRCP Revision
  264. 264. Primary biliary cirrhosis - the M rule mnemonic? 132a BADRAWY MRCP Revision
  265. 265. IgM - anti-Mitochondrial antibodies, M2 subtype - Middle aged females 132b BADRAWY MRCP Revision
  266. 266. What is rheumatoid factor? 133a BADRAWY MRCP Revision
  267. 267. IgM antibody against IgG 133b BADRAWY MRCP Revision
  268. 268. CLL - investigation of choice? 134a BADRAWY MRCP Revision
  269. 269. immunophenotyping 134b BADRAWY MRCP Revision
  270. 270. Nicotinic acid MoA 135a BADRAWY MRCP Revision
  271. 271. increases HDL levels 135b BADRAWY MRCP Revision
  272. 272. Essential tremor: inheritance, aggravants / relievants 136a BADRAWY MRCP Revision
  273. 273. Inheritance: AD Aggravants: Arms outstretched Relievants: Alcohol, propanolol 136b BADRAWY MRCP Revision
  274. 274. Ciclosporin + tacrolimus - MOA: 137a BADRAWY MRCP Revision
  275. 275. inhibit calcineurin thus decreasing IL-2 137b BADRAWY MRCP Revision
  276. 276. Statins - MoA? 138a BADRAWY MRCP Revision
  277. 277. inhibit HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis 138b BADRAWY MRCP Revision
  278. 278. Bisphosphonates MoA 139a BADRAWY MRCP Revision
  279. 279. inhibit osteoclasts,prevent steroid incduced osteoperosis (vitamin D also). 139b BADRAWY MRCP Revision
  280. 280. Clopidogrel MoA: 140a BADRAWY MRCP Revision
  281. 281. inhibits ADP binding to platelet receptors 140b BADRAWY MRCP Revision
  282. 282. Dipyridamole - MoA 141a BADRAWY MRCP Revision
  283. 283. inhibits phosphodiesterase 141b BADRAWY MRCP Revision
  284. 284. Digoxin - MoA 142a BADRAWY MRCP Revision
  285. 285. inhibits the Na+/K+ ATPase pump 142b BADRAWY MRCP Revision
  286. 286. Isoniazid SEs: 143a BADRAWY MRCP Revision
  287. 287. inhibits the P450 system, causes peripheral neuropathy 143b BADRAWY MRCP Revision
  288. 288. Allopurinol MoA 144a BADRAWY MRCP Revision
  289. 289. inhibits xanthine oxidase 144b BADRAWY MRCP Revision
  290. 290. Symptom control in non- CF bronchiectasis? 145a BADRAWY MRCP Revision
  291. 291. inspiratory muscle training + postural drainage 145b BADRAWY MRCP Revision
  292. 292. Complete heart block following an ANterior MI - ?pacing 146a BADRAWY MRCP Revision
  293. 293. is AN indication for pacing, unlike with an inferior MI 146b BADRAWY MRCP Revision
  294. 294. Streptococcus pneumoniae 147a BADRAWY MRCP Revision
  295. 295. is associated with cold sores 147b BADRAWY MRCP Revision
  296. 296. Streptococcus bovis endocarditis 148a BADRAWY MRCP Revision
  297. 297. is associated with colorectal cancer 148b BADRAWY MRCP Revision
  298. 298. Legionella pneumophilia 149a BADRAWY MRCP Revision
  299. 299. is best diagnosed by the urinary antigen test 149b BADRAWY MRCP Revision
  300. 300. Complete heart block following an INferior MI - ? pacing 150a BADRAWY MRCP Revision
  301. 301. Is Not an indication for pacing, unlike with an anterior MI 150b BADRAWY MRCP Revision
  302. 302. Most common cause of occupational asthma? 151a BADRAWY MRCP Revision
  303. 303. Isocyanates 151b BADRAWY MRCP Revision
  304. 304. Lichen sclerosus: 152a BADRAWY MRCP Revision
  305. 305. itchy white spots typically seen on the vulva of elderly women 152b BADRAWY MRCP Revision
  306. 306. Polycythaemia rubra vera - genetic cause? 153a BADRAWY MRCP Revision
  307. 307. JAK2 mutation 153b BADRAWY MRCP Revision
  308. 308. Hypertension - step 4 rx? 154a BADRAWY MRCP Revision
