2. Definition of hemoptysisDefinition of hemoptysis
Causes ofof hemoptysishemoptysisCauses
Differential diagnosis of hemoptysisof hemoptysisDifferential diagnosis
Diagnosis of hemoptysisof hemoptysisDiagnosis
Treatment of hemoptysisof hemoptysisTreatment
ContentsContents
3. Pulmonary Bleeding
Pulmonary Bleeding (or pulmonary haemorrhage) is
an acute bleeding from the lung, from the upper respiratory tract and
the trachea, and the alveoli. When evident clinically, the condition is
usually massive.[1] The onset of pulmonary hemorrhage is characterized
by cough productive of blood (hemoptysis) and worsening of oxygenation
leading to cyanosis.[1] Treatment should be immediate and should include
tracheal suction, oxygen, positive pressure ventilation, and correction of
underlying abnormalities (e.g. disorders of coagulation). A blood
transfusion may be necessary.
4. HemoptysisHemoptysis is defined as coughing of bloodis defined as coughing of blood
originating from below the vocal cords.originating from below the vocal cords.
The wordword "hemoptysis"The "hemoptysis" comes fromfrom thethe GreekGreekcomes
"haima" meaning "blood“ & "ptysis" which means "a"haima" meaning "blood“ & "ptysis" which means "a
spitting".spitting".
Hemoptysis can range fromHemoptysis can range from blood-streakingblood-streaking ofof
sputum to the presence of gross blood in the absencesputum to the presence of gross blood in the absence
of any accompanying sputum.of any accompanying sputum.
DefinitionDefinition
5. Life threateningthreatening (or)(or) MassiveMassive hemoptysishemoptysisLife isis
defined as coughing of blood > 150 ml/time (or)blood > 150 ml/time (or) > 600> 600defined as coughing of
ml/24 hours.ml/24 hours.
Only 5% of hemoptysishemoptysis isis massiveOnly 5% of massive but mortality isbut mortality is 80%.80%.
DefinitionDefinition
10. Sources:Sources:
1.1. Bronchial circulation.circulation.Bronchial
2.2. Pulmonary circulation.Pulmonary circulation.
3.3. Anatomizes between pulmonary & bronchialbetween pulmonary & bronchial circulation.circulation.Anatomizes
Mechanisms:Mechanisms:
1.1. Vessel engorgement.engorgement.Vessel
2.2. Erosion (or) rupture of vessels.Erosion (or) rupture of vessels.
3.3. Mucosal ulceration.ulceration.Mucosal
4.4. Vascular granulation tissue.granulation tissue.Vascular
Mechanism & Sources of HemoptysisHemoptysisMechanism & Sources of
11. Make sure that thisthis isis True Hemoptysis.Make sure that True Hemoptysis.
Identify the SeverityIdentify the Severity of hemoptysis.of hemoptysis.
Clinical cluesclues inin HistoryClinical History & Examination.& Examination.
Diagnostic Investigations.Diagnostic Investigations.
Appropriate Treatment.Appropriate Treatment.
