SlideShare ist ein Scribd-Unternehmen logo
1 von 31
Downloaden Sie, um offline zu lesen
BioWorma
WHAT IS IT?
Duddingtonia flagrans
A natural strain of fungus isolated from the
environment, found around the world, with application
as a biological control for larvae of parasitic
nematodes of grazing animals.
WHY DO WE NEED IT?
Duddingtonia flagrans
• Resistance to anthelmintics is getting worse all the time
• Need for reduced reliance on chemicals to control worms.
• Emergence of integrated parasite management (IPM)
programs.
HOW DO WE USE IT?
Duddingtonia flagrans
• Firstly complete Faecal Egg Count (FEC)
• Based on FEC results, treat the animals with an effective
chemical wormer/anthelmintic
• Move animals onto low-worm pasture
• Administer D. flagrans in daily rations
HOW DOES IT WORK?
Duddingtonia flagrans
• By feeding a supplement containing inert fungal spores
which pass into the manure, having no effect within the
animal.
• Breaks the parasites’ life cycle by trapping, paralysing and
consuming infective larvae within the animal’s manure.
• Equally-effective against resistant parasites
• D. flagrans is a natural organism isolated in Australia by
CSIRO in early 1990’s
• Products are safe for animals, people and the environment
• Products are palatable, easy to use and have good shelf
life.
Duddingtonia flagrans
Duddingtonia flagrans spore
Duddingtonia flagrans
Trapping network
Duddingtonia flagrans
8 hours post capture
Duddingtonia flagrans
48 hours post capture
Livamol® is the ideal delivery vehicle for BioWorma®, providing a
nutritious base of proteins, energy plus added vitamins and minerals which
are important for the development and maintenance of immunity of young,
growing and grazing animals.
Animals receiving adequate feed, maintaining good condition through good
nutrition are better able to cope with parasitism and this has a positive
impact on their resistance and resilience to worms.
CATTLE TRIALS
GOAT
TRIALS
SHEEP TRIALS
Commercially, the most important roundworms/nematodes for
cattle, sheep & goats are:
• Haemonchus spp. - No.1 in the world and occurs in warm and moist regions,
mostly mixed infections and occurs globally
• Teladorsagia (Ostertagia) spp. - No.1 in the world in temperate climates, mostly
mixed infections and occurs globally
• Trichostrongylus spp. - Mostly in mixed infections, globally
• Nematodirus spp. - Mainly temperate climate, mostly mixed infections, globally
• Cooperia spp. - Mainly in warm and moist regions, mostly mixed infections, globally
Mixed infections = several worm species, as above infecting the host animal at
the same time.
HORSE
TRIALS
Commercially, the most important roundworms/nematodes
for horses are:
•Cyathostomins (small strongyles (small red worms or cyathostomes) - No.1 problem in horses
worldwide. Mostly in mixed infections.
•Parascaris equorum. Ascarids - A serious problem, particularly for young animals, globally.
•Strongylus spp. - One of the most harmful parasites of horses. Mostly in mixed infections.
•Strongyloides westeri - A serious threat for young foals, mainly in warm and moist regions,
globally.
•Trichostrongylus axei - A serious problem worldwide, particularly for young animals.
•Habronema spp. - Can be regionally quite important. Found globally.
Mixed infections = several worm species as above infecting the host animal at
the same time.
EXOTIC
ANIMALS
Slides courtesy
Dr Jim Miller
(LSU) & Dr
Deidre Fontenot
(DAK)
ZOO ANIMALS
(a happy customer)
Duddingtonia flagrans reduces the number of gastrointestinal
nematodes (GIN) larvae on pasture, which is significantly
greater than a chemical wormer can do within the animal
(overall averages below):
84%
HORSES
81%
CATTLE
86%
GOATS
68%
SHEEP
There is widespread chemical resistance and
multi-resistance in production animals (sheep, cattle & goats)
including:
Haemonchus (Barber’s Pole or wire worm),
Teladorsagia (Brown stomach worm),
Trichlostronglus (Black Scour or Hair worm),
Cooperia spp. (Intestinal Worm),
Nematodirus (Thread-necked Worm)
The extent of resistance is best documented in production animals and a
recent survey of sheep in Australia (Playford et al., 2014) found widespread
resistance in the common sheep parasites (Teladorsagia,Trichostrongylus
and Haemonchus) to broad-spectrum anthelmintics:
96% prevalence for benzimidazoles
