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T h e M o d e r n
To n s i l l e c To M y
History
Indications
Innovative Techniques and Comorbidites
Intracapsular tonsillectomy
Harmonic scalpel
Laser
Coblation
Adjuvant Therapy
Local Anesthesia: Bupivacaine
Perioperative Dexamethasone
Postoperative Antibiotics
Current Practice Patterns
History
Aulus Cornelius Celsus
1stCentury AD
“the tonsils are loosened by scraping around them and
then torn out” with a finger
Used vinegar and medication for postoperative hemostasis
Aetius of Amida
6thCentury AD
Hook and knife method
Philip Syng Physick (“Father of American surgery”)
First to develop the tonsillotome
Mackenzie
Late 1800s
Made tonsillotome use common
Partial versus complete tonsil removal
1906 William Lincoln Ballenger recommended
complete removal of tonsil with the capsule intact
1909 George Ernest Waugh credited as first to
describe complete tonsillectomy
1911-1917 Crowe reviewed 1000 tonsillectomies
Use of Crowe-Davis mouth gag
Sharp dissection
History
Indications
AAO-HNS
published
guidelines in 1995
Clinical Indicators
Compendium
Tonsillar disease
refractory to
medical therapy
3/+ infections/year
Hypertrophy
Dental malocclusion
Orofacial growth affected
Upper airway obstruction
Dysphagia
Sleep disorders
Cardiopulmonary complications
Peritonsillar abscess
Halitosis due to chronic tonsillitis
Chronic/recurrent tonsillitis with Strep
carrier state
Unilateral hypertrophy, presumed
neoplasm
American Academy of Otolaryngology-Head and Neck Surgery: 1995 Clinical indicators
compendium, Alexandria, Virginia, 1995, American Academy of Otolaryngology-Head and Neck
Surgery
Indications
Paradise et al, 1984
Parallel randomized and
non-randomized clinical
trials to evaluate the
efficacy of tonsillectomy in
the pediatric population
with recurrent pharyngitis
Criteria
7/+ episodes in last 1 year
5/+ episodes in last 2 years
3/+ episodes in last 3 years
Clinical features of each episode
Fever
Lymphadenopathy
Tonsillar/pharyngeal exudate
Positive Ăź-hemolytic streptococcus test
Medically treated
Paradise et al
Paradise conclusions
Tonsillectomy was efficacious for 2 years and
possibly a third in reducing frequency and
severity of subsequent episodes
Paradise criteria adopted by many
otolaryngologists
Paradise et al
Paradise et al, 2002
2 parallel randomized controlled trials to evaluate
efficacy of tonsillectomy in moderately affected
children
Surgical criteria not as stringent as those in previous
study
Results
Incidence of subsequent pharyngitis in surgical groups
significantly lower than control group for 3 years
postoperatively
However, overall incidence of recurrence was low
Concluded that surgical criteria must remain stringent
Innovative Techniques
Intracapsular
Tonsillectomy
Harmonic Scalpel
Laser
Coblation
Guiding Principle:
reduce morbidity
Hemorrhage
Pain
Diet
Activity
Cost
Intracapsular Tonsillectomy
Koltai et al, 2002
Retrospective case series (312)
Tonsillar hypertrophy causing sleep disordered
breathing
Intracapsular tonsillectomy (150)
Microdebrider at 1500 rpm in oscillating mode
Hemostasis with suction cautery
Total tonsillectomy (162)
Subcapsular
Group
Intracapsular
EBL(mL)
25
Immediate
Postop
Hemorrhage
0
Delayed
Postop
Hemorrhage
1
Postop
Dehydration
1
150
Total
Tonsillectomy
30 0 6 5
162
Koltai PJ et al: Intracapsular Partial tonsillectomy for tonsillar hypertrophy in children. Laryngoscope
112:17-19, 2002.
Koltai et al.
Statistically significant results
Intracapsular group had lower pain scores at each postoperative
time interval: POD 1-3, 4-6,7-9, after 9
Intracapsular group had earlier return to normal activity
Intracapsular group had less analgesic use
Conclusions
Tonsil capsule is not violated thereby avoiding pharyngeal muscle
exposure to secretions, injury, and inflammation
As a result, postoperative pain and recovery time reduced
Weaknesses
Retrospective study: Recall bias
Tonsillar regrowth
Surgical experience
Koltai et al.
Sorin et al., 2004
Retrospective review with follow up (278)
11 Complications (3.9%)
9 with tonsillar regrowth with snoring
2 required completion tonsillectomy
1 with immediate self-limited bleeding
1 with delayed bleeding
Complications of Intracapsular
Tonsillectomy
Sorin A et al: Complications of microdebrider-assisted powered intracapsular tonsillectomy
and adenoidectomy. Laryngoscope 114:297-300, 2004.
Sorin et al.
