3. Role in the Kidney – Control of Na Excretion BN-Ki BN-Ka BN-Ki BN-Ka www.freelivedoctor.com
4. ○ BN-Kitasoco ● BN-Katholiek Influence of NaCl load on systolic BP in 2 strains of rats Influence of various Na diets at week 7 Influence of 2% NaCl diet from 7-11 weeks www.freelivedoctor.com
11. Neointimal/Total artery Area (%) Saline Losartan HOE 140 Ramipril Ramipril + HOE 140 Effect of various treatments on neointima formation in the carotid artery 2 weeks after balloon injury www.freelivedoctor.com
12. Effect of various treatments on neointima formation in the carotid artery 2 weeks after balloon injury Saline L-NAME Ramipril Ramipril + L-NAME Neointimal area/Total artery area % * # + # * P<0.05 vs Saline; +:P<0.05 vs. Ramipril; #: P<0.05 vs. L-NAME www.freelivedoctor.com
15. LVP LV dP/dt HR CF LDH CPK Lactate Lactate Glycogen ATP CP Bradykinin Ramiprilat % Change vs. Control Cardiodynamic Venous Effluent Myocardial tissue www.freelivedoctor.com
16. LVP LV dP/dt HR CF LDH CPK Lactate Lactate Glycogen ATP CP Cardiodynamic Venous Effluent Myocardial tissue Ramipril Ramipril + Icatibant Reversal by Kinin Antagonist of Cardioprotective Effect of ACE Inhibitor www.freelivedoctor.com
17. Control PC PC+Icat. Icat. BK+Icat. BK Role of Bradykinin in the cardioprotective effects of Ischemic preconditioning on myocardial infarct size in the rabbit. PC: 5 min occlusion followed by 10 min reperfusion followed by 30 min occlusion. Similar protection achieved with exogenous BK. Infarct Size www.freelivedoctor.com
18. Infarct Size Heart:Body Weight Ratio Moexepril Effect of Chronic Treatment with Moexipril±Icatibant and Losartan on Infarct Size and Cardiac Mass Moexepril +Icatibant Losartan Moexepril Moexepril +Icatibant Losartan www.freelivedoctor.com
19. HOE 140 Enalapril Control Enalapril HOE 140 HOE/Enal mg/day Urinary Albumin Excretion Rate in Diabetic Rats www.freelivedoctor.com
20. ACE Inhibitor AII Receptor Blocker Blocks formation of AII incompletely Blocks Kininase II ↑ Kinins ↓ AII effects & aldosterone PROTECTION Blocks AT-1R AT-2R Free More complete Inhibition of AII effects Preserve Anti- proliferative effect www.freelivedoctor.com