Glomerular Filtration rate and its determinants.pptx
12. eclampsia and severe_preeclampsia_rev_19.5.10.
1. IN PARTNERSHIP WITH
Liverpool School of Tropical Medicine
LiverpoolAssociates in Tropical Health
Eclampsia and severe
preeclampsia
Eclampsia and Severe
Pre-eclampsia
2. Aims
To recognise eclampsia and severe pre-
eclampsia
To practise an effective response to a
woman with eclampsia (fit) or severe
pre-eclampsia
To achieve competence in those skills
3. Principles of management
Stabilise mother and then deliver fetus
Treat and prevent fits
Treat blood pressure
Attention to fluid balance
Be aware of and prevent complications
4. Signs and Symptoms of Pre-Eclampsia
• Headache
• Blurred vision
• Upper epigastric pain
• Hyperreflexia/clonus
Diagnosis:
BP > 140/90
Urine protien +
7. Fitting or unconscious
Call for help
Recovery position
Open and maintain airway
iv access and give magnesium sulphate
1 litre Ringer’s lactate to be given very
slowly iv
8. Magnesium sulphate
The anticonvulsant of choice
Loading dose is given IV and IM
4g given IV (dilutent N/S!)
10g IM (diluent 2% Lignocaine)
Give 5g to each buttock
If unable to give IV loading dose give IM
loading dose only
9. Magnesium Sulphate: Maintenance
dose
IV route
Magnesium sulphate (10g) in 1000 ml normal
Saline IV infusion at rate of 1g/hour
OR
IM route
After loading dose continue with 5 g IM every 4
hours
Continue maintenance dose until 24 hours
after birth or 24 hours after last convulsion
10. Magnesium caution!
Do not give the next dose of magnesium if
Absent knee jerk
Urine output less than 100 mls in last 4
hours
Respiratory rate less than 16 breaths per
minute
11. • If respiratory rate less than 16 breaths /
minute stop magnesium and give
calcium gluconate 1 g iv over 10
minutes
12. Magnesium Sulphate
If convulsions recur give an additional
2-4g iv over 10-15 minutes
Consider giving lower dose (2g) if
patient is small and/ or weight is less
than 70kgs
13. Magnesium sulphate has various
concentrations
For IV injection concentration of
magnesium should not exceed 20%
20% solution=200mg/ml
14. Diazepam
Only use if magnesium not available or
magnesium toxicity develops
15. Blood pressure
Uncontrolled blood pressure leads to
intracranial haemorrhage and death
Monitor
Treat if BP diastolic >110 mm Hg or
systolic >160 mmHg
Nifedipine, hydralazine, labetalol
according to local protocol
16. Delivery
Assess fetal heart, gestational age, lie of the
baby and assess cervix
Vaginal delivery or CS?
Vaginal if no maternal or fetal distress, no
obstetric contraindication and cervix
favourable
CS if repeated fits, fetal distress or
unfavourable cervix
17. Fluid
Careful fluid balance required
Capillaries are ‘leaky’ therefore control fluid
input to prevent pulmonary oedema
Monitor closely via fluid in and output chart
Restrict iv fluids to 30 drops per minute
19. Monitor!
HR
BP
Urine Output
RR
Reflexes
Fluid in and output
Temperature
Fundi
Bloods (platelets, clotting, Hb,
renal function)
20. After delivery
Monitor, monitor, monitor
Remember (pre-)eclampsia get worse or
first fit can occur in post partum period
Continue magnesium for 24 hours after
delivery or after last fit – no need to “tail
off”
22. IN PARTNERSHIP WITH
Liverpool School of Tropical Medicine
LiverpoolAssociates in Tropical Health
RECAP
Recognition of Eclampsia and Severe pre-
eclampsia
Management of fits and blood pressure
Decision on delivery
Monitoring of patient
Complications