Intracapsular Tonsillectomy in
Children Under 3 Years
Bent et al., 2004
Retrospective cohort
study (226)
36 patients < 36 mo
186 patients > 36
mo
Bent et al: Ambulatory powered intracapsular tonsillectomy and adenoidectomy in children
younger than 3 years. Arch Otolaryngol Head Neck Surg 130:1197-1200, 2004.
Conclusions
Intracapsular tonsillectomy is safe and
efficacious in children under 3 years for
tonsillar hypertrophy and sleep disordered
breathing without need for admission
Limitations
Retrospective study
Uneven distribution
Long term results of tonsillar regrowth
unknown
Bent et al.
Harmonic Scalpel Tonsillectomy
Ultrasonic dissector and coagulator
Vibratory energy
Cutting: sharp blade with frequency of 55.5
kHz over distance of 80 ÎĽm
Coagulating: vibration breaks H-bonds,
thermal energy
50° – 100° C
Electrocautery 150° – 400° C
Willging et al., 2003
Single-blind, randomized prospective study (117)
Harmonic scalpel versus electrocautery
Indications: recurrent infection and hypertrophy with
airway obstruction
Outcomes measured: intraoperative bleeding,
operative time, postoperative hemorrhage
Questionnaire used for assessment of postop pain,
ability to eat and drink, and level of activity
Harmonic Scalpel Tonsillectomy
Operative time statistically significant
Harmonic scalpel 8 min 42 sec
Electrocautery 4 min 33 sec
No significant difference in intraoperative blood
loss and postoperative ability to eat and drink
Level of activity for the first postop day
significantly lower in harmonic scalpel group
Postoperative pain scores tended to be lower in
harmonic scalpel group
Postoperative bleeding
Harmonic scalpel: 6
Electrocautery: 3
Not statistically significant
Willging et al
Laser Tonsillectomy
Kothari et al, 2002
Prospective double-blind randomized controlled trial
(151)
Compare the use of KTP laser tonsillectomy versus cold
dissection and snare
KTP 532 laser at 10W, continuous beam
Outcomes measured
Operative time
Operative bleeding
Postoperative pain
Postoperative advancement to diet
Results
Operative time:
Laser 12 min
Dissection 10 min
Not statistically significant
Intraoperative blood loss
Laser 20 mL
Dissection 95 mL
Statistically significant
Laser group with higher postop pain scores
Laser group with greater difficulty resuming postoperative diet
Readmission for delayed hemorrhage was 8% in the laser group
and 4% in the dissection group
Not statistically significant
Kothari et al
Kothari et al
Kolthari P et al: A prospective double-blind randomized controlled trial comparing the
suitability of KTP laser tonsillectomy with conventional dissection tonsillectomy for day
case surgery. Clin. Otolaryngol. 27:369–373, 2002.
Conclusion
KTP laser provides little benefit over
dissection tonsillectomy except to minimize
intraoperative bleeding
Limitations
Technical expertise
Electrocautery not included
Kothari et al
Coblation Tonsillectomy
Bipolar radiofrequency energy transferred to
sodium molecules to create an ion or plasma
field
This thin layer of plasma is utilized to ablate
tissues at molecular level
No need for electrocautery for hemostasis
Temperature from 40° to 85° C
Electrocautery at 20W: above 400° C
Chang et al, 2005
Prospective randomized double-blinded
controlled study (101)
Compared intracapsular tonsillectomy using
coblation versus traditional subcapsular
tonsillectomy in children
OSA
Sleep disordered breathing
Coblation Tonsillectomy
Coblation
From surface out laterally
Coblate 9 setting to ablate tissues
Coblate 5 setting to coagulate
Capsule not penetrated
Electrocautery
Bovie set to 20 W
Outcomes measured
Questionnaire
Pain
Analgesics
Nausea/vomiting
Diet
Activity
Complications
Chang et al
Chang et al
Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy.
Otolaryngol Head Neck Surg 132:273-280, 2005.
Chang et al
Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy.
Otolaryngol Head Neck Surg 132:273-280, 2005.
Chang et al
Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy.
Otolaryngol Head Neck Surg 132:273-280, 2005.
Chang et al
Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy.
Otolaryngol Head Neck Surg 132:273-280, 2005.
