Enz Kinetics

2 (of many) Conditions Necessary for an Organism to be Labeled as Alive: ,[object Object],[object Object],[object Object],[object Object]

-Free Energy is plotted against the progress of the chemical reaction.

Enzymes – From Greek meaning “in yeast” ,[object Object],[object Object],[object Object],[object Object],Lehninger 4 th edition

Binding Energy ,[object Object],[object Object],[object Object],[object Object],[object Object]

Enzyme Kinetics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Initial Velocity ,[object Object],[object Object],[object Object],[object Object],[object Object],Lehinger – 4 th edition

General Theory of Enzyme Action ,[object Object],[object Object],[object Object],[object Object],Lehinger – 4 th edition

Steady-state Kinetics ,[object Object],[object Object],[object Object],[object Object]

Relationship between [S] and reaction rate ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Relationship between V max and V 0 and K m ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Lehinger – 4 th edition

Lineweaver-Burke Plot ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Lehninger, 4 th ed. www.bio.mtu.edu/campbell/401lec12p6.html

K m ,[object Object],[object Object],[object Object],Lehninger, 4 th ed.

K cat ,[object Object],[object Object],[object Object],[object Object],[object Object]

The Specificity Constant ,[object Object],[object Object],[object Object],Lehninger, 4 th ed.

Catalysis of Reactions with >1 Substrate ,[object Object],Lehninger, 4 th ed.

[object Object],[object Object],[object Object],[object Object],Lehninger, 4 th ed.

Enzyme Inhibition ,[object Object],[object Object],[object Object],[object Object],[object Object]

Inhibition of Enzymes – Reversible Inhibition ,[object Object],[object Object],[object Object],[object Object],Lehninger, 4 th ed.

Competitive Inhibition – “Apparent Km” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ritonavir http://en.wikipedia.org/wiki/Enzyme_inhibitor

Uncompetitive Inhibition - “Apparent Km” ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mixed Inhibition ,[object Object],Lehninger, 4 th ed.

http://images.google.com/imgres?imgurl=http://www.ucl.ac.uk/~ucbcdab/enzass/images/Dixon%2520comp.png&imgrefurl=http://www.ucl.ac.uk/~ucbcdab/enzass/inhibition.htm&usg=__kT3CyjZDh73oVD5KPC6D8JcOq3Y=&h=429&w=535&sz=16&hl=en&start=18&um=1&tbnid=hv6UO92puA1LM:&tbnh=106&tbnw=132&prev=/images%3Fq%3Dcompetitive%2Binhibitor%26um%3D1%26hl%3Den%26client%3Dfirefox-a%26rls%3Dorg.mozilla:en-US:official%26sa%3DN ,[object Object],[object Object],[object Object]

Irreversible Inhibition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],en.wikipedia.org/wiki/Enzyme_inhibitor

Chymotrypsin ,[object Object],[object Object],[object Object],Lehninger, 4 th ed.

Protein Kinase A ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

Practice Problems ,[object Object],[object Object],[object Object],[object Object],[object Object]

Enz Kinetics

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