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9/16/15	
   1	
  
Electrochemical
pH
Ionic Strength
Biological
Mechanical Electrical
Magnetic
Light
Temperature
What is “S...
9/16/15	
   2	
  
Increase stability and
promote an ordered
architecture
Decrease
extensive surface
functionalization
for ...
Yang, X.; Moosa, B.; Deng, L.; Zhoa, L; Khashab, N. M. *
“Polymer Chemistry 2011, 2, 2543–2547.
Biomedical: pH-Triggered M...
Deng, Lin; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang; Khashab, N. M. * RSC adv. 2012, 2,
12909–12...
Deng, Lin; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang; Khashab, N. M. * RSC adv. 2012, 2,
12909–12...
Biomedical: Magnetically Triggered Theranostic Platform
for Remote Cancer Cells Therapy and Imaging
!
General Scheme
Zhang...
Biomedical: Magnetically Triggered Theranostic Platform
for Remote Cancer Cells Therapy and Imaging
!
Zhang, W.; Deng, L.;...
Biomedical: Photo-Triggered Membrane Based on Inter-
particle Crosslinking for Decreasing Diffusion Rates
PHCA microsphere...
Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502...
Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502...
Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502...
Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502...
Biomedical: Photoresponsive Bridged Silsesquioxane
Nanoparticles with Tunable Morphology
1hν	

laserH
+
+
+
+
+ +
+
+
++
+...
BS NPs
Hollow BS NPs
200 nm
100 nm
H
+
+
+
+
+ +
+
+
++
+
H
+
+
+
+
+ +
+
+
++
+
H2O
H2O
EtOH
Origin
Irradiated
Or
e
Irra
e
4.05 ppm
Irra
e
4.00
3.75
Irradiated
Or
e
4.00
3.75
O
+ − +
O
−
+
1hν	

laser
1hν	

laser
Po...
Hollow BS NPs
DNA
1hν	

laser
Zeta Potential (mV)	
ChargeDist.(a.u.)	
-100 -50 0 50 100	
-39 mV
+46 mV
1hν	

H
+
+
+
+
+ +...
Angew. Chem. Int. Ed. 2015, accepted DOI: 10.1002/anie.201501615R1 and 10.1002/ange.201501615R1 (Cover image, Highlighted
...
-100
-80
-60
-40
-20
0
20
40
60
80
100
Before Irradiation After Irradiation
SN
(control)
Zeta	
  Potential	
  (mV)
NBSN-1 ...
3	
  µm 	
  500	
  nm
	
  500	
  nm
	
  	
  	
  	
  200	
  	
  nm	
   29	
  
hν	

	
  500	
  nm
ELECTROSTATIC DISASSEMBLY OF COLLOISOMES
UPON LASER IRRADIATION
30	
  
0	
  
20	
  
40	
  
60	
  
80	
  
100	
  
0	
   5	
   10	
   15	
   20	
  
Release	
  (%)
Time	
  (min)
Cargo loaded
Collo...
Biomedical: AuNC@BSA Gated MSNs
+
+
+
+
+
+
+
+
Fluorescent
AuNC@BSAn-
Cargo3loaded
MSN3NH3
+
+
-
+
+
+
+
+
+
+
--
+
+
+
+...
a b
3 µm
c d
50 nm 50 nm
100 nm
!
Size%Distribution%(%)
Diameter%(nm)
2.5%nm
!
Biomedical: AuNC@BSA Gated MSNs
Cell	
  Viability	
  (%)
NPs	
  Concentration	
  (µg.mL-­‐1)
100
80
60
40
20
0
0	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
...
!
Absorption
Wavelength1(nm)
Emission
645$nm364$nm
496$nm
!
Biomedical: AuNC@BSA Gated MSNs
Red$Channel$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$Blue$Channel$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$Merged
Saline
Control
Hoe4loaded$
MS...
S
L
T
K
Lu
Saline
Control
a Merged222222222222222222222222Red2Channel22222222222 Blue2Channel2 Red+Blue2Channel22222222
L
...
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Xie, J.; Zheng, Y.; Ying, J. Y. J. Am. Chem. S...
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Kha...
Sensitivity
Selectivity
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsa...
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Kha...
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Kha...
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Kha...
Sensing: Protein-Directed Synthesis of Highly
Fluorescent Gold Nanoclusters
Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Kha...
Biomedical: Zippered Release from Polymer
Gated Carbon Nanotubes
!
Mashat, A.; Deng, L; Altawashi, A.; Sougrat, R.; Wang, ...
Biomedical: Zippered Release from Polymer
Gated Carbon Nanotubes
Mashat, A.; Deng, L; Altawashi, A.; Sougrat, R.; Wang, G....
Chen, Ye; Tao, Jing; Deng, Lin; Li, Liang; Li, Jun; Yang, Yang; Khashab, N. M.* ACS App. Mater. Inter. 2013, 5, 7478–
7484...
Chen, Ye; Tao, Jing; Deng, Lin; Li, Liang; Li, Jun; Yang, Yang; Khashab, N. M.* ACS App. Mater. Inter. 2013, 5, 7478–7484....
Chen, Ye; Tao, Jing; Song, Li; Khashab, N. M. * ACS App. Mater. Inter. 2014, 6, 9013–9022.
Composites: Polyfluorene Wrappe...
Chen, Ye; Tao, Jing; Song, Li; Khashab, N. M. * ACS App. Mater. Inter. 2014, 6, 9013–9022.
Composites: Polyfluorene Wrappe...
Composites: Surface Modification of Multiwall Carbon
Nanotubes with Cationic Conjugated Polyelectrolytes
General Scheme
Ez...
Composites: Surface Modification of Multiwall Carbon
Nanotubes with Cationic Conjugated Polyelectrolytes
Ezzeddine, A.; Ch...
KAUST	
  on	
  the	
  Red	
  Sea
Spring 2016 internships and graduate students
Applications
are now open for submission
ht...
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Innovatival Functionalized Nanomaterials for Biomedicalm Sensing and Composites Applications

