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Drug Discovery Forces and Lead Identification

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This document discusses the key principles and processes involved in drug discovery and drug-receptor interactions. It outlines the steps of choosing a disease target, identifying a bioassay to test potential drug candidates, finding and isolating lead compounds, determining a drug's structure and effects, and identifying forces that cause drug-receptor binding such as covalent bonding, hydrogen bonding, and hydrophobic interactions. The goal is to discover and develop safe and effective therapeutic drugs through a scientific process.

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LEAD DISCOVERY AND FORCES INVOLVED IN DRUG INTERACTIONS Presented by: SANCHIT KUMAR SRIVASTAV M.PHARM (PHARMACEUTICAL CHEMISTRY)
CONTENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
INTRODUCTION: Various efforts were made to isolate and purify the active principles of various remedies by using following principles involved in drug discovery & drug development as: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
DRUG TARGET ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Identifying a bioassay ,[object Object],[object Object],[object Object],[object Object]
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Finding a Lead compound ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
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Isolation & Purification ,[object Object],[object Object],[object Object]
Drug Metabolism It involves the Phase-1 and Phase-2 metabolism. Identification of Pharmacophore Once it is established which groups are important for a drug’s activity, we move to the next step- the identification of the lead compound. The pharmacophore summarizes the important functional group which are important for the activity and their relative position in the space with respect to each other.
Toxicity Testing ,[object Object],[object Object],[object Object]
Clinical Trials ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Forces Involved In Drug Receptor Interactions ,[object Object],[object Object],[object Object]
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Drug Discovery Forces and Lead Identification

  • 1. LEAD DISCOVERY AND FORCES INVOLVED IN DRUG INTERACTIONS Presented by: SANCHIT KUMAR SRIVASTAV M.PHARM (PHARMACEUTICAL CHEMISTRY)
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  • 10. Drug Metabolism It involves the Phase-1 and Phase-2 metabolism. Identification of Pharmacophore Once it is established which groups are important for a drug’s activity, we move to the next step- the identification of the lead compound. The pharmacophore summarizes the important functional group which are important for the activity and their relative position in the space with respect to each other.
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Editor's Notes

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