Weaknesses
Study compares intracapsular technique with
subcapsular technique
Capsule and therefore underlying pharyngeal tissues not
violated
Does not account for possible long term possibility of
tonsillar regrowth
Similar study performed by Chan et al, 2004
Stoker et al, 2004 performed similar study but
used coblation for blunt dissection to perform
total tonsillectomy
Chan and Stoker had similar results in reduction
of postoperative morbidity
Chang et al
Coblation Tonsillectomy
Future considerations
To evaluate coblation for
intracapsular tonsillectomy,
a fair study would use
another intracapsular
technique such as power-
assisted tonsillectomy with
a microdebrider
Adjuvant Therapies
Aims are to reduce comorbidities of
tonsillectomy
Reduce pain
Reduce nausea
Resume diet
Resume activity
Reduce overall postoperative cost
Local Anesthetic: Bupivacaine
Steroids: Dexamethasone
Postoperative Antibiotics
Local Anesthetic
Tonsils innervated by:
Tonsillar branches of glossopharyngeal nerve
Palatine nerves of V2
Lingual branches of V3
Bupivacaine: amide anesthetic
High lipid solubility and protein binding
Rapid onset with effect lasting 6-9 hours
Violaris and Tuffin, 1989
Prospective double-blind controlled trial to
evaluate the application of topical bupivacaine
versus saline following tonsillectomy in the
same patient
The side treated with bupivacaine had higher
pain scores than saline
Local Anesthetic
Nordahl et al, 1999
Prospective double-blind randomized trial with three
treatment arms, intraoperative injections
42 with saline (9mg/ml)
41 with saline (9mg/ml) and epinephrine (5ÎĽg/ml)
43 with bupivacaine (2.5mg/ml) and epinephrine (5ÎĽg/ml)
Injections in tonsillar pillars and uvula
Postoperative pain scores recorded at varying
intervals
Varying experience of otolaryngologist performing
injection and tonsillectomy
Local Anesthetic
Nordahl et al
Nordahl SHG, Albrektsen G, Guttormsen AB, Pedersen IL, Breidablikk H-J. Effect of bupivacaine on
pain after tonsillectomy: a randomized clinical trial. Acta Otolaryngol (Stockh) 119:369–376, 1999.
Results
Only statistically significant pain score was with
swallowing (without food) in the bupivacaine and epi
group
Patients treated by experienced otolaryngologist in
the bupivacaine and epi group had lowest pain scores
Patients treated by less experienced otolaryngologists
in the bupivacaine and epi group had highest pain
scores
No difference in analgesic consumption among
groups
Limitations
Technique not specified for tonsillectomy
Number of patients treated by experienced or less
experienced otolaryngologists not specified
Nordahl et al
Kountakis et al, 2002
Prospective randomized blinded and
controlled study in adults (34)
10 mL 0.5% bupivacaine vs 10 mL NS
Electrocautery tonsillectomy
Daily questionnaires for 10 days
Pain score
Analgesic required
Oral intake
Local Anesthetic
Kountakis SE: Effectiveness of Perioperative Bupivacaine
Infiltration in Tonsillectomy Patients. Am J Otolaryngol 23:76-80,
2002.
Kountakis et al
No significant difference in pain, analgesic
use and oral intake among groups
Bupivacaine group more comfortable in
initial period following tonsillectomy
Significant variation in pain score when
bupivacaine wore off
Kountakis et al
Intraoperative Steroids
Systemic corticosteroids known
for mood elevation, appetite
stimulation, anti-inflammatory and
antiemetic effect
Used during chemotherapy to treat
nausea
Exact antiemetic mechanism
unknown
Dexamethasone
Half-Life 36 – 72 hours
Low cost $0.25/4mg
Steward et al, 2001
Meta-analysis of 8 double-blinded randomized
controlled trials using dexamethasone for
children undergoing tonsillectomy
Outcomes measured
Postoperative emesis
Return to soft or solid diet
Postoperative pain
Single dose 0.15 – 1.0 mg/kg
Sensitivity analyses performed
Intraoperative Dexamethasone
Steward et al
Steward et al: Do steroids reduce morbidity of tonsillectomy? Meta-analysis of randomized
trials. Laryngoscope 111:1712-1718, 2001.
Postoperative pain was not analyzed
Missing data and different measurements
No adverse events from Dexamethasone
Strength
Sensitivity analyses
Dose recommended 1 mg/kg
Weakness
Cannot be generalized to adult population
Steward et al
Carr et al, 1999
Double-blind randomized controlled trial (34)
Adults undergoing electrocautery
tonsillectomy
Dexamethasone (20mg) vs. saline
Outcomes measured
Postoperative pain
Analgesic use
Intraoperative Dexamethasone
Carr et al
Carr MM et al: Effect of steroids on posttonsillectomy pain in adults. Arch
Otolaryngol Head Neck Surg 125:1361-1364, 1999.
A
M
P
M
C
o
d
e
i
n
e
A
c
e
t
a
m
Although the dexamethasone group had
lower pain scores this was not statistically
significant
No difference in groups for number of
days off of work or to return to normal diet
Dexamethasone group tended to require
less analgesia but not statistically
significant for 10 days postoperatively
Carr et al
Postoperative Antibiotics
Decrease bacterial colonization of
pharyngeal tissues to reduce inflammation
following tonsillectomy
Pain reduction
Improving oral intake
Possibly decreasing postoperative
bleeding
Controversial: Bacterial Resistance
Telian et al, 1986
Randomized controlled trial to evaluate the
effect of ampicillin on recovery from
tonsillectomy in children
Ampicillin group had significantly fewer fevers,
improved oral intake, and had fewer days to
return to normal activity
Postoperative Antibiotics
Colreavy et al, 1999
Randomized controlled trial in children(78)
Amoxicillin/clavunanic acid
Outcomes measured:
Bacterial profiles
Postoperative pain scores
Days to normal diet
Analgesic use
Postoperative Antibiotics
Colreavy et al
Colreavy MP et al: Antibiotic prophylaxis post-tonsillectomy: is it of benefit? Int J Ped Otorhino
50:15-22, 1999.
