10. Graphic design, technical documents and brochure
Are you sick?
We need your help
Are you healthy?
Become part of a study that aims to improve If you answered Yes to either question, the MURDOCK Study is
health care for our community and the world looking for your help to improve the health care of our community
and the world.
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(704) 250-5861
Participants receive a $10 gift
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card for a one-time enrollment visit
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IRB Protocol #11196
IRB Protocol #11196
10
11. May, 2011 www.dtmi.duke.edu Vol.1 Issue 1
May 2011 www.dtmi.duke.edu Vol. 1, Issue 1
Feinglos and Chen launch study in patients Upcoming Events
Accessing the cGMP Cell and
with Type I diabetes and Gastroparesis Clinical Research Molecular Therapeutics Facility
Many Type I diabetic patients have gastrointesti- tadalafil for 7 days. The outcome will be Training Program
nal problems. It has been estimated that 20%-40% have measured by improvement in gastric Accepting Applications The Duke Translational
gastroparesis , a condition in which muscles in the stom- emptying time. Small human studies May 15 Research Institute (DTRI), along
ach do not function normally and are prevented from have shown varying effects of a similar with investment from the School
emptying properly. The condition is of ED drug, on gastric emptying Research Career Day
of Medicine, offers a cGMP
major importance and concern to dia- time. Both ED drugs may work by relax- May 20
shared resource to enable the
betic patients, interfering with diges- ing certain smooth muscles in the stom-
tion, causing nausea and vomiting, ach, thereby enabling proper flow of
ESC: Heart Failure Congress translation of novel research and
and making blood sugar levels difficult digested food from the stomach to the May 21- 24 clinical applications in cellular and
to control. duodenum. However, other drugs in the molecular therapy—and it‘s avail-
QuERY Day
Current treatments for gastro- same class as tadalafil present several Louis Chen, MD able to any investigator requiring
Quality Evidence Based
paresis are limited, do not offer relief drawbacks, in particular short half-lives, lab space and/or specialized
for many patients, and may come with requiring multiple daily dosing if used to treat gastropare- Practice Research and You
a host of physical and psychological sis. Daily tadalafil is a formulation that has become avail- May 27 equipment. Facility users have
access to consulting and informa- Medical Science Research Building (MSRB)
Mark Feinglos, MD side effects, including depression, able to consumers in recent years. Its long half-life may
anxiety, and neuromuscular dysfunc- provide long-term relief from gastroparesis with a once-a- 4th Annual Community tional services from experts in diverse translational areas, including molecular thera-
tion. Device-oriented approaches do exist, such as acu- day pill. If the current proof-of-concept study shows re- Engagement National peutics and regulatory affairs. Researchers can also take advantage of consultation
puncture and gastric stimulation, but their efficacy varies. sults, Drs. Feinglos and Chen hope to follow with a larg- Conference in translating current lab protocols into cGMP compliant protocols.
Mark Feinglos, MD, CM, Division Chief, of Endo- er, randomized study. August 30-31 Located in the Medical Sciences Research Building I, this facility houses
crinology, Metabolism, and Nutrition at Duke and Louis Dr. Feinglos is excited about the potential for this
Chen, MD, MBA, Endocrinology Fellow, with the support state-of-the-art equipment and provides the environment and infrastructure required
study in Type I diabetic patients with gastroparesis, and
of a $20,000 DCRU Pilot Study grant and drug donation by the FDA to manufacture investigational cell-based and molecular therapeutic prod-
the support he has received from the DCRU. “This pilot
from Lilly, are studying whether the use of the erectile ucts for pre-clinical and Phase I/II clinical studies.
dysfunction (ED) drug tadalafil (Cialis®) improves gastric study wouldn’t have happened without DCRU’s generous See Facility page 3
financial and staff support, as well as the forward-thinking Contact us
emptying in adult patients with diabetes and gastropare-
sis. In this pilot study, 10 men and women with Type I individuals who work there; they have been unbelievably General Inquiries:
diabetes and gastroparesis will each take a daily dose of accommodating.” dtriprojectoffice@mc.duke.edu Duke proteomics core facility receives two
“next generation” mass spectrometers
Kurtzberg and Team move forward with
Durham Office:
Cynthia Chavious The Duke University School of Medicine and NCRR have provided funding to
919.668.8546
the Duke Proteomics Core Facility for the purchase of two, state-of-the-art, ―next gen-
Cerebral Palsy cord blood study Angelique Kosempa
919.668.4677
Kannapolis Office:
eration‖ mass spectrometers, listing for nearly $1 million each. Designed for open,
unbiased differential expression proteomics experiments, these Synapt G2 High Defi-
In March, 2010, the Robert- the translational work of Drs. Joanne Director of the Carolinas Cord Blood nition Mass Spectrometers (Waters Corp.) are high-resolution exact mass instruments
704.250.5850
son Foundation awarded Duke Uni- Kurtzberg, Gordon Worley, Ricky Bank, and her team have been in- that not only provide a 2X increase in sample capacity for the facility, but also offer
versity $10.2 million to develop a Goldstein, and Mohamad Mikati. As vestigating the therapeutic use of
state-of-the- a result of this grant, Dr. Kurtzberg umbilical cord blood stem cells, spe- Project Office: the following notable improvements in analytical capabilities for biomarker discovery:
art clinical and formed a team with these research- cifically to treat some genetic disor- Lynn Sutton 1) Improved quantitative precision via a 4X increase in mass resolution. 2) Improved
translational ers and added, Alan Song, Jessica ders in children. Now, in a major lynn.sutton@duke.edu linear dynamic range of quantitation via use of a new class of ion detector; the new
cell therapy Sun, and Kate Gustafson, to launch effort to illustrate improvement in 919.668.8925 instruments increase this to 3.5 to 4 orders of magnitude. 3)Improved proteome cov-
program (CT) a study to evaluate whether a single functional status of children with CP, Consulting & Outreach :
erage within and across samples via time-aligned parallel fragmentation experiments
2
, a shared intravenous infusion of a child's own Dr. Kurtzberg, Dr. Jessica Sun, and Wayne Beyer, PhD
resource facil- umbilical cord stem cells will cure or the research team are able to move using unique ion-mobility optics (LC/MS/Ion-Mobility/MS). 4) Capability for analysis of
wayne.beyer@duke.edu
ity advancing at least lessen the severity of Cere- forward with the first placebo- Technologies & Resources: proteins on the basis of their cross sectional area, allowing unique structural studies
cell-based bral Palsy (CP) in children. controlled, randomized, crossover Virginia Burns , PhD of proteins due to unique Ion Mobility optics. For example, the new instruments permit
therapy re- For decades, Kurtzberg, Di- clinical trial of its kind. virginia.burns@duke.edu the study of changes in protein conformation as a function of ligand binding and struc-
search—partly rector of Duke’s Pediatric Bone Mar- 919.668.4647 tural studies of protein multimers.
Joanne Kurtzberg, MD in support of row and Transplant program and See Next generation page 3
See Kurtzberg page 4
11
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