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Edmund T. Pratt Jr. School of Engineering at Duke University 2011-2012 dukeng 
FCIEMAS 
A Catalyst for Pratt’s 
Architectural, Technological 
and Social Transformation 
Engineering Opportunities at the 
Marine Lab: Duke’s True East Campus 
Life after The Grand Challenges 
Engineering and Music at Duke 
www.pratt.duke.edu | www.dukengineer.pratt.duke.edu
ineer
dukengineer Edmund T. Pratt Jr. School of Engineering at Duke University 2011-2012 
on the lighter side 
Crossword Challange | The Life of an Engineer 
www.pratt.duke.edu 
letters 
2 From the Editor 
3 From the Dean 
4 From the ESG President 
5 From the EGSC President 
education 
6 Engineering & Music at Duke 
8 CE 185: Design Project 
10 Engineering Student Government 
features 
12 Life After The Grand Challenges 
16 Duke’s True East Campus 
20 Engineering Preception Changes 
Year-Year 
22 COVER 
FCIEMAS: A Catalyst for Pratt's 
Architectural, Technological and 
Social Transformation 
research 
26 BME: Soft Matter 
28 BME: Synthetic Biology 
30 ECE: Fluid Cloaking 
32 SMiF Center 
profiles 
36 Motorsports 
38 Smart Home 
summer stories 
40 Building Bridges to Form Connections 
42 Pratt Fellows 
44 RTI Biologics Internship 
alumni news 
46 Alumni Profile: J. Michael Pearson 
47 Class Notes 
50 In Memory 
development 
54 Letter from EAC President 
55 Annual Fund Statistics 
58 Honor Roll 
Editor 
Tejen Shah 
Associate Editors 
Anirudh Mohan 
Cameron McKay 
Jimmy Zhong 
Lauren Shwisberg 
Tom Mercer 
Wyatt Shields 
DukEngineer Writers 
Jade Brown 
Hersh Desai 
Ajeet Hansra 
Jennifer Hewitt 
Nooshin Kiarashi 
Rachel Lance 
Nathan Li 
Cameron McKay 
Anirudh Mohan 
James Mullally 
Katy Riccione 
Tejen Shah 
Wyatt Shields 
Lauren Shwisberg 
Emily Sloan 
Visakha Suresh 
Suzana Vallejo-Heligon 
Justin Yu 
Jimmy Zhong 
Consulting Editor 
Richard Merritt 
Webmaster 
Meng Kang 
Designer 
Lacey Chylack 
phasefivecreative,inc 
Technical Support 
Mandy Ferguson 
Photographer: Becca Bau p.72
letters From the Editor 
We are proud to bring you the 2011-12 issue of the DukEngineer Magazine, which features the 
2 dukengineer 2012 
experiences and accomplishments of Pratt School of Engineering students, faculty and alumni. 
The cover story this year focuses on Fitzpatrick Center for Interdisciplinary Engineering, Medicine 
and Applied Sciences (FCIEMAS). It has been operational for about seven years, and we wanted to 
reflect on the impact it has had on the Duke community and to explore the architectural innovations incorpo-rated 
in the building that often go unnoticed by passersby. 
We have decided to cover some stories, such as the Grand Challenge Scholar (GCS) program, Smart Home, 
Shared Material’s Instrumentation Facility (SMiF) and the Motorsports club, that we have covered in the past 
but from a slightly different perspective. Over the past two years, the GCS program was mainly written from a 
programming perspective. This year we take a look at the life after the GCS program and see how the program 
has helped recently graduated GC scholars succeed professionally. We also look at the progress and invalu-able 
contributions Smart Home, SMiF and Motorsports have made to different aspects of Pratt community. 
We continue to cover the cutting-edge research of our faculty and graduate students. We profile Gabriel 
Lopez’s research on soft matter that could potentially help develop coating that would prevent bacteria from 
sticking to solid surfaces. We also showcase Yaroslav Urzhumov and David Smith’s research on a fluid cloak 
that helps hide an object from a flowing fluid. Finally, we profile Lingchong You’s research in synthetic biology 
that has wide-ranging applications from diagnosing new cancers to finding new ways of fabricating materials. 
Pratt has evolved significantly over the past few years, and there are exciting new opportunities available to 
engineers who want to dabble in liberal arts. Some of these interdisciplinary opportunities are not as visible on 
campus, and we have two articles in this year’s magazine that showcase these opportunities. The first article 
is related to interesting research opportunities available for engineers at the Duke Marine Lab in Beaufort. The 
second article highlights how music is intertwined with the Pratt curriculum and there are ample opportunities 
for engineers to pursue their passion for music. 
Furthermore, we have continued the recent tradition of featuring students summer experiences related to 
internships, Pratt Fellows research and international services trips. This year we have writers at different 
phases in their careers: from freshmen to seniors, to grad school and beyond. Therefore, we 
have an interesting piece on how perspective of being an engineer changes from year to 
year. The last page of the publication features “The Lighter Side” article that we hope 
will make this issue of DukEngineer magazine entertaining. 
We would like to thank our writers, Pratt faculty, architects at Zimmer Gunsul 
Frasca and all the other members of the Pratt community who helped us throughout 
the process of publishing this magazine. We would also like to thank our advisor, 
Richard Merritt with the Pratt Communications Department for his patience and 
invaluable support. We hope that you will share comments, questions and concerns 
with us through our website at: http://www.dukengineer.pratt.duke.edu. 
Enjoy! 
Tejen Shah 
Editor, DukEngineer Magazine 2011-12 
B.S.E in Biomedical Engineering ‘13
2012 dukengineer 3 
Last spring I had the great pleasure to experience an 
impressive example of engineering in action. One of our 
students, Katrina Wisdom, combined her knowledge of 
the laws of physics with her passion for dance. In her 
presentation, and performance, entitled “Fouette Turns and 
Fourier Series,” she explained and demonstrated the subtle inter-sections 
of engineering and dance. 
At one point, three volunteer dancers were asked perform 
turns in a synchronized fashion. I’m sure you’ve seen these turns. 
On one leg, with eyes fixated on one spot, they spun until their 
heads whipped around to gaze the same spot. Over and over 
again. As they spun faster and faster, a “resonance” made it 
appear that they were spinning even faster and with less effort 
than if they had been dancing alone. Katrina cleverly used art to 
provide an insight into an underlying scientific phenomenon – 
namely oscillations — that an average person could grasp. 
As I think back to that day, I sense a similar metaphorical res-onance 
taking place here at Pratt – instead of three dancers 
working together cooperatively, I see faculty, students and staff 
providing a certain “resonance” that makes this a great place to 
be. Every day, I feel a palpable momentum driving all aspects of 
our mission forward. 
By just about any measure, Pratt is a growing, thriving envi-ronment 
to live, learn and teach. And with the way the future 
looks, I don’t foresee that momentum slowing down. 
Research expenditures have increased dramatically. For U.S. 
News and World Reporting rankings, we reported an increase 
from $74 million to $87.5 million in research expenditures. Our 
actual number is closer to $94 million when we include subcon-tracts. 
This is very close to our longstanding goal of reaching 
$100 million in research, in the league of engineering research 
powerhouses. 
Pratt landed a $20 million endowment for the Duke Coulter 
Translation Partnership and a $13.6 million to fund a regional 
center for soft matter research. 
But what we are really all about here at Pratt is people. What 
the research growth enables us to do is offer richer learning 
opportunities and to more students. 
For example, we graduated 62 new Ph.D.s in the spring, an 
increase of 10 more students than the previous year. 
We launched our new master of engineering program last fall 
with seven distinct degree concentrations spanning all four of 
our departments. The goal is to provide an alternative to the tra-ditional, 
research-focused master of science curriculum and give 
students a competitive edge in their industry careers. Students 
gain business acumen to help them navigate corporate environ-ments 
and better prepare for project management while gaining 
real world, practical research skills. The new degree is driving 
masters growth at Pratt, which rose from 360 to 418 students. 
In another sign that the Duke-Pratt brand is hot, masters appli-cations 
are up nearly 70 percent for next fall. 
This fall, a new bachelors of science degree in energy engi-neering 
is set to launch. It will give students an opportunity to 
pursue a second major in an exciting interdisciplinary subject 
matter that spans all four Pratt departments. We expect to add 
to the Pratt faculty two professors of the practice with industry 
experience in the energy sector. These individuals will support 
both the energy engineering second major, and the energy and 
environment certificate we jointly administer with the Nicholas 
School of the Environment. 
Together with the Trinity College of Arts and Sciences, we are 
developing a Duke-wide undergraduate entrepreneurship pro-gram 
that will include both curricular and extracurricular ele-ments 
such as practicums, startup opportunities, and intern-ships. 
We hope to launch this fall. 
The list goes go on and on. 
As you read the informative and creative stories in this issue 
– all written by Pratt students – I’m sure you’ll get a clear pic-ture 
of how amazingly diverse, creative and dedicated are the 
people who make up the Pratt community. 
Where else could I kick up my heels at a student presentation 
like Katrina’s or the annual E-Ball? Or build Ritz Cracker-Cheez 
Whiz towers, toss bean bags or race in sacks on a gorgeous sum-mer 
day in front of Hudson Hall? We all know it is an awe-some 
responsibility to train – or become — the next generation 
of problem-solvers, but it’s also great to have fun. 
What a great place to be! 
Tom Katsouleas 
Dean, Pratt School of Engineering 
Dear Friends of Pratt, 
From the Dean
From the ESG President 
4 dukengineer 2012 
Greetings from Engineering Student Government, 
2011 has been an outstanding year for Engineering Student Government, thanks 
to the incredible efforts of each one of our members, and the enthusiasm of 
the engineering students. We have seen productive growth of the organization 
and further enhancements to the Pratt student experience. With new leader-ship 
being elected in January, we look forward to another year of serving the 
student body. Be sure to check out information on our events and projects, 
and leave feedback at: http://esg.pratt.duke.edu/. 
In March, ESG hosted the annual E-Ball 
at the top floor of the University 
Tower – the first time in several years that 
it has been off campus. The event saw 
huge demand and all who attended 
enjoyed an unforgettable night bonding 
with classmates and friends alike. E-Social, 
the staple E-Quad happy hour of 
sorts also saw a change from the usual this 
year with the addition of “Super-E-Socials” 
once a month. With plentiful 
food and an emphasis on planned pro-gramming, 
these events brought together 
several engineering clubs and students 
from many all class years. We hope to 
continue to see many underclassmen at 
these events, so as to further solidify the 
Pratt bond that transcends class year. Our 
other E-events, including E-Picnics, E-Oktoberfest, 
and E-Kickball, have been 
hits as always, especially the E-Shirts this 
year: Pratt Bracket and Cheat Shirt. 
A year ago, ESG created the 
Academic Action Committee. This 
group of extremely active students is 
charged with creating positive change in 
the academic environment in Pratt in a 
rapid timeframe. They delivered in a big 
way this year in creating an engineering 
skills course that took place for the first 
time this fall. The fall course is broken 
into four modules each teaching an 
applied engineering skill, and has 
received rave reviews. 
Finally, we have spent some time to 
revise our decades-old constitution to 
bring it up to date with our current goals 
and operations. In this revision, we have 
added a new position on ESG, the indus-try 
relations chair. This ESG member, 
the first of whom will be elected in 
January, will continue our already strong 
efforts in bringing companies to E-Socials 
to provide networking opportunities to 
students. 
ESG looks forward to continuing a 
tradition of making Pratt life in some 
regards more bearable, but in most 
regards flat-out awesome. We invite any 
and all feedback and if you are particular-ly 
interested, run for election for one of 
our positions. I hope to see you at our 
next event! 
Sincerely, 
David Piech 
President, Engineering Student Government
2012 dukengineer 5 
t Duke, we find ourselves surrounded 
by an illustrious faculty whose history of 
groundbreaking research inspires us to 
both follow in their footsteps and blaze 
new trails forward. This sense of ambi-tion 
and drive is reinforced by our peers 
-- hardworking, creative individuals 
truly committed to pursuing their 
goals. We find ourselves in awe of the 
accomplishments of those graduating 
and amazed at how bright each incom-ing 
class is. 
While it is easy to get caught up in 
our academics, whether studying for a 
midterm or submitting a paper to a jour-nal, 
Duke’s Engineering Graduate 
Student Council (EGSC) believes that 
there is more to graduate school than just 
our individual bodies of academic work. 
This principle guides the council’s 
efforts, as we aim to foster positive rela-tionships 
between graduate students, and 
help each other maintain a healthy work-life 
balance during our time in Pratt. 
This year, EGSC has taken on co-sponsorship 
of E-socials, working with 
the undergrads to continue to improve 
Pratt’s popular weekly happy hour and 
make sure it appeals to our graduate 
community. We’re excited to bring offi-cial 
graduate student involvement to the 
Pratt tradition, and believe that events 
like E-Socials give us opportunities to 
interact and get to know one another 
outside of the laboratory and classroom. 
Our goal is to ensure that each social 
event we are involved with brings 
unique value to all members of Pratt, 
whether it is networking with potential 
employers at E-Social or Halloween-themed 
bowling with other graduate 
departments. We believe that the con-nections, 
whether made over beer and 
pizza or a couple of frames, can build 
lasting relationships, and that those 
relationships will make up a valuable 
network down the road. We think that 
leaving campus should not mean leaving 
the Duke community, and that being a 
Blue Devil comes with a lifetime mem-bership. 
The biggest event that EGSC hosted 
this fall was the 
Mahato Memorial 
“Envisioning the 
Invisible” event. 
Held in memory of 
former graduate 
student Abhijit 
Mahato, the event 
included a photog-raphy 
contest to 
celebrate Abhijit’s 
interest in combin-ing 
science and 
visualization, as 
well as a lecture by 
Nickolay Hristov, 
entitled “Pixels, 
Frames and 3D 
Models: Visual 
Storytelling for the Modern Naturalist.” 
The event was a big success, and EGSC 
hopes to continue the program in perpe-tuity. 
The best entries from the contest 
are on display all year in the CIEMAS 
atrium, highlighting the cross-discipli-nary 
interests of our students and faculty. 
EGSC also seeks to help students 
prepare themselves for careers beyond 
graduation, and to give them perspec-tive 
on the work going on across engi-neering. 
For students from all programs 
seeking careers in all fields (industry, 
academia, entrepreneurship, government 
and otherwise), EGSC wants to make 
sure that they have interesting and use-ful 
exposure to as many future opportu-nities 
as possible. This has included 
seminars, bringing industry representa-tives 
to campus to meet with students 
and keeping students informed about 
career fairs and other important events. 
This year, we are also working with the 
faculty and administration to develop a 
vision of the future of Pratt and the 
kind of programming that build our 
already-strong reputation. 
EGSC cannot achieve its goals with-out 
the help of volunteers. Membership 
in EGSC is open, and all students are 
encouraged to attend our monthly meet-ings 
to help us improve the graduate 
experience and to pull off the events 
themselves. Creative thinking enables us 
to stretch our budget and fund new 
activities and all ideas are welcome. 
Peter Hollender (E’09) is a third-year 
graduate student pursuing a Ph.D. in bio-medical 
engineering and the president of 
the Engineering Graduate Student Council. 
From the EGSC President A 
We believe 
that the 
connections, 
whether made 
over beer and 
pizza or a 
couple of 
frames, can 
build lasting 
relationships, 
and that those 
relationships 
will make up 
a valuable 
network down 
the road.
Education 
A Few Things You May Not Have Known About 
Engineering and Music at Duke 
As freshmen in Engineering 53 with 
Michael Gustafson, assistant professor of 
the practice in electrical and computer 
engineering, students are given the 
opportunity to combine their knowledge 
of Matlab with their interest in music. 
In lab, students’ iPods are connected to 
circuit boards that are wired to the com-puters. 
Students then choose 10 seconds 
of their favorite song to manipulate in 
various ways. Students adjust the fre-quency 
ranges with different Matlab 
algorithms. 
After playing back each adjustment 
to the clip, sophomore Lauren Morrison 
remembered, “how exciting it was after 
each modification, to listen to how the 
song was affected.” Eventually, the song 
was altered beyond recognition. Lauren 
said “after repeating the same 10 seconds 
of my favorite song over and over for the 
whole lab period, I no longer wanted to 
hear it again!” Each student brings their 
own style of music to the lab, personaliz-ing 
their learning experience of Matlab. 
When Clark Bray, assistant professor 
of the practice of mathematics, lectures 
his students on linear differential equa-tions, 
he uses music to help his students 
better understand the beat frequency 
when there are multiple frequencies. He 
explains why certain notes played on a 
piano are more pleasing to hear than 
others because of sine and cosine waves. 
When listening to music, we usually 
hear multiple frequencies simultaneous-ly. 
Bray explained that when you hit a 
Every day as we walk to and from class listening to music on our 
iPods, attend engineering lectures, and participate in labs and 
independent projects, engineering and music are united. In Pratt, 
from the first freshman courses to senior design projects, music 
is intertwined with our curriculum. 
When C and C# are played simultaneous they 
create a harsh dissonant sound because the 
frequencies are very close together.
2012 dukengineer 7 
middle C and C# note on the piano at 
once the noise is unpleasant because the 
frequencies of the two notes are very 
close together, specifically C: 261 Hz 
and C#: 277 Hz. Because the difference 
between the two notes is small, the beat 
frequency is also small and thus the 
notes are dissonant, creating a 
harsh rattling noise. In contrast, 
playing middle C and C an 
octave higher, the beat frequen-cy 
will be larger and the notes 
will be consonant. 
In BME 153, biomedical 
engineering juniors are charged 
with the unusual task of build-ing 
and designing an electric 
guitar. The class focuses on the basic prin-ciples 
of electronic instrumentation with 
biomedical examples. Although not 
obvious at first, there are many connec-tions 
between biomedical engineering and 
designing and building electric guitars. 
Medical devices to aid those who have a 
hearing impediment or are 
deaf have similar electronics 
to electric guitars. 
Two Pratt seniors, 
Lindsay Johnson and Corey 
Weiner, combined their pas-sion 
for music with their 
knowledge of engineering to 
design a custom electronic 
musical device for a para-lyzed 
musician. In 1985, the musician 
was paralyzed from the chest down in a 
diving accident, impeding his ability to 
play the electric bass guitar, one of his 
greatest passions in life. The “hammered 
bass guitar” was built for biomedial 
engineering instructor Laurence Bohs’ 
class for biomedical engineering seniors. 
This course challenges students to design 
devices that will improve handicapped 
people’s lives. The custom electric 
device has round sensor pads that, when 
struck with wooden hammers, produce 
electric guitar sounds. Inside the ham-mered 
bass are three musical instrument 
digital interfaces (MIDI,) that convert 
each hammer hit on each pad into a 
note. The pads have “piezoelectric” 
material that translates pressure into a 
signal. This device can be plugged into 
any keyboard or other synthesizer. 
From learning about Matlab and fre-quencies, 
to studying differential equa-tions 
and sound waves, to building 
musical instruments for class assign-ments, 
the influence of music in engi-neering 
is all around us at Duke. 
Jade Brown is a sophomore majoring in 
mechanical engineering. 
Ipods are used in Egr53 lab to graph and analyze frequencies in Matlab 
Although not 
obvious at first, 
there are many 
connections 
between 
biomedical 
engineering 
and designing 
and building 
electric guitars.
T 
From Idea to Implementation 
One student’s experience with CE 185: Engineering Sustainable Design and Construction he Engineering 
properly repair the bridge, locals desper-ately 
Sustainable Design and 
needed assistance. 
Construction course (CE 
Kathryn Latham, a junior civil engineer, 
185) offers students a 
was one of the students who worked on 
unique experience not typically found in 
this culvert bridge design and offered her 
other courses at Duke. According to 
perspective. “In most other engineering 
Associate Professor of the Practice David 
classes, you’re just doing problem sets. 
