1. © 2009 NHS National Genetics Education and Development Centre Genetics and Genomics for Healthcare
www.geneticseducation.nhs.uk
Clinical photographs - Mitochondrial
Inheritance
The following slide contains clinical photographs of the retina showing Leber hereditary
optic neuropathy, with a photograph showing a normal retina for comparison.

2. © 2009 NHS National Genetics Education and Development Centre Genetics and Genomics for Healthcare
www.geneticseducation.nhs.uk
Fig. 1.6 ©Scion Publishing Ltd
Photos courtesy of Mr Graeme Black
Leber hereditary optic neuropathy
(a) Optic disc 3 weeks after patient noted reduction in vision; note hyperemia of disc with blurred margins. (b)
Retina of uncle; vision lost several years previously. Note pallor of disc particularly temporally corresponding to
optic atrophy. (c) Normal retina.
Photos courtesy of Mr Graeme Black, St Mary’s Hospital, Manchester.