Physio Gi Hormones13.

Endocrine Control of Gastrointestinal Function Dr.Mohammad Shaikhani

GI Hormones Glucose, AA Fatty acids Duodenum Jejunum Insulin secretion Gastric acid secretion GIP Acid fat Duodenum Pepsin secretion Pancreatic juice secretion enzymes bicarbonate Pancreatic exocirne growth Secretin Peptides, AA Fatty acids>8C Acid Duodenum Jejunum Gall Bladder contraction Pancreatic juice secretion enzyme bicarbonate Pancreatic exocirne growth CCK Peptides, AA Distention Vagal activity Antrum duodenum Gastric acid secretion Growth of oxyntic gland mucosa Gastrin Secretion stimulus Release site Action Hormone

GI Hormones Glucose Fat Ileum unknown Enteroglucagon Protein Fat Glucose Pancreas Pancreatic juice secretion enzyme bicarbonate Pancreatic polypeptide Unknown Duodenum Jejunum Gastric and duodenal motility Motilin Secretion stimulus Release site Action Peptide

Neurocrines Gastric mucosa Muscosa and smooth muscle of GI tract Stimulates gastrin secretion Stimulates smooth muscle contraction Inhibits intestinal secretion Bombesin or GRP Enkephalins Duodenum Jejunum Relaxes sphincters Relaxes gut circular muscle Stimulates intestinal secretion Simulates pancreatic secretion VIP Release site Action Peptide

Activation of pancreatic proteases in small intestine ,[object Object]

Hormone secretions of small intestine: CCK ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Primarily duodenal mucosa Actions Stimuli for secretion Site of secretion

CCK: most important stimulus for gall bladder contraction & release of bile into small intestine

Hormone secretions of the small intestine: secretin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Primarily duodenal mucosa Actions Stimuli for secretion Site of secretion

Hormone secretions of the small intestine: CCK ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hormone secretions of the small intestine: Gastrin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hormone secretions of the small intestine: secretin ,[object Object],[object Object],[object Object]

Hormone secretions of the small intestine: VIP ,[object Object],[object Object],[object Object],[object Object]

Hormone secretions of the small intestine: Motilin ,[object Object],[object Object],[object Object],[object Object],[object Object]

Hormone secretions of the small intestine: GIP ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GLP-1: effects in humans GLP-1 is secreted from L-cells of the jejunum and ileum That in turn… ,[object Object],[object Object],[object Object],Long-term effects in animal models: ,[object Object],[object Object],[object Object],Drucker. Curr Pharm Des. 2001 Drucker. Mol Endocrinol . 2003 After food ingestion…

Hormone secretions of the SI : Ghrelin ,[object Object],[object Object],[object Object],[object Object]

Physio Gi Hormones13.

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