Schaad, the course is focused on the 
But with this course, you have the oppor-tunity 
design and testing of solutions to com-plex 
to create and implement your 
interdisciplinary design products in a 
design. You learn what it’s like to work 
service-learning context. Design projects 
for a real client.” 
from last semester ranged from stream 
Schaad structured the class so that 
restoration in Beaufort, North Carolina, 
students would have the opportunity to 
to rice-farming in Libya. 
learn about the social and environmental 
One of the projects that attracted the 
impacts of the design projects. 
most attention was a culvert bridge reha-bilitation 
Occasionally, guest speakers would stop 
project in El Salvador. Nine of 
in to lecture on sustainable design. “It 
the 24 students enrolled in CE 185 spent 
was a good balance,” said Latham. 
the semester working on this design. The 
“[Schaad] would float around and help us 
original culvert bridge is 37 years old and 
when we needed it. He would give us 
was used by farmers and other locals to 
advice when we were stuck.” 
transport crops and to reach vital 
While everyone in the class worked 
resources in the rural El Salvador commu-nity. 
on a design for a real-world problem, only 
Due to frequent flooding, the bridge 
about a third of the students went on to 
was in a severely dilapidated state. 
implement the designs they completed in 
Without the means or knowledge to 
class. For Latham, traveling to El Salvador 
to apply the design was the 
best part of the experience. 
However, upon arriving in El 
Salvador, she quickly realized 
that the challenges did not end 
with the completion of the 
design at the end of the course. 
During the semester, effec-tively 
communicating with 
people in such a rural, under-developed 
area proved to be a 
great obstacle for Latham and 
the other students. As a result, 
the students had to make sev-eral 
assumptions during the 
The culvert bridge 
during a minor flood. 
These floods, which 
occur nearly daily 
during the rainy 
season, are the main 
contributor to the 
erosion and dilapida-tion 
on the bridge 
8 dukengineer 2012 education
design process. These assumptions includ-ed 
things like the velocity of the water, 
precise dimensions of the bridge, and 
what the bridge was made of. “It was a 
little frustrating because we had done all 
of this work during the semester, but 
once arriving at the site, we had to redo a 
lot of the design,” Latham said. 
While these challenges were tiring, 
they did not go unappreciated. “The 
implementation was a lot more interest-ing 
when we hit those speed bumps 
because once we were at the site, I felt I 
was able to use those design and problem 
solving skills that we learned in class,” 
said Latham. 
CE 185 also allows students to see 
that the application of skills learned in 
the classroom may not always be what 
they expect. “Another thing we experi-enced 
is that sometimes what we learn— 
the technical stuff, really specific ways to 
do stuff—that’s not always the best way 
to get something done,” Latham said. 
“We found that the locals would have 
much better solutions to problems than 
we could ever come up with. It was inter-esting 
to let that go and 
realize that our technical 
education might need to 
be augmented a little 
bit.” 
When asked if she would recommend 
this course to another student, Latham 
responded without the slightest hint of 
hesitation: “Definitely. For many engi-neering 
students, especially underclass-men, 
it’s difficult to find an opportunity 
Duke University students 
and local community mem-bers 
collaborate on pouring 
a new reinforced concrete 
slab on the existing culvert 
bridge. The new slab was 
one of the main components 
of the design worked on in 
the CE 185 course. 
to participate in this type of design. It’s 
very rewarding to be involved from start 
to finish on a project like this.” 
Jennifer Hewitt is a sophomore biomedical 
engineer who assisted with the implementa-tion 
of the culvert bridge design. 
The culvert bridge during a minor flood. These floods, which occur nearly daily during the 
rainy season, are the main contributor to the erosion and dilapidation on the bridge
The Many Facesof Pratt 
The Engineering Student Government (ESG) is an administrative 
organization run by students to make the four-year Pratt expe-rience 
all the more worthwhile. ESG takes a three-pronged 
approach to changing Pratt life for the better: planning events 
that bring the engineering student body closer together, making 
student-oriented academic policy changes, organizing service 
and outreach initiatives for the Durham community. 
10 dukengineer 2012 
ESG is made up of 11 students, head-ed 
by executive president David Piech, a 
senior. Sitting in a conference room on 
the third floor of CIEMAS, spoke ani-matedly 
about the role of ESG and the 
effect it has both on its members and the 
student body it governs. 
“ESG is really to make the lives of stu-dents 
and their experience here at Pratt 
all the better. We make it fun … we 
help solve some of the problems,” he 
explained. He went on to elaborate 
about the society’s dogma. “We’re a laid-back 
organization … but at the same 
time, we focus on getting things done. 
We want our members to be trained as 
leaders, to set up their own initiatives 
and to get things done.” 
ESG officers are encouraged to take on 
pet projects in areas that interest them, 
from fostering a sense of belonging with-in 
each graduating class to performing 
service in the local community. For 
Left: An ice sculpture from the E-Ball
education 
; 
Left: E-social 
example, last year, the 2014 class presi-dent 
Nathan Li had foam fingers with the 
ESG logo emblazoned on them made for 
Pratt students to take to the Duke- 
Michigan men’s basketball game. 
For engineering students, it is often 
quipped that life is all work and no play. 
The ESG goes to great lengths to ensure 
that this is most definitely not the case. 
Weekly E-Socials held on E-Quad bring 
freshmen to faculty members together to 
mingle over free food. The E-Picnic, 
held once each semester, is on a much 
grander scale, with a live band, geeky 
games and competitions, and of course, 
the iconic (not to mention, free) Pratt 
tee-shirts that make Trinity students 
green with envy. The annual E-Ball 
serves as a more formal social gathering, 
giving students the opportunity to dress 
up, put on their dancing shoes, and 
enjoy a night of elegance in the company 
of the fellow Pratt classmates (and a few 
of their Trinity dates). 
In terms of policy, for a while, ESG 
dealt with matters on an ad hoc basis. 
All this changed August 2010 with the 
creation of the Academic Advising 
Committee (AAC), an undergraduate 
panel aimed at influencing administra-tive 
policy. Members are chosen using an 
application and interview process to 
screen for students who are truly inter-ested 
in making a lasting difference in 
Pratt. Although a nascent organization, 
it has already made an impact on the 
Pratt community. 
Dianna Liu, a senior who is the vice 
president of ESG and a member of the 
AAC, explained some of the major 
accomplishments of the committee. This 
past year alone, the AAC managed to 
prevent the Hudson computer cluster 
from being converted into office space. 
Using the overwhelmingly negative stu-dent 
response to the idea, the AAC con-vinced 
Pratt administration to keep the 
cluster and the two groups are now 
working together to redesign Hudson to 
reflect the growing needs of the faculty 
and students. 
Another major accomplishment under 
AAC’s belt is the establishment of a new 
skills course: EGR 165, created in 
response to the complaints of Pratt BME 
graduates who, upon entering the world 
of industrial engineering, realized that 
there were some gaps in their technical 
knowledge. Duke BME students now 
have the opportunity to learn to use 
tools like Maple and SolidWorks before 
going into industry. The AAC has really 
grown into its own and is currently tack-ling 
issues concerning student-advisor 
compatibility, overall student-faculty 
interaction, and freshman transitioning 
into the Pratt community. 
ESG has also extended its resources to 
giving back to the local community. The 
community chair, Emily Sloan, has 
spearheaded an effort to 
make the world of sci-ence 
more interesting 
to local schoolchildren. 
She has worked to set 
up a program for Pratt 
students to act as 
Science Olympiad 
coaches in a local mid-dle 
school. Previously 
the school lacked the 
resources or faculty 
interest to actively pur-sue 
the idea, but Pratt 
students have stepped 
in to fill the void. The 
volunteers visit the 
school on a regular 
basis and help the stu-dents 
prepare for com-petitions, 
providing 
these children the 
opportunity to pursue 
scientific knowledge in an extracurricu-lar 
setting. 
The ESG and the AAC both serve as 
influential groups in the Pratt communi-ty, 
focusing on everything from social 
activities to policy changes to communi-ty 
service. The life of Pratt students is 
made all the more multidimensional by 
the efforts of these two student-run 
organizations. 
Visakha Suresh is a sophomore double 
majoring in biomedical engineering and 
biology. 
Engineers at the 2011 Duke-Michigan men’s basketball game
Features 
Life After 
The Grand Challenges 
The National Academy of Engineering (NAE) Grand Challenge Scholars Program (GCSP) 
had its roots in 2008, when the NAE selected 14 Grand Challenges for Engineering that are of 
utmost importance to secure a viable future for society. For the past 100 years, the greatest engi-neering 
achievements are mainly defined by inventions such as the airplane or lasers. However, 
when an NAE committee was selecting the new engineering grand challenges, a paradigm shift 
came to light. Almost all of the challenges require technological innovation, but more importantly, they 
require engineers to span across multiple fields such as public policy and other humanities to tackle the 
problem from a systems approach. The challenges address problems from the basic necessities of life such 
as how we will feed ourselves with how to Manage the nitrogen cycle or Provide energy from fusion to the issues 
of the modern era with how to Secure cyberspace and Enhance virtual reality. 
12 dukengineer 2012 
“We created the national program to 
encourage students to develop the skillset 
and mindset to address the grand chal-lenges 
of engineering over the course of 
their careers,” said Tom Katsouleas, dean 
of the Pratt School of Engineering. “The 
thought was that if we could create a 
cadre of a couple thousand graduates a 
year nationwide, we could make a differ-ence 
in the world. With the growth of 
the program to over 40 peer schools, I 
am optimistic we will do just that.” 
The Grand Challenge Scholars Program at 
Duke has graduated two classes of schol-ars— 
Simon Scholars and Stavros 
Niarchos Foundation Scholars—and the 
inaugural class graduated in 2010. As a 
part of the Duke GCSP, every student 
must complete a portfolio satisfying five 
requirements: a research-based 
practicum, interdisciplinary curriculum, 
entrepreneurial component, global com-ponent, 
and a service-learning compo-nent. 
The Grand Challenge Scholars have 
taken these varied experiences beyond 
Duke and continue to do great things in 
industry, academia, and the public/non-profit 
sector. 
The first class NAE Grand Challenge 
Simon Scholars included a Fulbright 
Scholar who is now attending graduate 
school in aerospace engineering in 
England; a M.D./Ph.D. student at the 
University of California, Los Angeles; an 
associate manager at Google working in a 
rotational program before heading to
2012 dukengineer 13 
Harvard Business School for a Masters of 
Business Adminsitration; and a volunteer 
working in India who has now taken a 
position in environmental engineering, 
among many others. 
The second class to graduate, called 
NAE Grand Challenge Stavros Niarchos 
Foundation Scholars, continued achieving 
greatness in the fields of their respective 
challenges. Among their ranks is a Ph.D. 
candidate in biomedical engineering at 
Duke, a business analyst for Capital One, 
a Rhodes Scholar at Oxford, and a mas-ter’s 
student at Stanford studying civil 
and environmental engineering. 
Niru Maheswaranathan, a 2011 GCSP 
graduate, chose the Reverse-engineer the 
brain grand challenge as his focus while 
at Duke. Maheswaranathan felt that 
understanding how the brain works from 
a fundamental engineering point of view 
would allow us to develop better thera-pies 
for neurological diseases as well as 
build more intelligent machines. While 
an undergraduate, he used the GCSP to 
study neuroscience from both the scien-tific 
and engineering point of view. 
Maheswaranathan says the research com-ponent 
of the program was very impact-ful 
in that it gave him the opportunity to 
dive into the field that he had become 
very passionate about. The GCSP first 
got Maheswaranathan interested in neu-roscience- 
related questions, and he has 
continued along that path and is now a 
Ph.D. candidate in the neurosciences 
graduate program at Stanford University. 
Anna Brown, also a 2011 Niarchos 
Foundation Scholar, chose to work on the 
Engineer better medicines challenge. She 
pursued a wide range of activities from 
working in radiation biologist Professor 
Mark Dewhirst’s lab as a Pratt 
Undergraduate Research Fellow with the 
goal of improving endoscopic imaging 
Niru Maheswaranathan, currently a Ph.D. candidate in neurosciences at Stanford University
14 dukengineer 2012 
technology in order to better characterize 
the boundaries of tumors. She travelled 
multiple times across international bor-ders 
with Project HEAL (Health 
Education and Awareness in Latin 
America) to provide health education ini-tiatives 
to women and children in 
Honduras. 
One powerful sentiment that Brown 
and other scholars have echoed was that 
the GCSP was complementary to the 
things that they were already doing and 
helped unify two very different interests 
such as intensive academic research and 
developing world humanitarian work. 
The GCSP Program integrated well with 
other programs already established at 
Duke such as the Pratt Fellows Program, 
DukeEngage, and Engineers with 
Borders. 
Brown discovered that she enjoyed the 
intellectual environment found in the lab 
due to her GCSP and Pratt Fellows expe-rience 
and is now pursuing a research-based 
masters of philosophy in oncology 
at Cambridge, with funding from Cancer 
Research UK. When she’s done, she 
plans on returning to Duke to attend 
medical school. When Brown attended 
the Grand Challenges Summit conference 
as a student, she noted that people were 
addressing the same grand challenges 
from very different fields and hopes to 
apply this approach towards her work in 
radiation oncology in the future. 
Undergraduate Jared Dunnmon, a 
Niarchos Foundation Scholar, worked on 
a multitude of projects that actually tar-geted 
two of the grand challenges: Restore 
and improve urban infrastructure and Make 
solar energy economical. He combined these 
efforts into a project to make alternative 
energy economical. During his GCSP 
experience, he worked on projects rang-ing 
from developing a novel method of 
mass public transportation in conjunc-tion 
with NASA scientists, to working as 
an unpaid intern with the Director of 
Climate Protection Initiatives for the 
City of San Francisco, through 
DukeEngage. There he spearheaded a 
project to use new technology involving 
algae to help treat the city’s wastewater. 
Dunnmon said “being a Grand 
Challenge Scholar allowed me to themat-ically 
combine a great number of my dif-ferent 
interests into a cohesive package, 
which I would imagine made my scholar-ship 
application stand out a bit.” He is 
now a Rhodes Scholar and is at Oxford 
University studying applied mathematics 
after which he intends to return to the 
U.S. to pursue his doctorate in engineer- 
Jared Dunnmon, current Rhodes 
Scholar, tackled two energy-themed 
challenges
Anna Brown, currently pursuing an oncology degree at Cambridge, worked with Project HEAL in Honduras 
2012 dukengineer 15 
ing with a focus on non-fossil energy 
technologies. 
In addition to those who are continu-ing 
their education, some of the GCSP 
graduates are making their mark in 
industry. Eric Thorne, a Stavros Niarchos 
Foundation Scholar, is currently working 
as a business transformation consultant 
for IBM as a part of the Consulting by 
Degrees Program. Thorne chose to 
address how to Make solar energy economical 
challenge. As a component of his GCSP 
experience, Thorne used his GCSP fund-ing 
to travel to Uganda to work with a 
solar start-up, Village Energy, where he 
got to work hands-on developing an 
actual product. 
Thorne said, “The Grand Challenge 
Scholars Program was a nice way to 
bridge the divide between the pure serv-ice 
aspect of community-minded work 
and the pure engineering aspects of the 
Pratt Fellows Program. It allows you to 
gain a wide array of experiences and see 
how they intersect to make a real 
impact.” 
GCSP graduate Ben Gagne is working 
in industry. He is a Duke MEMS gradu-ate 
with a certificate in aerospace engi-neering 
and is currently working for GE 
Aviation in the Edison Engineering 
Development Program designing jet 
engines. Gagne felt that placing your 
work within the larger context of the 
challenge gave it more meaning. Gagne 
also notes that the GCSP allows students 
to showcase a wide variety of skills such 
as entrepreneurship, teamwork, and a 
global mindset that are highly valued by 
employers. 
It seems apparent that the Duke GCSP 
graduates are leading successful and ful-filling 
lives, partially due to the knowl-edge 
and experiences gained from their 
GCSP experience at Duke. Whether still 
addressing their Grand Challenge or 
being involved in a more tangential man-ner, 
the GCSP has graduated a group of 
engineers who are a great boon to society. 
To learn more about joining the Grand 
Challenge Scholars Program, contact 
Assistant Dean of Education and 
Outreach Programs Martha Absher at 
mabsher@duke.edu or visit the Duke GCSP 
website at http://www.pratt.duke.edu/ grand-challengescholars. 
Hersh Desai is a sophomore majoring in 
biomedical engineering and minoring in 
finance who hopes to make a lasting 
impact on the world for the better. 
features
Duke’s True 
East Campus 
FGenerally, engineering 
homework and lounging 
on the beach aren’t com-patible. 
At the Duke 
University Marine Lab, 
however, there is ample opportunity for 
Pratt students to earn credits and enjoy 
beautiful, coastal North Carolina. 
Located on Pivers Island, the Duke 
University Marine Lab is a fully operable 
satellite campus with classrooms, labora-tory 
space, a library, a dining hall, com-munal 
student spaces, and dormitories. In 
addition to these traditional facilities, the 
Marine Lab has some more unique ameni-ties: 
kayaks and canoes for student use, a 
“So if you find a cool science question 
that you want to address, you have to make the tool. Some people shy 
away from that, but I thought that was part of the fun.” 
16 dukengineer 2012 
swim dock, and two research vessels. 
While the Marine Lab curriculum has 
historically catered to students studying 
environmental science, biology, or earth 
and ocean sciences, there are many oppor-tunities 
for engineers. 
Dr. Cindy Van Dover, the current 
Director of the Marine Lab, strongly 
believes in the application of technology 
to the ocean sciences. After receiving her 
Ph.D. from the Massachusetts Institute of 
Technology and Woods Hole 
Oceanographic Institution Joint 
Program, Van Dover piloted the deep-sea 
submersible ALVIN, which enabled her 
to make groundbreaking discoveries 
related to deep-sea hydrothermal vent 
communities. 
“Innovation in research,” Van Dover 
notes, ”often comes about both by under-standing 
what the next set of key ques-tions 
are and by designing and building 
the instrument…that can help deliver the 
answers.” 
Another strong proponent of the neces-sity 
of technological innovation in marine 
science is joint Pratt-Nicholas School 
Professor Doug Nowacek. Also a graduate 
of the MIT and Woods Hole PhD pro-gram, 
Nowacek’s research focuses on bioa-coustics 
and signal processing. As a result 
of his faculty appointment in the 
Electrical and Computer Engineering 
(ECE) Department, he frequently visits 
main campus to interact with students 
and faculty. He became interested in 
the technology-development side of 
oceanography when a mentor at Woods 
features
The Susan Hudson is one of the research vessels at the Duke University Marine Lab 
2012 dukengineer 17 
Hole explained to him that oceanography 
was still a very young field, and that 
many of the tools necessary to answer 
research questions they were pursuing did 
not yet exist. 
“So if you find a cool science question 
that you want to address,” he explains, 
“you have to make the tool, and some peo-ple 
shy away from that but I thought that 
was part of the fun.” 
This belief in technology inspired the 
idea of an ‘Engineering Semester’ at the 
Marine Lab, designed with courses to 
attract engineers, and provide at least one 
engineering area elective credit. Courses 
include: Marine Molecular Microbiology, 
Marine Molecular Ecology, Introduction to 
Bioacoustics, Introduction to Physical 
Oceanography, and Independent Study. 
Nowacek’s bioacoustics course and inde-pendent 
study are offered in the ECE 
department as ECE182L and ECE 191, 
respectively. The other courses may be of 
interest to engineering students due to 
their quantitative nature. 
One of the most important considera-tions 
for engineering students interested 
in spending time at the Marine Lab is 
advance schedule planning. Graduation 
requirements such as courses in the 
Natural Sciences and Social Science cate-gories 
can easily be fulfilled in a semester 
at the Marine Lab, and there are certainly 
advantages to doing so. During both 
semesters, the Marine Lab offers signature 
Travel Courses where students go on field-study 
trips to locations such as Puerto 
Rico, Singapore, Costa Rica. Courses at 
the Marine Lab also take many field trips; 
students in summer marine science classes 
often spend a few hours per day collecting 
critters and taking excursions to surround-ing 
islands. 
Martin Steren, ME ’12, had a strong 
interest in ocean science before studying at 
the Marine Lab, and arranged his schedule 
to spend fall semester of junior year in 
Beaufort. “As long as I can remember I 
have had an interest in marine biology, “ 
Martin explained, “and I would love to use 
my engineering background to help devel-op 
devices to study marine animals.” 
Martin spent his semester taking classes 
and assisting an ECE student with his 
Students collect critters as part of Marine 
Invertebrate Zoology class
project in antenna design for whale track-ing 
devices. 
