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1. Dr Pradeep Mahajan

2. THE AGING MYTH
 Our lives are a giant forest, and the second we're born
a fire is set to it. During our lives we can do things to
FAN those flames (like by not eating right, abusing
drugs, etc) and burn the forest down faster.
 We can also do things to SLOW it down, too.
 But you can't douse that fire totally
 It ALWAYS burns.
 And eventually, ALL our forests burn down.

3. “We may already be too late, Mr. Parker.”

4. Aging is the Largest Killer
 In India 1 in 25 will be a senior citizen in 2020
 This ratio is several times higher in the Western
countries
 With state of the art technologies we can now evaluate
the status of aging in the body and monitor it.
 We also have technologies that can reduce the rate of
aging at the cellular and molecular level
 This is evidenced by improvement in all the
Physiological, Biochemical and Molecular parameters
of Aging

5. So...what is 'aging', exactly?
Aging is:
The life-long accumulation of damage to the tissues,
cells, and molecules of the body that occurs as an
intrinsic side-effect of the body's normal operation.
The body can tolerate some damage, but too much of it
causes disease and disability.

10. Genetics of Aging:
 Aging is not a passive activity,
 But an actively regulated metabolic process
 Specific genes identified that regulate aging,
 Aging and Longevity are only partially under genetic influence
 Rest of Gain is from Nutrition
 It is possible to increase life span by environmental modification;
 caloric restriction can increase life span
 dysregulation of glucose homeostasis is a hallmark of aging in
humans
 type 2 diabetes, a disease of glucose homeostasis, is a form of
accelerated aging
 Aging and Diabetes are both common risk factors for a wide range of
diseases
 Aging and Diabetes are related at a molecular level

14. Average lifespan with Aging
diseases

15. The Future of Living Well to 100
 Healthy aging presents an enormous challenge
 Advances in biological sciences provide the knowledge and tools needed
to
 understand nutrition at genetic and molecular levels and
 elevate the scientific basis underlying nutritional recommendations
 Understanding roles requires interdisciplinary cooperation of:
 nutrition
 genetics,
 inflammation
 Developing partnerships among specialties to promote the goal of
healthy aging
 come together as a science community
 generate the evidence base to influence recommendations
 Value of nutrition and genetics in achieving healthy aging
Am. J. Clinical Nutrition, Feb 2006; 83: 488s - 490s. Gordon W Duff, Peter Libby, José M Ordovas, and Philip R Reilly

16. The Different Paths to 100
 Most centenarians do not have significant disability
 90% of centenarians functionally independent @ ave. age
of 92 years
 A more enabling point of view emerges to achieve extreme
old age :
 The older an individual gets, the healthier he or she has
been
 Centenarians show
 Relative resistance to age-related diseases
 Slower aging

17.  Where are we heading
 1 centenarian per 10,000 persons in the United States
NOW
 1 centenarian per 5,000 persons for industrialized
nations SOON
 Ability to survive to extreme old age appears to be the
result of:
 Complex combination of
 Genetics,
 Environment
 Lifestyle (Diet, Exercise, Social Activities), and Luck

18.  The Future Path lies in:
 Better Perinatal Nutrition = Omega-3, Nutrients
 Genetics of the Very Old
 Identifying the molecular drivers of longevity or
mortality = omega 3/6 ratio
 Discovering and targeting the pathways mediating aging
and disease susceptibility
 Developing preventive and therapeutic agents that will
allow aging in good health

20. How to Delay, Reverse The Aging?
i.e Anti Aging
 Remove the damage or Inactive molecules and
cells
 Restore function to several molecules by repair &
Replacement
 Modify the Genetic Program to prevent the aging
process from continuing
How are we going to do Above changes...???

21. Antiaging Treatment Approaches
Hoslistic
YOGA
Neutra-
Ceuticals
&
Supple-
ments
Biologica
ls
GFCs/
BQ-A
SUPERFOODS
Stem cells
Therapy
&Banking
Immuno
Modulators
Prognostic &
Diagnostics

22. Who Can take Anti-Aging
Treatment
 Absolutely healthy aging (King of Good Times)
 Patients with age related diseases (Struggler King)
 Aging patients with serious & Advanced diseases
(Bankrupt King)

23. Holistic approach to Anti-aging Therapy
Congnitive Behavioral Therapy(W C Bushwell 2006)
What How
 Enhancing Self healing
capacities
 Mobilization of dormant
or sleeping stem cells
 Activate body immune
system
 Decreasing Free radicals
 Link between nutrition &
gene to be established
 telomers
 Diet – Veg & Fruits,
Green Tea
 Workout, Meditation,
Breathing Exercises
 Coping the stress
 Calorie Restrictions
 Antioxidants
 Growth hormone
supplements

24. Congnitive Behavioural Therapy
 Main action is on bone marrow and pineal gland
 Increasing molecular mediators like DHEA, IL4, IL10
& Melatonin & Growth hormones
 Enhancing health and anti aging effects using
dormant stem cells & immune system

25. “Not only to give more years to life
but especially to give more life to
years by stem cells therapy…”

26. Human
 An Adult Human once a tiny cell, is a self assembling
machine made of trillions of microscopic components
 Roughly a human being consist of
~7 x 1027 atoms and ~5 x 105 molecular genetic particles.
 Here we see = Gene proteins- an organic nano
structure working with molecular precession to form
complete cell.
 At age 30 around 30 million stem cells are in
circulation

27. Types / Sources of stem cells

28. Stem cells proportion with aging
growing cells > apoptic cells (Child)
Growing cells = apoptic cells (Mature
person)
Growing Cells < apoptic cells (Aging Starts)

29. Why Stem Cells...
 Stem cells and biological science is poised to
become next revolution in medicine to provide
exciting and promising alternatives to most
traditional solutions (allopathic), surgery and
drugs within the reach of everyday people.
 “Treating Today’s medical Problem with
tomorrow's solution.”

30. Gene Therapy
 If aging may be Reversed by expressing of key genes
then gene therapy holds a great future promise
 Delivers major information of aging in human body
 Involves use of vector for specific purpose for inserting
DNAs in cells
 RNAi
 Limitation:- Small Bandwidth for information

31. Cell Therapy
 Cell therapy has greater bandwidth
 Cells can be genetically engineered In vitro prior to be
used for treatment.

32. THE ADVANTAGES Of Stem Cell Anti-Aging Treatment
 Stem Cells from your own body are used
 No chemicals or drugs are needed
 Better breathing and sleeping pattern.
 Energy levels restored
 Age spots fade
 Complexion brightens and skin softens
 No more expensive supplements or creams required
 Hormones are re-balanced
 Sugar levels controlled

33.  Heightened sexual drive
 Increased metabolism and surprisingly an average 4-7
kg weight loss.
 Hair color darkening and volume increasing.
 There is also a better control of blood pressure and
improved vision
 Emotional and cognitive improvement occurs,
memory improves, concentration ability increases and
your ability to handle complex tasks, as you did before,
is regained.

34. God Seed
Changing
the soul of Man...

35. The God seed will
take over the
Programming
the DNA

36. God Seed

37. “You carry your own natural repairing
kits in your own body…!”
www.stemrx.in
twitter: @StemRx
Stem cells
Genetic code