  309. 309. K+ < 4.5 then spironolactone - K+ > 4.5 then higher-dose thiazide- like diuretic 154b BADRAWY MRCP Revision
  310. 310. Pneumonia in an alcoholic - pathogen? 155a BADRAWY MRCP Revision
  311. 311. Klebsiella 155b BADRAWY MRCP Revision
  312. 312. BTS COPD: breathless despite PRN inhalers, and FEV1 < 50% 156a BADRAWY MRCP Revision
  313. 313. LABA + ICS or LAMA 156b BADRAWY MRCP Revision
  314. 314. BTS COPD: breathless despite PRN inhalers, and FEV1 > 50%: 157a BADRAWY MRCP Revision
  315. 315. LABA or LAMA 157b BADRAWY MRCP Revision
  316. 316. Polymorphic eruption of pregnancy - CFs? 158a BADRAWY MRCP Revision
  317. 317. Last trimester, may see vesicles, but no blistering 158b BADRAWY MRCP Revision
  318. 318. Cerebellar signs, contralateral sensory loss & ipsilateral Horner's = 159a BADRAWY MRCP Revision
  319. 319. Lateral medullary syndrome - PICA lesion - 159b BADRAWY MRCP Revision
  320. 320. Mucocutaneous ulceration following travel - key differential? 160a BADRAWY MRCP Revision
  321. 321. Leishmania brasiliensis 160b BADRAWY MRCP Revision
  322. 322. Most common presenting symptom in myelofibrosis? 161a BADRAWY MRCP Revision
  323. 323. lethargy 161b BADRAWY MRCP Revision
  324. 324. Safest TCA in overdosage? 162a BADRAWY MRCP Revision
  325. 325. Lofepramine 162b BADRAWY MRCP Revision
  326. 326. Second heart sound (S2) - loud, soft, fixed split, reversed split? 163a BADRAWY MRCP Revision
  327. 327. loud: hypertension - soft: AS - fixed split: ASD - reversed split: LBBB 163b BADRAWY MRCP Revision
  328. 328. ESR in polycythaemia rubra vera 164a BADRAWY MRCP Revision
  329. 329. low 164b BADRAWY MRCP Revision
  330. 330. Oxygen dissociation curve - shifts Left? 165a BADRAWY MRCP Revision
  331. 331. Lower oxygen delivery - Lower acidity, temp, 2-3 DPG - also HbF, carboxy/methaemoglobin - 165b BADRAWY MRCP Revision
  332. 332. Most common lung cancer type in non-smokers? 166a BADRAWY MRCP Revision
  333. 333. Lung adenocarcinoma - peripheral lesion 166b BADRAWY MRCP Revision
  334. 334. Gallop rhythm (S3) is an early sign of? 167a BADRAWY MRCP Revision
  335. 335. LVF 167b BADRAWY MRCP Revision
  336. 336. Hodgkin's lymphoma - best prognosis = 168a BADRAWY MRCP Revision
  337. 337. lymphocyte predominant 168b BADRAWY MRCP Revision
  338. 338. Patients with Sjogren's syndrome have an increased risk of which malignancy? 169a BADRAWY MRCP Revision
  339. 339. lymphoid malignancies 169b BADRAWY MRCP Revision
  340. 340. Rx for Mycoplasma pneumonia 170a BADRAWY MRCP Revision
  341. 341. Macrolides. If allergic =doxycycline 170b BADRAWY MRCP Revision
  342. 342. Eclampsia - first-line treatment 171a BADRAWY MRCP Revision
  343. 343. magnesium sulphate 171b BADRAWY MRCP Revision
  344. 344. Sarcoidosis prognosis? 172a BADRAWY MRCP Revision
  345. 345. Majority of patients get better without treatment 172b BADRAWY MRCP Revision
  346. 346. PTH level in primary hyperparathyroidism 173a BADRAWY MRCP Revision
  347. 347. may be normal 173b BADRAWY MRCP Revision
  348. 348. TNF-#alpha# inhibitors 174a BADRAWY MRCP Revision
  349. 349. may reactivate TB 174b BADRAWY MRCP Revision
  350. 350. Choosing prosthetic heart valves 175a BADRAWY MRCP Revision
  351. 351. mechanical valves last longer and tend to be given to younger patients 175b BADRAWY MRCP Revision
  352. 352. Prolactinoma management -medical or surgical? 176a BADRAWY MRCP Revision
  353. 353. medical therapy is almost always first-line 176b BADRAWY MRCP Revision