Pratt students have the opportunity to 
perform research within the intimate, 
supportive Marine Lab environment. In 
addition to Nowacek’s electrical engi-neering 
projects, many other Marine Lab 
faculty have engineering-related research 
interests. 
Upon arrival at the Marine Lab, Van 
Dover says engineering students would 
find faculty members who are “keen to 
put their design and analytical skills to 
work to consider a marine research prob-lem 
in a new light.” 
Jim Hench’s research lab in physical 
oceanography has hosted students inter-ested 
in fluid dynamics and complex 
modeling, and features an operable salt-water 
flume for experiments. In addi-tion, 
students with interest in program-ming 
and software development may 
want to look to Dave Johnston. He has 
been a pioneer in digital learning, work-ing 
with the computer science depart-ment 
to develop interactive iPad appli-cations 
to replace textbooks in his 
Marine Mammals and Marine 
Megafauna classes. 
On top of these faculty, Van Dover 
says, “there’s scope for field testing of 
ocean instruments developed on cam-pus.” 
She also mentions the updated 
teleconference capabilities at the Marine 
Lab, noting that it would be easy for 
students on campus to stay connected to 
mentors on Piver’s Island. 
With these mentors, Pratt students 
have been able to earn independent 
study credit, participate in Marine Lab 
research scholarship summer programs, 
and even do research for Pratt Fellows. 
The administration and faculty at the 
Marine Lab is willing to work with stu-dents 
18 dukengineer 2012 
A saltwater flume is available for student use for fluid dynamics experiments 
to meet their needs. Nowacek is 
happy to report that he has now worked 
with students in all four engineering 
disciplines, “I sit in the ECE but I’ve 
always wanted it to be something that 
we could offer opportunities to any 
department in Pratt.” 
Even if students cannot spend a 
semester away from Durham, the Marine 
Lab offers a variety of summer courses 
and research scholarship programs. Ross 
Taggart, CEE ’12, spent a summer at the 
Marine Lab as a participant in the 
Bookhout Research Scholarship program. 
The Bookhout Scholarship funds stu-dents 
to take a class during first summer 
session and perform an independent 
study project during the second summer 
session, both related to marine inverte-brates. 
For his research project, Ross 
studied the response of blue crabs to 
acoustic signals. 
In addition to the more obvious perks 
of proximity to the beach, small class 
sizes, transportation and admission to 
Cameron Indoor during basketball sea-son, 
and Chef Sly’s delicious cooking, 
spending time at the Marine Lab may be 
a rewarding intellectual experience for 
engineers. Both Van Dover and Nowacek 
site the potential draw for engineers to 
ocean science. “The oceans are an engi-neer’s 
dream world, I should think,” Van 
Dover stated. Most notably, ocean engi-neering 
forces engineers to face a whole 
new set of design challenges due to fac-tors 
such as high salinity and pressure. 
“Its using what you’ve already learned 
and what you’re learning and applying 
it in a novel context, “ Nowacek 
explained, “between what we don’t 
know about the oceans as well as the 
environment for which you have to 
engineer, to me, should be a really fun 
“Cross-trainingis always a powerful way 
to prepare for a career, and engineering and marine 
science and oceanography are natural partners.”
2012 dukengineer 19 
challenge for any young engineer.” 
After graduation, engineers with 
marine experience have many education 
options. Van Dover notes that, “cross-training 
Students can relax on the porch of the Repass Center 
is always a powerful way to pre-pare 
for a career, and engineering and 
marine science and oceanography are nat-ural 
partners.” In addition, she notes that 
they may even have an advantage. 
“Students with an undergraduate back-ground 
in engineering who choose to pur-sue 
a graduate degree in marine science or 
oceanography are going to be in demand, 
especially since the future of oceanogra-phy 
is in advanced technologies.” 
Likewise, both Nowacek and Van 
Dover express that industry, especially 
the energy sector, would employ engi-neers 
with marine backgrounds. More 
importantly, the ocean needs motivated 
engineers, in the interest of conservation. 
Nowacek explains, “if we have better 
engineered things, well, we don’t have 
Deepwater Horizon. There’s always 
going to be the push to get into ever 
more difficult and tricky situations, and 
the only way we’re going to guarantee, 
or at least minimize the risk of that is 
to have really well-engineered compo-nents 
and tools.” 
Aside from the energy sector, there are 
companies that design and build ocean 
equipment. The Marine Lab has a con-nection 
with iRobot’s maritime division, 
based in Durham; they bring their new 
equipment for testing in Beaufort. One 
of Nowacek’s ECE students worked on a 
project integrating an acoustic detector 
with a Seaglider to collect continuous 
sound data, participating in a summer 
internship with iRobot, and supple-menting 
with independent study credit. 
Both Ross and Martin note that they 
will continue to pursue their interest in 
marine science after graduation, and 
they believe their time spent in 
Beaufort will help them achieve these 
goals. Martin says that his dream job 
would be to work as an engineer devel-oping 
tools at Woods Hole. He believes 
that the relationships he has developed 
at the Marine Lab will, “prove invalu-able 
to [his] future job search.” 
For students still searching for post-graduation 
options, the Marine Lab may 
expose engineers to a whole new set of 
opportunities. During his summer at the 
Marine Lab, Ross discovered a new pas-sion. 
“My research and studies at the 
Marine Lab sparked my interest in the 
marine environment and aquatic chem-istry 
which will definitely influence my 
choice of career.” 
Interestingly, Nowacek started to seri-ously 
consider marine science after par-ticipating 
in a summer research experi-ence 
in college which gave students 
from small liberal arts colleges the 
opportunity to do research at Duke and 
Davidson. The project he was assigned 
to was in Beaufort at the Marine Lab. 
Pratt students who have spent time at 
the Marine Lab enthusiastically reflect 
on their experiences. In addition to 
interesting research opportunities and 
unique classroom experiences, students 
say that that spending time on the 
island is a lot of fun. Ross speaks posi-tively 
saying, “the Marine Lab was one 
of [his] most memorable experiences at 
Duke”, and encouraging everyone to 
spend at least a summer session there 
because “the Marine Lab has something 
for everyone.” 
Martin echoes this sentiment remi-niscing 
that his semester there was 
“without a doubt [his] favorite semester 
at Duke. I loved all the classes I was in 
and the people there were great.” Even 
after years of working in the field, 
Nowacek expresses content and excite-ment. 
“I love this, you work great 
places. It’s a work hard, play hard thing. 
You work your tail off, and then you 
walk outside and you’re in the ocean.” 
So, the next time your problem sets 
are getting you down, think about plan-ning 
to spend some time at the beach. 
Lauren Shwisberg is senior studying Civil 
and Environmental Engineering with a cer-tificate 
in Marine Science and Conservation 
Leadership. She spent two summers at the 
Duke University Marine Lab. 
features
Engineering Perception 
Changes Year to Year 
Before you can determine how a perspective has 
changed, first you must determine what exactly you 
are looking at. What is constant, but seen from a 
different angle for the first time. In engineering, 
it’s the work. The high workload has been the only 
constant throughout the years. 
As a child, stealthily disassembling the kitchen appliances was 
far more work than playing with Barbies; as an undergrad, calcu-lus 
was far more work than sociology; as a working engineer, 
repeatedly building and testing prototypes was 
far more work than filing papers or answering 
phones. Yet, for some reason, we all still do it. 
Something pushes us toward engineering 
despite the all-nighters and partial differential 
equations. Having fought through undergrad 
and a master’s degree without fully grasping 
the role of an engineer, I am returning to grad-uate 
school for the second time with a com-pletely 
new perspective on the point, the func-tion, 
and the ultimate goal of all this work. 
As undergraduates, students are mainly fol-lowing 
the paths laid out for them. The 
homework assignments are taxing, and while 
calculus and physics are interesting enough, at 
those levels they’re still far too vague to be 
practically usable. It’s not until the upper-level 
courses that these theories actually become specific enough 
to have a place and a purpose in the world. So why do it? Why 
not switch to something simpler? For me, it was because of 
those rare moments when phenomena that seemed mysterious 
suddenly became understandable. When I combined gravity and 
inertia and predicted where that ball would land. When I 
learned about muscle structure, and how contractile force was 
determined. Solving these little mysteries just wasn’t going to 
happen in any other major, and finally understanding these 
answers was more than worth the long nights at the library. 
In graduate school, the perspective shifts dramatically. Yes, 
there are still classes with structured learning regimens and end-less 
theories, but in graduate school there is also research. 
Graduate school was the first place I was ever asked to take a the-ory 
I had learned from a class and apply it to explain something 
new. The work of all that memorization and all those proofs 
suddenly makes sense when, for the first time, you can draw con-clusions 
not found in any textbook. It’s a scary moment, the first 
time you realize there are no more answers in the back of the 
20 dukengineer 2012 
book. The knowledge you have suddenly becomes a lot more 
valuable. 
The working world makes the point of all this effort even 
clearer still. As an engineer for the Navy, I designed and built 
underwater breathing systems. The four other people on the 
project team and I laboriously and painstaking designed, 
machined, tested, and redesigned every single part of something 
that would eventually keep a human being alive. And every sin-gle 
part required some skill I worked hard to learn in engineer-ing 
school. How do you configure the oxygen 
sensors? Circuits class. How do you ensure 
that the gases are properly mixed in the 
breathing loop? Fluid mechanics. Because I 
survived the workload, because I managed to 
power through all the math and the science, I 
made something that lets a person survive 
underwater. The theory, the studying, and 
the homework assignments all come to 
fruition because as an engineer you are able to 
physically create something useful. There is 
nothing more satisfying. 
The first time I went through graduate 
school, I got sick. Instead of completing my 
Ph.D. as planned, I ended up dropping with a 
master’s degree to deal with my illness. It 
was one of the greatest regrets of my life, 
until the Navy offered me the chance to go back. For me gradu-ate 
school, and Duke are the fulfillment of a very long-standing 
dream. 
With a Ph.D., I’ll be able to lead my own research, to decide 
what questions I want to try to answer next. Still, sometimes it 
is tempting to lose the perspective I’ve gained over the past few 
years. Today my brain was utterly masticated by a math exam, 
but it is important to remember that there is a purpose to all the 
trauma. There is a model of pulmonary hemodynamics I would 
like to solve, and this class has shown me how. Hopefully, this 
model will be used to create a device that can save lives. While 
all the work and the tedious assignments are difficult, they are 
what will ultimately enable all of us engineers to create some-thing 
amazing. That urge to create is what drives us to become 
engineers in the first place. Perspectives on why we do it may 
change from year to year, but the work is always worth it. 
Rachel Lance is a Ph.D. student in Prof. Craig Henriquez’s lab in 
biomedical engineering.
The theory, the studying, 
and the homework assignments 
all come to fruition because 
as an engineer you are able to physically 
create something useful. 
features caption
COVERSTORY 
FCIEMAS 
A Catalyst for Pratt's Architectural, Technological and Social Transformation 
Seven years later, FCIEMAS has devel-oped 
into a foundation of learning and 
research for both Pratt and the greater sci-ence 
community at Duke University. But 
in addition to the project laboratories, 
research facilities, state-of-the-art clean 
rooms, and “intellectual collision spaces”, 
most passersby have little idea of the 
extensive mechanical systems and architec-tural 
innovations housed within the unas-suming 
Duke stone and brick exterior. 
In this article, we will talk about how 
FCIEMAS as a new facility was integrat-ed 
into Duke’s existing campus aesthetic, 
reflect on the impact FCIEMAS has had 
on the greater Duke community after 
seven years of operation and explore its 
salient features that often go unnoticed. 
The exterior façade of the FCIEMAS 
building incorporates both Duke stone, 
the primary material of West Campus, 
and brick, the material used in Hudson 
Hall. This creates a modern aesthetic, 
sympathetic to both historic West 
Campus and the existing engineering 
buildings. 
D. Bartley Guthrie, AIA, a principal 
22 dukengineer 2012 
at ZGF who served as principal-in-charge 
for the FCIEMAS project 
explained that, “unlike the monochro-matic 
red brick used in Hudson Hall, 
the brick used in the FCIEMAS building 
is a complex palette of different colors 
that is meant to be complementary to 
the native or indigenous stone that was 
quarried in the Duke Forest.” 
This ‘Duke brick’ blend was devel-oped 
after an intense analysis of the 
color palette present in Duke stone. 
Originally developed by the University 
Architect John Pearce, Duke Executive 
Vice President Tallman Trask III, and 
architect César Pelli for another campus 
project, the architects at ZGF made 
minor alterations to the mix for the 
FCIEMAS façade. In addition to materi-al 
similarity, the FCIEMAS building 
structure mimics gothic West Campus 
with tower elements at each corner. 
“The inclusion of tower elements 
marking the corners of the building 
blocks is derivative of the [campus] core 
and careful attention was paid to make 
the tower elements Duke tower ele-ments,” 
Guthrie said. 
Furthermore, Guthrie described that 
The architects at Zimmer Gunsul Frasca (ZGF) in Washington, D.C. 
were faced with a complex task when they were hired to design a 
building to represent the future of Duke’s engineering program. 
Their goal was to create a building that would not only serve as a center 
for advanced technological development, but also as a collaborative 
space for the engineering and scientific community at Duke. In August 
of 2004, when the Fitzpatrick Center for Interdisciplinary Engineering, 
Medicine, and Applied Science (FCIEMAS) was first unveiled it was 
hailed as an environment that would serve as a melting pot for scien-tists 
and students of different backgrounds to collide and collaborate. 
Smart Bridge 
TIMOTHY HURSLEY, ZGF ARCHITECTS LLP
TIMOTHY HURSLEY, ZGF ARCHITECTS LLP 
2012 dukengineer 23 
the main challenge in the development 
of the conceptual design for FCIEMAS 
was, “to build the project in such a way 
that it creates a bridge between the his-toric 
core of campus, and what was con-sidered 
the engineering and research 
domain of campus.” 
This design goal is clearly realized in 
the finished structure; en-route to the 
engineering quadrangle from historic 
West Campus, pedestrians now descend 
down the steps and pass under the 
bridges connecting the east and west 
complexes of the FCIEMAS facility. 
These two bridges are actually “smart 
bridges.” They house an optical fiber sen-sor 
system that can detect microscale 
dimensional changes in the building 
structure, including information on 
stress, strain, and temperature. Fifteen 
separate optical fiber sensors make up the 
optical fiber sensor array. Spaced about a 
meter apart from one another, the sensors 
are capable of detecting changes on the 
order of 1/10,000th percent. A display 
monitor on the third floor bridge allows 
passerby to view the effects of wind, tem-perature, 
and pedestrians. The bridges 
are not the only place where optical fiber 
arrays are installed. One can also find 
them running underneath the main hall-way 
floor, where sensors under certain 
marked tiles feed information to the con-trol 
room, which then wirelessly controls 
a video camera. Using the information 
from the optical sensors, a smart camera 
shifts and focuses to remain gazed on the 
moving pedestrian. 
In addition to the aesthetic and aca-demic 
integration, FCIEMAS completely 
transformed the social landscape of the 
engineering and research section of cam-pus. 
Prior to the construction of 
FCIEMAS, Teer and Hudson Hall stood 
alone on Science Drive, which connected 
all the way through to Research Drive. 
Eliminating the road in front of Hudson 
Hall and terminating it in a roundabout 
in front of the physics building led to the 
creation of a communal outdoor space for 
the Pratt School of Engineering. This 
communal space is now known as ‘e-quad’ 
and is host to many student events 
throughout the year. 
Chris Brasier, AIA, director of the 
architectural engineering certificate pro-gram 
stressed the importance of outdoor 
spaces to a college campus. He said, “on 
most college campuses the outdoor 
space, in terms of the social life on cam-pus, 
is the ‘connective tissue’ that brings 
the buildings together and gives them 
some sort of common identity.” This 
concept was instrumental in uniting the 
stylistically different buildings that 
house most of the Pratt School of 
Engineering on the e-quad. 
Apart from the outdoor communal 
space, the FCIEMAS building contains 
Engineering Quad 
In addition to the aesthetic and academic integration, FCIEMAS 
completely transformed the social landscape of the engineering 
and research section of campus.
many unique architectural spaces and 
features, many of which are intended to 
provide space for students and faculty to 
interact. The centerpiece, and most fre-quented 
space of the FCIEMAS building, 
is the three-story atrium. Guthrie and 
his team chose to direct focus to the atri-um 
because he believes that space is rep-resentative 
of the goals of the building: 
“to contribute to student faculty interac-tion 
in a positive way, not only for them 
to work, but to meet and share ideas.” 
With its iconic suspended staircases, 
abundance of natural light, and varied 
interior material palette, the atrium has 
become a popular space for Pratt to hold 
large events. Hilary Cavanaugh, CEE’12 
and architectural engineering certificate 
student, frequently studies in the atrium 
of the FCIEMAS building. Some of the 
attraction of spending time in the atri-um, 
she noted, is the interesting architec-ture. 
“I like the natural light, the open-ness, 
and the mix of materials,” Hilary 
said. “For example, the second floor is 
slate, and the upstairs floor is wood.” 
Some of the other unique interior 
interactive spaces include Twinnie’s 
Café, and the beautiful Mumma faculty 
commons. Even the bathrooms in 
FCIEMAS reflect the sense of collabora-tion 
between engineering and sciences. 
The tiles in the women’s restrooms are 
patterned in the shape of the BRCA1, a 
breast cancer type 1 susceptibility pro-tein 
that is associated with tumor sup-pression 
and cancer. The bone morpho-genetic 
protein (BMP1), a protein that 
induces bone and cartilage development, 
graces the tiles of the men’s restrooms. 
The optical fiber sensors on the smart 
bridge and protein tiles in the bathroom 
are just two examples of the way the 
architects’ integrated work from the 
FCIEMAS departments into the archi-tecture 
of the building itself. Another 
example is the etched flit designs drawn 
on the Fitzpatrick windows. During the 
construction phase of the building, the 
dean of Pratt challenged all professors to 
submit pieces of art, which substantiat-ed 
the link between engineering and the 
FCIEMAS Atrium and Twinnies Cafe 
PETER WILSON, ZGF ARCHITECTS LLP TIMOTHY HURSLEY, ZGF ARCHITECTS LLP
2012 dukengineer 25 
life sciences. The two 
winning submissions 
were Leonardo Da 
Vinci’s “Spectra” and 
Adrian Bejan’s 
“Constructal Tree.” 
Bejan is a mechanical 
engineering professor 
at Duke and the pio-neer 
of a field called 
BRCA1 diagram used in tiling pattern for women’s restrooms 
constructal theory. 
According to this 
theory, all systems, both 
biological and inanimate, 
evolve in a way that increas-es 
access to flow. 
Bejan described the flow 
of the students and faculty 
of the Fitzpatrick center. “I 
think the design works. It is 
about geometry… a draw-ing 
on a map… it’s about 
what you see from above 
which is the space in which 
all of us flow, in which we 
bounce off ideas.” 
In explaining the con-structal 
tree and its rele-vance 
to the Fitzpatrick 
Center goals, Bejan said that 
“the tree is a facsimile of the 
human design in the same 
way that the wrench is a fac-simile 
of the human hand.” 
He referred to a picture 
hanging on his office door 
taken by Sylvie Lorente, 
coauthor of his book on con-structal 
theory and Pratt 
adjunct professor. The pic-ture 
shows the constructal 
tree on a Fitzpatrick win-dow, 
Leonardo Da Vinci's ‘Spectra’ pattern on glass walls 
the branches of a natu-ral 
tree visible in the reflec-tion. 
“There is a double meaning here… 
the constructal tree and the real one, the 
superposition of the drawing and the 
natural tree,” Bejan said. “These ideas 
are inscribed into the building through 
which we flow during our life as profes-sors 
and students. This kind of stuff is 
very good for the soul of the institution. 
There are plenty of ideas being created 
here. Duke University has a presence 
and a signature in the world of ideas.” 
In addition to the etched flit window 
designs and other integrative features, 
FCIEMAS has several unique lab spaces 
like the Duke Immersive Virtual 
Environment (DiVE) and the Shared 
Material 
Instrumentation 
Facility (SMiF). 
