renin angeotensin pharmaclogy

1. 
RENIN ANGIOTENSIN
SYSTEM
sadaqat ali

2. 
 synthesized as a preprohormone (prorenin)
 synthesized and stored in the juxtaglomerular
apparatus of the nephron
 An important modulator of angiotensin production
RENIN

3. 
 Plays a key role in the regulation of
 fluid and electrolyte balance
 arterial blood pressure
 Excessive activity can result in
 hypertension
 disorders of fluid and electrolyte homeostasis
ANGIOTENSIN II

4. 
 Blood Pressure
 Increase BP
 Adrenal Cortex
 stimulate aldosterone synthesis
Actions

5. 
 Kidney
 increase proximal tubular sodium reabsorption
 inhibit the secretion of renin
Actions

6.  Central Nervous System
 increase secretion of vasopressin
 increase secretion of ACTH
 Cell Growth
 mitogenic for vascular and cardiac muscle cells
Actions

7. 
 AT1 receptor → Gq-coupled receptor
 AT2 receptor → nitric oxide mediated
Receptors

8. 
 Angiotensin-Converting Enzyme Inhibitors
 Captopril, enalapril
 Angiotensin Receptor Blockers
 Losartan, valsartan, irbesartan, candesartan,
olmesartan, telmisartan
 Renin Inhibitors
 Aliskiren → Inhibits catalytic activity of renin
Drugs

9. 
 CNS → neurotransmitter
 GIT → transmitter in ENS and as a local hormone
 Involved in behavior, anxiety, depression, nausea, and emesis
 a potent arteriolar vasodilator
 causes contraction of venous, intestinal, and bronchial
smooth muscle
 stimulates secretion by the salivary glands
 causes diuresis and natriuresis by the kidneys
SUBSTANCE P