O’Reilly et al, 2003
Randomized double-blinded controlled trial of the
effect of antibiotics in adults following tonsillectomy
Study group given intraoperative and postoperative
antibiotics while control group did not receive any
Outcomes measured
Postoperative bleeding
Postoperative pain
If PCP was contacted following surgery for pain/antibiotics
Postoperative Antibiotics
Results
Antibiotic administration had no influence on
postoperative pain and bleeding in adults
Weaknesses
Tonsillectomy technique not standardized
Recall bias
Patients questioned at follow-up or by mailed questionnaire
High drop out rate
High delayed hemorrhage in both groups (24%)
O’Reilly et al
Current Practice Patterns
In 2004, Krishna et al. conducted a 13
question survey of AAO-HNS members
regarding tonsillectomy (418)
Experience
Technique, and why
Local anesthetic
Perioperative steroids, and why
Postoperative antibiotics, and why
Krishna P et al: Current practice patterns in tonsillectomy and perioperative care. Int J of Ped
Otorhinolaryngology 68:779-784, 2004.
Krishna et al.
Technique
Monopolar electrocautery used most often
Greatest for otolaryngologists in practice < 20 years
Hemostasis
Sharp dissection most common for group in
practice > 20 years
Decreased pain
Method of hemostasis not mentioned
Local Anesthetic evenly distributed
Krishna et al.
Steroids
Most respondents used steroids
Decreased pain
Decreased nausea
Decreased swelling
Those in practice > 20 years less likely
Postoperative Antibiotics
Decreased pain
Decreased infection/inflammation
Faster Healing
Krishna et al.
Conclusions
Tonsillectomy is a surgical procedure that
carries significant postoperative morbidity
To minimize postoperative morbidity
various techniques and adjuvant therapies
have been studied
There are many options available and it
behooves an otolaryngologist to stay as
up to date as possible
SourcesAmerican Academy of Otolaryngology-Head and Neck Surgery: 1995 Clinical indicators compendium, Alexandria, Virginia, 1995, American Academy of Otolaryngology-
Head and Neck Surgery.
Bent et al: Ambulatory powered intracapsular tonsillectomy and adenoidectomy in children younger than 3 years. Arch Otolaryngol Head Neck Surg 130:1197-1200, 2004.
Bluestone CD: Current indications for tonsillectomy and adenoidectomy, Ann Otol Rhinol Laryngol Suppl 155:58, 1992.
Carr MM et al: Effect of steroids on posttonsillectomy pain in adults. Arch Otolaryngol Head Neck Surg 125:1361-1364, 1999.
Chan KH et al: Randomized, controlled, multisite study of intracapsular tonsillectomy using low-temperature plasma excision. Arch Otolaryngol Head Neck Surg
130:1303-1307, 2004.
Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy. Otolaryngol Head Neck Surg 132:273-280, 2005.
Christensen PH, Schonsted-Madsen U: Unilateral immediate tonsillectomy as the treatment of peritonsillar abscesses: results with special attention to pharyngitis, J
Laryngol Otol 97:1105, 1983.
Colreavy MP et al: Antibiotic prophylaxis post-tonsillectomy: is it of benefit? Int J Ped Otorhino 50:15-22, 1999.
Curtin JM: The history of tonsil and adenoid surgery, Otol Clin North Am 20:415, 1987.
Herzon FS: Peritonsillar abscess: incidence, current management practices and a proposal for treatment guidelines, Laryngoscope (Suppl) 74:1, 1995.
Jebeles JA, Reilly JS, Gutierrez JF, et al: The effect of pre-incisional infiltration of tonsils with bupivacaine on the pain following tonsillectomy under general anesthesia.
Pain 47:305-308, 1991.
Koempel, JA: On the origin of tonsillectomy and the dissection method, Laryngoscope 112:1583-1586, 2002.
Koltai PJ et al: Intracapsular Partial tonsillectomy for tonsillar hypertrophy in children. Laryngoscope 112:17-19, 2002.
Kolthari P et al: A prospective double-blind randomized controlled trial comparing the suitability of KTP laser tonsillectomy with conventional dissection tonsillectomy for
day
case surgery. Clin. Otolaryngol. 27:369–373, 2002.
Kountakis SE: Effectiveness of perioperative bupivacaine infiltration in tonsillectomy patients. Am J Otolaryngol 23:76-80, 2002.
Krishna P et al: Current practice patterns in tonsillectomy and perioperative care. Int J of Ped Otorhinolaryngology 68:779-784, 2004.
Liboon J et al: A comparison of mucosal incisions made by scalpel, CO2 laser, electrocautery, and constant-voltage eletrocautery. Otolaryngol Head Neck Surg 116:379-
385, 1997.
