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Outlines some basic structure and functioning of muscles during contraction
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The ppt aims to explain the molecular basis of skeletal muscle contraction and certain applied aspects of the same. Sources include Guyton and Hall's Textbook of Physiology (South-Asia edition, Vol. 2) and C.L. Ghai's Textbook for Practical Physiology.
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Striated muscle contracts to move limbs and maintain posture. The contraction of skeletal muscles is an energy-requiring process. In order to perform the mechanical work of contraction, actin and myosin utilize the chemical energy of the molecule adenosine triphosphate (ATP).Muscle contraction results from a chain of events that begins with a nerve impulse traveling in the upper motor neuron from the cerebral cortex in the brain to the spinal cord.When the signal to contract is sent along a nerve to the muscle, the actin and myosin are activated. Myosin works as a motor, hydrolyzing adenosine triphosphate (ATP) to release energy in such a way that a myosin filament moves along an actin… Excitation–Contraction Coupling Excitation–contraction coupling is the link (transduction) between the action potential generated in the sarcolemma and the start of a muscle contraction. Sliding Filament Model of Contraction For a muscle cell to contract, the sarcomere must shorten. However, thick and thin filaments—the components of sarcomeres—do not shorten. Instead, they slide by one another, causing the sarcomere to shorten while the filaments remain the same length. The sliding filament theory of muscle contraction was developed to fit the differences observed in the named bands on the sarcomere at different degrees of muscle contraction and relaxation. The mechanism of contraction is the binding of myosin to actin, forming cross-bridges that generate filament movement
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Muscles
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Muscles
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The Cross Bridge
Cycle
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molecule is then hydrolysed while the myosin head is unattached. The ADP & Pi formed remain bound to the myosin head.
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Neuromuscular junction:
Note Ach = Acetylcholine
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Sarcoplasmic Reticulum
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Download now