96% prevalence for levamisole
87% prevalence for ivermectin
77% prevalence for abamectin
54% prevalence for moxidectin
Study published by Meat & Livestock Australia Limited
(Lane et al., 2015) estimates the total losses per annum due
to internal parasites:
• Sheep $A436 million ($US327m/$EU305m) with production losses ranging from $1.29 - $28.29
per animal
• Cattle $A93.6 million ($US70m/$EU66m) with production losses ranging from $0.44 - $3.59 per
animal
• Goats $A2.54 million ($US1.9m/$EU1.8m) with production losses ranging from $0 - $5.34 per
animal
Separately there is no production loss data for horses but the estimated annual costs of worming
ranges from $A15.00 - $120.00 per animal.
Did you know: It has been estimated 10% of
the parasite population is within the host animal
vs 90% is on the pasture.
http://www.wormboss.com.au/tests-tools/management-tools/drench-resistance/using-refugia-to-prolong-drench-life.php
Duddingtonia flagrans
• If 10% of worms are within the animal and a wormer is
95% (?) effective: 10 x 0.95% = 9.5% reduction
• If 90% worms are on pasture and Df is 70% effective:
90% x 0.70 = 63% (7 times more) via manure
Duddingtonia flagrans
The Duddingtonia project
THINGS WE’VE HAD TO CONSIDER (Overnight success)
 Optimisation of spore production:
 Dosage & delivery:
 Product formulation & manufacturing:
 Shelf life studies:
 Efficacy trials (GCP):
 Safety studies in target animals (GCP):
 Residue studies (GLP) and exposure models:
 DNA fingerprinting and genome:
 Culture collection lodgement:
 Toxicology studies in lab animals (GLP):
 Physical testing (GLP):
 Environmental safety:
 Intellectual Property:
 Submission to Regulators
DONE
DONE
DONE
DONE
DONE
DONE
DONE
DONE
DONE
DONE
DONE
DONE
DONE
ONGOING
Active Constituents: Each gram contains:
a minimum of 500,0000 chlamydospores
Daily feeding rates: 6g/100kg bodyweight
USA 0.1 oz/each 100lbs bodyweight
Available: Veterinarians, Premixers and
Feedmills
Withholding periods: Meat & Milk: 0 days
Packsizes: 2kg,7.5kg,15kg, 25kg
USA – 15lbs and 30lbs pails
Active Constituents: Each gram contains: a
minimum of 30,000 chlamydospores
Daily feeding rates: 100g/100kg bodyweight
USA 1.6 oz/each 100lbs bodyweight
Available: Stores & End users (farmers etc)
Withholding periods: Meat & Milk: 0 days
Packsizes: 7.5kg and 15kg pails
USA – 15lbs and 30lbs pails
1.Treat animals with a suitable oral, injectable, or pour-on
wormer/anthelmintic to rid the animals of worms, then
begin administration of BioWorma®.
2. Move the treated animals onto low worm pasture (that
is, pasture that has not been grazed by the same animal
species for a minimum of 6 weeks).
3. The most worm-susceptible are young animals (from 3
months up to 18-24 months of age) and periparturient
females (last month of pregnancy and while producing
milk), as they are the most likely to have less resistance to
worm infestation due to low immunity. Do not
underestimate pasture contamination by adult stock, even
animals with low fecal egg counts (FECs), considering the
volume of fecal material adult stock place on pasture.
4. Thoroughly mix BioWorma® with feed, feed
supplements, premixes or concentrates, and commence
daily administration of the resultant mixture to minimize
pasture infectivity and maintain the low worm status of the
animals.
5. BioWorma® will begin to work within the first day and
may be fed continuously when warm, moist climatic
conditions are conducive to parasitic nematode activity.
6. BioWorma® is for use during periods when conditions
are conducive to larval development and transmission
onto pasture at temperatures above 40° Fahrenheit (5°
Celsius).
7. Use BioWorma® in conjunction with the specified
worm management strategy for your area by contacting
your Veterinarian, Animal Health Advisor or Government
Advisory groups for a strategic Integrated Parasite
Management (IPM) plan. It is important to consider the
principles of refugia.
8. Periodically check the worm burden and monitor the
effectiveness of the worm management system. Options
include fecal egg counts (FECs), the fecal egg count
reduction test (FECRT) and/or identifying worm species
by using fecal larval cultures (FLCs). Re-treatment with
an effective chemical wormer may be indicated (consult
your Veterinarian).
More Information:
www.bioworma.com