  354. 354. Autosomal recessive conditions tend to be ?? with what exceptions? 177a BADRAWY MRCP Revision
  355. 355. Metabolic. Exception = inherited ataxias 177b BADRAWY MRCP Revision
  356. 356. Acne rosacea treatment: - 178a BADRAWY MRCP Revision
  357. 357. mild/moderate: topical metronidazole - severe/resistant: oral tetracycline 178b BADRAWY MRCP Revision
  358. 358. Kearns-Sayre syndrome - 179a BADRAWY MRCP Revision
  359. 359. mitochondrial inheritance - onset < 20-years-old - external ophthalmoplegia - retinitis pigmentosa 179b BADRAWY MRCP Revision
  360. 360. Common topical steroids and their potency? 180a BADRAWY MRCP Revision
  361. 361. moderate: Clobetasone butyrate 0.05% - potent: Betamethasone valerate 0.1% - very potent: Clobetasol propionate 0.05% 180b BADRAWY MRCP Revision
  362. 362. Magnesium sulphate - monitoring 181a BADRAWY MRCP Revision
  363. 363. monitor reflexes + respiratory rate 181b BADRAWY MRCP Revision
  364. 364. Cetuximab - MoA? 182a BADRAWY MRCP Revision
  365. 365. monoclonal antibody against the epidermal growth factor receptor 182b BADRAWY MRCP Revision
  366. 366. Trastuzumab (Herceptin) - 183a BADRAWY MRCP Revision
  367. 367. monoclonal antibody that acts on the HER2/neu receptor 183b BADRAWY MRCP Revision
  368. 368. Anorexia features - 184a BADRAWY MRCP Revision
  369. 369. most things low - G's and C's raised: growth hormone, glucose, salivary glands, cortisol, cholesterol, carotinaemia 184b BADRAWY MRCP Revision
  370. 370. Rises first following MI? 185a BADRAWY MRCP Revision
  371. 371. Myoglobin 185b BADRAWY MRCP Revision
  372. 372. Hypercholesterolaemia rather than hypertriglyceridaemia: 186a BADRAWY MRCP Revision
  373. 373. nephrotic syndrome, cholestasis, hypothyroidism 186b BADRAWY MRCP Revision
  374. 374. Signs suggesting TTP rather than HUS? 187a BADRAWY MRCP Revision
  375. 375. Neuro signs and purpura point towards TTP 187b BADRAWY MRCP Revision
  376. 376. Motor neuron disease - treatment: 188a BADRAWY MRCP Revision
  377. 377. NIV is better than riluzole 188b BADRAWY MRCP Revision
  378. 378. AF treatment: young man, no TIA or risk factors, 189a BADRAWY MRCP Revision
  379. 379. no treatment is now preferred to aspirin 189b BADRAWY MRCP Revision
  380. 380. Hodgkin's lymphoma - most common type = 190a BADRAWY MRCP Revision
  381. 381. nodular sclerosing 190b BADRAWY MRCP Revision
  382. 382. Renal tubular acidosis - anion gap? 191a BADRAWY MRCP Revision
  383. 383. normal anion gap 191b BADRAWY MRCP Revision
  384. 384. Urinary incontinence + gait abnormality + dementia. Diagnosis? 192a BADRAWY MRCP Revision
  385. 385. normal pressure hydrocephalus 192b BADRAWY MRCP Revision
  386. 386. Rx metastatic bone pain 193a BADRAWY MRCP Revision
  387. 387. NSAIDs, bisphosphonates or radiotherapy 193b BADRAWY MRCP Revision
  388. 388. Acromegaly diagnosis? 194a BADRAWY MRCP Revision
  389. 389. oral glucose tolerance with growth hormone measurements 194b BADRAWY MRCP Revision
  390. 390. Cushing's syndrome - best test to diagnose? 195a BADRAWY MRCP Revision
  391. 391. overnight dexamethasone suppression test 195b BADRAWY MRCP Revision
  392. 392. Drug metabolism - phase I components? 196a BADRAWY MRCP Revision
  393. 393. oxidation, reduction, hydrolysis 196b BADRAWY MRCP Revision
  394. 394. Antiphospholipid syndrome: APPT, PLTs 197a BADRAWY MRCP Revision
  395. 395. Paradoxically prolonged APTT + low platelets 197b BADRAWY MRCP Revision
