El documento repite continuamente la fecha "viernes 3 de diciembre de 2010" y contiene imágenes anatómicas del cerebro y su irrigación sanguínea. Explica conceptos clave como la unidad neurovascular, la barrera hematoencefálica y los mecanismos de protección del flujo sanguíneo cerebral.
82. 81
Garun odoleztatzea
viernes 3 de diciembre de 2010
83. 81
Garun odoleztatzea
Enrike G. Argandoña
Neurozientzia kliniko eta esperimentaleko laborategia (LaNCE)
Euskal Herriko Unibertsitatea
http://www.ehu.es/LaNCE
Iruñea. Uztaila 2006
viernes 3 de diciembre de 2010
94. 85
Garun odoleztatzea
Babes mekanismoak
viernes 3 de diciembre de 2010
95. 85
Garun odoleztatzea
Babes mekanismoak
Zirkulazio sistemikoaren kontrola
viernes 3 de diciembre de 2010
96. 85
Garun odoleztatzea
Babes mekanismoak
Zirkulazio sistemikoaren kontrola
Garun-odol basoen autorregulazioa
viernes 3 de diciembre de 2010
97. 85
Garun odoleztatzea
Babes mekanismoak
Zirkulazio sistemikoaren kontrola
Garun-odol basoen autorregulazioa
Fluxuaren banaketa
viernes 3 de diciembre de 2010
138. a
Tipos de transporte
b c d e
Paracellular aqueous Transcellular Transport proteins Receptor-mediated Adsorptive
pathway lipophilic transcytosis transcytosis
pathway
Water-soluble Lipid-soluble Glucose, Vinca alkaloids, Insulin, Albumin, other
agents agents amino acids, Cyclosporin A, transferrin plasma proteins
nucleosides AZT
+++
+ +
+++
Blood –––– +
–+ + –
+ +
–+ + –
+
Tight
junction
–+ + + –
+ +
–+ + + –
– –
Endothelium – –
+++
Brain + +
+++
Astrocyte Astrocyte
Figure 3 | Pathways across the blood–brain barrier. A schematic diagram of the endothelial cells that form the blood–
brain barrier (BBB) and their associations with the perivascular endfeet of astrocytes. The main routes for molecular
traffic across the BBB are shown. a | Normally, the tight junctions severely restrict penetration of water-soluble
viernes 3 de diciembre de 2010
139. 119
Unidad neurogliovascular
euron
Review
ure 4. Schematic of the Neurovascular Unit
Endothelial cells and pericytes are separated by the basement membrane. Pericyte processes sheathe most of the outer side of the basement membr
nts of contact, pericytes communicate directly with endothelial cells through the synapse-like peg-socket contacts. Astrocytic endfoot processes uns
microvessel wall, which is made up of endothelial cells and pericytes. Resting microglia have a ‘‘ramified’’ shape. In cases of neuronal disorders th
imary vascular origin, circulating neurotoxins may cross the BBB to reach their neuronal targets, or proinflammatory signals from the vascular cells or r
illary blood flow may disrupt normal synaptic transmission and trigger neuronal injury (arrow 1). Microglia recruited from the blood or within the brain
viernes 3 de diciembre de 2010
sel wall can sense signals from neurons (arrow 2). Activated endothelium, microglia, and astrocytes signal back to neurons, which in most cases agg