Weitere ähnliche Inhalte

Was ist angesagt? (20)

Galenicals ahd kerala
Galenicals ahd keralaGalenicals ahd kerala
Galenicals ahd kerala
 
Wound management
Wound managementWound management
Wound management
 
Calf diarrhoea
Calf diarrhoeaCalf diarrhoea
Calf diarrhoea
 
Lesson 8 artificial insemination in the equine
Lesson 8 artificial insemination in the equineLesson 8 artificial insemination in the equine
Lesson 8 artificial insemination in the equine
 
Guinea fowl farming
Guinea fowl farmingGuinea fowl farming
Guinea fowl farming
 
Common causes of abortions in dairy animals and their management
Common causes of abortions in dairy animals and their managementCommon causes of abortions in dairy animals and their management
Common causes of abortions in dairy animals and their management
 
Small rodents
Small rodentsSmall rodents
Small rodents
 
Camel pox
Camel poxCamel pox
Camel pox
 
Pig Dieases
Pig DieasesPig Dieases
Pig Dieases
 
Parasite control in sheep
Parasite control in sheepParasite control in sheep
Parasite control in sheep
 
Louces
LoucesLouces
Louces
 
unit sheep and goat behavior
unit sheep and goat behaviorunit sheep and goat behavior
unit sheep and goat behavior
 
Bed bugs Presentation
Bed bugs PresentationBed bugs Presentation
Bed bugs Presentation
 
Store grain pests A Lecture By Mr Allah Dad Khan
Store grain pests  A Lecture By Mr Allah Dad KhanStore grain pests  A Lecture By Mr Allah Dad Khan
Store grain pests A Lecture By Mr Allah Dad Khan
 
Lice of pet animals
Lice of pet animalsLice of pet animals
Lice of pet animals
 
Rinderpest vpm
Rinderpest vpmRinderpest vpm
Rinderpest vpm
 
GLANDERS
GLANDERSGLANDERS
GLANDERS
 
Post parturient-hemoglobinuria
Post parturient-hemoglobinuriaPost parturient-hemoglobinuria
Post parturient-hemoglobinuria
 
Avian Crop Affections
Avian Crop AffectionsAvian Crop Affections
Avian Crop Affections
 
Hypomagnesaemia
HypomagnesaemiaHypomagnesaemia
Hypomagnesaemia
 

Ähnlich wie BioWorma

Managing Internal Parasites in Sheep and Goats
Managing Internal Parasites in Sheep and GoatsManaging Internal Parasites in Sheep and Goats
Managing Internal Parasites in Sheep and GoatsGardening
 

Ähnlich wie BioWorma (20)

10 Things You Should Know About Parasites
10 Things You Should Know About Parasites10 Things You Should Know About Parasites
10 Things You Should Know About Parasites
 
Managing Internal Parasites in Sheep and Goats
Managing Internal Parasites in Sheep and GoatsManaging Internal Parasites in Sheep and Goats
Managing Internal Parasites in Sheep and Goats
 
FAMACHA For the Control of Barber Pole Worm (Haemonchus contortus) in Small R...
FAMACHA For the Control of Barber Pole Worm (Haemonchus contortus) in Small R...FAMACHA For the Control of Barber Pole Worm (Haemonchus contortus) in Small R...
FAMACHA For the Control of Barber Pole Worm (Haemonchus contortus) in Small R...
 
