Presented by: Jie Zheng, Debiao Li, Fabio Maggioni, Dana Abendschein, Orlando Simonetti, Gerhard Laub, J Paul Finn, Robert J Gropler, Friedrich M Cavagna

1. Single Session of MR Coronary Angiography and Myocardial Perfusion Imaging Using a New Blood Pool Compound B-22956 (Gadocoletic Acid): Initial Experience in a Porcine Model of Coronary Artery Disease Jie Zheng, Debiao Li, Fabio Maggioni, Dana Abendschein, Orlando Simonetti, Gerhard Laub, J Paul Finn, Robert J Gropler, Friedrich M Cavagna Zheng J et al, Investigative Radiology 2005;40:604-613

2. POSITIVE NON DIAGNOSTIC POSITIVE NON DIAGNOSTIC Diagnostic Decision Tree for Coronary Artery Disease ~ 4.4 m procedures/y Stress ECG Ultrasound $ 400.- rule out CAD medication Stress Perfusion Imaging Nuclear Medicine rule out CAD medication ~ 2.2 m procedures/y X-Ray Coronary Angiography or IVUS $ 300.- ~ 13 m procedures/y Radiation Invasive NEGATIVE NEGATIVE $ 700.- >$ 3,000.-

6. MPR Images (Siemens Symphony 1.5T) after 0.125 mmol/kg Injection of B-22956/1 [ Res. : 0.7  0.7  0.7 mm 3 ] 1 min postcontrast 33 min postcontrast 17 min postcontrast RCA

7. Res. : 1.0  1.0  2.0 (1.0) mm 3 Volume Rendering 3D MR Coronary Angiography in Pigs after B-22956/1 (0.1 mmol/kg b.w.) RCA RCA LAD LCx

8. B-22956/1 0.02 mmol/kg 2.7 s 6.4 s 9.1 s 16.4 s 20.0 s 23.6 s Conventional Gadolinium (FDA approved MRI contrast agent) ® 0.04 mmol/kg 2.4 s 5.6 s 8.0 s 14.4 s 17.6 s 20.8 s Myocardial Perfusion Imaging in Pig @ 1.5T (IR-True FISP TR/TE/  : 3.5/1.8/70°)

10. Pig 2: LCx, Mild Stenosis < 50% LCx LAD X-ray 50-70% Post-BH Post-NAV

11. Pig 2: RCA, Moderate Stenosis 50-70% 50-70% X-ray Post-BH Post-NAV

12. Pig 1: RCA, High Grade Stenosis > 95% RCA X-ray RCA Post-NAV

13. Pig 1: RCA, Perfusion High Grade Stenosis > 95% Low Perfusion in RCA Normal Perfusion in LAD LV RV LAD RCA