Dag Andersson - CEO Diaverum Presentation at the INSEAD Health Summit 2010 Paris, Chronic Diseases Panel,

1. Chronic Diseases – The Everyday Epidemic Dag Andersson CEO Diaverum Renal Services Group October 8, 2010 - Paris, France

8. Prevalence of risk factors for CKD in US population October 8, 2010 Table 2. Prevalence of Risk Factors for Chronic Kidney Disease in US Population Risk Factor Estimated Prevalence Estimated No. Diabetes mellitus Diagnosed 5.1 10.2 million Undiagnosed 2.7 5.4 million Hypertension 24.0 43.1 million Obesity 19.8 35.5 million Systemic lupus erythematosus 0.05 239,000 Functioning kidney graft 0.03 88,311 African American 12.3 34.7 million Hispanic or Latino (of any race) 12.5 35.3 million American Indian and Alaska Native 0.9 2.5 million Age 60-70 7.3 20.3 million Age ≥ 70 9.2 25.5 million Acute kidney injury 0.14 363,000 Daily NSAID use 5.2 13 million Yearly NSAID use 30 75 million Note: Prevalence values expressed as percent of US population. Values for systemic lupus erythematosus, functioning kidney graft, acute kidney disease, and NSAID use are approximate. Abbreviation: NSAID, nonsteroidal anti-inflammatory drug. Source: American Journal Of Kidney Disease

9. End-stage renal disease due to diabetes October 8, 2010 Source: USRDS

11. Prevalence of end-stage renal disease October 8, 2010

17. Type of dialysis providers (excluding non-profit) and market growth rates October 8, 2010 Source: Fresenius Medical Care Annual Report 2008; Diaverum market intelligence

18. Reimbursement per treatment in hemodialysis varies among countries October 8, 2010 EUR

22. Clinical and sociodemographic risk factors for CKD October 8, 2010 Table 1. Potential Risk Factors for Susceptibility to and Initiation of Chronic Kidney Disease Clinical Factors Sociodemographic Factors Diabetes Older age Hypertension US ethnic minority status (African American, American Obesity Indian, Hispanic, Asian, or Pacific Islander) Autoimmune diseases Exposure to certain chemical and environmental conditions Systemic infections Low income/education Urinary tract infections Urinary stones Lower urinary tract obstruction Neoplasia Family history of chronic kidney disease Recovery from acute kidney injury Reduction in kidney mass Exposure to certain drugs Low birth weight Adapted with permission from National Kidney Foundation Clinical Practice Guidelines for CKD.5 Source: American Journal Of Kidney Desease

23. Criteria for the definition of CKD October 8, 2010 Table 4. Criteria for the Definition of Chronic Kidney Disease Structural or functional abnormalities of the kidneys for at least 3 months, as manifested by either: (1) Kidney damage, with or without decreased glomerular filtration rate (GFR), as defined by: ● pathologic abnormalities ● markers of kidney damage – urinary abnormalities (proteinuria) – blood abnormalities (renal tubular syndromes) – imaging abnormalities – kidney transplantation ● kidney transplant recipients (2) GFR 60 mL/min/1.73 m2, with or without kidney damage Source: American Journal Of Kidney Disease