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محاضرة الدكتورة نيفين الخشاب المقامة في مركز البحوث ضمن سلسلة أفق بحثية مميزة

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Innovatival Functionalized Nanomaterials for Biomedicalm Sensing and Composites Applications

  1. 1. 9/16/15   1   Electrochemical pH Ionic Strength Biological Mechanical Electrical Magnetic Light Temperature What is “SMART”? External   S+muli   Internal   S+muli  
  2. 2. 9/16/15   2   Increase stability and promote an ordered architecture Decrease extensive surface functionalization for eventual degradation Hard Soft Inorganic Organic Hybrid Materials Hybrid Materials
  3. 3. Yang, X.; Moosa, B.; Deng, L.; Zhoa, L; Khashab, N. M. * “Polymer Chemistry 2011, 2, 2543–2547. Biomedical: pH-Triggered Micellar Membrane for Controlled Release Microchips ! 0 5 10 15 20 0 10 20 30 40 50 b time (h) DOXrelease(wt%) pH=4.0 pH=5.0 pH=6.0 pH=7.0 pH=8.0 pH=9.0 ! General Scheme Assembly and Application
  4. 4. Deng, Lin; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang; Khashab, N. M. * RSC adv. 2012, 2, 12909–12914 Biomedical: Enzymatically Triggered System Based on Hyaluronic Acid Micelles General Scheme
  5. 5. Deng, Lin; Wang, Guangchao; Ren, Jian; Zhang, Bei; Yan, Jingjing; Li, Wengang; Khashab, N. M. * RSC adv. 2012, 2, 12909–12914. Biomedical: Enzymatically Triggered System Based on Hyaluronic Acid Micelles
  6. 6. Biomedical: Magnetically Triggered Theranostic Platform for Remote Cancer Cells Therapy and Imaging ! General Scheme Zhang, W.; Deng, L.; Wang, G.; Guo, X.; Li, Q.; Zhang, J.; Khashab, N. M. * Part. Pat. Syst. Charact. 2014, 31, 985–993.
  7. 7. Biomedical: Magnetically Triggered Theranostic Platform for Remote Cancer Cells Therapy and Imaging ! Zhang, W.; Deng, L.; Wang, G.; Guo, X.; Li, Q.; Zhang, J.; Khashab, N. M. * Part. Pat. Syst. Charact. 2014, 31, 985–993.
  8. 8. Biomedical: Photo-Triggered Membrane Based on Inter- particle Crosslinking for Decreasing Diffusion Rates PHCA microspheres EC membrane IrradiationDrug Reservoir Drug Reservoir Lower Efflux Crosslinking (A) Membrane PMMA device Reservoir for drug loading (B) (C1) (C3)(C2) b c a d (A) (B) Song, L., Moosa, M., Li, W.; Khashab, N. M.* J. Mater. Chem. B 2015, 3, 1208–1216.
  9. 9. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522) . Biomedical: Graphene Oxide-Wrapped Gold Nanorods General Scheme ! “Two-Step” Raman Imaging-Guided Chemo-Photothermal Cancer Therapy
  10. 10. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522) Biomedical: Graphene Oxide-Wrapped Gold Nanorods !
  11. 11. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522) . Biomedical: Graphene Oxide-Wrapped Gold Nanorods SERS mapping of Doxorubicin (a) and Graphene oxide (b) on AuNRs, ratio of Doxorubicin to graphene oxide (c), and overlap image (d) in Hela cell
  12. 12. Deng, L.; Li, Q.; Yang, Y.;Omar, H; Tang, N.; Zhang,J.; Nie, Z.; Khashab, N. M.* Chem. Eur. J. 2015, accepted (chem.201502522) . Biomedical: Graphene Oxide-Wrapped Gold Nanorods
