Diese Präsentation wurde erfolgreich gemeldet.
Wir verwenden Ihre LinkedIn Profilangaben und Informationen zu Ihren Aktivitäten, um Anzeigen zu personalisieren und Ihnen relevantere Inhalte anzuzeigen. Sie können Ihre Anzeigeneinstellungen jederzeit ändern.


4.186 Aufrufe

Veröffentlicht am


Veröffentlicht in: Internet
  • Hey guys! Who wants to chat with me? More photos with me here 👉 http://www.bit.ly/katekoxx
    Sind Sie sicher, dass Sie …  Ja  Nein
    Ihre Nachricht erscheint hier


  1. 1. Made by Rasel Mahbub Dept.Of pharmacy Jagannath University 01915923493
  2. 2. PROPOFOL  Introduction: Propofol is an intravenous sedative- hypnotic that was introduced for clinical use in 1977. Since the introduction of propofol into cliical practice, it has become the intravenous induction agents include rapid induction of general anaesthesia.
  3. 3.  Pharmacology: Propofol is commonly used for conscious sedation, as an anaesthetic indiction agent for the maintenance of general anaesthesia.  Propofol is a subsituted iso-propyl-phenol formulated as a 1% aqueous solution. The propofol emulsion formulation contain soybean oil, glycesol & egg lecithin.
  4. 4. Structure: Propofol
  5. 5. Mechanism of action  The mechanism of action of propofol is related to its interaction with ‘gamma aminobutyric’ acid (GABA) which is the principle inhibitory neurotransmitter in the CNS.  Propofol works by increasing GABA mediated inhibitory tone in the CNS.  Propofol decrease the rate of dissociation of the GABA from the receptor, thereby increasing the duration of GABA activated opening of the chloride channel resulting hyperpolarization of the cell membrane.
  6. 6. Mechanism of Action Propofol Activation of GABA receptor Increase transmembrane cl conductance Hyperpolarization of post synaptic membrane Functional inhibition of the post synaptic membrane.
  7. 7. Mechanism of Action
  8. 8. Pharmacokinetics  Bioavailability: N/A  Protein binding: 95%-99%  Metabolism: Liver  Onset of action: 15-30 seconds  Biological half life: 30-60 min  Duration of action: 5-10 min  Excretion: Liver
  9. 9. Indication  Starting or maintaining anaesthesia during certain surgeries, tests or procedure.  Used for sedation.  ICU patients and mechanically ventilated patients.  Bronchodilation.
  10. 10. Contraindication  Hypersensityvity to propofol which contain: soybean oil, egg or egg product.  Obsterical procedures.  It is not recommended for use in nursing mothers.  It is not recommended for anaesthesia in children below the age of 3 yrs.
  11. 11. Interactions  Halothane, enflurane, isoflurane drug.  Narcotic drug such as: morphine, meperidine  Doxylamine drugs  Clonazepam drugs  Antidepressant such as:  amoxapine  amitriptyline  doxepin  Barbiturates such as:  pentobarbital  secobarbital
  12. 12. Side effects  Nausea  Cough  Burning or stining around the IV needle.  Itching or skin rash  Numbness or tingly feeling  Confusion  Agitation  Anxiety  Muscle pain  Discolored urine
  13. 13. Brand name in BangladeshBrand name Contains Dosage form Manufacture POFOL I.V Propofol 10mg/ml I.V injection Popular pharmaceuticals FRESOFOL Propofol 10mg/ml I.V injection Fresenius kabi/HYE impex international RECOFOL Propofol 10mg/ml I.V injection Bayer Schering oy/Tajarat
  14. 14. Doses  Usual adult dose for anaesthesia: Less than 55 years: Anaesthetic induction: 40 mg IV every 10 seconds until induction onset. Maintenance of Anaesthesia: IV infusion 100 to 200 mcg/kg/min. cardiac anaesthesia: Induction : 20 mg every 10 second until induction onset. Maintenance: 100-150 mcg/kg/min
  15. 15.  ICU sedation: initial continuous IV: 5mcg/kg/min  Maintenance: 5 to 50 mcg/kg/min.  Usual pediatric dose for anaesthesia: 3 to 16 years : Induction: 2.5 to 3.5 mg/kg over 20 to 30 second. Maintenance: 125 to 300 mcg/kg/min.