  396. 396. Progressive supranuclear palsy CFs? 198a BADRAWY MRCP Revision
  397. 397. Absent voluntary downward gaze, normal dolls eye . i.e. Occulomotor nuclei intact, supranuclear Pathology. parkinsonism 198b BADRAWY MRCP Revision
  398. 398. SSRI with high incidence of discontinuation symptoms? 199a BADRAWY MRCP Revision
  399. 399. Paroxetine 199b BADRAWY MRCP Revision
  400. 400. Collapsing pulse - which congenital heart defect? 200a BADRAWY MRCP Revision
  401. 401. Patent ductus arteriosus - 200b BADRAWY MRCP Revision
  402. 402. Vincristine - important SE? 201a BADRAWY MRCP Revision
  403. 403. peripheral neuropathy 201b BADRAWY MRCP Revision
  404. 404. Drugs with zero-order (saturation) kinetics - 202a BADRAWY MRCP Revision
  405. 405. phenytoin - alcohol 202b BADRAWY MRCP Revision
  406. 406. Causes of gingival hyperplasia? 203a BADRAWY MRCP Revision
  407. 407. phenytoin, ciclosporin, calcium channel blockers and AML 203b BADRAWY MRCP Revision
  408. 408. TTP first-line Rx? 204a BADRAWY MRCP Revision
  409. 409. Plasma exchange 204b BADRAWY MRCP Revision
  410. 410. Painful third nerve palsy - key differential? 205a BADRAWY MRCP Revision
  411. 411. posterior communicating artery aneurysm 205b BADRAWY MRCP Revision
  412. 412. Horner's syndrome - anhydrosis absent = 206a BADRAWY MRCP Revision
  413. 413. post-ganglionic lesion: carotid artery 206b BADRAWY MRCP Revision
  414. 414. Rx Minimal change glomerulonephritis? 207a BADRAWY MRCP Revision
  415. 415. prednisolone 207b BADRAWY MRCP Revision
  416. 416. Horner's syndrome - anhydrosis of just face = 208a BADRAWY MRCP Revision
  417. 417. pre-ganglionic lesion: Pancoast's, cervical rib 208b BADRAWY MRCP Revision
  418. 418. Causes of raised prolactin? 209a BADRAWY MRCP Revision
  419. 419. pregnancy - prolactinoma - physiological - polycystic ovarian syndrome - primary hypothyroidism - phenothiazines, metoclopramide, domperidone 209b BADRAWY MRCP Revision
  420. 420. Taxanes (e.g. Docetaxel) MoA? 210a BADRAWY MRCP Revision
  421. 421. prevent microtubule disassembly 210b BADRAWY MRCP Revision
  422. 422. Infective endocarditis - strongest risk factor 211a BADRAWY MRCP Revision
  423. 423. previous episode of infective endocarditis 211b BADRAWY MRCP Revision
  424. 424. Ptosis + dilated pupil vs Ptosis + constricted pupil 212a BADRAWY MRCP Revision
  425. 425. Ptosis + dilated pupil = 3rd nerve palsy; Ptosis + constricted pupil = Horner's 212b BADRAWY MRCP Revision
  426. 426. Lichen - planus: 213a BADRAWY MRCP Revision
  427. 427. purple, pruritic, papular, polygonal rash on flexor surfaces. Wickham's striae over surface. Oral involvement common 213b BADRAWY MRCP Revision
  428. 428. Oxygen dissociation curve - shifts Right? 214a BADRAWY MRCP Revision
  429. 429. Raised oxygen delivery - Raised acidity, temp, 2-3 DPG 214b BADRAWY MRCP Revision
  430. 430. HbA1C - when to recheck after change in therapy? 215a BADRAWY MRCP Revision
  431. 431. recheck after 2-3 months 215b BADRAWY MRCP Revision
  432. 432. Inferior MI - 216a BADRAWY MRCP Revision
  433. 433. right coronary artery lesion 216b BADRAWY MRCP Revision
  434. 434. Farmers lung pathogen 217a BADRAWY MRCP Revision
  435. 435. Saccharopolyspora rectivirgula 217b BADRAWY MRCP Revision
  436. 436. Erythema nodosum is associated with a good prognosis in what systemic condition? 218a BADRAWY MRCP Revision
  437. 437. sarcoidosis 218b BADRAWY MRCP Revision
