Dengue fever is caused by four serotypes of the dengue virus and is transmitted by the Aedes aegypti mosquito. It is one of the most prevalent mosquito-borne viral diseases in humans, affecting tropical and sub-tropical regions worldwide. When multiple serotypes infect a person simultaneously or sequentially, it can result in the more severe dengue hemorrhagic fever characterized by increased capillary permeability and plasma leakage leading to shock.

1. DENGUE
Introduction
Dengue fever is an acute febrile infectious disease, caused by all
four serotypes (DEN 1, 2, 3 or 4) of a virus from genus Flavivirus,
called dengue virus. It’s the most prevalent flavivirus infection of
humans, with a worldwide distribution in the tropics and warm
areas of the temperate zone corresponding to that of the principal
vector, Aedes aegypti (A. aegypti) When simultaneous