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Nils Gehlenborg, PhD
Department of Biomedical Informatics
Harvard Medical School
http://gehlenborglab.org @ngehlenborghttp://gehlenborglab.org
A Unified Approach to Exploration,
Authoring, and Communication
with Reproducible Visualizations
http://gehlenborglab.org
http://gehlenborglab.org
http://gehlenborglab.org
Data
Machine
Human
http://gehlenborglab.org
Machine
Human
Data
Methods for Data Visualization and Exploration
Tools for Reproducible Research
What are applications
of data visualization?
PUBLICATION
experiment
DATA
INSIGHT HYPOTHESIS
interpretation
hypothesis
generation
EXPLANATION
“Storytelling”
PUBLICATION
experiment
DATA
INSIGHT HYPOTHESIS
interpretation
hypothesis
generation
EXPLORATION
EXPLANATION
“Storytelling”
“Pattern Discovery”
PUBLICATION
experiment
DATA
INSIGHT HYPOTHESIS
interpretation
HYPOTHESIS
hypothesis
generation
EXPLORATION
EXPLANATION
“Storytelling”
“Pattern Discovery”
HYPOTHESIS-DRIVEN DISCOVERY
PUBLICATION
experiment
DATA
INSIGHT HYPOTHESIS
interpretation
DATA
hypothesis
generation
EXPLORATION
EXPLANATION
“Storytelling”
“Pattern Discovery”
DATA-DRIVEN DISCOVERY
Insight
EXPLORATION EXPLANATION
Image Editing ToolCytoscape
Insight
EXPLORATION EXPLANATION
Image Editing ToolCytoscape
DATA PIXELS
Image Editing ToolCytoscape
DATA PIXELS
DATA PIXELS
Dead wood?
Hard to move
Keeps on giving!
Best part
Easy to share
Low-hanging fruit?
Why should we care?
Nature asked 1,576 researchers if there
is a reproducibility crisis in science.
M Baker, Nature 533, 452-454, 2016
0% 100%
No crisis (3%)
Don’t know (7%)
Slight crisis (38%)
M Baker, Nature 533, 452-454, 2016
Significant crisis (52%)
Nature asked 1,576 researchers if there
is a reproducibility crisis in science.
M Baker, Nature 533, 452-454, 2016
Intentional?
Inability to capture everything?
Inability to communicate everything?
M Baker, Nature 533, 452-454, 2016
Intentional?
Inability to capture everything?
Inability to communicate everything?
SOCIAL ISSUE
TECHNICAL ISSUES
M Baker, Nature 533, 452-454, 2016
Why does this matter
for visualization?
Discovery of Tumor Subtypes
PROBLEM 1
Visualize overlap of patient sets across two or more stratifications.
PROBLEM 2
Visualize characteristics of patient sets within a stratification of interest.
StratomeX: Exploratory Data Visualization
M Streit, A Lex, S Gratzl, C Partl, D Schmalstieg, H Pfister, P Park, N Gehlenborg, Nature Methods (2014)
M Streit, A Lex, S Gratzl, C Partl, D Schmalstieg, H Pfister, P Park, N Gehlenborg, Nature Methods (2014)
Discovery of Tumor Subtypes
PROBLEM 3
Identify relevant stratifications, pathways, and clinical variables.
Discovery of Tumor Subtypes
PROBLEM 1
Visualize overlap of patient sets across two or more stratifications.
PROBLEM 2
Visualize characteristics of patient sets within a stratification of interest.
StratomeX: Exploratory Data Visualization
M Streit, A Lex, S Gratzl, C Partl, D Schmalstieg, H Pfister, P Park, N Gehlenborg, Nature Methods (2014)
Is there a mutation that overlaps with this mRNA cluster?
Is there a CNV that affects survival?
Is there a pathway that is enriched in this cluster?
Query
Stratifications
Clinical Params
Pathways
Guided
Exploration
M Streit, A Lex, S Gratzl, C Partl, D Schmalstieg, H Pfister, P Park, N Gehlenborg, Nature Methods (2014)
Query
Rank
Visualize
Stratifications
Clinical Params
Pathways
Guided
Exploration
M Streit, A Lex, S Gratzl, C Partl, D Schmalstieg, H Pfister, P Park, N Gehlenborg, Nature Methods (2014)
?
And now what?
DATA-DRIVEN DISCOVERY
PUBLICATION
experiment
DATA
INSIGHT HYPOTHESIS
interpretation
DATA
hypothesis
generation
EXPLORATION
EXPLANATION
“Storytelling”
“Pattern Discovery”
DATA-DRIVEN DISCOVERY
PUBLICATION
experiment
DATA
INSIGHT HYPOTHESIS
interpretation
DATA
hypothesis
generation
EXPLORATION
EXPLANATION
“Storytelling”
“Pattern Discovery”
DATA-DRIVEN COMMUNICATION
DATA-DRIVEN DISCOVERY
finding figure/videoAuthoringExploration Presentation
DATA-DRIVEN COMMUNICATION
finding figure/videoAuthoringExploration Presentation
Current Model
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
finding figure/videoAuthoringloration Pre
What we show.
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
finding figure/videoAuthoringloration Pre
What we show.
What we tell.
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
finding figure/videoAuthoringloration Pre
What we show.
What we did.
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
finding figure/videoAuthoringloration Pre
What we show.
What we did.
DATA-DRIVEN DISCOVERY
CLUE
vistories
Authoring
Exploration Presentation
Vistories
DATA-DRIVEN COMMUNICATION
DATA-DRIVEN DISCOVERY
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
Exploration
Authoring
Presentation
VISTORY = visualization + story + history
VISTORY = visualization + story + history
Do collaborative data analysis.
Use during peer-review.
Publish with a paper.
Embed in a presentation.
49
50
H Stitz et al., to appear in Proceedings of VAST 2018
Marc Streit Lab: Vistories in Action
Retrieval and Analysis of Visualization Provenance
H Stitz et al., work in progress
Marc Streit Lab: Vistories in Action
Vistories integration with Jupyter Notebooks
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
Reproducible
Interactive
Visualizations
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
http://vistories.org
DATA-DRIVEN DISCOVERY
DATA-DRIVEN COMMUNICATION
http://vistories.org
SAMUEL GRATZL
ALEXANDER LEX
MARC STREIT
Vistory “Visualization”

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STOPPED FLOW METHOD & APPLICATION MURUGAVENI B.pptx
 

A Unified Approach to Exploration, Authoring, and Communication with Reproducible Visualizations