Roche Quantitative Systems Pharmacology methodology workshop February 4th-5th, 2016, Basel, Switzerland Bringing multi-level systems pharmacology models to life Natal van Riel Abstract Computational modelling in Systems Medicine and Systems Pharmacology addresses biological processes at different levels and scales. The quantification of model parameters from experimental data is a complicated task. It will be addressed how variance in data propagates into parameter estimates and, more importantly, model predictions. The Analysis of Dynamic Adaptations in Parameter Trajectories (ADAPT) approach is discussed as method to model dynamics at multiple time-scales. Two examples will be provided: 1) modelling of longitudinal data in a cohort of Type 2 Diabetics using different medication, and 2) the application in preclinical research studying the effect of liver X receptor activation on HDL metabolism and liver steatosis.