Then-Pratt Dean 
Christina Johnson 
hired Rachael Brady, 
who was a research 
programmer for the 
first Cave Automated 
Virtual Environment 
(CAVE) at the 
University of Illinois, 
to develop a similar system in 
the newest engineering build-ing 
at Duke. Brady heads the 
Pratt Visualization Technology 
Group, which designed, built, 
and runs the DiVE. 
The DiVE received funding 
from the National Science 
Foundation (NSF) and went 
online in 2005. It consists of a 
six 3-meter square panels, 
including the floor and ceil-ing. 
David Bullock, the gener-al 
contractor for the DiVE, 
chose screens for the side pan-els, 
but Plexiglas for the floor 
and ceiling for added durabili-ty. 
The ceiling panel is sup-ported 
from the roof of the 
room that encloses the DiVE 
so that the side panels can be 
replaced easily. These panels 
are rear-projected with high-resolution 
stereographic 
images, much in the same way 
a movie projector casts images 
on a screen. Additionally, the 
DiVE is equipped with head 
and hand tracking software, a 
more accurate and advanced 
version of the technology 
widely available in Nintendo’s 
TIMOTHY HURSLEY, ZGF ARCHITECTS LLP 
Wii video game system. 
The DiVE is Duke’s only multi-disci-plinary 
full immersion technology and 
the first installation of a six-sided CAVE 
system. The DiVE represents a unique 
opportunity to interact with three-dimen-sional 
data in an active way, Brady said. 
Not only is the virtual reality visible to features
the observer on all sides, but the special 
stereo glasses also provide depth to the 
flat images. To further engage active 
interactions with the virtual environ-ment, 
a motion-sensing “wand” can be 
used to control navigation and move-ment 
of objects, which is then projected 
in real time. These features have attract-ed 
attention from around the Duke 
research community, leading to many 
interdisciplinary projects utilizing the 
DiVE from Pratt, Trinity College of Arts 
and Sciences, and even Duke University 
Hospital. 
One department that has utilized the 
DiVE for cutting-edge research has been 
Duke’s Center for Cognitive 
Neuroscience. One exciting paper pub-lished 
in the Journal of Cognitive 
Neuroscience by Kevin LaBar explored the 
concepts of fear and fear retention. 
LaBar’s experiments took place in the 
DiVE to understand how humans extin-guish 
fear and anxiety with the help of 
contextual location tools. 
The DiVE is also home to a myriad of 
student-led projects and instructional 
tools. Civil engineering students can uti-lize 
the virtual reality technology to 
“tour” structures they have modeled in 
one of their design courses; doing so 
allows these students to tweak their 
designs after experiencing their work in 
a way that would otherwise be impossi-ble 
with small, physical models. Also, 
the DiVE is equipped with software that 
can present a model of the human brain, 
which is implemented in neurobiology 
and medical school courses. Even 
Divinity School students can gain travel 
through time and space to experience a 
The DiVE is Duke’s only multi-disciplinary full immersion technology 
and the first installation of a six-sided CAVE system. 
computer model of Solomon’s Temple 
right here in Durham. 
Currently, programmers are working 
to update the DiVE to accept MATLAB 
commands, meaning that Duke students 
26 dukengineer 2012 
can physically experience the graphical 
outputs of their code in this common 
coding language. Also, the Fitzpatrick 
Institute for Photonics, a department 
housed in FCIEMAS, has recently 
accepted its first postdoctoral candidate 
whose work will focus on using the 
DiVE to study display fidelity and inter-action 
fidelity in the context of a fully 
immersed environment.
2012 dukengineer 27 
With advances in the realm of virtual 
reality also comes the need to promote 
the DiVE as a medium for more studies, 
both in and out of Pratt. Students from 
every department at Duke are encour-aged 
to apply to use the DiVE for their 
projects. Those interested in learning 
more about Duke’s innovative virtual 
reality and visualization research and 
experiencing this technology firsthand 
are encouraged to visit vis.duke.edu or 
attend one of the weekly open houses on 
Thursdays at 4:30 pm. 
In addition to these unique lab spaces, 
the Fitzpatrick Center was also one of 
the first buildings on Duke’s campus to 
achieve LEED (Leadership in Energy and 
Environmental Design) certification, 
awarded by the United States Green 
Building Council. Isabelle Arnold, 
LEED AP BD+C, is an associate at ZGF 
and served as the LEED coordinator on 
the project. While designed with sus-tainability 
in mind, Arnold explained, 
“We did not start the project thinking 
we were going to pursue LEED; LEED 
was a very young system at the time.” 
The decision was made to pursue LEED 
Certification later in the design process. 
However, Arnold noted that there were 
very few changes to the design itself 
once the goal of LEED Certification was 
solidified stating “the pieces were in 
place.” 
To achieve its LEED silver certifica-tion, 
a variety of environmental features 
were implemented. The Fitzpatrick 
Center earned points in five major LEED 
categories: site selection, water efficiency, 
energy and atmosphere, indoor environ-mental 
quality, and materials and 
resources. The most innovative environ-mental 
measure implemented, Arnold 
said, is the economic organization of the 
building program. Laboratory spaces 
with unique air quality or water needs 
were ‘blocked’ together, significantly 
reducing energy consumption. Similarly, 
offices were placed all along the perime-ter 
of the building to receive as much 
daylight as possible. 
Guthrie said that the final product, 
“[FCIEMAS] is really a unique assem-blage 
of different types of program and 
hopefully it’s creating a really exciting 
mix of research and student life.” 
When Bejan was asked if he believed 
that the Fitzpatrick Center had success-fully 
accomplished its goal of creating an 
interactive collision and interaction space 
between intellectuals of different disci-plines, 
Bejan offered a guarded yes, but 
stressed that a great idea transcends bor-ders. 
“I think that people work together, 
as creators of ideas, because they are 
attracted to the idea,” he explained. 
“Collaboration is lot like a lightning 
bolt from the cloud to the church 
steeple. Completely unknown before it 
happens, but striking when it does, and 
memorable when there is impact on the 
ground.” 
Cameron McKay, Jimmy Zhong, Lauren 
Shwisberg and Tejen Shah 
PETER WILSON, ZGF ARCHITECTS LLP
Research 
Cutting Edge Soft Matter 
A look into the field of soft materials research 
28 dukengineer 2012 
Recently, the National Science Foundation funded a massive $13.6 million under-taking 
to establish the Triangle Materials Research Science and Engineering 
Center (MRSEC) in North Carolina. The MRSEC — an intercollegiate collab-oration 
between the schools in the Research Triangle area, namely Duke 
University, North Carolina State University, University of North 
Carolina – Chapel Hill, and North Carolina Central University — will 
focus on advancing the current knowledge in the field of “soft matter” research. A 
team of 20 faculty members from across these four schools has assembled in an effort 
to develop intricate new types of soft matter that exhibit unique functional properties. 
Leading this team of MRSEC investigators is Gabriel Lopez, Ph.D., Pratt professor of 
biomedical engineering and mechanical engineering and materials science. Lopez 
received his Ph.D. from the University of Washington by developing a method for 
changing the surface properties of different materials by coating them with ultrathin 
polymer layers. He continued his research as a postdoc-toral 
fellow at Harvard University, where he studied 
how to control cell growth using micropatterns in sur-face 
chemistry of culture substrates. Lopez came to 
Duke in January 2010 after establishing a biomedical 
engineering program at the University of New Mexico. 
At Duke, Lopez has been focused on conducting 
research in the area of soft matter. “Soft matter,” Lopez 
said “is basically a designation for a class of condensed 
matter that is based on the energy required to deform it. 
If the matter in question deforms easily at ambient con-ditions, 
then it is considered soft matter.” 
Some basic examples of soft matter include rubber, 
polymers, gels, liquid crystals, and suspensions of fine 
particles, many of which we use every day in the form 
of tires, plastic containers, cosmetic supplies, deter-gents, 
and foods. However, it has also become apparent 
that scientists can take advantage of many more of the 
unique properties of soft matter. Lopez believes that “a 
Prof. Gabriel Lopez analyzing new soft materials for the MRSEC
frontier with regard to these materials is 
how we can take advantage of the fact 
that it is possible to design them to 
undergo programmed deformation on 
their own.” 
For example, Lopez seeks to capitalize 
on the fact that many of these materials 
are responsive to small environmental 
changes. 
Recently, Lopez and his research team 
published a paper concerning the cre-ation 
of a soft material coating that is 
able to change its structure with regard 
to slight fluctuations in tempera-ture. 
The premise of his work, 
which was funded by the Office of 
Naval Research, was to develop a 
type of coating that would be able 
to prevent bacteria from sticking 
to solid surfaces, an important 
goal with implications in many 
naval operations. When bacteria 
began to grow on these surfaces, 
slight variations in temperature 
would cause the coating to change 
its chemical structure, and in turn 
the bacteria would no longer be 
able to cling onto that surface. 
This method was shown to be very 
effective for the removal of bacte-ria 
from solid surfaces. 
In collaboration with Xuanhe 
Zhao, assistant professor of mechanical 
engineering and materials science, the 
group is now working on developing a 
new type of soft material coating that 
can change their surface properties in 
response to the applied voltage, instead 
of a change in temperature. Current test-ing 
is taking place at the Duke Marine 
Lab, where the team is hoping that 
applying electric fields to their soft 
material will be able to eliminate 
colonies of bacteria as well as settlements 
of larger organisms such as barnacles. 
(From left to right) Phanindhar Shivapooja, 
Prof. Xuanhe Zhao, and Qiming Wang holding 
a sheet of Kapton for biofilm release 
In another research initiative under 
the MRSEC umbrella, members of the 
Lopez group are synthesizing new 
microparticles from different polymeric 
materials. These particles are known as 
colloids when they are suspended in liq-uids 
and like other colloidal suspensions 
(including milk) they exhibit a milky 
appearance because of the way they scat-ter 
room light. The group is studying 
how these new materials respond to the 
application of acoustic fields with an eye 
toward developing new particulate 
materials for drug delivery, 
ultrasound imaging, medical 
diagnostic tests and three-dimensional 
colloidal assemblies. 
Continued research will only 
provide more insight and more 
knowledge about the properties 
and applications of soft materials, 
and scientists are only beginning 
to discover the benefits and uses 
that the wondrous world of soft 
matter can provide. The efforts of 
Lopez and the MRSEC show that 
inquiries into the field of soft 
matter are able to produce hard, 
tangible results. 
Justin Yu is a freshman majoring in 
Biomedical Engineering. 
Leah Johnson showing a sample 
of colliodal suspensions.
A Natural Analog for 
Synthetic Biology 
L 
ingchong You, Ph.D., joined Duke University 
six years ago as a jointly-appointed assistant professor in 
the Department of Biomedical Engineering and Institute 
for Genome Sciences and Policy, launching his lab in 
synthetic biology research. Synthetic biology is a rela-tively 
30 dukengineer 2012 
new field that combines elements from biology 
and engineering to design and construct new biological 
systems that carry out a desired function. You’s group 
engineers gene regulatory networks and uses such syn-thetic 
systems as tools to quantitatively analyze dynamic 
properties of cellular networks. 
Synthetic biology began as a field largely focused on 
employing the tools of genetic engineering to reconfigure 
metabolic pathways of cells to perform new functions, such 
as the production of therapeutic compounds or the micro-bial 
breakdown of toxins. Synthetic biologists use recombi-nant 
DNA technology to piece together gene networks that 
produce proteins of interest or confer a desired function, in 
the same way that electrical engineers use resistors and 
capacitors to piece together electrical circuits to generate 
desired outputs. 
Over the last ten years, synthetic biology has expanded 
its reach to encompass the use of engineered gene circuits to 
analyze questions in biology. In line with this notion, the 
You group employs the approach of synthetic biology, cou-pled 
with mathematical modeling, to engineer bacterial 
population dynamics, quantify interactions in cellular net-works, 
and address unresolved questions in biology. 
Researchers in the You group have successfully constructed 
a synthetic predator-prey ecosystem consisting of two bacteri-al 
populations. The predator population kills the prey by 
causing production of a killer protein in the prey, while the 
prey population rescues the predators by inducing the pro-duction 
of an antidote protein in the predator. 
Along these same lines, researchers in the You lab have 
also engineered bacterial populations 
that exhibit other ecological characteris-tics, 
including altruistic death, wherein 
the death of some individuals aids in the 
overall survival of the population, and 
the Allee effect wherein a population 
cannot survive below a critical popula-tion 
density. These engineered ecosys-tems 
enable the study of population 
dynamics, within such contexts as 
Katy Riccione 
Over the last ten years, 
synthetic biology 
has expanded its reach to 
encompass the use of 
engineered gene circuits 
to analyze questions in biology.
A microbial swarmbot is a small population of bacterial cells that are autonomously regulated 
by synthetic gene circuits and are encapsulated in microcapsules built from synthetic or natu-ral 
2012 dukengineer 31 
antibiotic resistance and species invasion, 
under a level of control that is not possi-ble 
in natural ecosystems. 
In addition to engineering synthetic 
gene circuits, the You group develops 
mathematical models that function as a 
simplified lens through which one can 
characterize biological networks. Such 
models, coupled with experimental vali-dation, 
are used extensively in the You 
lab to analyze a number of cellular net-works, 
including the aforementioned 
synthetic ecosystems, as well as networks 
that govern cell cycle entry and self-organized 
pattern formation. The group 
has used such an approach to elucidate a 
mode of gene regulation of potential 
importance in mitigating abnormal cell 
growth. They have found that expression 
of E2F, a protein family that controls 
genes essential for cell cycle entry, is 
highest under normal levels of growth 
factors but decreases in the presence of 
higher levels of growth factors (a charac-teristic 
of tumor cells), pointing to a 
potential mechanism that may play a 
role in modulating the development of 
cancer. 
In addition, other members of the You 
lab apply modeling towards studying a 
synthetic circuit that programs self-induced 
pattern formation as a potential 
means of understanding similar processes 
in nature, such as limb bud outgrowth 
and tissue stratification. 
Through their work in engineering 
and analyzing synthetic gene circuits, 
researchers in the You lab have also 
stumbled upon phenomena that chal-lenge 
common notions and assumptions 
in synthetic biology. In designing sys-tems, 
synthetic biologists generally 
polymers. 
assume a simple well-defined interface 
between the gene circuit and the host 
organism. The You group, however, has 
revealed that underlying and frequently 
overlooked parameters within the engi-neered 
system, such as the physical 
amount of the genes in the circuit 
(termed copy number) and how the 
engineered gene circuits affect growth of 
the host organism, can fundamentally 
change the predicted output of the sys-tem. 
Such findings have vast implica-tions 
for the field of synthetic biology, as 
they highlight the importance of under-standing 
how “hidden interactions” 
affect the behavior of the engineered 
gene networks. 
A central theme of the You lab is 
making use of synthetic biological sys-tems 
as analogs of natural systems in 
order to address biological questions and 
better understand the dynamics of cellu-lar 
networks. 
Ongoing projects could lead to new 
ways of fabricating materials, diagnosing 
and treating cancers, and fighting bacte-rial 
infections. In addition to such prac-tical 
applications, You envisions synthet-ic 
biology “likely transforming how 
future students learn biology.” 
It is not too far-fetched to conceive of 
students in an introductory biology 
course fiddling with gene circuits to bet-ter 
understand cells in the same way that 
students in an introductory physics 
course fool around with resistors and 
capacitors to better understand electron-ics, 
You said. On an even grander scale, 
bioengineers like to think of a world 
where organisms are designed to mass-produce 
therapeutic compounds, materi-als, 
and biofuels, making such products 
potentially cheaper and more accessible. 
Katy Riccione is a biomedical engineering 
Ph.D. candidate at Duke University. 
research
Fluid Cloaking 
When most people hear the word cloaking, they 
think of Harry Potter’s invisibility cloak. Real-world 
cloaking, however, is defined as hiding 
an object from a detector or a probe. The idea 
of fluid cloaking was first conceived last year 
by Research Professor Yaroslav Urzhumov and David Smith, the 
William Bejan Professor of Electrical and Computer Engineering. 
A fluid cloak hides an object from a flowing fluid, allowing it to 
flow as if that object didn’t exist. Reversing the perspective, the 
object can move without disturbing the fluid. 
An object moving through a fluid normally 
interacts with it in two different ways. First, 
there is a drag force, which is essentially fric-tion 
in fluids. Second, the object physically 
pushes the fluid as it moves, leaving a void 
An example of an isotropically 
permeable metamaterial. 
which the fluid rushes into. Fluid cloaking eliminates these 
interactions. A submarine that can move without any drag 
essentially shoots through the water like a rocket in free space, 
potentially saving energy and also eliminating wake. Without 
any wake, a submarine can roam completely undetected. 
Cloaking works by taking advantage of artificially engineered 
structures called metamaterials. The metamaterials act like a 
porous mesh case that can alter the flow of fluid. 
“In layman terms, the structure sucks in the water in front 
of it, reroutes the water around it, and 
ejects the water at carefully engineered 
positions,” Urzhumov explains. The fluid 
must be accelerated at key areas so that the 
momentum and pressure of the fluid will 
be preserved as it passes through the cloak. 
32 dukengineer 2012 
In layman terms, the 
structure sucks in the 
water in front of it, 
reroutes the water around 
it, and ejects the water 
at carefully engineered 
positions.
A computer demonstration of a fluid 
cloak redirecting streamlines 
around an object 
2012 dukengineer 33 
Urzhumov continues, “Because 
the streamlines have the same 
velocity in magnitude and direc-tion, 
it’s as if nothing really hap-pened.” 
The idea is similar in theory to 
other forms of cloaking such as 
electromagnetic and acoustic 
cloaking. However, cloaking of 
the fluid flow is revolutionary in 
certain aspects. In the other forms 
of cloaking, handling waves 
comes with innate limitations. 
“The need for wave velocities 
of particles inside that exceed 
the wave velocity outside is 
what limits the operation of 
optical and electromagnetic 
cloaks to only certain wave-lengths. 
It is not possible to 
cover the entire spectrum 
because that would violate 
causality,” Urzhumov says. 
In addition, optical cloaking 
metamaterials are typically reso-nant 
at selected frequencies, 
which leads to unwanted attenu-ation. 
Fluid cloaking has noth-ing 
to do with waves, resonances 
or frequencies; therefore it oper-ates 
with any fluid and any 
structural composition of the 
metamaterial. On the other 
hand, fluid flow cloaking 
requires physically moving a 
tangible substance. This factor 
leads to various complications concerning pressure drop, which 
can be compensated using micropump arrays. These microp-umps 
Urzhumov showing a machine that analyzes 
metamaterial properties 
must use energy; therefore, the question of whether such 
cloaks will be energy efficient remains unclear. 
The properties of cloaks comes from both the metamaterial 
composition and structure. In the case of fluid cloaking, the com-position 
is virtually irrelevant, and only the structure of the meta-material 
unit cell matters. The challenge comes from designing a 
structure that has anisotropic permeability with a gradient. An 
anisotropically permeable, graded structure would allow the cloak 
to work regardless of the fluid’s direction. A gradient is necessary 
because some fluid molecules must travel longer distances than 
the others, which forces acceleration to vary throughout the struc-ture. 
Currently, there is no rigorous mathematical theory for fluid research 
cloaking, so the research focuses 
on computer simulation and 
optimization. 
Urzhumov says, “The way I 
see this, the simplest structure 
would be a unit cell containing 
metal blades oriented perpendi-cular 
to each other so that you 
can independently control the 
permeability in all three direc-tions.” 
By rotating a blade to a 
certain angle with a flow direc-tion, 
the fluid is allowed to flow 
easily in that direction. This will 
allow the structure to be 
anisotropically permeable. 
Urzhumov adds, “Then, different 
thickness of the blades would 
allow different permeability 
magnitudes and create the neces-sary 
gradient… Micropumps 
will be added to ensure pressure 
loss compensation.” 
Conceived earlier this year, 
this innovative technology has 
already attracted a lot of atten-tion 
from the experts. “I don’t 
know if I can see this approach 
scaled up for large ships, but 
realistically I can see this tech-nology 
for highly maneuver-able, 
stealthy unmanned sub-marines,” 
Urzhumov says. 