  438. 438. Combined B- and T-cell disorders 219a BADRAWY MRCP Revision
  439. 439. SCID WAS ataxic (SCID, Wiskott-Aldrich syndrome, ataxic telangiectasia) 219b BADRAWY MRCP Revision
  440. 440. Pulsus alternans? 220a BADRAWY MRCP Revision
  441. 441. seen in left ventricular failure 220b BADRAWY MRCP Revision
  442. 442. HOCM - poor prognostic factor on echo = 221a BADRAWY MRCP Revision
  443. 443. septal wall thickness of > 3cm 221b BADRAWY MRCP Revision
  444. 444. Detecting occupational asthma? 222a BADRAWY MRCP Revision
  445. 445. Serial peak flow measurements at work and at home 222b BADRAWY MRCP Revision
  446. 446. Mycoplasma diagnosis 223a BADRAWY MRCP Revision
  447. 447. Serology 223b BADRAWY MRCP Revision
  448. 448. Dx Addison's disease 224a BADRAWY MRCP Revision
  449. 449. short synacthen test 224b BADRAWY MRCP Revision
  450. 450. Epilepsy medication: first- line - generalised seizure: 225a BADRAWY MRCP Revision
  451. 451. sodium valproate - 225b BADRAWY MRCP Revision
  452. 452. Syringomyelia - CFs? 226a BADRAWY MRCP Revision
  453. 453. spinothalamic sensory loss (pain and temperature) 226b BADRAWY MRCP Revision
  454. 454. Asthma diagnosis - first line investigation in intermediate probability? 227a BADRAWY MRCP Revision
  455. 455. Spirometry 227b BADRAWY MRCP Revision
  456. 456. Paraneoplastic features of lung cancer - squamous cell vs small cell? 228a BADRAWY MRCP Revision
  457. 457. squamous cell: PTHrp, clubbing, HPOA - small cell: ADH, ACTH, Lambert- Eaton syndrome 228b BADRAWY MRCP Revision
  458. 458. Pneumonia following influenza - pathogen? 229a BADRAWY MRCP Revision
  459. 459. Staphylococcus aureus pneumonia 229b BADRAWY MRCP Revision
  460. 460. Most common cause of endocarditis if < 2 months post valve surgery 230a BADRAWY MRCP Revision
  461. 461. Staphylococcus epidermidis 230b BADRAWY MRCP Revision
  462. 462. Asthma diagnosis - first line investigation in high probability? 231a BADRAWY MRCP Revision
  463. 463. Start treatment 231b BADRAWY MRCP Revision
  464. 464. Infective endocarditis - good prognosis 232a BADRAWY MRCP Revision
  465. 465. streptococcal infection 232b BADRAWY MRCP Revision
  466. 466. Most common cause of endocarditis 233a BADRAWY MRCP Revision
  467. 467. Streptococcus viridans 233b BADRAWY MRCP Revision
  468. 468. Antipsychotics in the elderly -> risk of? 234a BADRAWY MRCP Revision
  469. 469. stroke and VTE 234b BADRAWY MRCP Revision
  470. 470. Autosomal dominant conditions tend to be ?? - with what exceptions? 235a BADRAWY MRCP Revision
  471. 471. Structural. Exceptions = hyperlipidaemia type II, hypokalaemic periodic paralysis 235b BADRAWY MRCP Revision
  472. 472. Cluster headache - acute treatment 236a BADRAWY MRCP Revision
  473. 473. subcutaneous sumatriptan + 100% O2 236b BADRAWY MRCP Revision
  474. 474. Bullous pemphigoid key features? 237a BADRAWY MRCP Revision
  475. 475. Subepidermal, hemidesmosomal BP antigens, rarely involves mucosa, tense pruritic blisters, older people 237b BADRAWY MRCP Revision
  476. 476. Diagnosing insulinoma? 238a BADRAWY MRCP Revision
  477. 477. supervised prolonged fasting 238b BADRAWY MRCP Revision
  478. 478. Cryptosporidium diarrhoea Rx 239a BADRAWY MRCP Revision
  479. 479. Supportive therapy 239b BADRAWY MRCP Revision
  480. 480. Contraindications to lung cancer surgery 240a BADRAWY MRCP Revision
  481. 481. SVC obstruction, FEV < 1.5, MALIGNANT pleural effusion, and vocal cord paralysis 240b BADRAWY MRCP Revision
