Hematopoiesis 06 07

Hematopoiesis www.freelivedoctor.com

Hematopoiesis general ,[object Object],[object Object],www.freelivedoctor.com

Hematopoiesis general ,[object Object],[object Object],[object Object],www.freelivedoctor.com

Hematopoiesis general ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Hematopoiesis general ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Development of Blood Cells ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Development of Blood Cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

pluripotent stem cell committed stem cells Hematopoiesis www.freelivedoctor.com lymphoid stem cell trilineage myeloid stem cell

Hematopoiesis www.freelivedoctor.com Proliferative potential differentiation

Normal Marrow Composition granulocytes & precursors erythroid precursors Lymphocytes, monocytes unidentified or disintegrated cells www.freelivedoctor.com 60% 20% 10% 10%

Normal Marrow ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Myeloblast ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Promyelocyte ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Myelocyte ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Metamyelocyte ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Granulocyte maturation ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Lifespan of blood cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Hematopoietic Microenvironment ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Hematopoietic Response hypoxia infection antigen hemorrhage www.freelivedoctor.com RBC granulocyte/monocyte lymphocyte platelet

Hematopoietic Microenvironment Stromal cells : fibroblasts endothelial cells adipocytes www.freelivedoctor.com Growth Factors

Hematopoietic Growth Factors ( SCF, IL-6, GM-CSF , etc.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Basal Hematopoiesis G-CSF SCF: stem cell factor GM-CSF: granulocyte-macrophage colony-stimulating factor G-CSF: granulocyte colony-stimulating factor www.freelivedoctor.com SCF IL-6 GM-CSF

Antigen-amplified hematopoiesis www.freelivedoctor.com TNF  IL-3 GM-CSF IL-4 IL-1 TNF  IL-1 SCF IL-6 GM-CSF G-CSF Ag Ag

Hematopoietic Growth Factors (IL-6, GM-CSF, SCF, etc.) ,[object Object],[object Object],IL-1 TNF  G-CSF M-CSF T-cell GM-CSF IL-3 Fibroblast Endothelial cell IL-6 GM-CSF G-CSF www.freelivedoctor.com

Hematopoiesis GROWTH FACTORS ERYTHROPOIESIS GRANULOPOIESIS MEGAKARYOPOIESIS LYMPHOPOIESIS generation of each specific lineage of mature blood cells is regulated by a specific set of hematopoietic growth factors. www.freelivedoctor.com

Erythropoiesis ,[object Object],[object Object],[object Object],[object Object],[object Object],marrow stromal cells IL-3 (activated T-cells) hypoxia(liver, kidney) www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],Granulopoiesis G-CSF M-CSF www.freelivedoctor.com GM-CSF SCF IL-3 IL-5 IL-3 GM-CSF SCF IL-3

Megakaryopoiesis ,[object Object],GM-CSF IL-3 SCF IL-6 www.freelivedoctor.com

Lymphopoiesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com IL-7 SCF Fcg rec IL-4 IL-6 GM-CSF IL-6 IL-2 Ag TCR/CD3 CD28

B-cell maturation www.freelivedoctor.com

B-cell transformation www.freelivedoctor.com

Lymph node www.freelivedoctor.com

T-cell transformation www.freelivedoctor.com

Markers ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

RBC variation and irregularity www.freelivedoctor.com

anisocytosis poikilocytosis ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

elliptocytes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

spherocytes ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

leptocytes (target cells) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],beta thalassemia relative increase of cell membrane --> “target” formation www.freelivedoctor.com

schistocytes (cell fragments) ,[object Object],[object Object],[object Object],[object Object],[object Object],“ helmet cell” www.freelivedoctor.com

acanthocytes (irregular surface spicules) ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

echinocytes (crenated cells, burr cells) ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

bite cells ,[object Object],[object Object],www.freelivedoctor.com

dacrocytes (teardrop cells) ,[object Object],[object Object],www.freelivedoctor.com

drepanocytes (sickle cells) ,[object Object],www.freelivedoctor.com

rouleaux ,[object Object],[object Object],www.freelivedoctor.com

basophilic stippling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

sideroblast/siderocyte ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com ring sideroblasts intermediate sideroblast siderocyte

Howell-Jolly body ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Heinz bodies ,[object Object],[object Object],www.freelivedoctor.com

leukemoid reaction ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

leukemoid reaction hemolysis hemorrhage malignancy Hodgkin disease myelofibrosis TB burns eclampsia parasite infectious lymphocytosis pertussis TB www.freelivedoctor.com neutrophilic eosinophilic lymphocytic

leukoerythroblastic reaction solid tumors lymphomas myeloprolif dis acute leukemias benign hematologic conditions hemolysis misc. www.freelivedoctor.com

reactive WBC proliferations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

increased PMN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object], neoplasm (CML) : decreased LAP www.freelivedoctor.com

reactive WBC proliferations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

reactive WBC proliferations ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

infectious mononucleosis ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

[object Object],[object Object],infectious mononucleosis pathophysiology CD8 T-cells Atypical lymphocytes (Downey cells) Monocyte-like appearance (“mononucleosis”) Peripheral condensation of cytoplasm (“ballerina skirt” appearance) [enlargement] www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],infectious mononucleosis www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],infectious mononucleosis www.freelivedoctor.com

[object Object],[object Object],[object Object],[object Object],infectious mononucleosis www.freelivedoctor.com

lymphadenopathy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

lymphadenopathy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

Hematopoiesis 06 07

Recommended

Recommended

More Related Content

What's hot

What's hot (20)

Similar to Hematopoiesis 06 07

Similar to Hematopoiesis 06 07 (20)

More from raj kumar

More from raj kumar (20)

Hematopoiesis 06 07