The defense organizations 
could theoretically use this 
technology to let eavesdropping 
devices roam free in the territorial waters of any country. Also, 
marine experts can use fluid cloaking to observe underwater life 
without disturbing it. 
Urzhumov optimistically predicts, “This technology can be 
applied to small enough objects of any shape and kind. Seeing 
these micropumps as distributed propulsion systems, one can 
also envision aircrafts, ships and submarines doing arbitrary 
maneuvers in water, almost like UFOs in sci-fi movies. Unlike 
conventional aircrafts and ships, they do not have to rely on 
external streams of fluid. Such systems create the desired flow 
themselves.” 
Nathan Li is a Pratt sophomore majoring in biomedical and 
electrical engineering.
SMiF 
Propelling World Class Research at Duke University 
In 2000, a university strategic planning 
committee, which was a collection of top 
administrators working to create initia-tives 
for the university’s future, formed 
the “Materials Working Group” to help 
catalyze nanostructured and bio-inspired 
materials and device research. The group 
realized that there was a lack of equip-ment 
necessary to perform high-level 
research for the fabrication and characteri-zation 
of materials, devices, and nanos-tructures. 
Their solution to the problem 
was the creation of SMIF, Duke’s resource 
for advanced characterization and clean-room 
fabrication, which is available to 
34 dukengineer 2012 
undergraduates, graduate students, facul-ty, 
and non-university researchers alike. 
By 2002, SMIF obtained X-ray diffrac-tion 
and atomic force microscopy capabil-ities, 
originally located in the basement of 
the Levine Science Research Center. A 
year later, a scanning electron microscope 
in the physics building and a small clean-room 
in Hudson Hall were added to the 
SMIF arsenal. However, it was not until 
2007 that SMIF moved into the 12,000 
square foot facility where it currently 
operates. SMIF now has more than 65 
instruments serving the needs of more 
than 500 users across the Pratt School of 
Above: A Duke University researcher using a 
fluorescent microscope in the cleanroom “Bio Bay” 
Engineering, Trinity School of Arts & 
Sciences, the School of Medicine, neigh-boring 
universities, and companies across 
the Research Triangle Park. 
With the constant bustle in SMIF from 
its many users and projects, safety has 
always been an important consideration. 
SMIF director Mark Walters, Ph.D. explains, 
“The safety of students and researchers 
using our facility is our top priority, which 
is evidenced by the safety training and 
safety systems in the facility.” 
For instance, the toxic gas monitoring 
system in SMIF is a $1 million state-of-the- 
art system that can detect the type, 
amount, and location of any gas leak or 
chemical spill and immediately notify 
SMIF staff by wireless communication to 
any locality. There have been no incidents 
of injury since SMIF first opened. 
SMIF now not only offers its capabili-ties 
as a research facility, but also as an 
educational tool. The staff allows profes-sors 
to illustrate concepts from class at no 
charge. Further, several funding agencies, 
such as the LORD Foundation and the 
Donald M. Alstadt Fund, have enabled 
The culture of research at the Pratt School of Engineering 
serves as a model to many research institutions and 
industries across the globe. The high level of innova-tion, 
productivity, and advancement reflects a vibrant 
community of students, faculty and researchers across 
a range of disciplines in science and engineering. However, pioneer-ing 
research requires access to the most advanced equipment. 
That’s where the idea for the Shared Materials Instrumentation 
Facility (SMIF) began. 
Left: A Duke University Post-Doc analyzes an 
image of a microelectromechanical device 
collected on SMIF’s 3D Optical Profiler
Duke University students performing photolithography processing in the SMIF cleanroom 
2012 dukengineer 35 
undergraduates to use the equipment for 
research projects by covering the hourly 
access fees typically billed to its users for 
operational costs. Headlining this idea is 
the SMIF Undergraduate User Program, 
or SUUP, which encourages undergradu-ate 
research and innovation by supplying 
students up to $500 a month. There are 
currently 23 undergraduates participating 
in this program. 
There are many reasons why SMIF 
stands out among other noteworthy 
shared facilities. SMIF owns the only elec-tron 
beam lithography system in North 
Carolina, which is capable of producing 
structures at the nanoscale. It also has a 
$1 million dollar transmission electron 
microscope capable of cryogenic sample 
imaging and 3-D tomography. The SMIF 
cleanroom, which was the first such facili-ty 
in the nation to use a “Bio Bay” for the 
integration of biological materials, 
enabling the creation of novel sensors and 
biomedical devices. 
However, since the user fees of the 
facility only cover operational costs, the 
SMIF relies on external funding for new 
equipment and capabilities. Currently, the 
staff is looking into purchasing atomic 
layer deposition and dip pen lithography 
instruments for the cleanroom and 
focused ion beam and thermogravimetric 
analyzer instruments for characterization 
purposes. Together this equipment carries 
a heavy price tag of well over $1 million. 
Hired in 2002, Walters oversees many 
of the projects inside the facility. Walters 
works closely with a specialized team of 
talented engineers to keep the facility 
operational: Kirk Bryson, Jay Dalton, 
Michelle Gignac, and Tamika Craige. The 
Executive Director of SMIF, Nan Marie 
Jokerst, Ph.D., J.A. Jones Professor of 
Electrical and Computer Engineering, 
along with the advisory committee, leads 
the group by keeping the facility ahead of 
the technological curve. 
“The capabilities of SMIF and its staff 
are here to enable cutting edge research 
for the faculty and students of the Pratt 
School of Engineering and beyond,” 
Walters said. The SMIF staff assists 
researchers by conducting training cours-es, 
providing technical support, and keep-ing 
the facility stocked with chemicals 
and materials. 
Wyatt Shields is a Ph.D. student in Prof. 
Gabriel Lopez’s lab in biomedical 
engineering. 
research
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Dukengineer2012

  • 1. Edmund T. Pratt Jr. School of Engineering at Duke University 2011-2012 dukeng FCIEMAS A Catalyst for Pratt’s Architectural, Technological and Social Transformation Engineering Opportunities at the Marine Lab: Duke’s True East Campus Life after The Grand Challenges Engineering and Music at Duke www.pratt.duke.edu | www.dukengineer.pratt.duke.edu
  • 3. dukengineer Edmund T. Pratt Jr. School of Engineering at Duke University 2011-2012 on the lighter side Crossword Challange | The Life of an Engineer www.pratt.duke.edu letters 2 From the Editor 3 From the Dean 4 From the ESG President 5 From the EGSC President education 6 Engineering & Music at Duke 8 CE 185: Design Project 10 Engineering Student Government features 12 Life After The Grand Challenges 16 Duke’s True East Campus 20 Engineering Preception Changes Year-Year 22 COVER FCIEMAS: A Catalyst for Pratt's Architectural, Technological and Social Transformation research 26 BME: Soft Matter 28 BME: Synthetic Biology 30 ECE: Fluid Cloaking 32 SMiF Center profiles 36 Motorsports 38 Smart Home summer stories 40 Building Bridges to Form Connections 42 Pratt Fellows 44 RTI Biologics Internship alumni news 46 Alumni Profile: J. Michael Pearson 47 Class Notes 50 In Memory development 54 Letter from EAC President 55 Annual Fund Statistics 58 Honor Roll Editor Tejen Shah Associate Editors Anirudh Mohan Cameron McKay Jimmy Zhong Lauren Shwisberg Tom Mercer Wyatt Shields DukEngineer Writers Jade Brown Hersh Desai Ajeet Hansra Jennifer Hewitt Nooshin Kiarashi Rachel Lance Nathan Li Cameron McKay Anirudh Mohan James Mullally Katy Riccione Tejen Shah Wyatt Shields Lauren Shwisberg Emily Sloan Visakha Suresh Suzana Vallejo-Heligon Justin Yu Jimmy Zhong Consulting Editor Richard Merritt Webmaster Meng Kang Designer Lacey Chylack phasefivecreative,inc Technical Support Mandy Ferguson Photographer: Becca Bau p.72
  • 4. letters From the Editor We are proud to bring you the 2011-12 issue of the DukEngineer Magazine, which features the 2 dukengineer 2012 experiences and accomplishments of Pratt School of Engineering students, faculty and alumni. The cover story this year focuses on Fitzpatrick Center for Interdisciplinary Engineering, Medicine and Applied Sciences (FCIEMAS). It has been operational for about seven years, and we wanted to reflect on the impact it has had on the Duke community and to explore the architectural innovations incorpo-rated in the building that often go unnoticed by passersby. We have decided to cover some stories, such as the Grand Challenge Scholar (GCS) program, Smart Home, Shared Material’s Instrumentation Facility (SMiF) and the Motorsports club, that we have covered in the past but from a slightly different perspective. Over the past two years, the GCS program was mainly written from a programming perspective. This year we take a look at the life after the GCS program and see how the program has helped recently graduated GC scholars succeed professionally. We also look at the progress and invalu-able contributions Smart Home, SMiF and Motorsports have made to different aspects of Pratt community. We continue to cover the cutting-edge research of our faculty and graduate students. We profile Gabriel Lopez’s research on soft matter that could potentially help develop coating that would prevent bacteria from sticking to solid surfaces. We also showcase Yaroslav Urzhumov and David Smith’s research on a fluid cloak that helps hide an object from a flowing fluid. Finally, we profile Lingchong You’s research in synthetic biology that has wide-ranging applications from diagnosing new cancers to finding new ways of fabricating materials. Pratt has evolved significantly over the past few years, and there are exciting new opportunities available to engineers who want to dabble in liberal arts. Some of these interdisciplinary opportunities are not as visible on campus, and we have two articles in this year’s magazine that showcase these opportunities. The first article is related to interesting research opportunities available for engineers at the Duke Marine Lab in Beaufort. The second article highlights how music is intertwined with the Pratt curriculum and there are ample opportunities for engineers to pursue their passion for music. Furthermore, we have continued the recent tradition of featuring students summer experiences related to internships, Pratt Fellows research and international services trips. This year we have writers at different phases in their careers: from freshmen to seniors, to grad school and beyond. Therefore, we have an interesting piece on how perspective of being an engineer changes from year to year. The last page of the publication features “The Lighter Side” article that we hope will make this issue of DukEngineer magazine entertaining. We would like to thank our writers, Pratt faculty, architects at Zimmer Gunsul Frasca and all the other members of the Pratt community who helped us throughout the process of publishing this magazine. We would also like to thank our advisor, Richard Merritt with the Pratt Communications Department for his patience and invaluable support. We hope that you will share comments, questions and concerns with us through our website at: http://www.dukengineer.pratt.duke.edu. Enjoy! Tejen Shah Editor, DukEngineer Magazine 2011-12 B.S.E in Biomedical Engineering ‘13
  • 5. 2012 dukengineer 3 Last spring I had the great pleasure to experience an impressive example of engineering in action. One of our students, Katrina Wisdom, combined her knowledge of the laws of physics with her passion for dance. In her presentation, and performance, entitled “Fouette Turns and Fourier Series,” she explained and demonstrated the subtle inter-sections of engineering and dance. At one point, three volunteer dancers were asked perform turns in a synchronized fashion. I’m sure you’ve seen these turns. On one leg, with eyes fixated on one spot, they spun until their heads whipped around to gaze the same spot. Over and over again. As they spun faster and faster, a “resonance” made it appear that they were spinning even faster and with less effort than if they had been dancing alone. Katrina cleverly used art to provide an insight into an underlying scientific phenomenon – namely oscillations — that an average person could grasp. As I think back to that day, I sense a similar metaphorical res-onance taking place here at Pratt – instead of three dancers working together cooperatively, I see faculty, students and staff providing a certain “resonance” that makes this a great place to be. Every day, I feel a palpable momentum driving all aspects of our mission forward. By just about any measure, Pratt is a growing, thriving envi-ronment to live, learn and teach. And with the way the future looks, I don’t foresee that momentum slowing down. Research expenditures have increased dramatically. For U.S. News and World Reporting rankings, we reported an increase from $74 million to $87.5 million in research expenditures. Our actual number is closer to $94 million when we include subcon-tracts. This is very close to our longstanding goal of reaching $100 million in research, in the league of engineering research powerhouses. Pratt landed a $20 million endowment for the Duke Coulter Translation Partnership and a $13.6 million to fund a regional center for soft matter research. But what we are really all about here at Pratt is people. What the research growth enables us to do is offer richer learning opportunities and to more students. For example, we graduated 62 new Ph.D.s in the spring, an increase of 10 more students than the previous year. We launched our new master of engineering program last fall with seven distinct degree concentrations spanning all four of our departments. The goal is to provide an alternative to the tra-ditional, research-focused master of science curriculum and give students a competitive edge in their industry careers. Students gain business acumen to help them navigate corporate environ-ments and better prepare for project management while gaining real world, practical research skills. The new degree is driving masters growth at Pratt, which rose from 360 to 418 students. In another sign that the Duke-Pratt brand is hot, masters appli-cations are up nearly 70 percent for next fall. This fall, a new bachelors of science degree in energy engi-neering is set to launch. It will give students an opportunity to pursue a second major in an exciting interdisciplinary subject matter that spans all four Pratt departments. We expect to add to the Pratt faculty two professors of the practice with industry experience in the energy sector. These individuals will support both the energy engineering second major, and the energy and environment certificate we jointly administer with the Nicholas School of the Environment. Together with the Trinity College of Arts and Sciences, we are developing a Duke-wide undergraduate entrepreneurship pro-gram that will include both curricular and extracurricular ele-ments such as practicums, startup opportunities, and intern-ships. We hope to launch this fall. The list goes go on and on. As you read the informative and creative stories in this issue – all written by Pratt students – I’m sure you’ll get a clear pic-ture of how amazingly diverse, creative and dedicated are the people who make up the Pratt community. Where else could I kick up my heels at a student presentation like Katrina’s or the annual E-Ball? Or build Ritz Cracker-Cheez Whiz towers, toss bean bags or race in sacks on a gorgeous sum-mer day in front of Hudson Hall? We all know it is an awe-some responsibility to train – or become — the next generation of problem-solvers, but it’s also great to have fun. What a great place to be! Tom Katsouleas Dean, Pratt School of Engineering Dear Friends of Pratt, From the Dean
  • 6. From the ESG President 4 dukengineer 2012 Greetings from Engineering Student Government, 2011 has been an outstanding year for Engineering Student Government, thanks to the incredible efforts of each one of our members, and the enthusiasm of the engineering students. We have seen productive growth of the organization and further enhancements to the Pratt student experience. With new leader-ship being elected in January, we look forward to another year of serving the student body. Be sure to check out information on our events and projects, and leave feedback at: http://esg.pratt.duke.edu/. In March, ESG hosted the annual E-Ball at the top floor of the University Tower – the first time in several years that it has been off campus. The event saw huge demand and all who attended enjoyed an unforgettable night bonding with classmates and friends alike. E-Social, the staple E-Quad happy hour of sorts also saw a change from the usual this year with the addition of “Super-E-Socials” once a month. With plentiful food and an emphasis on planned pro-gramming, these events brought together several engineering clubs and students from many all class years. We hope to continue to see many underclassmen at these events, so as to further solidify the Pratt bond that transcends class year. Our other E-events, including E-Picnics, E-Oktoberfest, and E-Kickball, have been hits as always, especially the E-Shirts this year: Pratt Bracket and Cheat Shirt. A year ago, ESG created the Academic Action Committee. This group of extremely active students is charged with creating positive change in the academic environment in Pratt in a rapid timeframe. They delivered in a big way this year in creating an engineering skills course that took place for the first time this fall. The fall course is broken into four modules each teaching an applied engineering skill, and has received rave reviews. Finally, we have spent some time to revise our decades-old constitution to bring it up to date with our current goals and operations. In this revision, we have added a new position on ESG, the indus-try relations chair. This ESG member, the first of whom will be elected in January, will continue our already strong efforts in bringing companies to E-Socials to provide networking opportunities to students. ESG looks forward to continuing a tradition of making Pratt life in some regards more bearable, but in most regards flat-out awesome. We invite any and all feedback and if you are particular-ly interested, run for election for one of our positions. I hope to see you at our next event! Sincerely, David Piech President, Engineering Student Government
  • 7. 2012 dukengineer 5 t Duke, we find ourselves surrounded by an illustrious faculty whose history of groundbreaking research inspires us to both follow in their footsteps and blaze new trails forward. This sense of ambi-tion and drive is reinforced by our peers -- hardworking, creative individuals truly committed to pursuing their goals. We find ourselves in awe of the accomplishments of those graduating and amazed at how bright each incom-ing class is. While it is easy to get caught up in our academics, whether studying for a midterm or submitting a paper to a jour-nal, Duke’s Engineering Graduate Student Council (EGSC) believes that there is more to graduate school than just our individual bodies of academic work. This principle guides the council’s efforts, as we aim to foster positive rela-tionships between graduate students, and help each other maintain a healthy work-life balance during our time in Pratt. This year, EGSC has taken on co-sponsorship of E-socials, working with the undergrads to continue to improve Pratt’s popular weekly happy hour and make sure it appeals to our graduate community. We’re excited to bring offi-cial graduate student involvement to the Pratt tradition, and believe that events like E-Socials give us opportunities to interact and get to know one another outside of the laboratory and classroom. Our goal is to ensure that each social event we are involved with brings unique value to all members of Pratt, whether it is networking with potential employers at E-Social or Halloween-themed bowling with other graduate departments. We believe that the con-nections, whether made over beer and pizza or a couple of frames, can build lasting relationships, and that those relationships will make up a valuable network down the road. We think that leaving campus should not mean leaving the Duke community, and that being a Blue Devil comes with a lifetime mem-bership. The biggest event that EGSC hosted this fall was the Mahato Memorial “Envisioning the Invisible” event. Held in memory of former graduate student Abhijit Mahato, the event included a photog-raphy contest to celebrate Abhijit’s interest in combin-ing science and visualization, as well as a lecture by Nickolay Hristov, entitled “Pixels, Frames and 3D Models: Visual Storytelling for the Modern Naturalist.” The event was a big success, and EGSC hopes to continue the program in perpe-tuity. The best entries from the contest are on display all year in the CIEMAS atrium, highlighting the cross-discipli-nary interests of our students and faculty. EGSC also seeks to help students prepare themselves for careers beyond graduation, and to give them perspec-tive on the work going on across engi-neering. For students from all programs seeking careers in all fields (industry, academia, entrepreneurship, government and otherwise), EGSC wants to make sure that they have interesting and use-ful exposure to as many future opportu-nities as possible. This has included seminars, bringing industry representa-tives to campus to meet with students and keeping students informed about career fairs and other important events. This year, we are also working with the faculty and administration to develop a vision of the future of Pratt and the kind of programming that build our already-strong reputation. EGSC cannot achieve its goals with-out the help of volunteers. Membership in EGSC is open, and all students are encouraged to attend our monthly meet-ings to help us improve the graduate experience and to pull off the events themselves. Creative thinking enables us to stretch our budget and fund new activities and all ideas are welcome. Peter Hollender (E’09) is a third-year graduate student pursuing a Ph.D. in bio-medical engineering and the president of the Engineering Graduate Student Council. From the EGSC President A We believe that the connections, whether made over beer and pizza or a couple of frames, can build lasting relationships, and that those relationships will make up a valuable network down the road.
  • 8. Education A Few Things You May Not Have Known About Engineering and Music at Duke As freshmen in Engineering 53 with Michael Gustafson, assistant professor of the practice in electrical and computer engineering, students are given the opportunity to combine their knowledge of Matlab with their interest in music. In lab, students’ iPods are connected to circuit boards that are wired to the com-puters. Students then choose 10 seconds of their favorite song to manipulate in various ways. Students adjust the fre-quency ranges with different Matlab algorithms. After playing back each adjustment to the clip, sophomore Lauren Morrison remembered, “how exciting it was after each modification, to listen to how the song was affected.” Eventually, the song was altered beyond recognition. Lauren said “after repeating the same 10 seconds of my favorite song over and over for the whole lab period, I no longer wanted to hear it again!” Each student brings their own style of music to the lab, personaliz-ing their learning experience of Matlab. When Clark Bray, assistant professor of the practice of mathematics, lectures his students on linear differential equa-tions, he uses music to help his students better understand the beat frequency when there are multiple frequencies. He explains why certain notes played on a piano are more pleasing to hear than others because of sine and cosine waves. When listening to music, we usually hear multiple frequencies simultaneous-ly. Bray explained that when you hit a Every day as we walk to and from class listening to music on our iPods, attend engineering lectures, and participate in labs and independent projects, engineering and music are united. In Pratt, from the first freshman courses to senior design projects, music is intertwined with our curriculum. When C and C# are played simultaneous they create a harsh dissonant sound because the frequencies are very close together.