  482. 482. Reason for ^sweating in acromegaly 241a BADRAWY MRCP Revision
  483. 483. sweat gland hypertrophy 241b BADRAWY MRCP Revision
  484. 484. Alcohol withdrawal time to symptoms/signs 242a BADRAWY MRCP Revision
  485. 485. symptoms: 6-12 hours - seizures: 36 hours - delirium tremens: 72 hours 242b BADRAWY MRCP Revision
  486. 486. Genital ulcers - painless: 243a BADRAWY MRCP Revision
  487. 487. syphilis > lymphogranuloma venereum + granuloma inguinale 243b BADRAWY MRCP Revision
  488. 488. Philadelphia translocation? 244a BADRAWY MRCP Revision
  489. 489. t(9;22) 244b BADRAWY MRCP Revision
  490. 490. Congenital heart disease - cyanotic - most common cause: 245a BADRAWY MRCP Revision
  491. 491. TGA most common at birth, Fallot's most common overall - 245b BADRAWY MRCP Revision
  492. 492. Melanoma: single most important prognostic factor 246a BADRAWY MRCP Revision
  493. 493. the invasion depth of the tumour 246b BADRAWY MRCP Revision
  494. 494. Diuretic cause of hypercalcaemia? 247a BADRAWY MRCP Revision
  495. 495. Thiazides 247b BADRAWY MRCP Revision
  496. 496. Disproportionate microcytic anaemia - think? 248a BADRAWY MRCP Revision
  497. 497. think beta-thalassaemia trait 248b BADRAWY MRCP Revision
  498. 498. Hashimoto's thyroiditis is associated with which malignancy? 249a BADRAWY MRCP Revision
  499. 499. thyroid lymphoma 249b BADRAWY MRCP Revision
  500. 500. Impetigo - rx 250a BADRAWY MRCP Revision
  501. 501. topical fusidic acid --> oral flucloxacillin / topical retapamulin 250b BADRAWY MRCP Revision
  502. 502. Chlamydia - treatment 251a BADRAWY MRCP Revision
  503. 503. treat with azithromycin or doxycycline 251b BADRAWY MRCP Revision
  504. 504. JVP: giant v waves 252a BADRAWY MRCP Revision
  505. 505. tricuspid regurgitation 252b BADRAWY MRCP Revision
  506. 506. Associations in mesangiocapillary / membranoproliferative GN. Type 1 vs Type 2 253a BADRAWY MRCP Revision
  507. 507. type 1: cryoglobulinaemia, hepatitis C - type 2: partial lipodystrophy 253b BADRAWY MRCP Revision
  508. 508. Aortic dissection - Type A 254a BADRAWY MRCP Revision
  509. 509. type A - ascending aorta - control BP(IV labetalol) + surgery 254b BADRAWY MRCP Revision
  510. 510. Aortic dissection - Type B 255a BADRAWY MRCP Revision
  511. 511. type B - descending aorta - control BP(IV labetalol), no surgery 255b BADRAWY MRCP Revision
  512. 512. Diagnosing systemic mastocytosis? 256a BADRAWY MRCP Revision
  513. 513. Urinary histamine 256b BADRAWY MRCP Revision
  514. 514. Vigabatrin - important SE? 257a BADRAWY MRCP Revision
  515. 515. V for Vigabatrin - V for Visual field defects 257b BADRAWY MRCP Revision
  516. 516. Ventricular tachycardia - which antiarrhythmic is contraindicated? 258a BADRAWY MRCP Revision
  517. 517. verapamil 258b BADRAWY MRCP Revision
  518. 518. macrophages containing Periodic acid-Schiff (PAS) granules 259a BADRAWY MRCP Revision
  519. 519. Whipple's disease jejunal biopsy 259b BADRAWY MRCP Revision
  520. 520. PCI - biggest RF for stent thrombosis? 260a BADRAWY MRCP Revision
  521. 521. withdrawal of antiplatelets 260b BADRAWY MRCP Revision
  522. 522. Alport's syndrome inheritance 261a BADRAWY MRCP Revision
  523. 523. X-linked dominant (in the majority) 261b BADRAWY MRCP Revision
  524. 524. Keloid scars - more common in who and what body part? 262a BADRAWY MRCP Revision
  525. 525. young, black, male adults on the sternum 262b BADRAWY MRCP Revision