Internal Parasites Update
Internal Parasites UpdateInternal Parasites Update
Internal Parasites Update
 
Flea control
Flea controlFlea control
Flea control
 
Flea control
Flea controlFlea control
Flea control
 
Natural parasite control in small ruminants
Natural parasite control in small ruminantsNatural parasite control in small ruminants
Natural parasite control in small ruminants
 
Proper use of dewormers
Proper use of dewormersProper use of dewormers
Proper use of dewormers
 
Worm Wisdom
Worm WisdomWorm Wisdom
Worm Wisdom
 
Fleas Integrated Pest Management
Fleas Integrated Pest ManagementFleas Integrated Pest Management
Fleas Integrated Pest Management
 
Beyond antibiotics: minimizing drug use in small ruminants
Beyond antibiotics: minimizing drug use in small ruminantsBeyond antibiotics: minimizing drug use in small ruminants
Beyond antibiotics: minimizing drug use in small ruminants
 
Management of Internal Parasites in Small Ruminants
Management of  Internal Parasites in Small RuminantsManagement of  Internal Parasites in Small Ruminants
Management of Internal Parasites in Small Ruminants
 
MinimizingDrugUse
MinimizingDrugUseMinimizingDrugUse
MinimizingDrugUse
 
Pasture management to control internal parasites
Pasture management to control internal parasitesPasture management to control internal parasites
Pasture management to control internal parasites
 
IPM in Small Ruminants
IPM in Small RuminantsIPM in Small Ruminants
IPM in Small Ruminants
 
Parasites in Goats
Parasites in GoatsParasites in Goats
Parasites in Goats
 
Internal Parasites: What will work in 2018?
Internal Parasites: What will work in 2018?Internal Parasites: What will work in 2018?
Internal Parasites: What will work in 2018?
 
IPM
IPMIPM
IPM
 
Deworming right
Deworming rightDeworming right
Deworming right
 
Plant Health Care for Interior - Sclar
Plant Health Care for Interior - SclarPlant Health Care for Interior - Sclar
Plant Health Care for Interior - Sclar
 

Mehr von University of Maryland Extension Small Ruminant Program

Mehr von University of Maryland Extension Small Ruminant Program (20)

Making a profit with small ruminants (sheep/goats)
Making a profit with small ruminants (sheep/goats)Making a profit with small ruminants (sheep/goats)
Making a profit with small ruminants (sheep/goats)
 
Health Care of Pregnant ewes
Health Care of Pregnant ewesHealth Care of Pregnant ewes
Health Care of Pregnant ewes
 
Hoof Care of Sheep/Goats
Hoof Care of Sheep/GoatsHoof Care of Sheep/Goats
Hoof Care of Sheep/Goats
 
Proper deworming methods
Proper deworming methodsProper deworming methods
Proper deworming methods
 
Show me the signs
Show me the signsShow me the signs
Show me the signs
 
Copper: its complicated
Copper: its complicatedCopper: its complicated
Copper: its complicated
 
Pregnancy Toxemia in sheep
Pregnancy Toxemia in sheepPregnancy Toxemia in sheep
Pregnancy Toxemia in sheep
 
Goat Hoof Health
Goat Hoof HealthGoat Hoof Health
Goat Hoof Health
 
Goats 101
Goats 101Goats 101
Goats 101
 
Marketing them
Marketing themMarketing them
Marketing them
 
Keeping them healthy
Keeping them healthyKeeping them healthy
Keeping them healthy
 
Feeding them
Feeding themFeeding them
Feeding them
 
Raising them
Raising themRaising them
Raising them
 
Sheep 101
Sheep 101Sheep 101
Sheep 101
 
Dewormers and Dewormer Resistance: Introduction to Eye Scores
Dewormers and Dewormer Resistance: Introduction to Eye ScoresDewormers and Dewormer Resistance: Introduction to Eye Scores
Dewormers and Dewormer Resistance: Introduction to Eye Scores
 
FAMACHA eye anemia system
FAMACHA eye anemia systemFAMACHA eye anemia system
FAMACHA eye anemia system
 
Five Point Check
Five Point CheckFive Point Check
Five Point Check
 
Integrating Anthelmintics, FAMACHA and Other Alternative Measures for Control...
Integrating Anthelmintics, FAMACHA and Other Alternative Measures for Control...Integrating Anthelmintics, FAMACHA and Other Alternative Measures for Control...
Integrating Anthelmintics, FAMACHA and Other Alternative Measures for Control...
 