  • 9. 2012 dukengineer 7 middle C and C# note on the piano at once the noise is unpleasant because the frequencies of the two notes are very close together, specifically C: 261 Hz and C#: 277 Hz. Because the difference between the two notes is small, the beat frequency is also small and thus the notes are dissonant, creating a harsh rattling noise. In contrast, playing middle C and C an octave higher, the beat frequen-cy will be larger and the notes will be consonant. In BME 153, biomedical engineering juniors are charged with the unusual task of build-ing and designing an electric guitar. The class focuses on the basic prin-ciples of electronic instrumentation with biomedical examples. Although not obvious at first, there are many connec-tions between biomedical engineering and designing and building electric guitars. Medical devices to aid those who have a hearing impediment or are deaf have similar electronics to electric guitars. Two Pratt seniors, Lindsay Johnson and Corey Weiner, combined their pas-sion for music with their knowledge of engineering to design a custom electronic musical device for a para-lyzed musician. In 1985, the musician was paralyzed from the chest down in a diving accident, impeding his ability to play the electric bass guitar, one of his greatest passions in life. The “hammered bass guitar” was built for biomedial engineering instructor Laurence Bohs’ class for biomedical engineering seniors. This course challenges students to design devices that will improve handicapped people’s lives. The custom electric device has round sensor pads that, when struck with wooden hammers, produce electric guitar sounds. Inside the ham-mered bass are three musical instrument digital interfaces (MIDI,) that convert each hammer hit on each pad into a note. The pads have “piezoelectric” material that translates pressure into a signal. This device can be plugged into any keyboard or other synthesizer. From learning about Matlab and fre-quencies, to studying differential equa-tions and sound waves, to building musical instruments for class assign-ments, the influence of music in engi-neering is all around us at Duke. Jade Brown is a sophomore majoring in mechanical engineering. Ipods are used in Egr53 lab to graph and analyze frequencies in Matlab Although not obvious at first, there are many connections between biomedical engineering and designing and building electric guitars.
  • 10. T From Idea to Implementation One student’s experience with CE 185: Engineering Sustainable Design and Construction he Engineering properly repair the bridge, locals desper-ately Sustainable Design and needed assistance. Construction course (CE Kathryn Latham, a junior civil engineer, 185) offers students a was one of the students who worked on unique experience not typically found in this culvert bridge design and offered her other courses at Duke. According to perspective. “In most other engineering Associate Professor of the Practice David classes, you’re just doing problem sets. Schaad, the course is focused on the But with this course, you have the oppor-tunity design and testing of solutions to com-plex to create and implement your interdisciplinary design products in a design. You learn what it’s like to work service-learning context. Design projects for a real client.” from last semester ranged from stream Schaad structured the class so that restoration in Beaufort, North Carolina, students would have the opportunity to to rice-farming in Libya. learn about the social and environmental One of the projects that attracted the impacts of the design projects. most attention was a culvert bridge reha-bilitation Occasionally, guest speakers would stop project in El Salvador. Nine of in to lecture on sustainable design. “It the 24 students enrolled in CE 185 spent was a good balance,” said Latham. the semester working on this design. The “[Schaad] would float around and help us original culvert bridge is 37 years old and when we needed it. He would give us was used by farmers and other locals to advice when we were stuck.” transport crops and to reach vital While everyone in the class worked resources in the rural El Salvador commu-nity. on a design for a real-world problem, only Due to frequent flooding, the bridge about a third of the students went on to was in a severely dilapidated state. implement the designs they completed in Without the means or knowledge to class. For Latham, traveling to El Salvador to apply the design was the best part of the experience. However, upon arriving in El Salvador, she quickly realized that the challenges did not end with the completion of the design at the end of the course. During the semester, effec-tively communicating with people in such a rural, under-developed area proved to be a great obstacle for Latham and the other students. As a result, the students had to make sev-eral assumptions during the The culvert bridge during a minor flood. These floods, which occur nearly daily during the rainy season, are the main contributor to the erosion and dilapida-tion on the bridge 8 dukengineer 2012 education
  • 11. design process. These assumptions includ-ed things like the velocity of the water, precise dimensions of the bridge, and what the bridge was made of. “It was a little frustrating because we had done all of this work during the semester, but once arriving at the site, we had to redo a lot of the design,” Latham said. While these challenges were tiring, they did not go unappreciated. “The implementation was a lot more interest-ing when we hit those speed bumps because once we were at the site, I felt I was able to use those design and problem solving skills that we learned in class,” said Latham. CE 185 also allows students to see that the application of skills learned in the classroom may not always be what they expect. “Another thing we experi-enced is that sometimes what we learn— the technical stuff, really specific ways to do stuff—that’s not always the best way to get something done,” Latham said. “We found that the locals would have much better solutions to problems than we could ever come up with. It was inter-esting to let that go and realize that our technical education might need to be augmented a little bit.” When asked if she would recommend this course to another student, Latham responded without the slightest hint of hesitation: “Definitely. For many engi-neering students, especially underclass-men, it’s difficult to find an opportunity Duke University students and local community mem-bers collaborate on pouring a new reinforced concrete slab on the existing culvert bridge. The new slab was one of the main components of the design worked on in the CE 185 course. to participate in this type of design. It’s very rewarding to be involved from start to finish on a project like this.” Jennifer Hewitt is a sophomore biomedical engineer who assisted with the implementa-tion of the culvert bridge design. The culvert bridge during a minor flood. These floods, which occur nearly daily during the rainy season, are the main contributor to the erosion and dilapidation on the bridge
  • 12. The Many Facesof Pratt The Engineering Student Government (ESG) is an administrative organization run by students to make the four-year Pratt expe-rience all the more worthwhile. ESG takes a three-pronged approach to changing Pratt life for the better: planning events that bring the engineering student body closer together, making student-oriented academic policy changes, organizing service and outreach initiatives for the Durham community. 10 dukengineer 2012 ESG is made up of 11 students, head-ed by executive president David Piech, a senior. Sitting in a conference room on the third floor of CIEMAS, spoke ani-matedly about the role of ESG and the effect it has both on its members and the student body it governs. “ESG is really to make the lives of stu-dents and their experience here at Pratt all the better. We make it fun … we help solve some of the problems,” he explained. He went on to elaborate about the society’s dogma. “We’re a laid-back organization … but at the same time, we focus on getting things done. We want our members to be trained as leaders, to set up their own initiatives and to get things done.” ESG officers are encouraged to take on pet projects in areas that interest them, from fostering a sense of belonging with-in each graduating class to performing service in the local community. For Left: An ice sculpture from the E-Ball
  • 13. education ; Left: E-social example, last year, the 2014 class presi-dent Nathan Li had foam fingers with the ESG logo emblazoned on them made for Pratt students to take to the Duke- Michigan men’s basketball game. For engineering students, it is often quipped that life is all work and no play. The ESG goes to great lengths to ensure that this is most definitely not the case. Weekly E-Socials held on E-Quad bring freshmen to faculty members together to mingle over free food. The E-Picnic, held once each semester, is on a much grander scale, with a live band, geeky games and competitions, and of course, the iconic (not to mention, free) Pratt tee-shirts that make Trinity students green with envy. The annual E-Ball serves as a more formal social gathering, giving students the opportunity to dress up, put on their dancing shoes, and enjoy a night of elegance in the company of the fellow Pratt classmates (and a few of their Trinity dates). In terms of policy, for a while, ESG dealt with matters on an ad hoc basis. All this changed August 2010 with the creation of the Academic Advising Committee (AAC), an undergraduate panel aimed at influencing administra-tive policy. Members are chosen using an application and interview process to screen for students who are truly inter-ested in making a lasting difference in Pratt. Although a nascent organization, it has already made an impact on the Pratt community. Dianna Liu, a senior who is the vice president of ESG and a member of the AAC, explained some of the major accomplishments of the committee. This past year alone, the AAC managed to prevent the Hudson computer cluster from being converted into office space. Using the overwhelmingly negative stu-dent response to the idea, the AAC con-vinced Pratt administration to keep the cluster and the two groups are now working together to redesign Hudson to reflect the growing needs of the faculty and students. Another major accomplishment under AAC’s belt is the establishment of a new skills course: EGR 165, created in response to the complaints of Pratt BME graduates who, upon entering the world of industrial engineering, realized that there were some gaps in their technical knowledge. Duke BME students now have the opportunity to learn to use tools like Maple and SolidWorks before going into industry. The AAC has really grown into its own and is currently tack-ling issues concerning student-advisor compatibility, overall student-faculty interaction, and freshman transitioning into the Pratt community. ESG has also extended its resources to giving back to the local community. The community chair, Emily Sloan, has spearheaded an effort to make the world of sci-ence more interesting to local schoolchildren. She has worked to set up a program for Pratt students to act as Science Olympiad coaches in a local mid-dle school. Previously the school lacked the resources or faculty interest to actively pur-sue the idea, but Pratt students have stepped in to fill the void. The volunteers visit the school on a regular basis and help the stu-dents prepare for com-petitions, providing these children the opportunity to pursue scientific knowledge in an extracurricu-lar setting. The ESG and the AAC both serve as influential groups in the Pratt communi-ty, focusing on everything from social activities to policy changes to communi-ty service. The life of Pratt students is made all the more multidimensional by the efforts of these two student-run organizations. Visakha Suresh is a sophomore double majoring in biomedical engineering and biology. Engineers at the 2011 Duke-Michigan men’s basketball game
  • 14. Features Life After The Grand Challenges The National Academy of Engineering (NAE) Grand Challenge Scholars Program (GCSP) had its roots in 2008, when the NAE selected 14 Grand Challenges for Engineering that are of utmost importance to secure a viable future for society. For the past 100 years, the greatest engi-neering achievements are mainly defined by inventions such as the airplane or lasers. However, when an NAE committee was selecting the new engineering grand challenges, a paradigm shift came to light. Almost all of the challenges require technological innovation, but more importantly, they require engineers to span across multiple fields such as public policy and other humanities to tackle the problem from a systems approach. The challenges address problems from the basic necessities of life such as how we will feed ourselves with how to Manage the nitrogen cycle or Provide energy from fusion to the issues of the modern era with how to Secure cyberspace and Enhance virtual reality. 12 dukengineer 2012 “We created the national program to encourage students to develop the skillset and mindset to address the grand chal-lenges of engineering over the course of their careers,” said Tom Katsouleas, dean of the Pratt School of Engineering. “The thought was that if we could create a cadre of a couple thousand graduates a year nationwide, we could make a differ-ence in the world. With the growth of the program to over 40 peer schools, I am optimistic we will do just that.” The Grand Challenge Scholars Program at Duke has graduated two classes of schol-ars— Simon Scholars and Stavros Niarchos Foundation Scholars—and the inaugural class graduated in 2010. As a part of the Duke GCSP, every student must complete a portfolio satisfying five requirements: a research-based practicum, interdisciplinary curriculum, entrepreneurial component, global com-ponent, and a service-learning compo-nent. The Grand Challenge Scholars have taken these varied experiences beyond Duke and continue to do great things in industry, academia, and the public/non-profit sector. The first class NAE Grand Challenge Simon Scholars included a Fulbright Scholar who is now attending graduate school in aerospace engineering in England; a M.D./Ph.D. student at the University of California, Los Angeles; an associate manager at Google working in a rotational program before heading to
  • 15. 2012 dukengineer 13 Harvard Business School for a Masters of Business Adminsitration; and a volunteer working in India who has now taken a position in environmental engineering, among many others. The second class to graduate, called NAE Grand Challenge Stavros Niarchos Foundation Scholars, continued achieving greatness in the fields of their respective challenges. Among their ranks is a Ph.D. candidate in biomedical engineering at Duke, a business analyst for Capital One, a Rhodes Scholar at Oxford, and a mas-ter’s student at Stanford studying civil and environmental engineering. Niru Maheswaranathan, a 2011 GCSP graduate, chose the Reverse-engineer the brain grand challenge as his focus while at Duke. Maheswaranathan felt that understanding how the brain works from a fundamental engineering point of view would allow us to develop better thera-pies for neurological diseases as well as build more intelligent machines. While an undergraduate, he used the GCSP to study neuroscience from both the scien-tific and engineering point of view. Maheswaranathan says the research com-ponent of the program was very impact-ful in that it gave him the opportunity to dive into the field that he had become very passionate about. The GCSP first got Maheswaranathan interested in neu-roscience- related questions, and he has continued along that path and is now a Ph.D. candidate in the neurosciences graduate program at Stanford University. Anna Brown, also a 2011 Niarchos Foundation Scholar, chose to work on the Engineer better medicines challenge. She pursued a wide range of activities from working in radiation biologist Professor Mark Dewhirst’s lab as a Pratt Undergraduate Research Fellow with the goal of improving endoscopic imaging Niru Maheswaranathan, currently a Ph.D. candidate in neurosciences at Stanford University
  • 16. 14 dukengineer 2012 technology in order to better characterize the boundaries of tumors. She travelled multiple times across international bor-ders with Project HEAL (Health Education and Awareness in Latin America) to provide health education ini-tiatives to women and children in Honduras. One powerful sentiment that Brown and other scholars have echoed was that the GCSP was complementary to the things that they were already doing and helped unify two very different interests such as intensive academic research and developing world humanitarian work. The GCSP Program integrated well with other programs already established at Duke such as the Pratt Fellows Program, DukeEngage, and Engineers with Borders. Brown discovered that she enjoyed the intellectual environment found in the lab due to her GCSP and Pratt Fellows expe-rience and is now pursuing a research-based masters of philosophy in oncology at Cambridge, with funding from Cancer Research UK. When she’s done, she plans on returning to Duke to attend medical school. When Brown attended the Grand Challenges Summit conference as a student, she noted that people were addressing the same grand challenges from very different fields and hopes to apply this approach towards her work in radiation oncology in the future. Undergraduate Jared Dunnmon, a Niarchos Foundation Scholar, worked on a multitude of projects that actually tar-geted two of the grand challenges: Restore and improve urban infrastructure and Make solar energy economical. He combined these efforts into a project to make alternative energy economical. During his GCSP experience, he worked on projects rang-ing from developing a novel method of mass public transportation in conjunc-tion with NASA scientists, to working as an unpaid intern with the Director of Climate Protection Initiatives for the City of San Francisco, through DukeEngage. There he spearheaded a project to use new technology involving algae to help treat the city’s wastewater. Dunnmon said “being a Grand Challenge Scholar allowed me to themat-ically combine a great number of my dif-ferent interests into a cohesive package, which I would imagine made my scholar-ship application stand out a bit.” He is now a Rhodes Scholar and is at Oxford University studying applied mathematics after which he intends to return to the U.S. to pursue his doctorate in engineer- Jared Dunnmon, current Rhodes Scholar, tackled two energy-themed challenges
  • 17. Anna Brown, currently pursuing an oncology degree at Cambridge, worked with Project HEAL in Honduras 2012 dukengineer 15 ing with a focus on non-fossil energy technologies. In addition to those who are continu-ing their education, some of the GCSP graduates are making their mark in industry. Eric Thorne, a Stavros Niarchos Foundation Scholar, is currently working as a business transformation consultant for IBM as a part of the Consulting by Degrees Program. Thorne chose to address how to Make solar energy economical challenge. As a component of his GCSP experience, Thorne used his GCSP fund-ing to travel to Uganda to work with a solar start-up, Village Energy, where he got to work hands-on developing an actual product. Thorne said, “The Grand Challenge Scholars Program was a nice way to bridge the divide between the pure serv-ice aspect of community-minded work and the pure engineering aspects of the Pratt Fellows Program. It allows you to gain a wide array of experiences and see how they intersect to make a real impact.” GCSP graduate Ben Gagne is working in industry. He is a Duke MEMS gradu-ate with a certificate in aerospace engi-neering and is currently working for GE Aviation in the Edison Engineering Development Program designing jet engines. Gagne felt that placing your work within the larger context of the challenge gave it more meaning. Gagne also notes that the GCSP allows students to showcase a wide variety of skills such as entrepreneurship, teamwork, and a global mindset that are highly valued by employers. It seems apparent that the Duke GCSP graduates are leading successful and ful-filling lives, partially due to the knowl-edge and experiences gained from their GCSP experience at Duke. Whether still addressing their Grand Challenge or being involved in a more tangential man-ner, the GCSP has graduated a group of engineers who are a great boon to society. To learn more about joining the Grand Challenge Scholars Program, contact Assistant Dean of Education and Outreach Programs Martha Absher at mabsher@duke.edu or visit the Duke GCSP website at http://www.pratt.duke.edu/ grand-challengescholars. Hersh Desai is a sophomore majoring in biomedical engineering and minoring in finance who hopes to make a lasting impact on the world for the better. features
  • 18. Duke’s True East Campus FGenerally, engineering homework and lounging on the beach aren’t com-patible. At the Duke University Marine Lab, however, there is ample opportunity for Pratt students to earn credits and enjoy beautiful, coastal North Carolina. Located on Pivers Island, the Duke University Marine Lab is a fully operable satellite campus with classrooms, labora-tory space, a library, a dining hall, com-munal student spaces, and dormitories. In addition to these traditional facilities, the Marine Lab has some more unique ameni-ties: kayaks and canoes for student use, a “So if you find a cool science question that you want to address, you have to make the tool. Some people shy away from that, but I thought that was part of the fun.” 16 dukengineer 2012 swim dock, and two research vessels. While the Marine Lab curriculum has historically catered to students studying environmental science, biology, or earth and ocean sciences, there are many oppor-tunities for engineers. Dr. Cindy Van Dover, the current Director of the Marine Lab, strongly believes in the application of technology to the ocean sciences. After receiving her Ph.D. from the Massachusetts Institute of Technology and Woods Hole Oceanographic Institution Joint Program, Van Dover piloted the deep-sea submersible ALVIN, which enabled her to make groundbreaking discoveries related to deep-sea hydrothermal vent communities. “Innovation in research,” Van Dover notes, ”often comes about both by under-standing what the next set of key ques-tions are and by designing and building the instrument…that can help deliver the answers.” Another strong proponent of the neces-sity of technological innovation in marine science is joint Pratt-Nicholas School Professor Doug Nowacek. Also a graduate of the MIT and Woods Hole PhD pro-gram, Nowacek’s research focuses on bioa-coustics and signal processing. As a result of his faculty appointment in the Electrical and Computer Engineering (ECE) Department, he frequently visits main campus to interact with students and faculty. He became interested in the technology-development side of oceanography when a mentor at Woods features
  • 19. The Susan Hudson is one of the research vessels at the Duke University Marine Lab 2012 dukengineer 17 Hole explained to him that oceanography was still a very young field, and that many of the tools necessary to answer research questions they were pursuing did not yet exist. “So if you find a cool science question that you want to address,” he explains, “you have to make the tool, and some peo-ple shy away from that but I thought that was part of the fun.” This belief in technology inspired the idea of an ‘Engineering Semester’ at the Marine Lab, designed with courses to attract engineers, and provide at least one engineering area elective credit. Courses include: Marine Molecular Microbiology, Marine Molecular Ecology, Introduction to Bioacoustics, Introduction to Physical Oceanography, and Independent Study. Nowacek’s bioacoustics course and inde-pendent study are offered in the ECE department as ECE182L and ECE 191, respectively. The other courses may be of interest to engineering students due to their quantitative nature. One of the most important considera-tions for engineering students interested in spending time at the Marine Lab is advance schedule planning. Graduation requirements such as courses in the Natural Sciences and Social Science cate-gories can easily be fulfilled in a semester at the Marine Lab, and there are certainly advantages to doing so. During both semesters, the Marine Lab offers signature Travel Courses where students go on field-study trips to locations such as Puerto Rico, Singapore, Costa Rica. Courses at the Marine Lab also take many field trips; students in summer marine science classes often spend a few hours per day collecting critters and taking excursions to surround-ing islands. Martin Steren, ME ’12, had a strong interest in ocean science before studying at the Marine Lab, and arranged his schedule to spend fall semester of junior year in Beaufort. “As long as I can remember I have had an interest in marine biology, “ Martin explained, “and I would love to use my engineering background to help devel-op devices to study marine animals.” Martin spent his semester taking classes and assisting an ECE student with his Students collect critters as part of Marine Invertebrate Zoology class
  • 20. project in antenna design for whale track-ing devices. Pratt students have the opportunity to perform research within the intimate, supportive Marine Lab environment. In addition to Nowacek’s electrical engi-neering projects, many other Marine Lab faculty have engineering-related research interests. Upon arrival at the Marine Lab, Van Dover says engineering students would find faculty members who are “keen to put their design and analytical skills to work to consider a marine research prob-lem in a new light.” Jim Hench’s research lab in physical oceanography has hosted students inter-ested in fluid dynamics and complex modeling, and features an operable salt-water flume for experiments. In addi-tion, students with interest in program-ming and software development may want to look to Dave Johnston. He has been a pioneer in digital learning, work-ing with the computer science depart-ment to develop interactive iPad appli-cations to replace textbooks in his Marine Mammals and Marine Megafauna classes. On top of these faculty, Van Dover says, “there’s scope for field testing of ocean instruments developed on cam-pus.” She also mentions the updated teleconference capabilities at the Marine Lab, noting that it would be easy for students on campus to stay connected to mentors on Piver’s Island. With these mentors, Pratt students have been able to earn independent study credit, participate in Marine Lab research scholarship summer programs, and even do research for Pratt Fellows. The administration and faculty at the Marine Lab is willing to work with stu-dents 18 dukengineer 2012 A saltwater flume is available for student use for fluid dynamics experiments to meet their needs. Nowacek is happy to report that he has now worked with students in all four engineering disciplines, “I sit in the ECE but I’ve always wanted it to be something that we could offer opportunities to any department in Pratt.” Even if students cannot spend a semester away from Durham, the Marine Lab offers a variety of summer courses and research scholarship programs. Ross Taggart, CEE ’12, spent a summer at the Marine Lab as a participant in the Bookhout Research Scholarship program. The Bookhout Scholarship funds stu-dents to take a class during first summer session and perform an independent study project during the second summer session, both related to marine inverte-brates. For his research project, Ross studied the response of blue crabs to acoustic signals. In addition to the more obvious perks of proximity to the beach, small class sizes, transportation and admission to Cameron Indoor during basketball sea-son, and Chef Sly’s delicious cooking, spending time at the Marine Lab may be a rewarding intellectual experience for engineers. Both Van Dover and Nowacek site the potential draw for engineers to ocean science. “The oceans are an engi-neer’s dream world, I should think,” Van Dover stated. Most notably, ocean engi-neering forces engineers to face a whole new set of design challenges due to fac-tors such as high salinity and pressure. “Its using what you’ve already learned and what you’re learning and applying it in a novel context, “ Nowacek explained, “between what we don’t know about the oceans as well as the environment for which you have to engineer, to me, should be a really fun “Cross-trainingis always a powerful way to prepare for a career, and engineering and marine science and oceanography are natural partners.”
