Packaging of therapeutic active ingredients in a
Aerosols depends on the power of compressed
or liquefied gas to expel the contents from
4. Pharmaceutical aerosols:
Aerosol products containing therapeutically active ingredients
dissolved, suspended or emulsified in a propellant or a
mixture of solvent and propellant and intended for topical
application, for administration into one of the body cavities
(ear, rectum and vagina) or intended for administration
orally or nasally as fine solid particles or liquid mists through
the pulmonary airways, nasal passages or oral cavity.
• A dose can be removed with out contamination of
• The medication can be delivered directly to the
affected area in a desired form, such as spray, steam,
quick breaking foam or stable foam.
• Controlled and uniform dose is released
• Ease of convenience of application.
• The onset of action is faster because the medicament
is directly administered to the affected part.
A propellant is a chemical with a vapor pressure
greater than atmospheric pressure at 40°C (105°F.
1) It is responsible for developing the vapor pressure
within the container
2) Expel the product when the valve is opened and in
the atomization or foam production of the product.
3) When the propellant is a liquefied gas or
compressed gases, it can also serve as the solvent
or vehicle for the product concentrate.
They must be stand at pressure as high as 140 to 180 psig
(pounds per sq. inch gauge) at 1300 F.
Consist of sheet of that has been
electroplated on both sides with tin.
2. Aluminium :
Greater resistance to corrosion
Good for light sensitive drugs.
3. Glass Container:
Available with plastic or without
Compatible with many additives
No corrosion problems
Can have various shape because of
Not for light sensitive drug
4. Stainless steel:
Limited for smaller size
Extremely strong and resistant to
To delivered the drug in desired form.
To give proper amount of medication.
Not differ from valve to valve of medication in
Continuous spray valve:
usually used for topical
Dispersing of potent medication at proper dispersion/ spray
approximately 50 to 150 mg ±10 % of liquid materials at one
time use of same valve. (minimize wastage and errors of
These are specially designed
buttons which helps in delivering
the drug in desired form i.e., spray
, wet stream, foam or
solid stream. To ensure that
aerosol product is delivered in the
proper and desired form.
Different types of actuators
Solid steam actuators
Formulation of pharmaceutical
Contains two essential components
Product concentrate contains ingredients or mixture of active
ingredients and other such as solvents, antioxidants and surfactants.
May be single or blend of various propellants
Blends of propellant used in a p’ceutical formulation to achieve
desired solubility characteristics or various surfactants are mixed to
give the proper HLB value for emulsion system.
To give the desired vapor pressure, solubility & particle size.
21. Manufacturing of AEROLOS
• Addition of
In general Manufacturing of
aerosols takes place in two
FOR NON AQUEOUS
LOW TEMP (-40F),
CARRIED OUT AT