Lockhart R, Parker GS, Tami TA: Role of Quinsy tonsillectomy in the management of peritonsillar abscess, Ann Otol Rhinol Laryngol 100:569, 1991.
Martizez SA and Akin DP: Laser tonsillectomy and adenoidectomy. Otol Clin North Am 20:371-376, 1987.
Nordahl SHG, Albrektsen G, Guttormsen AB, Pedersen IL, Breidablikk H-J. Effect of bupivacaine on pain after tonsillectomy: a randomized clinical trial. Acta Otolaryngol
(Stockh) 119:369–376, 1999.
O’Reilly BJ et al: Is the routine use of antibiotics justified in adult tonsillectomy? Journal of Laryngology & Otology 117:382-385, 2003.
Paradise JL, Bluestone CD, Bachman RZ, et al: Efficacy of tonsillectomy for recurrent throat infection in severely affected children: results of parallel randomized and
nonrandomized clinical trials, N Engl J Med. 310:674–683, 1984.
Paradise JL, et al: Tonsillectomy and Adenotonsillectomy for Recurrent Throat Infection in Moderately Affected Children, Pediatrics 110(1):7, 2002.
Paradise JL, et al: Efficacy of adenoidectomy for recurrent otitis media in children previously treated with tympanostomy-tube placement: results of parallel randomized
and nonrandomized trials, JAMA 263:2066, 1990.
Rothschild MA, Catalano P, Biller HF: Ambulatory pediatric tonsillectomy and the identification of high-risk subgroups, Otolaryngol Head Neck Surg 110:203, 1994.
Sorin A et al: Complications of microdebrider-assisted powered intracapsular tonsillectomy and adenoidectomy. Laryngoscope 114:297-300, 2004.
Steward DL et al: Do steroids reduce morbidity of tonsillectomy? Meta-analysis of randomized trials. Laryngoscope 111:1712-1718, 2001.
Stoker KE et al: Pediatric total tonsillectomy using coblation compared to conventional electrosurgery: A prospective, controlled single-blind study. Otolaryngol Head Neck
Surg 130:666-675, 2004.
Telian SA et al: The effect of antibiotic therapy on recovery after tonsillectomy in children: a controlled study. Arch Otolaryngol Head Neck Surg 112:610–615, 1986.
Thomsen J and Gower V: Adjuvant therapies in children undergoing adenotonsillectomy. Laryngoscope 112:32-34, 2002.
Violaris NS, Tuffin JR: Can post-tonsillectomy pain be reduced by topical bupivacaine? Double blind controlled trial. J Laryngol Otol 103:592-593, 1989.
Walker RA, Syed ZA: Harmonic scalpel tonsillectomy versus electrocautery tonsillectomy: a comparative pilot study. Otolaryngol Head Neck Surg 125:449–455, 2001.
Wiatrak BJ et al: Harmonic scalpel for tonsillectomy. Laryngoscope 112:14-16, 2002.
Willging JP et al: Harmonic scalpel tonsillectomy in children: a randomized prospective study. Otolaryngol Head and Neck Surg 128:318-325, 2003.

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Modern Tonsillectomy: A Historical Review

  • 1. T h e M o d e r n To n s i l l e c To M y
  • 2. History Indications Innovative Techniques and Comorbidites Intracapsular tonsillectomy Harmonic scalpel Laser Coblation Adjuvant Therapy Local Anesthesia: Bupivacaine Perioperative Dexamethasone Postoperative Antibiotics Current Practice Patterns
  • 3. History Aulus Cornelius Celsus 1stCentury AD “the tonsils are loosened by scraping around them and then torn out” with a finger Used vinegar and medication for postoperative hemostasis Aetius of Amida 6thCentury AD Hook and knife method Philip Syng Physick (“Father of American surgery”) First to develop the tonsillotome Mackenzie Late 1800s Made tonsillotome use common
  • 4. Partial versus complete tonsil removal 1906 William Lincoln Ballenger recommended complete removal of tonsil with the capsule intact 1909 George Ernest Waugh credited as first to describe complete tonsillectomy 1911-1917 Crowe reviewed 1000 tonsillectomies Use of Crowe-Davis mouth gag Sharp dissection History
  • 5. Indications AAO-HNS published guidelines in 1995 Clinical Indicators Compendium Tonsillar disease refractory to medical therapy 3/+ infections/year Hypertrophy Dental malocclusion Orofacial growth affected Upper airway obstruction Dysphagia Sleep disorders Cardiopulmonary complications Peritonsillar abscess Halitosis due to chronic tonsillitis Chronic/recurrent tonsillitis with Strep carrier state Unilateral hypertrophy, presumed neoplasm American Academy of Otolaryngology-Head and Neck Surgery: 1995 Clinical indicators compendium, Alexandria, Virginia, 1995, American Academy of Otolaryngology-Head and Neck Surgery
  • 6. Indications Paradise et al, 1984 Parallel randomized and non-randomized clinical trials to evaluate the efficacy of tonsillectomy in the pediatric population with recurrent pharyngitis
  • 7. Criteria 7/+ episodes in last 1 year 5/+ episodes in last 2 years 3/+ episodes in last 3 years Clinical features of each episode Fever Lymphadenopathy Tonsillar/pharyngeal exudate Positive Ăź-hemolytic streptococcus test Medically treated Paradise et al
  • 8. Paradise conclusions Tonsillectomy was efficacious for 2 years and possibly a third in reducing frequency and severity of subsequent episodes Paradise criteria adopted by many otolaryngologists Paradise et al