  • 21. 2012 dukengineer 19 challenge for any young engineer.” After graduation, engineers with marine experience have many education options. Van Dover notes that, “cross-training Students can relax on the porch of the Repass Center is always a powerful way to pre-pare for a career, and engineering and marine science and oceanography are nat-ural partners.” In addition, she notes that they may even have an advantage. “Students with an undergraduate back-ground in engineering who choose to pur-sue a graduate degree in marine science or oceanography are going to be in demand, especially since the future of oceanogra-phy is in advanced technologies.” Likewise, both Nowacek and Van Dover express that industry, especially the energy sector, would employ engi-neers with marine backgrounds. More importantly, the ocean needs motivated engineers, in the interest of conservation. Nowacek explains, “if we have better engineered things, well, we don’t have Deepwater Horizon. There’s always going to be the push to get into ever more difficult and tricky situations, and the only way we’re going to guarantee, or at least minimize the risk of that is to have really well-engineered compo-nents and tools.” Aside from the energy sector, there are companies that design and build ocean equipment. The Marine Lab has a con-nection with iRobot’s maritime division, based in Durham; they bring their new equipment for testing in Beaufort. One of Nowacek’s ECE students worked on a project integrating an acoustic detector with a Seaglider to collect continuous sound data, participating in a summer internship with iRobot, and supple-menting with independent study credit. Both Ross and Martin note that they will continue to pursue their interest in marine science after graduation, and they believe their time spent in Beaufort will help them achieve these goals. Martin says that his dream job would be to work as an engineer devel-oping tools at Woods Hole. He believes that the relationships he has developed at the Marine Lab will, “prove invalu-able to [his] future job search.” For students still searching for post-graduation options, the Marine Lab may expose engineers to a whole new set of opportunities. During his summer at the Marine Lab, Ross discovered a new pas-sion. “My research and studies at the Marine Lab sparked my interest in the marine environment and aquatic chem-istry which will definitely influence my choice of career.” Interestingly, Nowacek started to seri-ously consider marine science after par-ticipating in a summer research experi-ence in college which gave students from small liberal arts colleges the opportunity to do research at Duke and Davidson. The project he was assigned to was in Beaufort at the Marine Lab. Pratt students who have spent time at the Marine Lab enthusiastically reflect on their experiences. In addition to interesting research opportunities and unique classroom experiences, students say that that spending time on the island is a lot of fun. Ross speaks posi-tively saying, “the Marine Lab was one of [his] most memorable experiences at Duke”, and encouraging everyone to spend at least a summer session there because “the Marine Lab has something for everyone.” Martin echoes this sentiment remi-niscing that his semester there was “without a doubt [his] favorite semester at Duke. I loved all the classes I was in and the people there were great.” Even after years of working in the field, Nowacek expresses content and excite-ment. “I love this, you work great places. It’s a work hard, play hard thing. You work your tail off, and then you walk outside and you’re in the ocean.” So, the next time your problem sets are getting you down, think about plan-ning to spend some time at the beach. Lauren Shwisberg is senior studying Civil and Environmental Engineering with a cer-tificate in Marine Science and Conservation Leadership. She spent two summers at the Duke University Marine Lab. features
  • 22. Engineering Perception Changes Year to Year Before you can determine how a perspective has changed, first you must determine what exactly you are looking at. What is constant, but seen from a different angle for the first time. In engineering, it’s the work. The high workload has been the only constant throughout the years. As a child, stealthily disassembling the kitchen appliances was far more work than playing with Barbies; as an undergrad, calcu-lus was far more work than sociology; as a working engineer, repeatedly building and testing prototypes was far more work than filing papers or answering phones. Yet, for some reason, we all still do it. Something pushes us toward engineering despite the all-nighters and partial differential equations. Having fought through undergrad and a master’s degree without fully grasping the role of an engineer, I am returning to grad-uate school for the second time with a com-pletely new perspective on the point, the func-tion, and the ultimate goal of all this work. As undergraduates, students are mainly fol-lowing the paths laid out for them. The homework assignments are taxing, and while calculus and physics are interesting enough, at those levels they’re still far too vague to be practically usable. It’s not until the upper-level courses that these theories actually become specific enough to have a place and a purpose in the world. So why do it? Why not switch to something simpler? For me, it was because of those rare moments when phenomena that seemed mysterious suddenly became understandable. When I combined gravity and inertia and predicted where that ball would land. When I learned about muscle structure, and how contractile force was determined. Solving these little mysteries just wasn’t going to happen in any other major, and finally understanding these answers was more than worth the long nights at the library. In graduate school, the perspective shifts dramatically. Yes, there are still classes with structured learning regimens and end-less theories, but in graduate school there is also research. Graduate school was the first place I was ever asked to take a the-ory I had learned from a class and apply it to explain something new. The work of all that memorization and all those proofs suddenly makes sense when, for the first time, you can draw con-clusions not found in any textbook. It’s a scary moment, the first time you realize there are no more answers in the back of the 20 dukengineer 2012 book. The knowledge you have suddenly becomes a lot more valuable. The working world makes the point of all this effort even clearer still. As an engineer for the Navy, I designed and built underwater breathing systems. The four other people on the project team and I laboriously and painstaking designed, machined, tested, and redesigned every single part of something that would eventually keep a human being alive. And every sin-gle part required some skill I worked hard to learn in engineer-ing school. How do you configure the oxygen sensors? Circuits class. How do you ensure that the gases are properly mixed in the breathing loop? Fluid mechanics. Because I survived the workload, because I managed to power through all the math and the science, I made something that lets a person survive underwater. The theory, the studying, and the homework assignments all come to fruition because as an engineer you are able to physically create something useful. There is nothing more satisfying. The first time I went through graduate school, I got sick. Instead of completing my Ph.D. as planned, I ended up dropping with a master’s degree to deal with my illness. It was one of the greatest regrets of my life, until the Navy offered me the chance to go back. For me gradu-ate school, and Duke are the fulfillment of a very long-standing dream. With a Ph.D., I’ll be able to lead my own research, to decide what questions I want to try to answer next. Still, sometimes it is tempting to lose the perspective I’ve gained over the past few years. Today my brain was utterly masticated by a math exam, but it is important to remember that there is a purpose to all the trauma. There is a model of pulmonary hemodynamics I would like to solve, and this class has shown me how. Hopefully, this model will be used to create a device that can save lives. While all the work and the tedious assignments are difficult, they are what will ultimately enable all of us engineers to create some-thing amazing. That urge to create is what drives us to become engineers in the first place. Perspectives on why we do it may change from year to year, but the work is always worth it. Rachel Lance is a Ph.D. student in Prof. Craig Henriquez’s lab in biomedical engineering.
  • 23. The theory, the studying, and the homework assignments all come to fruition because as an engineer you are able to physically create something useful. features caption
  • 24. COVERSTORY FCIEMAS A Catalyst for Pratt's Architectural, Technological and Social Transformation Seven years later, FCIEMAS has devel-oped into a foundation of learning and research for both Pratt and the greater sci-ence community at Duke University. But in addition to the project laboratories, research facilities, state-of-the-art clean rooms, and “intellectual collision spaces”, most passersby have little idea of the extensive mechanical systems and architec-tural innovations housed within the unas-suming Duke stone and brick exterior. In this article, we will talk about how FCIEMAS as a new facility was integrat-ed into Duke’s existing campus aesthetic, reflect on the impact FCIEMAS has had on the greater Duke community after seven years of operation and explore its salient features that often go unnoticed. The exterior façade of the FCIEMAS building incorporates both Duke stone, the primary material of West Campus, and brick, the material used in Hudson Hall. This creates a modern aesthetic, sympathetic to both historic West Campus and the existing engineering buildings. D. Bartley Guthrie, AIA, a principal 22 dukengineer 2012 at ZGF who served as principal-in-charge for the FCIEMAS project explained that, “unlike the monochro-matic red brick used in Hudson Hall, the brick used in the FCIEMAS building is a complex palette of different colors that is meant to be complementary to the native or indigenous stone that was quarried in the Duke Forest.” This ‘Duke brick’ blend was devel-oped after an intense analysis of the color palette present in Duke stone. Originally developed by the University Architect John Pearce, Duke Executive Vice President Tallman Trask III, and architect César Pelli for another campus project, the architects at ZGF made minor alterations to the mix for the FCIEMAS façade. In addition to materi-al similarity, the FCIEMAS building structure mimics gothic West Campus with tower elements at each corner. “The inclusion of tower elements marking the corners of the building blocks is derivative of the [campus] core and careful attention was paid to make the tower elements Duke tower ele-ments,” Guthrie said. Furthermore, Guthrie described that The architects at Zimmer Gunsul Frasca (ZGF) in Washington, D.C. were faced with a complex task when they were hired to design a building to represent the future of Duke’s engineering program. Their goal was to create a building that would not only serve as a center for advanced technological development, but also as a collaborative space for the engineering and scientific community at Duke. In August of 2004, when the Fitzpatrick Center for Interdisciplinary Engineering, Medicine, and Applied Science (FCIEMAS) was first unveiled it was hailed as an environment that would serve as a melting pot for scien-tists and students of different backgrounds to collide and collaborate. Smart Bridge TIMOTHY HURSLEY, ZGF ARCHITECTS LLP
  • 25. TIMOTHY HURSLEY, ZGF ARCHITECTS LLP 2012 dukengineer 23 the main challenge in the development of the conceptual design for FCIEMAS was, “to build the project in such a way that it creates a bridge between the his-toric core of campus, and what was con-sidered the engineering and research domain of campus.” This design goal is clearly realized in the finished structure; en-route to the engineering quadrangle from historic West Campus, pedestrians now descend down the steps and pass under the bridges connecting the east and west complexes of the FCIEMAS facility. These two bridges are actually “smart bridges.” They house an optical fiber sen-sor system that can detect microscale dimensional changes in the building structure, including information on stress, strain, and temperature. Fifteen separate optical fiber sensors make up the optical fiber sensor array. Spaced about a meter apart from one another, the sensors are capable of detecting changes on the order of 1/10,000th percent. A display monitor on the third floor bridge allows passerby to view the effects of wind, tem-perature, and pedestrians. The bridges are not the only place where optical fiber arrays are installed. One can also find them running underneath the main hall-way floor, where sensors under certain marked tiles feed information to the con-trol room, which then wirelessly controls a video camera. Using the information from the optical sensors, a smart camera shifts and focuses to remain gazed on the moving pedestrian. In addition to the aesthetic and aca-demic integration, FCIEMAS completely transformed the social landscape of the engineering and research section of cam-pus. Prior to the construction of FCIEMAS, Teer and Hudson Hall stood alone on Science Drive, which connected all the way through to Research Drive. Eliminating the road in front of Hudson Hall and terminating it in a roundabout in front of the physics building led to the creation of a communal outdoor space for the Pratt School of Engineering. This communal space is now known as ‘e-quad’ and is host to many student events throughout the year. Chris Brasier, AIA, director of the architectural engineering certificate pro-gram stressed the importance of outdoor spaces to a college campus. He said, “on most college campuses the outdoor space, in terms of the social life on cam-pus, is the ‘connective tissue’ that brings the buildings together and gives them some sort of common identity.” This concept was instrumental in uniting the stylistically different buildings that house most of the Pratt School of Engineering on the e-quad. Apart from the outdoor communal space, the FCIEMAS building contains Engineering Quad In addition to the aesthetic and academic integration, FCIEMAS completely transformed the social landscape of the engineering and research section of campus.
  • 26. many unique architectural spaces and features, many of which are intended to provide space for students and faculty to interact. The centerpiece, and most fre-quented space of the FCIEMAS building, is the three-story atrium. Guthrie and his team chose to direct focus to the atri-um because he believes that space is rep-resentative of the goals of the building: “to contribute to student faculty interac-tion in a positive way, not only for them to work, but to meet and share ideas.” With its iconic suspended staircases, abundance of natural light, and varied interior material palette, the atrium has become a popular space for Pratt to hold large events. Hilary Cavanaugh, CEE’12 and architectural engineering certificate student, frequently studies in the atrium of the FCIEMAS building. Some of the attraction of spending time in the atri-um, she noted, is the interesting architec-ture. “I like the natural light, the open-ness, and the mix of materials,” Hilary said. “For example, the second floor is slate, and the upstairs floor is wood.” Some of the other unique interior interactive spaces include Twinnie’s Café, and the beautiful Mumma faculty commons. Even the bathrooms in FCIEMAS reflect the sense of collabora-tion between engineering and sciences. The tiles in the women’s restrooms are patterned in the shape of the BRCA1, a breast cancer type 1 susceptibility pro-tein that is associated with tumor sup-pression and cancer. The bone morpho-genetic protein (BMP1), a protein that induces bone and cartilage development, graces the tiles of the men’s restrooms. The optical fiber sensors on the smart bridge and protein tiles in the bathroom are just two examples of the way the architects’ integrated work from the FCIEMAS departments into the archi-tecture of the building itself. Another example is the etched flit designs drawn on the Fitzpatrick windows. During the construction phase of the building, the dean of Pratt challenged all professors to submit pieces of art, which substantiat-ed the link between engineering and the FCIEMAS Atrium and Twinnies Cafe PETER WILSON, ZGF ARCHITECTS LLP TIMOTHY HURSLEY, ZGF ARCHITECTS LLP
  • 27. 2012 dukengineer 25 life sciences. The two winning submissions were Leonardo Da Vinci’s “Spectra” and Adrian Bejan’s “Constructal Tree.” Bejan is a mechanical engineering professor at Duke and the pio-neer of a field called BRCA1 diagram used in tiling pattern for women’s restrooms constructal theory. According to this theory, all systems, both biological and inanimate, evolve in a way that increas-es access to flow. Bejan described the flow of the students and faculty of the Fitzpatrick center. “I think the design works. It is about geometry… a draw-ing on a map… it’s about what you see from above which is the space in which all of us flow, in which we bounce off ideas.” In explaining the con-structal tree and its rele-vance to the Fitzpatrick Center goals, Bejan said that “the tree is a facsimile of the human design in the same way that the wrench is a fac-simile of the human hand.” He referred to a picture hanging on his office door taken by Sylvie Lorente, coauthor of his book on con-structal theory and Pratt adjunct professor. The pic-ture shows the constructal tree on a Fitzpatrick win-dow, Leonardo Da Vinci's ‘Spectra’ pattern on glass walls the branches of a natu-ral tree visible in the reflec-tion. “There is a double meaning here… the constructal tree and the real one, the superposition of the drawing and the natural tree,” Bejan said. “These ideas are inscribed into the building through which we flow during our life as profes-sors and students. This kind of stuff is very good for the soul of the institution. There are plenty of ideas being created here. Duke University has a presence and a signature in the world of ideas.” In addition to the etched flit window designs and other integrative features, FCIEMAS has several unique lab spaces like the Duke Immersive Virtual Environment (DiVE) and the Shared Material Instrumentation Facility (SMiF). Then-Pratt Dean Christina Johnson hired Rachael Brady, who was a research programmer for the first Cave Automated Virtual Environment (CAVE) at the University of Illinois, to develop a similar system in the newest engineering build-ing at Duke. Brady heads the Pratt Visualization Technology Group, which designed, built, and runs the DiVE. The DiVE received funding from the National Science Foundation (NSF) and went online in 2005. It consists of a six 3-meter square panels, including the floor and ceil-ing. David Bullock, the gener-al contractor for the DiVE, chose screens for the side pan-els, but Plexiglas for the floor and ceiling for added durabili-ty. The ceiling panel is sup-ported from the roof of the room that encloses the DiVE so that the side panels can be replaced easily. These panels are rear-projected with high-resolution stereographic images, much in the same way a movie projector casts images on a screen. Additionally, the DiVE is equipped with head and hand tracking software, a more accurate and advanced version of the technology widely available in Nintendo’s TIMOTHY HURSLEY, ZGF ARCHITECTS LLP Wii video game system. The DiVE is Duke’s only multi-disci-plinary full immersion technology and the first installation of a six-sided CAVE system. The DiVE represents a unique opportunity to interact with three-dimen-sional data in an active way, Brady said. Not only is the virtual reality visible to features
  • 28. the observer on all sides, but the special stereo glasses also provide depth to the flat images. To further engage active interactions with the virtual environ-ment, a motion-sensing “wand” can be used to control navigation and move-ment of objects, which is then projected in real time. These features have attract-ed attention from around the Duke research community, leading to many interdisciplinary projects utilizing the DiVE from Pratt, Trinity College of Arts and Sciences, and even Duke University Hospital. One department that has utilized the DiVE for cutting-edge research has been Duke’s Center for Cognitive Neuroscience. One exciting paper pub-lished in the Journal of Cognitive Neuroscience by Kevin LaBar explored the concepts of fear and fear retention. LaBar’s experiments took place in the DiVE to understand how humans extin-guish fear and anxiety with the help of contextual location tools. The DiVE is also home to a myriad of student-led projects and instructional tools. Civil engineering students can uti-lize the virtual reality technology to “tour” structures they have modeled in one of their design courses; doing so allows these students to tweak their designs after experiencing their work in a way that would otherwise be impossi-ble with small, physical models. Also, the DiVE is equipped with software that can present a model of the human brain, which is implemented in neurobiology and medical school courses. Even Divinity School students can gain travel through time and space to experience a The DiVE is Duke’s only multi-disciplinary full immersion technology and the first installation of a six-sided CAVE system. computer model of Solomon’s Temple right here in Durham. Currently, programmers are working to update the DiVE to accept MATLAB commands, meaning that Duke students 26 dukengineer 2012 can physically experience the graphical outputs of their code in this common coding language. Also, the Fitzpatrick Institute for Photonics, a department housed in FCIEMAS, has recently accepted its first postdoctoral candidate whose work will focus on using the DiVE to study display fidelity and inter-action fidelity in the context of a fully immersed environment.
