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DNA Repair Mechanisms Maria Fernanda Sánchez Rico Third Semester Medicine – UPB 2010
Folding
Folding
Introduction Cells have the ability to detect and repair the damage that DNA might suffer. When DNA sequence is damaged and left uncorrected, the cells can accumulate mutations and function improperly.  To prevent these kinds of failures, the cell has DNA repair mechanisms .
  Researchers identify DNA damage repair gene in Fanconi anemia pathwayNewswire The Rockefeller University(July 20, 2010)     
Researchers identify DNA damage repair gene in Fanconi anemia pathway ,[object Object]
When one of the proteins in the FA  pathway is damaged, the result is Fanconi Anemia, which can cause various forms of cancer.,[object Object]
Researchers identify DNA damage repair gene in Fanconi anemia pathway ,[object Object]
The nuclease domain can cut DNA
FAN1’s restorative ability lie in the capacity to interact with ubiquinated proteins.,[object Object]
Drug that Inhibits DNA-repair Enzyme Shrinks Some Breast and Ovarian TumorsNCI Cancer Bulletin(July 13, 2010)
Drug that Inhibits DNA-repair Enzyme Shrinks Some Breast and Ovarian Tumors ,[object Object]
Two phase II clinical trials were made to prove that olaparib shrinks tumors in women with inherited BRCA1 or BRCA2 mutations,[object Object]
27 women received 100mg of olaparib twice a day            tumors shrank in 6 women in this group.,[object Object]
24 received 100mg of olaparib twice a day         tumors shrank in 3 women in this group. ,[object Object]
Medical Utility
Medical Utility ,[object Object], 
Medical Utility Researchers identify DNA damage repair gene in Fanconi anemia pathway ,[object Object]
FAN1 might also be related with multiple types of cancer. 
Medical Utility Drug that Inhibits DNA-repair Enzyme Shrinks Some Breast and Ovarian Tumors ,[object Object]

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