  526. 526. Ankylosing spondylitis: CFs 263a BADRAWY MRCP Revision
  527. 527. Features - the 'A's • Apical fibrosis (CXR) • Anterior uveitis • Aortic regurgitation • Achilles tendonitis • AV node block • Amyloidosis • And cauda equina syndrome 263b BADRAWY MRCP Revision
  528. 528. Septic arthritis - most common organism? 264a BADRAWY MRCP Revision
  529. 529. Staphylococcus aureus 264b BADRAWY MRCP Revision
  530. 530. Low levels of which type of complement are associated with SLE? 265a BADRAWY MRCP Revision
  531. 531. C3, C4a and C4b 265b BADRAWY MRCP Revision
  532. 532. What should you check before starting azathioprine? 266a BADRAWY MRCP Revision
  533. 533. Check thiopurine methyltransferase deficiency (TPMT) before treatment 266b BADRAWY MRCP Revision
  534. 534. When to start allopurinol in gout? 267a BADRAWY MRCP Revision
  535. 535. >= 2 attacks in 12 month period. 267b BADRAWY MRCP Revision
  536. 536. Which cytokine is most important in pathophysiology of rheumatoid arthritis? 268a BADRAWY MRCP Revision
  537. 537. TNF 268b BADRAWY MRCP Revision
  538. 538. Nitric oxide - key effects 269a BADRAWY MRCP Revision
  539. 539. Vasodilation - mainly venodilation Inhibits platelet aggregation 269b BADRAWY MRCP Revision
  540. 540. Superiority vs equivalence vs non-inferiority. What sample sizes? 270a BADRAWY MRCP Revision
  541. 541. Superiority trial --> large sample size needed. 270b BADRAWY MRCP Revision
  542. 542. Clotting factors affected by warfarin? 271a BADRAWY MRCP Revision
  543. 543. Mnemonic = 1972 (Simon) - 10, 9, 7 and 2. 271b BADRAWY MRCP Revision
  544. 544. Adrenal cortex - what part releases what? 272a BADRAWY MRCP Revision
  545. 545. Mnemonic GFR - ACD 1) Glomerulosa (outer): Aldosterone 2) Fasciculata (middle): Cortisol 3) Reticularis (on inside): DHEA and androgens 272b BADRAWY MRCP Revision
  546. 546. Obese T2DM with abnormal LFTs - think of what disease? 273a BADRAWY MRCP Revision
  547. 547. non-alcoholic fatty liver disease 273b BADRAWY MRCP Revision
  548. 548. EBV-associated malignancies 274a BADRAWY MRCP Revision
  549. 549. Burkitt's lymphoma Hodgkin's lymphoma nasopharyngeal carcinoma HIV-associated central nervous system lymphomas Hairy leukoplakia (non malignant). 274b BADRAWY MRCP Revision
  550. 550. Associations between hypermetropia/myopia and glaucoma? 275a BADRAWY MRCP Revision
  551. 551. Acute angle closure glaucoma is associated with hypermetropia, where as primary open-angle glaucoma is associated with myopia 275b BADRAWY MRCP Revision
  552. 552. Antiphospholipid syndrome: key triad of features 276a BADRAWY MRCP Revision
  553. 553. arterial/venous thrombosis, miscarriage, livedo reticularis 276b BADRAWY MRCP Revision
  554. 554. Types of cells seen in CLL? 277a BADRAWY MRCP Revision
  555. 555. CLL is caused by a monoclonal proliferation of B-cell lymphocytes 277b BADRAWY MRCP Revision
  556. 556. Atrial natriuretic peptide - effect on vessels? 278a BADRAWY MRCP Revision
  557. 557. Atrial natriuretic peptide - powerful vasodilator 278b BADRAWY MRCP Revision
  558. 558. Most common cause of primary hyperaldosteronism 279a BADRAWY MRCP Revision
  559. 559. Bilateral idiopathic adrenal hyperplasia is the most common cause of primary hyperaldosteronism 279b BADRAWY MRCP Revision
  560. 560. Obesity - NICE bariatric referral cut offs 280a BADRAWY MRCP Revision
  561. 561. NICE bariatric referral cut- offs with risk factors (T2DM, BP etc): > 35 kg/m^2 no risk factors: > 40 kg/m^2 280b BADRAWY MRCP Revision
