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cardiac muscle.pptx

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Cardiovascular Physiology
Cardiovascular Physiology
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cardiac muscle.pptx

  1. 1. CHARECTERISTICS OF CARDIAC MUSCLE
  2. 2. • The heart is composed of three major types of cardiac muscle: • Atrial muscle • Ventricular muscle • Specialized excitatory and conductive muscle fibers • Three layers viz. Epicardium , Myocardium and Endocardium
  3. 3. • Show Striations and Involuntary • Plasma membrane is called sarcolemma • Sarco tubular system is different from skeletal muscle • Presence of Intercalated discs which contains desmosomes and gap junction. • Functions as syncytium • They have prolonged Action Potential and Plateau phase
  4. 4. Cardiac Muscle Skeletal Muscle Location of T tubules At Z line At A-I junction Diameter of T tubules More less L tubules Narrow tubular cistern (Diad) Large dialated cistern (triad)
  5. 5. The velocity of conduction of AP in both Atria and Ventricle is 0.3 to .05 m/s (1/10 of that of Skeletal muscle).
  6. 6. • Calcium induced Calcium release from sarcoplasmic reticulum during excitation contraction coupling. • Does not show Tetany • Has the property of Automatic rhythmic discharge and contraction
  7. 7. Rhythmic Discharge of SA Node
  8. 8. MYOCARDIAL ACTION POTENTIAL
  9. 9. • Rapid depolarization (Phase 0) – due to Na+ influx • Rapid Repolarization (Phase 1) - Due to closure of Na+ channels • Slow depolarization (Phase 2) - this is called Plateau phase and is maintained for 200 – 300 ms – due to Ca++ influx • Repolarization (Phase 3) – due to K+ efflux • Resting Membrane Potential (Phase 4)

Hinweis der Redaktion

  • ) the same fast sodium channels as those in skeletal muscle and (2) another entirely different population of slow calcium channels, which are also called calcium-sodium channels
  • DESMOSOMES ARE CELL ADHESIVE JUNCTIONS WHICH ARE ATTACHED TO INTERMEDIATE FILAMENTS(WHICH IS A TYPE OF CYTOSKELETAL FILAMENTS)
  • The normal refractory period of the ventricle is 0.25 to 0.30 second, which is about the duration of the prolonged plateau action potential. about 0.05 second during which the muscle is more dif- ficult than normal to excite but nevertheless can be excited by a very strong excitatory signal,
    AUTOMATICITY IS THE ABLITIY OF HEART TO ITITIATE THE BEAT CONTINOUSLY AND REGULARLY WITHIUT EXTERNAL STIMULATION
    However, it is the influx of extracellular Ca2+ through the voltage-sensitive DHPR in the T system that trig- gers calcium-induced calcium release through the RyR at the sarcoplasmic reticulum
  • RMP IS is unstable ranges from -60 to -40 MV DUE TO LEAKY NA and CA channels AND IT RISES SUCCesively between two beats. SYMPATHETIC STIMULATION INCREASES THE RATE OF DISCHARGE WHILE PARASYMPATETIC DOES VICEVERSA

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