  • 9. Paradise et al, 2002 2 parallel randomized controlled trials to evaluate efficacy of tonsillectomy in moderately affected children Surgical criteria not as stringent as those in previous study Results Incidence of subsequent pharyngitis in surgical groups significantly lower than control group for 3 years postoperatively However, overall incidence of recurrence was low Concluded that surgical criteria must remain stringent
  • 10. Innovative Techniques Intracapsular Tonsillectomy Harmonic Scalpel Laser Coblation Guiding Principle: reduce morbidity Hemorrhage Pain Diet Activity Cost
  • 11. Intracapsular Tonsillectomy Koltai et al, 2002 Retrospective case series (312) Tonsillar hypertrophy causing sleep disordered breathing Intracapsular tonsillectomy (150) Microdebrider at 1500 rpm in oscillating mode Hemostasis with suction cautery Total tonsillectomy (162) Subcapsular
  • 12. Group Intracapsular EBL(mL) 25 Immediate Postop Hemorrhage 0 Delayed Postop Hemorrhage 1 Postop Dehydration 1 150 Total Tonsillectomy 30 0 6 5 162 Koltai PJ et al: Intracapsular Partial tonsillectomy for tonsillar hypertrophy in children. Laryngoscope 112:17-19, 2002. Koltai et al.
  • 13. Statistically significant results Intracapsular group had lower pain scores at each postoperative time interval: POD 1-3, 4-6,7-9, after 9 Intracapsular group had earlier return to normal activity Intracapsular group had less analgesic use Conclusions Tonsil capsule is not violated thereby avoiding pharyngeal muscle exposure to secretions, injury, and inflammation As a result, postoperative pain and recovery time reduced Weaknesses Retrospective study: Recall bias Tonsillar regrowth Surgical experience Koltai et al.
  • 14. Sorin et al., 2004 Retrospective review with follow up (278) 11 Complications (3.9%) 9 with tonsillar regrowth with snoring 2 required completion tonsillectomy 1 with immediate self-limited bleeding 1 with delayed bleeding Complications of Intracapsular Tonsillectomy
  • 15. Sorin A et al: Complications of microdebrider-assisted powered intracapsular tonsillectomy and adenoidectomy. Laryngoscope 114:297-300, 2004. Sorin et al.
  • 16. Intracapsular Tonsillectomy in Children Under 3 Years Bent et al., 2004 Retrospective cohort study (226) 36 patients < 36 mo 186 patients > 36 mo Bent et al: Ambulatory powered intracapsular tonsillectomy and adenoidectomy in children younger than 3 years. Arch Otolaryngol Head Neck Surg 130:1197-1200, 2004.
  • 17. Conclusions Intracapsular tonsillectomy is safe and efficacious in children under 3 years for tonsillar hypertrophy and sleep disordered breathing without need for admission Limitations Retrospective study Uneven distribution Long term results of tonsillar regrowth unknown Bent et al.
  • 18. Harmonic Scalpel Tonsillectomy Ultrasonic dissector and coagulator Vibratory energy Cutting: sharp blade with frequency of 55.5 kHz over distance of 80 ÎĽm Coagulating: vibration breaks H-bonds, thermal energy 50° – 100° C Electrocautery 150° – 400° C
  • 19. Willging et al., 2003 Single-blind, randomized prospective study (117) Harmonic scalpel versus electrocautery Indications: recurrent infection and hypertrophy with airway obstruction Outcomes measured: intraoperative bleeding, operative time, postoperative hemorrhage Questionnaire used for assessment of postop pain, ability to eat and drink, and level of activity Harmonic Scalpel Tonsillectomy
  • 20. Operative time statistically significant Harmonic scalpel 8 min 42 sec Electrocautery 4 min 33 sec No significant difference in intraoperative blood loss and postoperative ability to eat and drink Level of activity for the first postop day significantly lower in harmonic scalpel group Postoperative pain scores tended to be lower in harmonic scalpel group Postoperative bleeding Harmonic scalpel: 6 Electrocautery: 3 Not statistically significant Willging et al
  • 21. Laser Tonsillectomy Kothari et al, 2002 Prospective double-blind randomized controlled trial (151) Compare the use of KTP laser tonsillectomy versus cold dissection and snare KTP 532 laser at 10W, continuous beam Outcomes measured Operative time Operative bleeding Postoperative pain Postoperative advancement to diet
  • 22. Results Operative time: Laser 12 min Dissection 10 min Not statistically significant Intraoperative blood loss Laser 20 mL Dissection 95 mL Statistically significant Laser group with higher postop pain scores Laser group with greater difficulty resuming postoperative diet Readmission for delayed hemorrhage was 8% in the laser group and 4% in the dissection group Not statistically significant Kothari et al
  • 23. Kothari et al Kolthari P et al: A prospective double-blind randomized controlled trial comparing the suitability of KTP laser tonsillectomy with conventional dissection tonsillectomy for day case surgery. Clin. Otolaryngol. 27:369–373, 2002.