Economical Parasite Control
Economical Parasite ControlEconomical Parasite Control
Economical Parasite Control
 
Growth and performance of lambs and kids on pasture
Growth and performance of lambs and kids on pastureGrowth and performance of lambs and kids on pasture
Growth and performance of lambs and kids on pasture
 

Kürzlich hochgeladen

Riddhi Kevadiya. WILLIAM SHAKESPEARE....
Riddhi Kevadiya. WILLIAM SHAKESPEARE....Riddhi Kevadiya. WILLIAM SHAKESPEARE....
Riddhi Kevadiya. WILLIAM SHAKESPEARE....Riddhi Kevadiya
 
Drug Information Services- DIC and Sources.
Drug Information Services- DIC and Sources.Drug Information Services- DIC and Sources.
Drug Information Services- DIC and Sources.raviapr7
 
How to Manage Cross-Selling in Odoo 17 Sales
How to Manage Cross-Selling in Odoo 17 SalesHow to Manage Cross-Selling in Odoo 17 Sales
How to Manage Cross-Selling in Odoo 17 SalesCeline George
 
Department of Health Compounder Question ‍Solution 2022.pdf
Department of Health Compounder Question ‍Solution 2022.pdfDepartment of Health Compounder Question ‍Solution 2022.pdf
Department of Health Compounder Question ‍Solution 2022.pdfMohonDas
 
SOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptx
SOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptxSOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptx
SOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptxSyedNadeemGillANi
 
Ultra structure and life cycle of Plasmodium.pptx
Ultra structure and life cycle of Plasmodium.pptxUltra structure and life cycle of Plasmodium.pptx
Ultra structure and life cycle of Plasmodium.pptxDr. Asif Anas
 
The Stolen Bacillus by Herbert George Wells
The Stolen Bacillus by Herbert George WellsThe Stolen Bacillus by Herbert George Wells
The Stolen Bacillus by Herbert George WellsEugene Lysak
 
Protein Structure - threading Protein modelling pptx
Protein Structure - threading Protein modelling pptxProtein Structure - threading Protein modelling pptx
Protein Structure - threading Protein modelling pptxvidhisharma994099
 
Diploma in Nursing Admission Test Question Solution 2023.pdf
Diploma in Nursing Admission Test Question Solution 2023.pdfDiploma in Nursing Admission Test Question Solution 2023.pdf
Diploma in Nursing Admission Test Question Solution 2023.pdfMohonDas
 
EBUS5423 Data Analytics and Reporting Bl
EBUS5423 Data Analytics and Reporting BlEBUS5423 Data Analytics and Reporting Bl
EBUS5423 Data Analytics and Reporting BlDr. Bruce A. Johnson
 
Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...
Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...
Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...Dr. Asif Anas
 
Optical Fibre and It's Applications.pptx
Optical Fibre and It's Applications.pptxOptical Fibre and It's Applications.pptx
Optical Fibre and It's Applications.pptxPurva Nikam
 
What is the Future of QuickBooks DeskTop?
What is the Future of QuickBooks DeskTop?What is the Future of QuickBooks DeskTop?
What is the Future of QuickBooks DeskTop?TechSoup
 
3.26.24 Race, the Draft, and the Vietnam War.pptx
3.26.24 Race, the Draft, and the Vietnam War.pptx3.26.24 Race, the Draft, and the Vietnam War.pptx
3.26.24 Race, the Draft, and the Vietnam War.pptxmary850239
 
CapTechU Doctoral Presentation -March 2024 slides.pptx
CapTechU Doctoral Presentation -March 2024 slides.pptxCapTechU Doctoral Presentation -March 2024 slides.pptx
CapTechU Doctoral Presentation -March 2024 slides.pptxCapitolTechU
 
In - Vivo and In - Vitro Correlation.pptx
In - Vivo and In - Vitro Correlation.pptxIn - Vivo and In - Vitro Correlation.pptx
In - Vivo and In - Vitro Correlation.pptxAditiChauhan701637
 
How to Solve Singleton Error in the Odoo 17
How to Solve Singleton Error in the  Odoo 17How to Solve Singleton Error in the  Odoo 17
How to Solve Singleton Error in the Odoo 17Celine George
 
ARTICULAR DISC OF TEMPOROMANDIBULAR JOINT
ARTICULAR DISC OF TEMPOROMANDIBULAR JOINTARTICULAR DISC OF TEMPOROMANDIBULAR JOINT
ARTICULAR DISC OF TEMPOROMANDIBULAR JOINTDR. SNEHA NAIR
 

Kürzlich hochgeladen (20)

Riddhi Kevadiya. WILLIAM SHAKESPEARE....
Riddhi Kevadiya. WILLIAM SHAKESPEARE....Riddhi Kevadiya. WILLIAM SHAKESPEARE....
Riddhi Kevadiya. WILLIAM SHAKESPEARE....
 