Clinical Approach for Management ofClinical Approach for Management of
HemoptysisHemoptysis
12. Important points to address in HistoryImportant points to address in History
Clinical CluesCluesClinical Suggested DiagnosisSuggested Diagnosis
Anticoagulant useuseAnticoagulant Medication effect, coagulation disordercoagulation disorderMedication effect,
Association with mensesAssociation with menses Catamenial hemoptysishemoptysisCatamenial
Dyspnea on exertion, fatigue,fatigue, orthopnea,
PND, frothy pink sputum
orthopnea,Dyspnea on exertion,
PND, frothy pink sputum
Congestive heart failure,failure, LtLt V.V. dysfunction,dysfunction, MSMSCongestive heart
Fever, productive coughproductive coughFever, URTI, acute bronchitis,acute bronchitis, pneumonia,pneumonia, lung abscesslung abscessURTI,
History of breast,breast, colon,colon, oror renalrenal cancerscancersHistory of Endobronchial metastatic lung diseasemetastatic lung diseaseEndobronchial
History of chronic lung disease,chronic lung disease, recurrentrecurrentHistory of
LRTI, cough with copious purulent sputumsputumLRTI, cough with copious purulent
Bronchiectasis, lung abscesslung abscessBronchiectasis,
Melena, alcoholism,alcoholism, chronic use ofchronic use of NSAIDsNSAIDsMelena, Gastritis, gastric orgastric or peptic ulcer,peptic ulcer, esophagealesophageal varicesvaricesGastritis,
Pleuritic chest pain,pain, calf tendernesscalf tendernessPleuritic chest Pulmonary embolism or infarctioninfarctionPulmonary embolism or
Tobacco useTobacco use Acute bronchitis, chronic bronchitis,chronic bronchitis, lung Ca,lung Ca, pneumoniapneumoniaAcute bronchitis,
Toxic symptomsToxic symptoms TuberculosisTuberculosis
Weight losslossWeight Emphysema, lung cancer,lung cancer, TB,TB, bronchiectasis,bronchiectasis, lung abscesslung abscessEmphysema,
13. True Hemoptysis Versus
Spurious (False) Hemoptysis
True Hemoptysis Versus
Spurious (False) Hemoptysis
True hemoptysisTrue hemoptysis False hemoptysisFalse hemoptysis
Below vocal cordscordsBelow vocal Above vocal cordscordsAbove vocal
Persists as blood tinged sputumblood tinged sputumPersists as Does not persistnot persistDoes
May be mixed with sputumMay be mixed with sputum Not mixed with sputumNot mixed with sputum
History of cardiopulmonary diseaseHistory of cardiopulmonary disease Obvious by ENT examinationObvious by ENT examination
CXR may be abnormalCXR may be abnormal Normal CXRCXRNormal
14. Hemoptysis Versus HematemsisHemoptysis Versus Hematemsis
HemoptysisHemoptysis HematemsisHematemsis
Coughing of bloodCoughing of blood Vomiting of bloodVomiting of blood
History of cardiopulmonary diseaseHistory of cardiopulmonary disease History of GIT diseaseHistory of GIT disease
Bright red in colorred in colorBright Dark brown in colorDark brown in color
Sputum remains blood stainedblood stained
after the attack for few days
Sputum remains
after the attack for few days
Usually followed by melenaUsually followed by melena
Mixed with sputumMixed with sputum Mixed with gastric contentscontentsMixed with gastric
Blood is frothyfrothyBlood is AirlessAirless
AlkalineAlkaline AcidicAcidic
Sputum contains hemosedrin
laden macrophages
Sputum contains hemosedrin
laden macrophages
NoNo
24. Advantages:Advantages:
1)Tomography is valuable in selected cases1)Tomography is valuable in selected cases to betterto better show theshow the
presencepresence
of lung cavities, solid masses,solid masses, and mediastinaland mediastinal & hilar& hilar LDN.LDN.of lung cavities,
2)Its2)Its complementary use with FOB givescomplementary use with FOB gives a greatera greater positive yield ofpositive yield of
pathology & is usefuluseful for excluding malignancy in high-risk patients.for excluding malignancy in high-risk patients.pathology & is
3)Allows3)Allows application of specialapplication of special imaging techniques:imaging techniques: e.g.,e.g.,
HRCT (1-3mm thickness section) →BronchiectasisHRCT (1-3mm thickness section) →Bronchiectasis
Spiral CT with pulmonary angiography →PESpiral CT with pulmonary angiography → PE
DiagnosisDiagnosis
Computed Tomographic Scan (CT)Computed Tomographic Scan (CT)
28. Advantages:Advantages:
1.1. It is diagnosticdiagnostic for centralfor central endobronchialendobronchial lesions.lesions.It is
2.2. Allows direct visualization of the bleeding site.direct visualization of the bleeding site.Allows
3.3. Permits tissue biopsy,tissue biopsy, bronchialbronchial lavage,lavage, or brushings for pathologicor brushings for pathologicPermits
diagnosis.diagnosis.