  • 24. Conclusion KTP laser provides little benefit over dissection tonsillectomy except to minimize intraoperative bleeding Limitations Technical expertise Electrocautery not included Kothari et al
  • 25. Coblation Tonsillectomy Bipolar radiofrequency energy transferred to sodium molecules to create an ion or plasma field This thin layer of plasma is utilized to ablate tissues at molecular level No need for electrocautery for hemostasis Temperature from 40° to 85° C Electrocautery at 20W: above 400° C
  • 26. Chang et al, 2005 Prospective randomized double-blinded controlled study (101) Compared intracapsular tonsillectomy using coblation versus traditional subcapsular tonsillectomy in children OSA Sleep disordered breathing Coblation Tonsillectomy
  • 27. Coblation From surface out laterally Coblate 9 setting to ablate tissues Coblate 5 setting to coagulate Capsule not penetrated Electrocautery Bovie set to 20 W Outcomes measured Questionnaire Pain Analgesics Nausea/vomiting Diet Activity Complications Chang et al
  • 28. Chang et al Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy. Otolaryngol Head Neck Surg 132:273-280, 2005.
  • 29. Chang et al Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy. Otolaryngol Head Neck Surg 132:273-280, 2005.
  • 30. Chang et al Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy. Otolaryngol Head Neck Surg 132:273-280, 2005.
  • 31. Chang et al Chang KW: Randomized controlled trial of coblation versus electrocautery tonsillectomy. Otolaryngol Head Neck Surg 132:273-280, 2005.
  • 32. Weaknesses Study compares intracapsular technique with subcapsular technique Capsule and therefore underlying pharyngeal tissues not violated Does not account for possible long term possibility of tonsillar regrowth Similar study performed by Chan et al, 2004 Stoker et al, 2004 performed similar study but used coblation for blunt dissection to perform total tonsillectomy Chan and Stoker had similar results in reduction of postoperative morbidity Chang et al
  • 33. Coblation Tonsillectomy Future considerations To evaluate coblation for intracapsular tonsillectomy, a fair study would use another intracapsular technique such as power- assisted tonsillectomy with a microdebrider
  • 34. Adjuvant Therapies Aims are to reduce comorbidities of tonsillectomy Reduce pain Reduce nausea Resume diet Resume activity Reduce overall postoperative cost Local Anesthetic: Bupivacaine Steroids: Dexamethasone Postoperative Antibiotics
  • 35. Local Anesthetic Tonsils innervated by: Tonsillar branches of glossopharyngeal nerve Palatine nerves of V2 Lingual branches of V3 Bupivacaine: amide anesthetic High lipid solubility and protein binding Rapid onset with effect lasting 6-9 hours
  • 36. Violaris and Tuffin, 1989 Prospective double-blind controlled trial to evaluate the application of topical bupivacaine versus saline following tonsillectomy in the same patient The side treated with bupivacaine had higher pain scores than saline Local Anesthetic
  • 37. Nordahl et al, 1999 Prospective double-blind randomized trial with three treatment arms, intraoperative injections 42 with saline (9mg/ml) 41 with saline (9mg/ml) and epinephrine (5ÎĽg/ml) 43 with bupivacaine (2.5mg/ml) and epinephrine (5ÎĽg/ml) Injections in tonsillar pillars and uvula Postoperative pain scores recorded at varying intervals Varying experience of otolaryngologist performing injection and tonsillectomy Local Anesthetic
  • 38. Nordahl et al Nordahl SHG, Albrektsen G, Guttormsen AB, Pedersen IL, Breidablikk H-J. Effect of bupivacaine on pain after tonsillectomy: a randomized clinical trial. Acta Otolaryngol (Stockh) 119:369–376, 1999.
