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Kidney function and nephrons.ppt
Kidney function and nephrons
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Answer: Kidneys are the functional units of renal system of rom urine and it is essential to maintain homeostasis. Blood is going to enter into the kidney through renal arteries followed by entry of afferent arterioles into the \"glomerulus of nephrons\" & leave the filtrate (according to concentration gradient) finally exists as efferent arteriole Kidneys are the major organs of urinary system. The filtration of blood takes place in the kidneys through the nephrons. Two ureters carry the urine from the kidneys to the urinary bladder. From the bladder, urine is excreted out through the urethra. Relatable analogy is presence of \"similar ureters\" and two bean shaped kidenys with nephrons The different stages in glomerular filtration or urine formation are. Filtration: The movement of water and solutes from the plasma into the renal tubules is known as filtration. The major driving force of the filtration is hydrostatic pressure in the glomerulus capillaries. Blood passes through the capillaries in the glomerulus, due to the hydrostatic pressure in the Bowman’s capsule, plasma is filtered into the Bowman\'s capsule except blood proteins (this is called ultra-filtration). This filtrate is called glomerular filtrate. Hydrostatic pressure is the pressure exerted by the filtrate in Bowman\'s capsule (15 mm Hg). Absorption (or reabsorption): It is the movement of water and solutes from the renal tubule into the plasma. The process of absorption mostly occurs in the proximal tubules (approximately 70% of the filtrate is reabsorbed from the proximal tubules). The process of reabsorption is driven by hydrostatic and oncotic pressure, which is strictly under hormonal regulation. Oncotic pressure is the pressure exerted by the blood proteins, which draws water in to the circulation. Secretion: Tubular reabsorption of water and other substances back to the blood occur while the glomerular filtrate passes through the tubular portion of nephron. About 99% of water and electrolytes are reabsorbed during this process by both active and passive reabsorption process. During tubular secretion, substances pass from the blood into renal tubules. Excretion: Urine from the renal tubules enter into the collecting duct à Papillary duct à Calyx à Renal pelvis à Ureters à Urinary bladder à Urethra (excreted out of the body.). Normal glomerular filtration rate in the Bowman’s capsule is from 90 to 120 ml / min/1.73 m2. Usually older people do have a bit lower normal GFR levels as it is naturally reduce with age. Given GFR is 35mL/min/1.73 m2 (moderate decrease), it tells about the patient’s kidney function that “a sign of chronic kidney disease” because of diabetes, high blood pressure followed by glomerulonephritis. It is better control blood pressure by hormonal release. The three stages of urine formation are 1. Filtration; 2. Tubular reabsorption & secretion; 3. Water conservation Glomerular filtration (GFR): The formation of urine includes 1. Glomerular filtration .
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Kidney function and nephrons
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More realistic view
of nephrons
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Changes in permeability
of collecting duct produce concentrated or non-concentrated urine
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