  • 29. 2012 dukengineer 27 With advances in the realm of virtual reality also comes the need to promote the DiVE as a medium for more studies, both in and out of Pratt. Students from every department at Duke are encour-aged to apply to use the DiVE for their projects. Those interested in learning more about Duke’s innovative virtual reality and visualization research and experiencing this technology firsthand are encouraged to visit vis.duke.edu or attend one of the weekly open houses on Thursdays at 4:30 pm. In addition to these unique lab spaces, the Fitzpatrick Center was also one of the first buildings on Duke’s campus to achieve LEED (Leadership in Energy and Environmental Design) certification, awarded by the United States Green Building Council. Isabelle Arnold, LEED AP BD+C, is an associate at ZGF and served as the LEED coordinator on the project. While designed with sus-tainability in mind, Arnold explained, “We did not start the project thinking we were going to pursue LEED; LEED was a very young system at the time.” The decision was made to pursue LEED Certification later in the design process. However, Arnold noted that there were very few changes to the design itself once the goal of LEED Certification was solidified stating “the pieces were in place.” To achieve its LEED silver certifica-tion, a variety of environmental features were implemented. The Fitzpatrick Center earned points in five major LEED categories: site selection, water efficiency, energy and atmosphere, indoor environ-mental quality, and materials and resources. The most innovative environ-mental measure implemented, Arnold said, is the economic organization of the building program. Laboratory spaces with unique air quality or water needs were ‘blocked’ together, significantly reducing energy consumption. Similarly, offices were placed all along the perime-ter of the building to receive as much daylight as possible. Guthrie said that the final product, “[FCIEMAS] is really a unique assem-blage of different types of program and hopefully it’s creating a really exciting mix of research and student life.” When Bejan was asked if he believed that the Fitzpatrick Center had success-fully accomplished its goal of creating an interactive collision and interaction space between intellectuals of different disci-plines, Bejan offered a guarded yes, but stressed that a great idea transcends bor-ders. “I think that people work together, as creators of ideas, because they are attracted to the idea,” he explained. “Collaboration is lot like a lightning bolt from the cloud to the church steeple. Completely unknown before it happens, but striking when it does, and memorable when there is impact on the ground.” Cameron McKay, Jimmy Zhong, Lauren Shwisberg and Tejen Shah PETER WILSON, ZGF ARCHITECTS LLP
  • 30. Research Cutting Edge Soft Matter A look into the field of soft materials research 28 dukengineer 2012 Recently, the National Science Foundation funded a massive $13.6 million under-taking to establish the Triangle Materials Research Science and Engineering Center (MRSEC) in North Carolina. The MRSEC — an intercollegiate collab-oration between the schools in the Research Triangle area, namely Duke University, North Carolina State University, University of North Carolina – Chapel Hill, and North Carolina Central University — will focus on advancing the current knowledge in the field of “soft matter” research. A team of 20 faculty members from across these four schools has assembled in an effort to develop intricate new types of soft matter that exhibit unique functional properties. Leading this team of MRSEC investigators is Gabriel Lopez, Ph.D., Pratt professor of biomedical engineering and mechanical engineering and materials science. Lopez received his Ph.D. from the University of Washington by developing a method for changing the surface properties of different materials by coating them with ultrathin polymer layers. He continued his research as a postdoc-toral fellow at Harvard University, where he studied how to control cell growth using micropatterns in sur-face chemistry of culture substrates. Lopez came to Duke in January 2010 after establishing a biomedical engineering program at the University of New Mexico. At Duke, Lopez has been focused on conducting research in the area of soft matter. “Soft matter,” Lopez said “is basically a designation for a class of condensed matter that is based on the energy required to deform it. If the matter in question deforms easily at ambient con-ditions, then it is considered soft matter.” Some basic examples of soft matter include rubber, polymers, gels, liquid crystals, and suspensions of fine particles, many of which we use every day in the form of tires, plastic containers, cosmetic supplies, deter-gents, and foods. However, it has also become apparent that scientists can take advantage of many more of the unique properties of soft matter. Lopez believes that “a Prof. Gabriel Lopez analyzing new soft materials for the MRSEC
  • 31. frontier with regard to these materials is how we can take advantage of the fact that it is possible to design them to undergo programmed deformation on their own.” For example, Lopez seeks to capitalize on the fact that many of these materials are responsive to small environmental changes. Recently, Lopez and his research team published a paper concerning the cre-ation of a soft material coating that is able to change its structure with regard to slight fluctuations in tempera-ture. The premise of his work, which was funded by the Office of Naval Research, was to develop a type of coating that would be able to prevent bacteria from sticking to solid surfaces, an important goal with implications in many naval operations. When bacteria began to grow on these surfaces, slight variations in temperature would cause the coating to change its chemical structure, and in turn the bacteria would no longer be able to cling onto that surface. This method was shown to be very effective for the removal of bacte-ria from solid surfaces. In collaboration with Xuanhe Zhao, assistant professor of mechanical engineering and materials science, the group is now working on developing a new type of soft material coating that can change their surface properties in response to the applied voltage, instead of a change in temperature. Current test-ing is taking place at the Duke Marine Lab, where the team is hoping that applying electric fields to their soft material will be able to eliminate colonies of bacteria as well as settlements of larger organisms such as barnacles. (From left to right) Phanindhar Shivapooja, Prof. Xuanhe Zhao, and Qiming Wang holding a sheet of Kapton for biofilm release In another research initiative under the MRSEC umbrella, members of the Lopez group are synthesizing new microparticles from different polymeric materials. These particles are known as colloids when they are suspended in liq-uids and like other colloidal suspensions (including milk) they exhibit a milky appearance because of the way they scat-ter room light. The group is studying how these new materials respond to the application of acoustic fields with an eye toward developing new particulate materials for drug delivery, ultrasound imaging, medical diagnostic tests and three-dimensional colloidal assemblies. Continued research will only provide more insight and more knowledge about the properties and applications of soft materials, and scientists are only beginning to discover the benefits and uses that the wondrous world of soft matter can provide. The efforts of Lopez and the MRSEC show that inquiries into the field of soft matter are able to produce hard, tangible results. Justin Yu is a freshman majoring in Biomedical Engineering. Leah Johnson showing a sample of colliodal suspensions.
  • 32. A Natural Analog for Synthetic Biology L ingchong You, Ph.D., joined Duke University six years ago as a jointly-appointed assistant professor in the Department of Biomedical Engineering and Institute for Genome Sciences and Policy, launching his lab in synthetic biology research. Synthetic biology is a rela-tively 30 dukengineer 2012 new field that combines elements from biology and engineering to design and construct new biological systems that carry out a desired function. You’s group engineers gene regulatory networks and uses such syn-thetic systems as tools to quantitatively analyze dynamic properties of cellular networks. Synthetic biology began as a field largely focused on employing the tools of genetic engineering to reconfigure metabolic pathways of cells to perform new functions, such as the production of therapeutic compounds or the micro-bial breakdown of toxins. Synthetic biologists use recombi-nant DNA technology to piece together gene networks that produce proteins of interest or confer a desired function, in the same way that electrical engineers use resistors and capacitors to piece together electrical circuits to generate desired outputs. Over the last ten years, synthetic biology has expanded its reach to encompass the use of engineered gene circuits to analyze questions in biology. In line with this notion, the You group employs the approach of synthetic biology, cou-pled with mathematical modeling, to engineer bacterial population dynamics, quantify interactions in cellular net-works, and address unresolved questions in biology. Researchers in the You group have successfully constructed a synthetic predator-prey ecosystem consisting of two bacteri-al populations. The predator population kills the prey by causing production of a killer protein in the prey, while the prey population rescues the predators by inducing the pro-duction of an antidote protein in the predator. Along these same lines, researchers in the You lab have also engineered bacterial populations that exhibit other ecological characteris-tics, including altruistic death, wherein the death of some individuals aids in the overall survival of the population, and the Allee effect wherein a population cannot survive below a critical popula-tion density. These engineered ecosys-tems enable the study of population dynamics, within such contexts as Katy Riccione Over the last ten years, synthetic biology has expanded its reach to encompass the use of engineered gene circuits to analyze questions in biology.
  • 33. A microbial swarmbot is a small population of bacterial cells that are autonomously regulated by synthetic gene circuits and are encapsulated in microcapsules built from synthetic or natu-ral 2012 dukengineer 31 antibiotic resistance and species invasion, under a level of control that is not possi-ble in natural ecosystems. In addition to engineering synthetic gene circuits, the You group develops mathematical models that function as a simplified lens through which one can characterize biological networks. Such models, coupled with experimental vali-dation, are used extensively in the You lab to analyze a number of cellular net-works, including the aforementioned synthetic ecosystems, as well as networks that govern cell cycle entry and self-organized pattern formation. The group has used such an approach to elucidate a mode of gene regulation of potential importance in mitigating abnormal cell growth. They have found that expression of E2F, a protein family that controls genes essential for cell cycle entry, is highest under normal levels of growth factors but decreases in the presence of higher levels of growth factors (a charac-teristic of tumor cells), pointing to a potential mechanism that may play a role in modulating the development of cancer. In addition, other members of the You lab apply modeling towards studying a synthetic circuit that programs self-induced pattern formation as a potential means of understanding similar processes in nature, such as limb bud outgrowth and tissue stratification. Through their work in engineering and analyzing synthetic gene circuits, researchers in the You lab have also stumbled upon phenomena that chal-lenge common notions and assumptions in synthetic biology. In designing sys-tems, synthetic biologists generally polymers. assume a simple well-defined interface between the gene circuit and the host organism. The You group, however, has revealed that underlying and frequently overlooked parameters within the engi-neered system, such as the physical amount of the genes in the circuit (termed copy number) and how the engineered gene circuits affect growth of the host organism, can fundamentally change the predicted output of the sys-tem. Such findings have vast implica-tions for the field of synthetic biology, as they highlight the importance of under-standing how “hidden interactions” affect the behavior of the engineered gene networks. A central theme of the You lab is making use of synthetic biological sys-tems as analogs of natural systems in order to address biological questions and better understand the dynamics of cellu-lar networks. Ongoing projects could lead to new ways of fabricating materials, diagnosing and treating cancers, and fighting bacte-rial infections. In addition to such prac-tical applications, You envisions synthet-ic biology “likely transforming how future students learn biology.” It is not too far-fetched to conceive of students in an introductory biology course fiddling with gene circuits to bet-ter understand cells in the same way that students in an introductory physics course fool around with resistors and capacitors to better understand electron-ics, You said. On an even grander scale, bioengineers like to think of a world where organisms are designed to mass-produce therapeutic compounds, materi-als, and biofuels, making such products potentially cheaper and more accessible. Katy Riccione is a biomedical engineering Ph.D. candidate at Duke University. research
  • 34. Fluid Cloaking When most people hear the word cloaking, they think of Harry Potter’s invisibility cloak. Real-world cloaking, however, is defined as hiding an object from a detector or a probe. The idea of fluid cloaking was first conceived last year by Research Professor Yaroslav Urzhumov and David Smith, the William Bejan Professor of Electrical and Computer Engineering. A fluid cloak hides an object from a flowing fluid, allowing it to flow as if that object didn’t exist. Reversing the perspective, the object can move without disturbing the fluid. An object moving through a fluid normally interacts with it in two different ways. First, there is a drag force, which is essentially fric-tion in fluids. Second, the object physically pushes the fluid as it moves, leaving a void An example of an isotropically permeable metamaterial. which the fluid rushes into. Fluid cloaking eliminates these interactions. A submarine that can move without any drag essentially shoots through the water like a rocket in free space, potentially saving energy and also eliminating wake. Without any wake, a submarine can roam completely undetected. Cloaking works by taking advantage of artificially engineered structures called metamaterials. The metamaterials act like a porous mesh case that can alter the flow of fluid. “In layman terms, the structure sucks in the water in front of it, reroutes the water around it, and ejects the water at carefully engineered positions,” Urzhumov explains. The fluid must be accelerated at key areas so that the momentum and pressure of the fluid will be preserved as it passes through the cloak. 32 dukengineer 2012 In layman terms, the structure sucks in the water in front of it, reroutes the water around it, and ejects the water at carefully engineered positions.
  • 35. A computer demonstration of a fluid cloak redirecting streamlines around an object 2012 dukengineer 33 Urzhumov continues, “Because the streamlines have the same velocity in magnitude and direc-tion, it’s as if nothing really hap-pened.” The idea is similar in theory to other forms of cloaking such as electromagnetic and acoustic cloaking. However, cloaking of the fluid flow is revolutionary in certain aspects. In the other forms of cloaking, handling waves comes with innate limitations. “The need for wave velocities of particles inside that exceed the wave velocity outside is what limits the operation of optical and electromagnetic cloaks to only certain wave-lengths. It is not possible to cover the entire spectrum because that would violate causality,” Urzhumov says. In addition, optical cloaking metamaterials are typically reso-nant at selected frequencies, which leads to unwanted attenu-ation. Fluid cloaking has noth-ing to do with waves, resonances or frequencies; therefore it oper-ates with any fluid and any structural composition of the metamaterial. On the other hand, fluid flow cloaking requires physically moving a tangible substance. This factor leads to various complications concerning pressure drop, which can be compensated using micropump arrays. These microp-umps Urzhumov showing a machine that analyzes metamaterial properties must use energy; therefore, the question of whether such cloaks will be energy efficient remains unclear. The properties of cloaks comes from both the metamaterial composition and structure. In the case of fluid cloaking, the com-position is virtually irrelevant, and only the structure of the meta-material unit cell matters. The challenge comes from designing a structure that has anisotropic permeability with a gradient. An anisotropically permeable, graded structure would allow the cloak to work regardless of the fluid’s direction. A gradient is necessary because some fluid molecules must travel longer distances than the others, which forces acceleration to vary throughout the struc-ture. Currently, there is no rigorous mathematical theory for fluid research cloaking, so the research focuses on computer simulation and optimization. Urzhumov says, “The way I see this, the simplest structure would be a unit cell containing metal blades oriented perpendi-cular to each other so that you can independently control the permeability in all three direc-tions.” By rotating a blade to a certain angle with a flow direc-tion, the fluid is allowed to flow easily in that direction. This will allow the structure to be anisotropically permeable. Urzhumov adds, “Then, different thickness of the blades would allow different permeability magnitudes and create the neces-sary gradient… Micropumps will be added to ensure pressure loss compensation.” Conceived earlier this year, this innovative technology has already attracted a lot of atten-tion from the experts. “I don’t know if I can see this approach scaled up for large ships, but realistically I can see this tech-nology for highly maneuver-able, stealthy unmanned sub-marines,” Urzhumov says. The defense organizations could theoretically use this technology to let eavesdropping devices roam free in the territorial waters of any country. Also, marine experts can use fluid cloaking to observe underwater life without disturbing it. Urzhumov optimistically predicts, “This technology can be applied to small enough objects of any shape and kind. Seeing these micropumps as distributed propulsion systems, one can also envision aircrafts, ships and submarines doing arbitrary maneuvers in water, almost like UFOs in sci-fi movies. Unlike conventional aircrafts and ships, they do not have to rely on external streams of fluid. Such systems create the desired flow themselves.” Nathan Li is a Pratt sophomore majoring in biomedical and electrical engineering.
  • 36. SMiF Propelling World Class Research at Duke University In 2000, a university strategic planning committee, which was a collection of top administrators working to create initia-tives for the university’s future, formed the “Materials Working Group” to help catalyze nanostructured and bio-inspired materials and device research. The group realized that there was a lack of equip-ment necessary to perform high-level research for the fabrication and characteri-zation of materials, devices, and nanos-tructures. Their solution to the problem was the creation of SMIF, Duke’s resource for advanced characterization and clean-room fabrication, which is available to 34 dukengineer 2012 undergraduates, graduate students, facul-ty, and non-university researchers alike. By 2002, SMIF obtained X-ray diffrac-tion and atomic force microscopy capabil-ities, originally located in the basement of the Levine Science Research Center. A year later, a scanning electron microscope in the physics building and a small clean-room in Hudson Hall were added to the SMIF arsenal. However, it was not until 2007 that SMIF moved into the 12,000 square foot facility where it currently operates. SMIF now has more than 65 instruments serving the needs of more than 500 users across the Pratt School of Above: A Duke University researcher using a fluorescent microscope in the cleanroom “Bio Bay” Engineering, Trinity School of Arts & Sciences, the School of Medicine, neigh-boring universities, and companies across the Research Triangle Park. With the constant bustle in SMIF from its many users and projects, safety has always been an important consideration. SMIF director Mark Walters, Ph.D. explains, “The safety of students and researchers using our facility is our top priority, which is evidenced by the safety training and safety systems in the facility.” For instance, the toxic gas monitoring system in SMIF is a $1 million state-of-the- art system that can detect the type, amount, and location of any gas leak or chemical spill and immediately notify SMIF staff by wireless communication to any locality. There have been no incidents of injury since SMIF first opened. SMIF now not only offers its capabili-ties as a research facility, but also as an educational tool. The staff allows profes-sors to illustrate concepts from class at no charge. Further, several funding agencies, such as the LORD Foundation and the Donald M. Alstadt Fund, have enabled The culture of research at the Pratt School of Engineering serves as a model to many research institutions and industries across the globe. The high level of innova-tion, productivity, and advancement reflects a vibrant community of students, faculty and researchers across a range of disciplines in science and engineering. However, pioneer-ing research requires access to the most advanced equipment. That’s where the idea for the Shared Materials Instrumentation Facility (SMIF) began. Left: A Duke University Post-Doc analyzes an image of a microelectromechanical device collected on SMIF’s 3D Optical Profiler
  • 37. Duke University students performing photolithography processing in the SMIF cleanroom 2012 dukengineer 35 undergraduates to use the equipment for research projects by covering the hourly access fees typically billed to its users for operational costs. Headlining this idea is the SMIF Undergraduate User Program, or SUUP, which encourages undergradu-ate research and innovation by supplying students up to $500 a month. There are currently 23 undergraduates participating in this program. There are many reasons why SMIF stands out among other noteworthy shared facilities. SMIF owns the only elec-tron beam lithography system in North Carolina, which is capable of producing structures at the nanoscale. It also has a $1 million dollar transmission electron microscope capable of cryogenic sample imaging and 3-D tomography. The SMIF cleanroom, which was the first such facili-ty in the nation to use a “Bio Bay” for the integration of biological materials, enabling the creation of novel sensors and biomedical devices. However, since the user fees of the facility only cover operational costs, the SMIF relies on external funding for new equipment and capabilities. Currently, the staff is looking into purchasing atomic layer deposition and dip pen lithography instruments for the cleanroom and focused ion beam and thermogravimetric analyzer instruments for characterization purposes. Together this equipment carries a heavy price tag of well over $1 million. Hired in 2002, Walters oversees many of the projects inside the facility. Walters works closely with a specialized team of talented engineers to keep the facility operational: Kirk Bryson, Jay Dalton, Michelle Gignac, and Tamika Craige. The Executive Director of SMIF, Nan Marie Jokerst, Ph.D., J.A. Jones Professor of Electrical and Computer Engineering, along with the advisory committee, leads the group by keeping the facility ahead of the technological curve. “The capabilities of SMIF and its staff are here to enable cutting edge research for the faculty and students of the Pratt School of Engineering and beyond,” Walters said. The SMIF staff assists researchers by conducting training cours-es, providing technical support, and keep-ing the facility stocked with chemicals and materials. Wyatt Shields is a Ph.D. student in Prof. Gabriel Lopez’s lab in biomedical engineering. research