  562. 562. CT most commonly associated with PBC 281a BADRAWY MRCP Revision
  563. 563. Sjogren's syndrome 281b BADRAWY MRCP Revision
  564. 564. How names of ART drugs relate to function 282a BADRAWY MRCP Revision
  565. 565. HIV drugs, rule of thumb: NRTIs end in 'ine' Pis: end in 'vir' NNRTIs: nevirapine, efavirenz 282b BADRAWY MRCP Revision
  566. 566. Interpreting the ACR results 283a BADRAWY MRCP Revision
  567. 567. in non-diabetics an ACR greater than 30 mg/mmol is considered clinically significant proteinuria in diabetics microalbuminuria (ACR greater than 2.5 mg/mmol in men and ACR greater than 3.5 mg/mmol in women) is considered clinically significant 283b BADRAWY MRCP Revision
  568. 568. Which antiepileptic is safe in breast feeding? 284a BADRAWY MRCP Revision
  569. 569. Breast feeding is acceptable with nearly all anti- epileptic drugs 284b BADRAWY MRCP Revision
  570. 570. ATN or prerenal uraemia? 285a BADRAWY MRCP Revision
  571. 571. In prerenal uraemia think of the kidneys holding on to sodium to preserve volume 285b BADRAWY MRCP Revision
  572. 572. Renal stones on x-ray 286a BADRAWY MRCP Revision
  573. 573. cystine stones: semi- opaque urate + xanthine stones: radio-lucent 286b BADRAWY MRCP Revision
  574. 574. Isoretinoin adverse effects? 287a BADRAWY MRCP Revision
  575. 575. teratogenicity - females MUST be taking contraception low mood dry eyes and lips raised triglycerides hair thinning nose bleeds 287b BADRAWY MRCP Revision
  576. 576. An important and common interaction with statins? 288a BADRAWY MRCP Revision
  577. 577. Statins + erythromycin/clarithromycin - an important and common interaction 288b BADRAWY MRCP Revision
  578. 578. Low CSF glucose but viral aetiology in meningitis? 289a BADRAWY MRCP Revision
  579. 579. Mumps meningitis is associated with a low glucose in up to a third of patients 289b BADRAWY MRCP Revision
  580. 580. Type of bladder cancer association with schistosomiasis 290a BADRAWY MRCP Revision
  581. 581. SchistoSomiaSiS is a risk factor for SquamouS cell bladder cancer 290b BADRAWY MRCP Revision
  582. 582. %tage of people with Hep C developing cirrhosis? 291a BADRAWY MRCP Revision
  583. 583. Liver cirrhosis will develop in around 20-30% of patients over 20-30 years 291b BADRAWY MRCP Revision
  584. 584. Rash on buttocks 292a BADRAWY MRCP Revision
  585. 585. Dermatitis herpetiformis (coeliac dx). 292b BADRAWY MRCP Revision
  586. 586. Obese woman, papilledema/headache 293a BADRAWY MRCP Revision
  587. 587. Benign Intercanial Hypertention. 293b BADRAWY MRCP Revision
  588. 588. Drug induced pneumonitis 294a BADRAWY MRCP Revision
  589. 589. methotrexate or amiodarone. 294b BADRAWY MRCP Revision
  590. 590. foreign travel, macpap rash/flu like illnes 295a BADRAWY MRCP Revision
  591. 591. HIV acute. 295b BADRAWY MRCP Revision
  592. 592. Splenectomy 296a BADRAWY MRCP Revision
  593. 593. need pneumococcal vaccine AT LEAST 2 weeks pre-op and for life. 296b BADRAWY MRCP Revision
  594. 594. Primary hrperparathyroidism 297a BADRAWY MRCP Revision
  595. 595. high Ca, normal/low PO4, normal/high PTH (in elderly). 297b BADRAWY MRCP Revision
  596. 596. Middle aged man with KNEE arthritis 298a BADRAWY MRCP Revision
  597. 597. gonococcal sepsis (older people ➜​ Staph). 298b BADRAWY MRCP Revision
  598. 598. Sarcoidosis, erythema nodosum, arthropathy 299a BADRAWY MRCP Revision