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INTRODUCTION TO CNS AND ITS
NEUROTRANSMITTERS
DR.RAHUL
Non specific CNS stimulants
 Act by blocking inhibitory neurotransmission
 Direct excitation
 EXAMPLES:
 Cocaine
 Alc...
Levels of CNS Depression
 Calming
 Drowsiness (sedation)
 Conscious sedation
 Sleep (hypnosis)
 Unconsciousness
 Sur...
Topics covered under CNS
 Sedative Hypnotics
 Preanaesthetic
Medications
 General Anesthesia
 Opioid analgesics
 Anti...
EXCITATOR
Y
INHIBITOR
Y
GLUTAMATE
RECEPTORS
GABAergic SYNAPSE
GABA
glutamate
glucose
Cl
-
GAD
Dopamine SystemDopamine System
Dopamine System
There are four major pathways for the
dopaminergic system in the brain:
I. The Nigro-Stiatal Pathway.
II. ...
Catecholamines
Tyrosine
⇓ Tyrosine hydroxylase
L-Dopa
⇓ Dopa decarboxylase
Dopamine (DA)
⇓ Dopamine β hydroxylase
Norepine...
Dopamine Synapse
DA
L-DOPA
Tyrosine
Tyrosine
Dopamine System
 DOPAMINE RECEPTORS
There are at least five subtypes of receptors:
Receptor
D1
D2
D3
D4
D5
Dopamine Reuptake System
Serotonetgic transmissionSerotonetgic transmission
Neurotransmitter
 Substance produced in the neuron
(synthesized), contained and secreted
by that neuron to transmit infor...
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations
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Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations

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Dr Rahul Kunkulol's Power point preparations

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Introduction to Central Nervous system Pharmacology : Dr Rahul Kunkulol's Power point preparations

  1. 1. INTRODUCTION TO CNS AND ITS NEUROTRANSMITTERS DR.RAHUL
  2. 2. Non specific CNS stimulants  Act by blocking inhibitory neurotransmission  Direct excitation  EXAMPLES:  Cocaine  Alcohol  Caffeines  Methylxanthines
  3. 3. Levels of CNS Depression  Calming  Drowsiness (sedation)  Conscious sedation  Sleep (hypnosis)  Unconsciousness  Surgical anesthesia  Coma  Respiratory collapse  Cardiovascular collapse  Death
  4. 4. Topics covered under CNS  Sedative Hypnotics  Preanaesthetic Medications  General Anesthesia  Opioid analgesics  Anti-parkinsonian agents  Antiepileptics  Psychopharmacology :  Antipsychotics  Antidepressants  Anti maniac
  5. 5. EXCITATOR Y INHIBITOR Y
  6. 6. GLUTAMATE RECEPTORS
  7. 7. GABAergic SYNAPSE GABA glutamate glucose Cl - GAD
  8. 8. Dopamine SystemDopamine System
  9. 9. Dopamine System There are four major pathways for the dopaminergic system in the brain: I. The Nigro-Stiatal Pathway. II. The Mesolimbic Pathway. III. The Mesocortical Pathway. IV. The Tuberoinfundibular Pathway.
  10. 10. Catecholamines Tyrosine ⇓ Tyrosine hydroxylase L-Dopa ⇓ Dopa decarboxylase Dopamine (DA) ⇓ Dopamine β hydroxylase Norepinephrine (NE) (Noradrenaline) Phenylethanolamine- ⇓ -N-methyltransferase Epinephrine (EPI) (Adrenaline)
  11. 11. Dopamine Synapse DA L-DOPA Tyrosine Tyrosine
  12. 12. Dopamine System  DOPAMINE RECEPTORS There are at least five subtypes of receptors: Receptor D1 D2 D3 D4 D5
  13. 13. Dopamine Reuptake System
  14. 14. Serotonetgic transmissionSerotonetgic transmission
  15. 15. Neurotransmitter  Substance produced in the neuron (synthesized), contained and secreted by that neuron to transmit information to postsynaptic target.

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