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Energy
Adenosine Triphosphate
1    Adenosine    Phosphate           Phosphate                Phosphate




2    Adenosine    Phosphate           Phosphate                Phosphate




                                                      ATPase




                 11
3   Adenosine                 Phosphate           ENERGY        Phosphate
• The energy released from the breakdown
  of ATP to ADP + P is converted to kinetic and heat
  energy.
• The bond then needs to be re-built to be broken
  down again to create more energy.
• There are four ways that this is done in the body:
       1.   ATP System
       2.   Phosphocreatine system
       3.   Lactic Acid System
       4.   Aerobic Energy System
Phosphocreatine System
• Phosphocreatine is found in the sarcoplasm.
• When the enzyme ‘creatine kinase’ is present:
 Phosphocreatine --------------> P + Creatine + Energy

• For every molecule of PC broken down, 1
  molecule of ATP is produced.
• No fatiguing by-products are released
• Occurs between approximately 3-10 seconds
  of exercise.
ATP production in the lactic acid
                system
• Involves the partial breakdown of glucose.
• The enzyme ‘Phosphofructokinase’ is released
  when levels of phosphocreatine drop, and begin
  to break down the glucose molecules.
• These molecules break down into two pyruvic
  acid molecules.
• When oxygen is not present, pyruvic acid is
  converted into lactic acid by the enzyme ‘lactate
  dehydrogenase’.
• For every mole of glycogen broken down, 2
  molecules of ATP are gained.
The Aerobic System

                             NO
   PYRUVIC ACID                       LACTIC ACID
                           OXYGEN


                                     H2O
                             2 ATP
      OXYGEN
                                              ELECTRON
                                           TRANSPORT CHAIN
ACETYL-COENZYME A


                             KREBS
    CITRIC ACID
                             CYCLE
                                                34
                                                ATP
= Pyruvate Dehydrogenase
The Aerobic System
• If Oxygen is present then the pyruvic acid will convert into
  oxygen, and then into acetyl co-enzyme A and then (due to
  PDH) into citric acid until proceeding on to Krebes Cycle.
• In the Krebes cycle, 2 molecules of ATP are created.
• Then after entering the “electron transport chain” 34
  molecules of ATP are created. Water is a by-product.
• Takes place in the mitochondria.
The relationship of:
               intensity, hydrogen and oxygen



                                                                    More
                    Muscle         More ATP                     hydrogen is    More oxygen
 Exercise                                        More glucose
                  contraction       must be                      released in   is required to
 becomes                                          is broken
                 requires more   resynthesized                  the electron   combine with
more intense                                        down
                      ATP                                         transport    the hydrogen
                                                                    chain
Energy From Fats and Proteins
  FATS
• Fat is stored in adipose tissue as triglycerides.
• Requires more oxygen than the breakdown of glycogen.
• The presence of lactic acid inhibits the fat breakdown.

 PROTEINS
• Our bodies only rarely use proteins for ATP re-synthesis.
• Only used when the body is in a state of exhaustion.
SUMMARY
                         ATP-PC SYSTEM     LACTIC ACID             AEROBIC
Site of reaction         Sarcoplasm        Sarcoplasm              Sarcoplasm + Mitochondria

Oxygen present           Anaerobic         Anaerobic               Aerobic

Fuel used                Phosphocreatine   Carbohydrates           Carbohydrate and Fat

Active enzyme            Creatine Kinase   Phosphofructokinase     Phosphofructokinase + Lipase


Enzyme activated by      ATP increase      Decrease in PC levels   Decrease in insulin levels

Relative speed           Very fast         Fast                    Slow

By-products              None              Lactic Acid             Carbon Dioxide and Water

Effects of by-products   None              Inhibits enzyme         None as easily expelled from body

Energy Yield             1                 2                       38

Threshold                3-10 seconds      1-2 minutes             Unlimited in sub-maximal exercise
OBLA (onset of blood lactate accumulation)

 • The point where blood lactate concentration
   rises to approximately 4mmol/l.
 • It is also the point where lactic acid cannot be
   removed quickly.
 • The lactate threshold is reached at a certain
   VO max. For elite athletes this will be at about
      2


   70-80%.
Excess post-exercise oxygen consumption
                 (EPOC)
  “The amount of oxygen consumed during recovery above that which would
  have ordinarily been consumed at rest.”

  Made up of two main components:
            • Alactacid Component – The fast replenishment stage
            • Lactacid Component - The slow replenishment stage
Stage          Time           Oxygen used      Function 1          Function 2     Function 3



Alactacid      Completed      Up to 4 litres   Re-saturate         Resynthesise   Resynthesise
Stage          within 2-3                      myoglobin           ATP            PC
               minutes                         with oxygen

Lactacid       Can take up    5-10 litres      Lactic acid         Replenishment Re-balance
Stage          to 2 hours                      removal             of muscle     body
                                                                   glycogen      temperature
                                                                   stores
Energy sources used in aerobic energy system

GLYCOLYSIS                  BETA OXIDISATION
Carbohydrates                Fats                                Proteins

Stored in the muscle as      Stored in adipose tissue as         Stored in muscle cells
glycogen                     triglycerides