Drug Information Services- DIC and Sources.
Drug Information Services- DIC and Sources.Drug Information Services- DIC and Sources.
Drug Information Services- DIC and Sources.
 
Finals of Kant get Marx 2.0 : a general politics quiz
Finals of Kant get Marx 2.0 : a general politics quizFinals of Kant get Marx 2.0 : a general politics quiz
Finals of Kant get Marx 2.0 : a general politics quiz
 
How to Manage Cross-Selling in Odoo 17 Sales
How to Manage Cross-Selling in Odoo 17 SalesHow to Manage Cross-Selling in Odoo 17 Sales
How to Manage Cross-Selling in Odoo 17 Sales
 
Department of Health Compounder Question ‍Solution 2022.pdf
Department of Health Compounder Question ‍Solution 2022.pdfDepartment of Health Compounder Question ‍Solution 2022.pdf
Department of Health Compounder Question ‍Solution 2022.pdf
 
SOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptx
SOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptxSOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptx
SOLIDE WASTE in Cameroon,,,,,,,,,,,,,,,,,,,,,,,,,,,.pptx
 
Ultra structure and life cycle of Plasmodium.pptx
Ultra structure and life cycle of Plasmodium.pptxUltra structure and life cycle of Plasmodium.pptx
Ultra structure and life cycle of Plasmodium.pptx
 
The Stolen Bacillus by Herbert George Wells
The Stolen Bacillus by Herbert George WellsThe Stolen Bacillus by Herbert George Wells
The Stolen Bacillus by Herbert George Wells
 
Protein Structure - threading Protein modelling pptx
Protein Structure - threading Protein modelling pptxProtein Structure - threading Protein modelling pptx
Protein Structure - threading Protein modelling pptx
 
Diploma in Nursing Admission Test Question Solution 2023.pdf
Diploma in Nursing Admission Test Question Solution 2023.pdfDiploma in Nursing Admission Test Question Solution 2023.pdf
Diploma in Nursing Admission Test Question Solution 2023.pdf
 
EBUS5423 Data Analytics and Reporting Bl
EBUS5423 Data Analytics and Reporting BlEBUS5423 Data Analytics and Reporting Bl
EBUS5423 Data Analytics and Reporting Bl
 
Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...
Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...
Unveiling the Intricacies of Leishmania donovani: Structure, Life Cycle, Path...
 
Optical Fibre and It's Applications.pptx
Optical Fibre and It's Applications.pptxOptical Fibre and It's Applications.pptx
Optical Fibre and It's Applications.pptx
 
What is the Future of QuickBooks DeskTop?
What is the Future of QuickBooks DeskTop?What is the Future of QuickBooks DeskTop?
What is the Future of QuickBooks DeskTop?
 
3.26.24 Race, the Draft, and the Vietnam War.pptx
3.26.24 Race, the Draft, and the Vietnam War.pptx3.26.24 Race, the Draft, and the Vietnam War.pptx
3.26.24 Race, the Draft, and the Vietnam War.pptx
 
CapTechU Doctoral Presentation -March 2024 slides.pptx
CapTechU Doctoral Presentation -March 2024 slides.pptxCapTechU Doctoral Presentation -March 2024 slides.pptx
CapTechU Doctoral Presentation -March 2024 slides.pptx
 
Personal Resilience in Project Management 2 - TV Edit 1a.pdf
Personal Resilience in Project Management 2 - TV Edit 1a.pdfPersonal Resilience in Project Management 2 - TV Edit 1a.pdf
Personal Resilience in Project Management 2 - TV Edit 1a.pdf
 
In - Vivo and In - Vitro Correlation.pptx
In - Vivo and In - Vitro Correlation.pptxIn - Vivo and In - Vitro Correlation.pptx
In - Vivo and In - Vitro Correlation.pptx
 
How to Solve Singleton Error in the Odoo 17
How to Solve Singleton Error in the  Odoo 17How to Solve Singleton Error in the  Odoo 17
How to Solve Singleton Error in the Odoo 17
 
