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Ribonucleic acid polymerase (RNAP) is an enzyme ubiquitous in biological systems. It catalyzes the synthesis of RNA biomolecules from DNA in the process of transcription. RNAP binds to a receptor in a probabilistic manner. We calculated the probability of RNAP binding from the Boltzmann equation and the law of mass action in an E. coli cell under biological conditions and derived a quantitative model which predicts the probability of RNAP binding in varying concentrations of repressor and nucleoid proteins.
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Ribonucleic acid polymerase (RNAP) is an enzyme ubiquitous in biological systems. It catalyzes the synthesis of RNA biomolecules from DNA in the process of transcription. RNAP binds to a receptor in a probabilistic manner. We calculated the probability of RNAP binding from the Boltzmann equation and the law of mass action in an E. coli cell under biological conditions and derived a quantitative model which predicts the probability of RNAP binding in varying concentrations of repressor and nucleoid proteins.
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