  • 39. Results Only statistically significant pain score was with swallowing (without food) in the bupivacaine and epi group Patients treated by experienced otolaryngologist in the bupivacaine and epi group had lowest pain scores Patients treated by less experienced otolaryngologists in the bupivacaine and epi group had highest pain scores No difference in analgesic consumption among groups Limitations Technique not specified for tonsillectomy Number of patients treated by experienced or less experienced otolaryngologists not specified Nordahl et al
  • 40. Kountakis et al, 2002 Prospective randomized blinded and controlled study in adults (34) 10 mL 0.5% bupivacaine vs 10 mL NS Electrocautery tonsillectomy Daily questionnaires for 10 days Pain score Analgesic required Oral intake Local Anesthetic
  • 41. Kountakis SE: Effectiveness of Perioperative Bupivacaine Infiltration in Tonsillectomy Patients. Am J Otolaryngol 23:76-80, 2002. Kountakis et al
  • 42. No significant difference in pain, analgesic use and oral intake among groups Bupivacaine group more comfortable in initial period following tonsillectomy Significant variation in pain score when bupivacaine wore off Kountakis et al
  • 43. Intraoperative Steroids Systemic corticosteroids known for mood elevation, appetite stimulation, anti-inflammatory and antiemetic effect Used during chemotherapy to treat nausea Exact antiemetic mechanism unknown Dexamethasone Half-Life 36 – 72 hours Low cost $0.25/4mg
  • 44. Steward et al, 2001 Meta-analysis of 8 double-blinded randomized controlled trials using dexamethasone for children undergoing tonsillectomy Outcomes measured Postoperative emesis Return to soft or solid diet Postoperative pain Single dose 0.15 – 1.0 mg/kg Sensitivity analyses performed Intraoperative Dexamethasone
  • 45. Steward et al Steward et al: Do steroids reduce morbidity of tonsillectomy? Meta-analysis of randomized trials. Laryngoscope 111:1712-1718, 2001.
  • 46. Postoperative pain was not analyzed Missing data and different measurements No adverse events from Dexamethasone Strength Sensitivity analyses Dose recommended 1 mg/kg Weakness Cannot be generalized to adult population Steward et al
  • 47. Carr et al, 1999 Double-blind randomized controlled trial (34) Adults undergoing electrocautery tonsillectomy Dexamethasone (20mg) vs. saline Outcomes measured Postoperative pain Analgesic use Intraoperative Dexamethasone
  • 48. Carr et al Carr MM et al: Effect of steroids on posttonsillectomy pain in adults. Arch Otolaryngol Head Neck Surg 125:1361-1364, 1999. A M P M C o d e i n e A c e t a m
  • 49. Although the dexamethasone group had lower pain scores this was not statistically significant No difference in groups for number of days off of work or to return to normal diet Dexamethasone group tended to require less analgesia but not statistically significant for 10 days postoperatively Carr et al
  • 50. Postoperative Antibiotics Decrease bacterial colonization of pharyngeal tissues to reduce inflammation following tonsillectomy Pain reduction Improving oral intake Possibly decreasing postoperative bleeding Controversial: Bacterial Resistance
  • 51. Telian et al, 1986 Randomized controlled trial to evaluate the effect of ampicillin on recovery from tonsillectomy in children Ampicillin group had significantly fewer fevers, improved oral intake, and had fewer days to return to normal activity Postoperative Antibiotics
  • 52. Colreavy et al, 1999 Randomized controlled trial in children(78) Amoxicillin/clavunanic acid Outcomes measured: Bacterial profiles Postoperative pain scores Days to normal diet Analgesic use Postoperative Antibiotics
  • 53. Colreavy et al Colreavy MP et al: Antibiotic prophylaxis post-tonsillectomy: is it of benefit? Int J Ped Otorhino 50:15-22, 1999.
  • 54. O’Reilly et al, 2003 Randomized double-blinded controlled trial of the effect of antibiotics in adults following tonsillectomy Study group given intraoperative and postoperative antibiotics while control group did not receive any Outcomes measured Postoperative bleeding Postoperative pain If PCP was contacted following surgery for pain/antibiotics Postoperative Antibiotics
  • 55. Results Antibiotic administration had no influence on postoperative pain and bleeding in adults Weaknesses Tonsillectomy technique not standardized Recall bias Patients questioned at follow-up or by mailed questionnaire High drop out rate High delayed hemorrhage in both groups (24%) O’Reilly et al
  • 56. Current Practice Patterns In 2004, Krishna et al. conducted a 13 question survey of AAO-HNS members regarding tonsillectomy (418) Experience Technique, and why Local anesthetic Perioperative steroids, and why Postoperative antibiotics, and why
  • 57. Krishna P et al: Current practice patterns in tonsillectomy and perioperative care. Int J of Ped Otorhinolaryngology 68:779-784, 2004. Krishna et al.
  • 58. Technique Monopolar electrocautery used most often Greatest for otolaryngologists in practice < 20 years Hemostasis Sharp dissection most common for group in practice > 20 years Decreased pain Method of hemostasis not mentioned Local Anesthetic evenly distributed Krishna et al.
  • 59. Steroids Most respondents used steroids Decreased pain Decreased nausea Decreased swelling Those in practice > 20 years less likely Postoperative Antibiotics Decreased pain Decreased infection/inflammation Faster Healing Krishna et al.
  • 60. Conclusions Tonsillectomy is a surgical procedure that carries significant postoperative morbidity To minimize postoperative morbidity various techniques and adjuvant therapies have been studied There are many options available and it behooves an otolaryngologist to stay as up to date as possible
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