ARTICULAR DISC OF TEMPOROMANDIBULAR JOINT
ARTICULAR DISC OF TEMPOROMANDIBULAR JOINTARTICULAR DISC OF TEMPOROMANDIBULAR JOINT
ARTICULAR DISC OF TEMPOROMANDIBULAR JOINT
 

BioWorma

  • 2. WHAT IS IT? Duddingtonia flagrans A natural strain of fungus isolated from the environment, found around the world, with application as a biological control for larvae of parasitic nematodes of grazing animals.
  • 3. WHY DO WE NEED IT? Duddingtonia flagrans • Resistance to anthelmintics is getting worse all the time • Need for reduced reliance on chemicals to control worms. • Emergence of integrated parasite management (IPM) programs.
  • 4. HOW DO WE USE IT? Duddingtonia flagrans • Firstly complete Faecal Egg Count (FEC) • Based on FEC results, treat the animals with an effective chemical wormer/anthelmintic • Move animals onto low-worm pasture • Administer D. flagrans in daily rations
  • 5. HOW DOES IT WORK? Duddingtonia flagrans • By feeding a supplement containing inert fungal spores which pass into the manure, having no effect within the animal. • Breaks the parasites’ life cycle by trapping, paralysing and consuming infective larvae within the animal’s manure. • Equally-effective against resistant parasites
  • 6. • D. flagrans is a natural organism isolated in Australia by CSIRO in early 1990’s • Products are safe for animals, people and the environment • Products are palatable, easy to use and have good shelf life. Duddingtonia flagrans
  • 11. Livamol® is the ideal delivery vehicle for BioWorma®, providing a nutritious base of proteins, energy plus added vitamins and minerals which are important for the development and maintenance of immunity of young, growing and grazing animals. Animals receiving adequate feed, maintaining good condition through good nutrition are better able to cope with parasitism and this has a positive impact on their resistance and resilience to worms.
  • 15. Commercially, the most important roundworms/nematodes for cattle, sheep & goats are: • Haemonchus spp. - No.1 in the world and occurs in warm and moist regions, mostly mixed infections and occurs globally • Teladorsagia (Ostertagia) spp. - No.1 in the world in temperate climates, mostly mixed infections and occurs globally • Trichostrongylus spp. - Mostly in mixed infections, globally • Nematodirus spp. - Mainly temperate climate, mostly mixed infections, globally • Cooperia spp. - Mainly in warm and moist regions, mostly mixed infections, globally Mixed infections = several worm species, as above infecting the host animal at the same time.
  • 17. Commercially, the most important roundworms/nematodes for horses are: •Cyathostomins (small strongyles (small red worms or cyathostomes) - No.1 problem in horses worldwide. Mostly in mixed infections. •Parascaris equorum. Ascarids - A serious problem, particularly for young animals, globally. •Strongylus spp. - One of the most harmful parasites of horses. Mostly in mixed infections. •Strongyloides westeri - A serious threat for young foals, mainly in warm and moist regions, globally. •Trichostrongylus axei - A serious problem worldwide, particularly for young animals. •Habronema spp. - Can be regionally quite important. Found globally. Mixed infections = several worm species as above infecting the host animal at the same time.
  • 18. EXOTIC ANIMALS Slides courtesy Dr Jim Miller (LSU) & Dr Deidre Fontenot (DAK)
  • 19. ZOO ANIMALS (a happy customer)
  • 20. Duddingtonia flagrans reduces the number of gastrointestinal nematodes (GIN) larvae on pasture, which is significantly greater than a chemical wormer can do within the animal (overall averages below): 84% HORSES 81% CATTLE 86% GOATS 68% SHEEP
  • 21. There is widespread chemical resistance and multi-resistance in production animals (sheep, cattle & goats) including: Haemonchus (Barber’s Pole or wire worm), Teladorsagia (Brown stomach worm), Trichlostronglus (Black Scour or Hair worm), Cooperia spp. (Intestinal Worm), Nematodirus (Thread-necked Worm)
  • 22. The extent of resistance is best documented in production animals and a recent survey of sheep in Australia (Playford et al., 2014) found widespread resistance in the common sheep parasites (Teladorsagia,Trichostrongylus and Haemonchus) to broad-spectrum anthelmintics: 96% prevalence for benzimidazoles 96% prevalence for levamisole 87% prevalence for ivermectin 77% prevalence for abamectin 54% prevalence for moxidectin
