drug

1. INDOMETHACIN
GENERIC NAME : INDOMETHACIN
ROUTE : Oral, Eye drops, and suppository
DOSE : 25 -50 mg BD-TDS .
PHARMACOLOGICAL CLASS: NSAIDS ; non- selective COXinhibitors (indole derivatives)
MECHANISM OF ACTION:
 It has potent anti inflammatory effect
 It is highly potent inhibitor of prostaglandin (PG) synthesis
 It inhibits the migration of neutrophils to inflamed area
 It prompt the antipyretic action
 It relieves only inflammatory or tissue injury related pain
 In toxic doses it uncouples oxidative phosphorylation
THERAPEUTIC USES :
 Ankylosing spondylitis
 Acute gout
 Psoriatic arthritis
ADVERSE EFFECTS :
 GIT : gastric irritation, nausea, anorexia, GI bleeding, diarrhoea
 CNS : frontal headache,dizziness, ataxia, mental confusion, hallucination, depression and
psychosis
 Leucopenia, rashes,hypersensitivity reactions
 Increased bleeding due to decreased platelet aggregability
CONRAINDICATION :
 Epileptic patients
 Psychiatric patients
 Patients with renal disease, pregnant women, and in children .