  13. 13. Biomedical: Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology 1hν laserH + + + + + + + + ++ + - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Fatieiev, Y.; Croissant, J.; Julfakyan, K.; Deng, L.; Anjum, D.H.; Gurinov, A.; Khashab, N.M. Nanoscale 2015, DOI: 10.1039/ C5NR03065J
  14. 14. BS NPs Hollow BS NPs 200 nm 100 nm H + + + + + + + + ++ + H + + + + + + + + ++ + H2O H2O EtOH
  15. 15. Origin Irradiated Or e Irra e 4.05 ppm Irra e 4.00 3.75 Irradiated Or e 4.00 3.75 O + − + O − + 1hν laser 1hν laser Positive Zeta potential Negative Zeta potential Fatieiev, Y.; Croissant, J.; Julfakyan, K.; Deng, L.; Anjum, D.H.; Gurinov, A.; Khashab, N.M. Nanoscale 2015, DOI: 10.1039/ C5NR03065J
  16. 16. Hollow BS NPs DNA 1hν laser Zeta Potential (mV) ChargeDist.(a.u.) -100 -50 0 50 100 -39 mV +46 mV 1hν H + + + + + + + + ++ + - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - H + + + + + + + + ++ + Fatieiev, Y.; Croissant, J.; Julfakyan, K.; Deng, L.; Anjum, D.H.; Gurinov, A.; Khashab, N.M. Nanoscale 2015, DOI: 10.1039/ C5NR03065J
  17. 17. Angew. Chem. Int. Ed. 2015, accepted DOI: 10.1002/anie.201501615R1 and 10.1002/ange.201501615R1 (Cover image, Highlighted by Nature Middle East) Biomedical: Light Triggered Colloidosomes - + - + -+ - +-+ - + - + - + - + - + - + - + - - - - -- - --- - - - - - - - - - - - - - - hv Stable colloidosome Unstable colloidosomeDissociation of colloidosome NBSN-2 NBSN-1 - + + - -+ -+ + - + - - + + - + Oil phase Water phase Emulsion with two types of NPs A - -- - -- - - - - - - - - - -- - - - - - - - C B
  18. 18. -100 -80 -60 -40 -20 0 20 40 60 80 100 Before Irradiation After Irradiation SN (control) Zeta  Potential  (mV) NBSN-1 NBSN-2 S (c hν Positive Neutral - - + NP- NP+NB+ SURFACE CHARGE OF NP- & NP+ NANOBUILDING BLOCKS COMPATIBLE WITH THE COLLOIDOSOME ASSEMBLY/DISASSEMBLY 28   Biomedical: Light Triggered Colloidosomes
  19. 19. 3  µm  500  nm  500  nm        200    nm   29  
  20. 20. hν  500  nm ELECTROSTATIC DISASSEMBLY OF COLLOISOMES UPON LASER IRRADIATION 30  
  21. 21. 0   20   40   60   80   100   0   5   10   15   20   Release  (%) Time  (min) Cargo loaded Colloidosomes OFF ON OFF ON hν hν hν 31  Angew. Chem. Int. Ed. 2015, accepted DOI: 10.1002/anie.201501615R1 and 10.1002/ange.201501615R1 (Cover image, Highlighted by Nature Middle East)
  22. 22. Biomedical: AuNC@BSA Gated MSNs + + + + + + + + Fluorescent AuNC@BSAn- Cargo3loaded MSN3NH3 + + - + + + + + + + -- + + + + + + + ++ + H+ pH 7.4 pH 5.0 Release9(%) pH 5.0 pH 7.4 b Time9(h) a !
  23. 23. a b 3 µm c d 50 nm 50 nm 100 nm ! Size%Distribution%(%) Diameter%(nm) 2.5%nm ! Biomedical: AuNC@BSA Gated MSNs
  24. 24. Cell  Viability  (%) NPs  Concentration  (µg.mL-­‐1) 100 80 60 40 20 0 0                          10                  20                    30                    50                  100                150         Cell$Viability$(%) MSN$NH2+DOX MSN$AuNC@BSA+DOX DOX$Concentration$(µg.mL91) ! Biomedical: AuNC@BSA Gated MSNs
  25. 25. ! Absorption Wavelength1(nm) Emission 645$nm364$nm 496$nm ! Biomedical: AuNC@BSA Gated MSNs
  26. 26. Red$Channel$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$Blue$Channel$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$Merged Saline Control Hoe4loaded$ MSN4AuNC@BSA a b ! Biomedical: AuNC@BSA Gated MSNs