4.4. FOB also can provide direct therapy in casestherapy in cases of non massiveof non massiveFOB also can provide direct
hemoptysis:hemoptysis:
Instillation of diluted adrenaline.Instillation of diluted adrenaline.
Iced cooled saline.Iced cooled saline.
Wedging & temponade →Fogarty catheterWedging & temponade → balloonFogarty catheter balloon
DiagnosisDiagnosis
Fiberoptic Bronchoscopy (FOB)Fiberoptic Bronchoscopy (FOB)
36. Management ofof HemoptysisHemoptysisManagement
GoalGoal ::
1.1. Evaluate the severity of hemoptysis.hemoptysis.Evaluate the severity of
2. Airway protection & patency.2. Airway protection & patency.
3. Identify the site of3. Identify the site of bleeding.bleeding.
4. Protect the contralateral un involved lung.4. Protect the contralateral un involved lung.
5. Stop the bleeding.5. Stop the bleeding.
6. Treatment6. Treatment ofof the cause ofthe cause of bleeding.bleeding.
38. Management of MassiveMassiveManagement of
HemoptysisHemoptysis
I.I. MedicalMedical ::
Endotacheal tube (single wide bore (or) double lumen).double lumen).Endotacheal tube (single wide bore (or)
Position of the patientthe patient sitting (or)sitting (or) bleeding side downbleeding side downPosition of
Large bore IV line fluids,fluids, blood transfusionblood transfusion (EXCEPT??)Large bore IV line (EXCEPT??)
Supplemental Oxygen/ Mechanical ventilation.Mechanical ventilation.Supplemental Oxygen/
Avoid cough suppressants (if(if necessarynecessary Benzodiazepine).Benzodiazepine).Avoid cough suppressants
Pitressin (Vasopressin) 0.2-0.4 units/min.0.2-0.4 units/min. IV.IV.Pitressin (Vasopressin)
39. Management of MassiveMassiveManagement of
HemoptysisHemoptysis
II.II. SurgicalSurgical ::
Emergency resection forEmergency resection for
bronchogenic mass.bronchogenic mass.
Resection ofof bronchogenicbronchogenicResection
mass after patientmass after patient
stabilization.stabilization.
Surgical resection forSurgical resection for
aspergilloma.aspergilloma.
40. Management of MassiveMassiveManagement of
HemoptysisHemoptysis
III. EndobronchialIII. Endobronchial ::
Identify: SIdentify: Source, Rource, Rate & to Sate & to Slow (or) Alow (or) Arrest bleeding.rrest bleeding.
43. IV.Endovascular:IV. Endovascular:
First results of embolization were published in 1973embolization were published in 1973.First results of .
In most patients
bronchial arteries
the bleeding originates fromIn most patients the bleeding originates from
bronchial arteries rather than pulmonary arteries.rather than pulmonary arteries.
Transcatheter embolization is effective in immediateTranscatheter embolization is effective in immediate
control ofof massive hemoptysismassive hemoptysis (73% -(73% - 98%).98%).control
Recurrence may be caused by:Recurrence may be caused by:
Incomplete embolization of artery.Incomplete embolization of artery.
Recanalization of previously embolized artery.Recanalization of previously embolized artery.
Revascularization through collateral circulation.circulation.Revascularization through collateral
Progression of basic lung disease.lung disease.Progression of basic
Management of MassiveMassiveManagement of
HemoptysisHemoptysis
44. Management of MassiveMassiveManagement of
HemoptysisHemoptysis
ICU AdmissionICU Admission
Conservative Medical CareConservative Medical Care
Rigid BronchoscopeRigid Bronchoscope
Hemoptysis stopHemoptysis stop
Investigate the causeInvestigate the cause
Hemoptysis did not stopHemoptysis did not stop
Surgical/EmbolizationSurgical/Embolization