Glucose                      Fatty Acids                         Amino Acids
                                             ATTACHES TO FATTY
                                             ACIDS AND
                                             TRANSPORTED IN
                                             BLOOD


                                OXYGEN

                             ACETYL - COENZYME                         Glucose = 38 ATP
                                                                     Fatty Acids = 130 ATP


                      THROUGH AEROBIC ENERGY SYSTEM

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  • 2. Adenosine Triphosphate 1 Adenosine Phosphate Phosphate Phosphate 2 Adenosine Phosphate Phosphate Phosphate ATPase 11 3 Adenosine Phosphate ENERGY Phosphate
  • 3. • The energy released from the breakdown of ATP to ADP + P is converted to kinetic and heat energy. • The bond then needs to be re-built to be broken down again to create more energy. • There are four ways that this is done in the body: 1. ATP System 2. Phosphocreatine system 3. Lactic Acid System 4. Aerobic Energy System
  • 4. Phosphocreatine System • Phosphocreatine is found in the sarcoplasm. • When the enzyme ‘creatine kinase’ is present: Phosphocreatine --------------> P + Creatine + Energy • For every molecule of PC broken down, 1 molecule of ATP is produced. • No fatiguing by-products are released • Occurs between approximately 3-10 seconds of exercise.
  • 5. ATP production in the lactic acid system • Involves the partial breakdown of glucose. • The enzyme ‘Phosphofructokinase’ is released when levels of phosphocreatine drop, and begin to break down the glucose molecules. • These molecules break down into two pyruvic acid molecules. • When oxygen is not present, pyruvic acid is converted into lactic acid by the enzyme ‘lactate dehydrogenase’. • For every mole of glycogen broken down, 2 molecules of ATP are gained.
  • 6. The Aerobic System NO PYRUVIC ACID LACTIC ACID OXYGEN H2O 2 ATP OXYGEN ELECTRON TRANSPORT CHAIN ACETYL-COENZYME A KREBS CITRIC ACID CYCLE 34 ATP = Pyruvate Dehydrogenase
  • 7. The Aerobic System • If Oxygen is present then the pyruvic acid will convert into oxygen, and then into acetyl co-enzyme A and then (due to PDH) into citric acid until proceeding on to Krebes Cycle. • In the Krebes cycle, 2 molecules of ATP are created. • Then after entering the “electron transport chain” 34 molecules of ATP are created. Water is a by-product. • Takes place in the mitochondria.
  • 8. The relationship of: intensity, hydrogen and oxygen More Muscle More ATP hydrogen is More oxygen Exercise More glucose contraction must be released in is required to becomes is broken requires more resynthesized the electron combine with more intense down ATP transport the hydrogen chain
  • 9. Energy From Fats and Proteins FATS • Fat is stored in adipose tissue as triglycerides. • Requires more oxygen than the breakdown of glycogen. • The presence of lactic acid inhibits the fat breakdown. PROTEINS • Our bodies only rarely use proteins for ATP re-synthesis. • Only used when the body is in a state of exhaustion.
  • 10. SUMMARY ATP-PC SYSTEM LACTIC ACID AEROBIC Site of reaction Sarcoplasm Sarcoplasm Sarcoplasm + Mitochondria Oxygen present Anaerobic Anaerobic Aerobic Fuel used Phosphocreatine Carbohydrates Carbohydrate and Fat Active enzyme Creatine Kinase Phosphofructokinase Phosphofructokinase + Lipase Enzyme activated by ATP increase Decrease in PC levels Decrease in insulin levels Relative speed Very fast Fast Slow By-products None Lactic Acid Carbon Dioxide and Water Effects of by-products None Inhibits enzyme None as easily expelled from body Energy Yield 1 2 38 Threshold 3-10 seconds 1-2 minutes Unlimited in sub-maximal exercise
  • 11. OBLA (onset of blood lactate accumulation) • The point where blood lactate concentration rises to approximately 4mmol/l. • It is also the point where lactic acid cannot be removed quickly. • The lactate threshold is reached at a certain VO max. For elite athletes this will be at about 2 70-80%.
  • 12. Excess post-exercise oxygen consumption (EPOC) “The amount of oxygen consumed during recovery above that which would have ordinarily been consumed at rest.” Made up of two main components: • Alactacid Component – The fast replenishment stage • Lactacid Component - The slow replenishment stage Stage Time Oxygen used Function 1 Function 2 Function 3 Alactacid Completed Up to 4 litres Re-saturate Resynthesise Resynthesise Stage within 2-3 myoglobin ATP PC minutes with oxygen Lactacid Can take up 5-10 litres Lactic acid Replenishment Re-balance Stage to 2 hours removal of muscle body glycogen temperature stores
  • 13. Energy sources used in aerobic energy system GLYCOLYSIS BETA OXIDISATION Carbohydrates Fats Proteins Stored in the muscle as Stored in adipose tissue as Stored in muscle cells glycogen triglycerides Glucose Fatty Acids Amino Acids ATTACHES TO FATTY ACIDS AND TRANSPORTED IN BLOOD OXYGEN ACETYL - COENZYME Glucose = 38 ATP Fatty Acids = 130 ATP THROUGH AEROBIC ENERGY SYSTEM