English students sofia. Immunology

2. Immune recognition and injury of self tissues (autoimmunity) results from a loss of self tolerance. Definition

4. Causes of Autoimmunity

8. Molecular Mechanisms of Autoimmunity

9. Cross-Reactivity Molecular Mechanisms of Autoimmunity

11. Molecular mimicry- model in IDDM Molecular Mechanisms of Autoimmunity

17. Immune dysregulation A defect in any arm of the immune system can trigger autoimmunity Complement T cells B cells

21. Th1/Th2 immune response

22. Cytokine Dysregulation in Autoimmunity CD = Crohn’s Disease

28. H LA testing in diseases

29. HLA association with IDDM in Bulgarian population

30. HLA association with MS and JCA in Bulgarian population

31. Вероятен молекулен модел за автоимунна болест  - верига  - верига 57-58 3-ти HVR: 70-74

32. Exceptions to the Rule – Simple Genetic Autoimmune Illnesses Failure of apoptotic death of self reactive T or B cells FAS, FASL ALPS (autoimmune lymphoproliferative syndrome ) Decreased generation of Tregs FOXP3 IPEX (Immunodysregulation, polyendocrinopathy, enteropathy, X-linked) Decreased expression of self-antigens in the thymus, resulting is a defect in negative selection AIRE APS-1 (Autoimmune polyglandular syndrome type 1) Mechanism Gene Disease

38. Estrogens and Autoimmunity

39. Nature Immunology 2 , 777 - 780 (2001) Sex differences in autoimmunity

40. Pathogenetic mechanisms of Autoimmune diseases

52. Pathogenesis of SLE

60. Examples of Organ Specific Lungs of a patient with Goodpasture’s Vitiligo Hashimoto’s disease (thyroiditis)

61. Examples of Systemic Autoimmunity SLE