  27. 27. S L T K Lu Saline Control a Merged222222222222222222222222Red2Channel22222222222 Blue2Channel2 Red+Blue2Channel22222222 L T K Lu b Hoe9loaded2 MSN9AuNC@BSA ! Submitted Biomedical: AuNC@BSA Gated MSNs
  28. 28. Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Xie, J.; Zheng, Y.; Ying, J. Y. J. Am. Chem. Soc., 2009, 131, 888
  29. 29. Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
  30. 30. Sensitivity Selectivity Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
  31. 31. Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
  32. 32. Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
  33. 33. Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
  34. 34. Sensing: Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters Hu, L.; Deng, L.; Alsaiari, S.; Zhang, D.; Khashab, N. M. Anal. Chem., 2014, 86, 4989–4994.
  35. 35. Biomedical: Zippered Release from Polymer Gated Carbon Nanotubes ! Mashat, A.; Deng, L; Altawashi, A.; Sougrat, R.; Wang, G.; Khashab, N. M. * “Zippered Release from Polymer Gated Carbon Nanotubes” J. Mater. Chem. 2012, 22, 11503–11508. General Scheme
  36. 36. Biomedical: Zippered Release from Polymer Gated Carbon Nanotubes Mashat, A.; Deng, L; Altawashi, A.; Sougrat, R.; Wang, G.; Khashab, N. M. * “Zippered Release from Polymer Gated Carbon Nanotubes” J. Mater. Chem. 2012, 22, 11503–11508. !
  37. 37. Chen, Ye; Tao, Jing; Deng, Lin; Li, Liang; Li, Jun; Yang, Yang; Khashab, N. M.* ACS App. Mater. Inter. 2013, 5, 7478– 7484. . Composites: PEI/Bucky Gels Nanocomposites with Superior Conductivity and Thermal Stability ! General Scheme
  38. 38. Chen, Ye; Tao, Jing; Deng, Lin; Li, Liang; Li, Jun; Yang, Yang; Khashab, N. M.* ACS App. Mater. Inter. 2013, 5, 7478–7484. Composites: PEI/Bucky Gels Nanocomposites with Superior Conductivity and Thermal Stability !
  39. 39. Chen, Ye; Tao, Jing; Song, Li; Khashab, N. M. * ACS App. Mater. Inter. 2014, 6, 9013–9022. Composites: Polyfluorene Wrapped Carbon nanotubes for Enhanced Interfacial Interactions General Scheme
  40. 40. Chen, Ye; Tao, Jing; Song, Li; Khashab, N. M. * ACS App. Mater. Inter. 2014, 6, 9013–9022. Composites: Polyfluorene Wrapped Carbon nanotubes for Enhanced Interfacial Interactions
  41. 41. Composites: Surface Modification of Multiwall Carbon Nanotubes with Cationic Conjugated Polyelectrolytes General Scheme Ezzeddine, A.; Chen, Z.; Schanze, K. S.; Khashab, N. M. ACS Appl. Mater. Interfaces, 2015, 7 , 12903–12913.
  42. 42. Composites: Surface Modification of Multiwall Carbon Nanotubes with Cationic Conjugated Polyelectrolytes Ezzeddine, A.; Chen, Z.; Schanze, K. S.; Khashab, N. M. ACS Appl. Mater. Interfaces, 2015, 7 , 12903–12913.
  43. 43. KAUST  on  the  Red  Sea Spring 2016 internships and graduate students Applications are now open for submission http://visitingstudent.kaust.edu.sa/Pages/Home.aspx Niveen.khashab@kaust.edu.sa
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    Mar. 11, 2016

محاضرة الدكتورة نيفين الخشاب المقامة في مركز البحوث ضمن سلسلة أفق بحثية مميزة

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