  • 23. Study published by Meat & Livestock Australia Limited (Lane et al., 2015) estimates the total losses per annum due to internal parasites: • Sheep $A436 million ($US327m/$EU305m) with production losses ranging from $1.29 - $28.29 per animal • Cattle $A93.6 million ($US70m/$EU66m) with production losses ranging from $0.44 - $3.59 per animal • Goats $A2.54 million ($US1.9m/$EU1.8m) with production losses ranging from $0 - $5.34 per animal Separately there is no production loss data for horses but the estimated annual costs of worming ranges from $A15.00 - $120.00 per animal.
  • 24. Did you know: It has been estimated 10% of the parasite population is within the host animal vs 90% is on the pasture. http://www.wormboss.com.au/tests-tools/management-tools/drench-resistance/using-refugia-to-prolong-drench-life.php Duddingtonia flagrans
  • 25. • If 10% of worms are within the animal and a wormer is 95% (?) effective: 10 x 0.95% = 9.5% reduction • If 90% worms are on pasture and Df is 70% effective: 90% x 0.70 = 63% (7 times more) via manure Duddingtonia flagrans
  • 26. The Duddingtonia project THINGS WE’VE HAD TO CONSIDER (Overnight success)  Optimisation of spore production:  Dosage & delivery:  Product formulation & manufacturing:  Shelf life studies:  Efficacy trials (GCP):  Safety studies in target animals (GCP):  Residue studies (GLP) and exposure models:  DNA fingerprinting and genome:  Culture collection lodgement:  Toxicology studies in lab animals (GLP):  Physical testing (GLP):  Environmental safety:  Intellectual Property:  Submission to Regulators DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE DONE ONGOING
  • 27. Active Constituents: Each gram contains: a minimum of 500,0000 chlamydospores Daily feeding rates: 6g/100kg bodyweight USA 0.1 oz/each 100lbs bodyweight Available: Veterinarians, Premixers and Feedmills Withholding periods: Meat & Milk: 0 days Packsizes: 2kg,7.5kg,15kg, 25kg USA – 15lbs and 30lbs pails
  • 28. Active Constituents: Each gram contains: a minimum of 30,000 chlamydospores Daily feeding rates: 100g/100kg bodyweight USA 1.6 oz/each 100lbs bodyweight Available: Stores & End users (farmers etc) Withholding periods: Meat & Milk: 0 days Packsizes: 7.5kg and 15kg pails USA – 15lbs and 30lbs pails
  • 29. 1.Treat animals with a suitable oral, injectable, or pour-on wormer/anthelmintic to rid the animals of worms, then begin administration of BioWorma®. 2. Move the treated animals onto low worm pasture (that is, pasture that has not been grazed by the same animal species for a minimum of 6 weeks). 3. The most worm-susceptible are young animals (from 3 months up to 18-24 months of age) and periparturient females (last month of pregnancy and while producing milk), as they are the most likely to have less resistance to worm infestation due to low immunity. Do not underestimate pasture contamination by adult stock, even animals with low fecal egg counts (FECs), considering the volume of fecal material adult stock place on pasture. 4. Thoroughly mix BioWorma® with feed, feed supplements, premixes or concentrates, and commence daily administration of the resultant mixture to minimize pasture infectivity and maintain the low worm status of the animals.
  • 30. 5. BioWorma® will begin to work within the first day and may be fed continuously when warm, moist climatic conditions are conducive to parasitic nematode activity. 6. BioWorma® is for use during periods when conditions are conducive to larval development and transmission onto pasture at temperatures above 40° Fahrenheit (5° Celsius). 7. Use BioWorma® in conjunction with the specified worm management strategy for your area by contacting your Veterinarian, Animal Health Advisor or Government Advisory groups for a strategic Integrated Parasite Management (IPM) plan. It is important to consider the principles of refugia. 8. Periodically check the worm burden and monitor the effectiveness of the worm management system. Options include fecal egg counts (FECs), the fecal egg count reduction test (FECRT) and/or identifying worm species by using fecal larval cultures (FLCs). Re-treatment with an effective chemical wormer may be indicated (consult your Veterinarian).